Shaanxi Bloom Tech Co., Ltd. yog ib qho ntawm cov neeg tsim khoom thiab cov khoom lag luam ntawm ferulic kua qaub yeej yog 1135-24-6 nyob hauv Suav teb. Txais tos rau kev lag luam wholesale loj zoo ferulic acid hmoov phoo ib 1135-24-6 kev muag khoom ntawm peb lub hoobkas. Cov kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Ferulic acid hmoov, nrog rau cov npe tshuaj ntawm 3-mexy-4-hydroxy-4-hydroxinnic acid thiab cov tshuaj siv tshuaj lom neeg ntawm C10H10o4, yog ib qho ntawm cov derivatives ntawm cinnamic acid. Hmoov daj, soluble hauv dej kub, ethanol, ethyl acetate, soluble me ntsis hauv roj av ether, benzene. Nws muaj cov ntsiab lus siab hauv ferula, angusticum chuanxiong, semen ziziphi spinasae thiab lwm yam khoom xyaw hauv Suav teb, thiab yog ib qho khoom xyaw hauv Suav teb, thiab yog ib qho khoom xyaw hauv Suav teb cov tshuaj suav. Nws muaj CIS thiab Trans ISOMERS, ob leeg yog teeb cov khib nyiab daj.
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Tshuaj Cov Qauv |
C10H10O4 |
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Muaj pes tsawg leej |
194.06 |
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Molecular hnyav |
194.19 |
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m/z |
194.06 (100.0%), 195.06 (10.8%) |
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Kev Ntsuam Xyuas |
C, 61.85; H, 5.19; O, 32.96 |
Hluav taws xob hluav taws xob tsis ua hauj lwm yog feem ntau tshwm sim los ntawm kev mob oxidative oxidative. Hluav taws xob puas tsuaj rau lub cev tuaj yeem muab faib ua kev puas tsuaj ncaj qha thiab kev puas tsuaj uas tsis ncaj ncees. Kev puas tsuaj ncaj qha, uas yog, hluav taws xob ncaj qha ua rau tawg ntawm qee cov molecules hauv cov hlwb; Kev raug mob yog tshwm sim los ntawm radiolysis ntawm dej, uas ua rau kev nce ntawm intracellular cov pa oxygen reasening. Yog li no, tshuaj tua kab mob tau siv dav hauv kev kho mob ntawm kev raug mob hluav taws xob.
Txhawm rau tiv thaiv cov hlwb los ntawm reactive oxygen hom (Ros) kev puas tsuaj, nws yog qhov tsim nyog los tswj cov kab ke ntawm cov tsev pheeb suab
Glutathione muab txoj kev txo qhov sib npaug rau kev hloov pauv ntawm hydrogen peroxide thiab lipid dej cawv, thiab tiv thaiv sulidhide rau hauv pab pawg sulfhydry los ntawm oxidative kev puas tsuaj. Tus nqi lim dej ntawm glutathione biosalyzed los ntawm glutamate cysteine ligase (gclc) thiab cov kev cai lij choj subunit (GCLM). Nicotinamide Adenine TinucleTide PhoospleTide nyob rau hauv cov ntaub so ntswg, uas tuaj yeem tswj hwm cov hlwb los txo cov kev txo qis ntawm cov ntsej muag sib luag thiab Thioredoxin.
Ferulic acid hmoov, raws li cov phenolic cog feem, muaj cov kev ua kom muaj zog thiab muaj lub luag haujlwm zoo hauv kev txhawb kev noj qab haus huv tib neeg. Ferulicic acid tuaj yeem ua kom cov ntsiab lus ntawm glutathione thiab nicotinamide adenine cinned hlwb, thiab muaj cov nyhuv tiv thaiv ntawm iradiated cov hlwb Opradiated. Heme poxyenase yog antioxidant enzyme, uas tuaj yeem hloov ua rau HEME rau BiliverDin thiab nws thiaj li mus rau antioxidant bilirubin. Ferulic acid tuaj yeem zoo tswj cov kev qhia ntawm cov enzyme no, yog li ua si lub luag haujlwm tiv thaiv hauv hluav taws xob.
2. Antioxidant muaj nuj nqi
Metabolism yog tus yam ntxwv ntawm lub neej. Nyob rau tib lub sijhawm, lub neej ib txwm tawm tsam los ntawm cov tshuaj oxygen ua haujlwm (tseem hu ua molecules hloov tshiab los yog molecules nyob rau hauv cov xeev tshwj xeeb nrog cov tshuab hluav taws xob tshwj xeeb nyob rau hauv lub orbit). Ob qho ntawm cov tshuaj no tuaj yeem koom nrog cov qog nqaij hlav lossis ntxias cov kabmob ntawm carcinogens yog hloov pauv cov kabmob hlwb kom txo qis kev puas tsuaj rau cov kabmob hlwb.
Qee qhov kev tshawb fawb tau qhia tias ferulic acid tuaj yeem tua dawb radicals thiab rov qab ua haujlwm ntawm lub neej. Ferulic acid yuav inhibit cov enzymes uas ua cov radicals dawb hauv lub neej. Ntawm lub hauv paus no, nws kuj tseem tuaj yeem nce cov enzymes uas tshem tawm cov radical dawb. Nyob rau tib lub sijhawm, ferulic acid tuaj yeem ua rau muaj kev ua si ntawm Anabolic enzyme thiab gluten glycation sulfoterase, thiab tswj cov feem ntawm cov tyrosinase. Cov kev tshawb fawb qhia tau hais tias ferulic acid muaj cov tshuaj tiv thaiv kab mob antioxidant zoo, thiab muaj qhov zoo tshaj plaws radicals, hydroxyl dawb radicals, poxynitro, thiab lwm yam.
3. Cov tshuaj tua kab mob thiab anti - propus functions
Txoj kev tshawb fawb pom tias tom qab cov nas tsuag kev xeem uas yog tus kab mob khaub thuas ua haujlwm tsis muaj kev kho mob ferulic, thiab cov pab pawg ntsuas tau kho thiab ua haujlwm Raws li kev tsom xam ntawm cov txiaj ntsig, kev tsim cov kev cuam tshuam, kev tsim tawm ntawm cov pab pawg xeem poob qis. Nyob rau hauv xyoo tsis ntev los no, muaj ntau cov lus ceeb toom hais txog qhov tseem ceeb tshaj plaws ntawm ferulic acid on cath txias (iv), ua pa) thiab tus kabmob HIV. Cov kev sib raug zoo ntawm ferulic acid thiab ua rau cov protein tau kawm hauv tib kab xov tooj ntawm tes. Raws li qhov tshwm sim, ferulic acid tuaj yeem tiv thaiv kev tsim cov protein no.
Ntawm lawv, ferulic acid muaj kev cuam tshuam ntawm HIV, uas ua rau nws muaj peev xwm ua rau ferulic acid los ua tus neeg tshuaj lom neeg kho mob yav tom ntej. Nws yog kev kwv yees hais tias lub tshuab inhibition in inhibition ntawm cov kab mob yog cuam tshuam nrog nws lub peev xwm los txo cov haujlwm ntawm xanthine oxidase. Qhov no vim tias hom enzyme no feem ntau yuav ua rau qee qhov mob. Nws yog kev xav tias cov ua haujlwm tua hluav taws xob ntawm ferulic acid feem ntau yog vim nws muaj zog inhibition nyob rau n {{acetyltransfertase hauv cov kab mob.
Cov hau hluav taws xob
Direct Extraction los ntawm cov nroj tsuag
Ferulic acid hmoovYuav tau txais los ntawm cov nroj tsuag hauv peb txoj kev: ua ntej, los ntawm kev sib xyaw ua ke ntawm ferulic acid thiab qee qhov thib ob, los ntawm tsob ntoo cell phab ntsa, thiab thib peb, los ntawm cov nqaij kab lis kev cai. Hauv cov nroj tsuag, ferulic acid feem ntau hla-}}} Txuas nrog polysacchar lossis tus kheej esterification lossis etherification los yog etherification los tsim ferulic acid. Feem ntau, cov qauv ester tau tawg los ntawm cov qauv alkali thiab enzyme coj los tso ferulic acid, thiab tom qab ntawd cov kuab tshuaj uas tsim nyog siv rau extraction.
Ferulic acid los ntawm phab ntsa cell tuaj yeem tso tawm thaum 4% sodium hydium hydroxide yog siv los ua kom muaj kev cuam tshuam ntawm chav tsev kub rau 24 h hauv qab cov nitrogen. Cov kev tshawb fawb tsis ntev los no tau pom tias feem ntau ferulic acid nyob rau hauv cov nplej bran tuaj yeem tso tawm nyob rau hauv ib lub sijhawm luv luv los ntawm kev nce qib kub thiab ntxiv cov neeg sawv cev tsim nyog. Qhov qis ntawm cov sodium hydrocide daws yuav tuaj yeem tso tawm feem ntau ntawm cov nplej bran ntawm cov nplej uas tsim nyog. Ntxiv sodium sulfite hauv cov txheej txheem rho tawm tuaj yeem nce rov qab tus nqi rov qab ntawm ferulic acid. Vim tias cov composion ntawm Alkali Dej cawv, tshwj xeeb tshaj yog cov khoom siv kua qaub, ntawm cov khoom sib cais ntawm cov pob zeb alkali yog mas cov qauv roj carbon adsorption mas Lub Oryzanol muaj cov txheej txheem ntawm ferulic acid, uas tshwm sim hauv daim ntawv ntawm ester thiab yog yooj yim rau decompose. Yog li ntawd, Oryzanol tuaj yeem yog hydrolyzed los ntawm alkali thiab tom qab ntawd acidified los npaj ferulic acid. Cov tshuaj hydrolysis ntawm Andyzanol los npaj ferulic acid yog ib qho yooj yim rau kev ua haujlwm, thiab cov txiaj ntsig yog nce txog 85.7%. Tus los ntawm - cov khoom yog dej cawv napalm. Ntxiv mus, Oryzanol muaj ntau qhov chaw, cov zis loj thiab tus nqi nruab nrab.
Ferulic acid Esterase yog ib qho enzyme uas tuaj yeem pub dawb ferulic acid los ntawm methyl ferulate, oligosaccharide ferulic ferulic acid. Fungi, cov kab mob thiab cov poov xab tuaj yeem zais ferula fereerase. Cov kev npaj enzyme tau npaj muaj ferulase thiab Arabinoxylanase tau npaj los ntawm submerged fermerged fermerged fermerged fermentation nrog asnepergillus niger raws li txoj kev lim. Kev npaj enzyme sib xyaw tau siv los ua ntawm cov nplej starchy bran. Nws tau pom tias qhov kev ua phem ntawm cov qoob num tom qab peb zaug ntawm kev ua tsis taus yog 55.46%.
Siv cov ntaub so ntswg cog yog ib txoj hauv kev tseem ceeb kom tau txais cov kua qaub ferulic. Qee qhov kev tshawb fawb tau pom tias cov nqaij kab lis kev cai ntawm qee cov nroj tsuag tuaj yeem tsim cov kua qaub ferulic acid derivatives nrog siab tawm los. Piv txwv li, dej solucose ferulate thiab sucrose ferulate thiab pob kws, nrog cov ntsiab lus li 20.0 μ mol / g callus (qhov hnyav). Hauv kev rho tawm ncaj qha, cov ntsiab lus ntawm ferulic acid yog tsawg, uas xav tau kev ua kom huv ntxiv.
Tshuaj Lom Neeg Hluav Taws Xob
The chemical synthesis of ferulic acid takes vanillin as the basic raw material, and the main organic reactions are Wittig Horner reaction and Kneoevenagel reaction.
Cov Wittig Horner cov tshuaj tiv thaiv ntawm Triethyl phosphate acetate thiab acetyl vanillin siv cov hauv paus muaj zog, thiab ferulic acidificial nrog fydrochloric acid. Cov qauv no yuav tsum tau tiv thaiv phebolly hydroxyl ua ntej, vim muaj cov pab pawg muaj zog ntawm carbonyyl, thiab nws yog ib qho yooj yim los tsim cov impurities los ntawm cov kev phiv tshuaj.
Ib qho me me ntawm cov organic puag hauv pyridine ntau li catalyst, vanillin thiab malicmin thiab malonic acid yauv ua kom tsim cov roj acid dhau los, thiab cov catalysts suav nrog Piperidine thiab Aniline. Txawm li cas los xij, lub sijhawm tiv thaiv ntev, txog li peb lub lis piam, thiab kev sib xyaw ntawm trans thiab CIS ferulic acid tau txais.
Biosynthesis yog siv ob peb cov kab mob sib kis los hloov cov roj ntsha uas muaj acid, xws li eugenol encnamate muab rho tawm los ntawm clove roj rau hauv ferulic acid. Biosynthesis yog cov qauv huv thiab zoo tshaj plaws, tab sis tsis muaj ib txoj kev ntau lawm.
Cais thiab ua kom huv txoj kev
Tam sim no, tsis muaj ntau txoj hauv kev los ua kom huv si ferulic acid. Nws yog feem ntau suav nrog cov kuab tshuaj rho tawm thiab txoj kev adsorption.
Cov kuab tshuaj uas feem ntau siv rau kev rho tawm cov roj solubility nrog cov kuab tshuaj thiab tom qab ntawd nws cov kuab tshuaj thiab tom qab ntawd Cov txheej txheem yooj yim, tab sis cov txiaj ntsig yog tsawg, thiab siv zog siv zog yog loj. Nws yog qhov feem ntau siv txoj kev los ua kom huv cov kua qaub ferulic acid.
Adsorption yog txoj kev huv uas tau kawm ntau zaus tam sim no. Lub ntsiab cai yog ntxiv cov ntaub ntawv adsorption adsorb thiab enrich ferulic acid hauv kev daws, thiab tom qab ntawd siv elute cov adsorbed ferulic acid. Cov pa roj carbon ntau, polystyrene hla-}} Linked cob, Pvpp thiab lwm cov adsorption xov xwm tau kuaj. Txoj kev tshawb no pom tias cov carbon ua kom zoo tshaj plaws rau cov khoom nruab nrab ferulic. Tom qab qhib cov pa roj carbon adsorption tiav, cov adsorbed ferulic acid tuaj yeem ntxuav tawm nrog ethanol. Tsis tas li ntawd, cov pa roj carbon ntau kuj yog cov khoom adsorption zoo heev. Tom qab cov kev daws teeb meem tau adsorbed los ntawm cov pa roj carbon ua haujlwm, thaum cov pa roj acid actively, cov tshuaj ntsuab ntshiab tuaj yeem tau txais los ntawm kev rho tawm ntawm kev tsis txaus siab.
Zoo & Kev Ntsuam Xyuas
Kev ua tau zoo kua chromatography:
Cov ntsiab lus ntawmFerulic acid hmoovtau txiav txim los ntawm HPLC. Cov txheej txheem yooj yim, sai sai, raug thiab meej. Raws li cov ntawv nyeem, theem txawb no tsuas yog admic acidic system, Methanol tshuaj acathoric acid system, thiab lwm yam ntawm methanol acid system, thiab lwm yam ntawm methanol tau hloov kho hauv kev sim. Cov ntsiab lus ntawm ferulic acid nyob rau hauv compound gingo kua tau txiav txim los ntawm HPLC. Lub mobile theem yog Methanol: 1% glacial acetic acid (455), qhov kev kuaj pom yog 320, tus nqi txaus yog 1.0, thiab kem kub yog 25 degree. Ferulic acid oxygen Noj tau yog 0.176-0.88 μ μ txog qhov tsis muaj nyob hauv cov kab ke.
Nyias txheej Scanning Txoj Kev:
Nyias txheej scanning kuj tseem yog ib qho ntawm cov txheej txheem feem ntau los txiav txim siab cov ntsiab lus ntawm ferulic acid. Hom no yog nrawm, tab sis nws rhiab tsis zoo. (6: 0.5: 3.5: 3.5) Tau siv los tsim tus neeg saib xyuas, thiab lub tsho ntev yog siv rau Sawtooth scanning. Lub ntsej muag ntxig yog 325 nm. Ruaj khov zoo.
Nyias Txheej Spectrophotometer Txuj Ci
Qhov kev txiav txim siab zoo ntawm Ferulic Acid tau muab rho tawm los ntawm Rye Bran, ib qho kev ua liaj ua teb los ntawm - cov khoom, tau nqa tawm los ntawm nyias txheej chromatographeter. Tus tsim tawm yog Dichhloromethane: acetoniturile: formic acid =75: 25:10; Cov txiaj ntsig tau pom tias txawm hais tias txoj kev spectrophotometer tau cuam tshuam los ntawm lwm feem, cov txheeb ze cuam tshuam ntawm HPLC tau hais txog 7% thiab kev rov ua haujlwm tau zoo.
High Performance capillary Electrophoresis:
Capillary tsam Electrophoresis yog qhov ntau tshaj plaws cov siv sib cais hom ntawm capillary Electropraphoresis. Nws yog tus cwj pwm los ntawm kev yooj yim, txuag, ceev, tsawg dua cov qauv thiab kev ua haujlwm tsis siv neeg. Cov ntsiab lus ntawm ferulic acid nyob rau hauv Angelica npaj tau raug kuaj los ntawm Hollow Fused Silica capillary, thiab nws tuaj yeem pom ntau yam ntawm G / ml, nrog kev ua kom zoo dua.
Cim npe nrov: Ferulic kua qaub hmoov CAS 1135-24-6, chaw tsim khoom, chaw tsim khoom, Hoobkas, yuav, nqe, loj, loj, rau muag