Tshiab indocyanine ntsuab, tseem hu ua IR-820, yog hom ze-infrared (NIR) dye uas tuav cov txiaj ntsig kev tshawb fawb tseem ceeb hauv kev tshawb fawb txog lub neej thiab kev tshawb fawb txog biomedical. Nws zoo nkaus li xim av crystalline khoom nrog lub melting point saum 300 degree. Nws nthuav tawm ib qho kev nqus dav dav ntawm 690 nm hauv cov tshuaj aqueous, muaj cov molar absorptivity ntawm 72 x 104 dm3mol-1cm-1. Qhov no ua rau nws yog qhov kev xaiv zoo tshaj plaws rau ntau daim ntawv thov hauv kev kho mob.
Raws li tus nqi -tus neeg saib xyuas zoo uas muaj cytotoxicity tsawg, nws yog siv rau hauv cov duab-kev coj noj coj ua photothermal kho rau kev kho mob qog noj ntshav. Nws kuj tseem ua tus neeg sawv cev sib txawv rau kev kuaj xyuas thiab ntsuas cov ntaub so ntswg uas muaj kab mob hauv cov tsiaj. Tsis tas li ntawd, nws siv los ua tus cim fluorescent hauv kev tshawb fawb tshuaj qhia txog nws qhov tseem ceeb hauv biomedical sciences.
Hauv cov ntsiab lus, nws yog ntau yam nyob ze -infrared dye nrog ntau yam kev siv hauv kev kho mob, kev kho, thiab kev tshawb fawb. Nws cov khoom tshwj xeeb ua rau nws muaj txiaj ntsig zoo hauv kev nce qib ntawm kev tshawb fawb biomedical thiab kev kho mob.
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Tshuaj Formula |
C46H50ClN2NaO6S2 |
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Exact Mass |
848.27 |
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Molecular Luj |
849.47 |
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m/z |
848.27 (100.0%), 849.27 (49.8%), 850.27 (32.0%), 851.27 (15.9%), 850.28 (12.1%), 850.27 (9.0%), 851.27 (4.5%), 852.27 (3.9%), 852.26 (2.9%), 849.27 (1.6%), 853.27 (1.4%), 850.27 (1.2%), 851.28 (1.1%), 852.27 (1.1%) |
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Elemental Analysis |
C, 65,04; H, 5,93; Cl, 4,17; N, 3,30; Nws, 2,71; 11.30 Nws; Ib., 7.55 |
Tshiab indocyanine ntsuab(IR-820) yog xim xim nrog ze-infrared absorption zog. Nws cov qauv tshuaj tshwj xeeb thiab cov khoom siv kho qhov muag ua rau nws siv dav hauv ntau yam xws li tshuaj, laser thiab infrared technology.
1. Kev kuaj mob thiab kuaj mob
Daim ntawv thov nyob rau hauv kev kho mob imaging yog tshwj xeeb yog tseem ceeb. Raws li nyob ze -infrared fluorescent zas xim, nws tuaj yeem zoo siab los ntawm qhov tshwj xeeb wavelengths ntawm lub teeb thiab emit ze rau -infrared fluorescence signals, yog li ua tiav kev pom ntawm cov ntaub so ntswg lom.
Infrared blood pool contrast: Nws tuaj yeem siv los ua tus neeg sawv cev ntawm lub pas dej infrared sib piv, txhaj rau hauv tus tsiaj lub cev los ntawm cov leeg lossis peritoneum, thiab siv nws cov yam ntxwv fluorescence nyob ze - cheeb tsam infrared kom pom tseeb cov qauv vascular thiab cov ntshav ntws tawm. Cov yam ntxwv no tseem ceeb tshwj xeeb hauv kev kuaj mob qog nqaij hlav, vim cov qog nqaij hlav feem ntau muaj qhov txawv txav vascular network. Infrared blood pool imaging tuaj yeem txheeb xyuas qhov chaw ntawm qhov txhab, muab pov thawj tseem ceeb rau kev kho mob tom ntej.
Kev kuaj xyuas cov ntaub so ntswg hauv cov tsiaj muaj sia: Hauv kev sim tsiaj nyob, nws tuaj yeem sib sau ua ke hauv cov ntaub so ntswg thiab ua tiav qhov chaw ntawm cov ntaub so ntswg los ntawm fluorescence imaging technology. Qhov no tsis yog - txoj kev tshawb nrhiav pom tsis tau tsuas yog txo qhov mob ntawm cov tsiaj sim, tab sis kuj txhim kho qhov raug thiab kev ntseeg siab ntawm cov ntaub ntawv sim.
Multimodal imaging: Nws kuj tuaj yeem ua ke nrog lwm cov fluorescent probes lossis cov txheej txheem kev yees duab kom ua tiav cov duab multimodal. Piv txwv li, kev sib txuas nrog cov txheej txheem kev yees duab xws li magnetic resonance imaging (MRI) lossis xam tomography (CT) tuaj yeem muab cov ntaub ntawv qhia txog anatomical thiab kev ua haujlwm ntau dua, txhim kho qhov tseeb thiab rhiab heev ntawm kev kuaj kab mob.
2. Kev kho mob qog nqaij hlav
Nws kuj tau pom muaj peev xwm zoo hauv kev kho mob qog noj ntshav. Nws qhov tshwj xeeb ze ntawm - tus yam ntxwv nqus infrared ua rau nws yog qhov zoo tshaj plaws photosensitizer rau cov duab -kev coj noj coj ua photothermal therapy thiab photodynamic therapy.
Daim duab qhia txog kev kho mob photothermal: Nyob rau hauv qhov irradiation ntawm ze - lub teeb infrared, nws tuaj yeem nqus lub teeb lub zog thiab hloov nws mus rau hauv lub zog cua sov, tsim cov teebmeem thermal hauv zos los tua cov qog hlwb. Txoj kev kho mob no muaj qhov zoo ntawm qhov tseeb, qhov cuam tshuam me me, thiab kev ua haujlwm siab, uas tuaj yeem txhim kho kev kho mob ntawm cov qog. Lub caij no, lub sijhawm tiag tiag - saib xyuas cov txheej txheem kho mob los ntawm fluorescence imaging technology tuaj yeem ua kom qhov tseeb thiab kev nyab xeeb ntawm kev kho mob.
Photodynamic therapy: Ntxiv nrog rau cov teebmeem photothermal, nws tseem tuaj yeem tsim cov pa oxygen reactive (ROS) nyob rau hauv lub teeb stimulation, uas tuaj yeem ua rau DNA thiab cell membrane qauv ntawm cov qog hlwb los ntawm oxidative kev nyuaj siab, yog li inducing qog cell apoptosis. Qhov kev ua haujlwm thib ob ntawm kev ua haujlwm no ua rau neoindocyanine ntsuab kom muaj txiaj ntsig zoo dua thiab txo cov kev mob tshwm sim hauv kev kho mob qog.
Targeted therapy: Los ntawm kev khi neoindocyanine ntsuab nrog cov tshuaj tiv thaiv tshwj xeeb lossis cov tshuaj, lub hom phiaj fluorescent probes lossis cov neeg nqa tshuaj tuaj yeem tsim kom ua tiav cov ntawv sau tshwj xeeb thiab taug qab cov qog hlwb. Txoj kev npaj khomob no tuaj yeem txhim kho kev ua tau zoo thiab kev nyab xeeb ntawm cov tshuaj, thiab txo qis kev puas tsuaj rau cov ntaub so ntswg.
3. Kev ntsuas lub siab ua haujlwm
Nws kuj tseem muaj qee qhov kev siv tus nqi hauv daim siab ua haujlwm. Txawm hais tias nws cov txheej txheem tshwj xeeb txawv ntawm classical indocyanine ntsuab (ICG), txoj kev ntsuas lub siab ua haujlwm tshiab tuaj yeem tsim kho raws li nws nyob ze -infrared fluorescence zog. Piv txwv li, los ntawm kev saib xyuas nws cov metabolism thiab tso tawm hauv daim siab, lub zog cia thiab lub peev xwm metabolic ntawm lub siab tuaj yeem raug soj ntsuam, muab lub hauv paus tseem ceeb rau kev kuaj mob thiab kho cov kab mob siab.
Nyob rau hauv lub tshav pob ntawm laser thiab infrared technology
1. Nyob ze infrared dyes
Raws li qhov zoo tshaj plaws nyob ze -infrared dye, nws muaj cov ntawv thov dav dav hauv kev siv tshuab laser thiab infrared. Nws siab molar absorptivity thiab dav nqus band ua rau nws zoo tagnrho nce nruab nrab lossis lim hauv cov khoom siv laser.
Laser nce nruab nrab: Hauv cov khoom- lub xeev lasers, ntsuab tuaj yeem siv los ua qhov nruab nrab kom ua tiav siab - lub zog thiab siab - laser emission los ntawm kev nqus lub teeb lub zog thiab hloov mus rau hauv cov zis laser. Hom laser no muaj cov nqi siv dav hauv kev lag luam, kev kho mob zoo nkauj thiab lwm yam haujlwm.
Infrared filter: Hauv infrared optical systems, nws tuaj yeem siv los ua lub lim kom cais thiab ntxuav cov spectra los ntawm kev nqus cov wavelengths tshwj xeeb ntawm lub teeb infrared thiab xa lwm cov wavelengths ntawm lub teeb.
Hom lim no ua lub luag haujlwm tseem ceeb hauv thaj chaw xws li kev yees duab infrared thiab kev sib txuas lus infrared.
2. Cov ntawv thov kev tshawb fawb txog kev lag luam thiab kev tshawb fawb
Ntxiv nrog rau cov khoom siv laser, nws kuj tuaj yeem siv rau hauv lwm yam kev lag luam thiab kev tshawb fawb txog kev lag luam. Piv txwv li, hauv cov ntaub ntawv tshawb fawb, nws cov khoom fluorescence tuaj yeem siv los kawm txog cov qauv thiab cov khoom ntawm cov khoom; Hauv kev tshawb fawb ib puag ncig, nws tuaj yeem siv los ua fluorescent sojntsuam txhawm rau kuaj cov pa phem lossis cov khoom tsis zoo hauv ib puag ncig; Hauv kev tshawb fawb txog biomedical, nws nyob ze -infrared fluorescence zog tuaj yeem siv rau kev kuaj xyuas ntawm tes, nrhiav cov molecular, thiab lwm yam kev sim.
Lwm qhov chaw muaj peev xwm thov tau
1. Biosensors
Nws muaj cov khoom fluorescence zoo heev thiab kev ruaj ntseg tshuaj, ua rau nws yog ib qho khoom siv zoo tshaj plaws hauv kev lag luam biosensors. Los ntawm kev khi nws nrog cov biomolecules tshwj xeeb xws li tshuaj tiv thaiv kab mob, enzymes, thiab lwm yam, siab - rhiab heev thiab kev xaiv siab biosensors tuaj yeem tsim kom pom cov hom phiaj molecules (xws li qabzib, proteins, DNA, thiab lwm yam) hauv cov qauv tshuaj lom neeg. Hom biosensor no muaj cov ntawv thov dav dav hauv thaj chaw xws li kuaj kab mob thiab kev saib xyuas ib puag ncig.
2. Kev txhim kho tshuaj
Hauv cov txheej txheem ntawm kev tsim tshuaj, nws tuaj yeem siv los ua tus cim fluorescent los saib xyuas qhov tseeb -lub sijhawm faib thiab cov metabolism ntawm cov tshuaj molecules hauv lub cev. Los ntawm fluorescence imaging technology, tsub zuj zuj thiab tso tawm kinetics ntawm cov tshuaj molecules nyob rau hauv lub hom phiaj cov ntaub so ntswg tuaj yeem pom pom, yog li ntsuas qhov ua tau zoo thiab kev nyab xeeb ntawm cov tshuaj. Tsis tas li ntawd, IR-820 kuj tseem siv tau los ua ib feem ntawm cov neeg nqa tshuaj los txhim kho kev siv tshuaj thiab txo cov kev mob tshwm sim los ntawm kev xa cov tshuaj molecules rau cov ntaub so ntswg.
3. Kev ruaj ntseg thiab tiv thaiv - ntsuas kev ua txhaum cai
Cov khoom fluorescence ntawmtshiab indocyanine ntsuabkuj tseem tuaj yeem siv rau hauv kev ruaj ntseg thiab tiv thaiv - cuav. Piv txwv li, nws tuaj yeem raug ntxiv rau kev tiv thaiv - cov ntawv cuav lossis cov khoom ntim khoom, thiab tawm cov teeb liab fluorescent nyob rau hauv cov teeb pom kev tshwj xeeb kom ua tiav cov khoom pov thawj tseeb thiab kev taug qab taug qab. Qhov kev tiv thaiv no -cov cuab yeej cuav no muaj qhov zoo ntawm qhov nyuaj rau kev rov ua dua thiab yooj yim los txheeb xyuas, thiab muaj txiaj ntsig ntawm daim ntawv thov dav hauv siab - khoom kawg, tshuaj, thiab lwm yam.
Kev Taw Qhia rau Tus Neeg Saib Xyuas Qhov Sib Txawv
Contrast agents, tseem hu ua contrast media, yog cov tshuaj tshuaj txhaj los yog noj rau hauv tib neeg lub cev cov ntaub so ntswg los yog lub cev los txhim kho kev ua tau zoo ntawm kev soj ntsuam cov duab. These substances, which have a density higher or lower than the surrounding tissues, create a contrast that allows certain imaging devices to produce clearer images.
Hom Contrast Agents
- Iodinated Contrast Agents (ICAs): Cov no yog cov feem ntau siv sib piv cov neeg sawv cev nyob rau hauv interventional radiology. Lawv muaj ntau qhov sib txawv ntawm iodine thiab feem ntau siv hauv vascular thiab lub cev kab noj hniav. Piv txwv xws li iopromide (Ultravist), iohexol (Omnipaque), thiab iopamidol (Isovue). Iodinated contrast agents tuaj yeem muab faib ua ionic thiab tsis yog - hom ionic. Tsis yog- cov tshuaj ionic feem ntau tsis tshua muaj tshuaj lom thiab muaj qhov tshwm sim tsawg dua ntawm cov tshuaj tiv thaiv tsis zoo piv rau cov tshuaj ionic.
- Barium sulfate: Hom kev sib piv no feem ntau yog siv hauv kev kuaj mob plab. Nws yog cov hmoov dawb, tsis muaj ntxhiab, tsis qab ntsev uas tov nrog dej los tsim kev ncua. Thaum noj, nws coats ntawm txoj hlab pas, lub plab, thiab cov hnyuv me, ua rau kom pom kev zoo dua thaum kuaj X-ray.
- Gadolinium-Raws li Contrast Agents: Cov neeg sawv cev no yog siv hauv kev sib nqus resonance imaging (MRI) los txhim kho qhov pom ntawm cov hlab ntsha thiab lwm yam qauv. Lawv muaj gadolinium, lanthanide keeb, chelated nrog ntau yam ligands los txhim kho kev ruaj ntseg thiab txo toxicity.
Daim ntawv thov
Cov neeg sawv cev sib txawv yog siv ntau yam ntawm cov txheej txheem duab, suav nrog tab sis tsis txwv rau:
Kev Ntsuas Tomography (CT) scans
Iodinated contrast agents yog txhaj tshuaj intravenously los txhim kho qhov pom ntawm cov hlab ntsha thiab lwm yam qauv.
Sib nqus Resonance Imaging (MRI)
Gadolinium-raws li tus neeg sawv cev sib txawv yog siv los txhim kho qhov sib txawv ntawm cov ntaub so ntswg.
X-Ray Imaging
Barium sulfate yog siv rau kev kuaj mob plab, thaum iodinated contrast agents yuav siv tau rau vascular imaging.
Ultrasound
Txawm hais tias tsis tshua siv, qee qhov sib piv cov neeg sawv cev tuaj yeem raug txhaj tshuaj los txhim kho cov duab ultrasound.
Kev Phem Tsis Zoo
Txawm hais tias tus neeg sawv cev sib txawv feem ntau muaj kev nyab xeeb, qee cov neeg mob yuav ntsib kev tsis zoo. Cov no tuaj yeem muaj los ntawm cov tsos mob me xws li xeev siab, ntuav, thiab edema mus rau qhov tshwm sim hnyav xws li anaphylaxis, poob siab, thiab coma. Yog li ntawd, nws yog ib qho tseem ceeb rau cov kws kho mob los tshuaj xyuas cov neeg mob rau kev ua xua rau cov neeg ua haujlwm sib txawv thiab saib xyuas lawv zoo thaum lub sijhawm thiab tom qab txheej txheem.
Kev txiav txim siab tshwj xeeb
- Lub raum ua haujlwm: Iodinated contrast agents tuaj yeem ua rau lub raum puas, tshwj xeeb tshaj yog nyob rau hauv cov neeg mob ua ntej - lub raum tsis zoo. Yog li ntawd, lub raum kev ua haujlwm yuav tsum tau soj ntsuam ua ntej siv cov tshuaj no.
- Thyroid Function: Txij li cov tshuaj iodinated sib piv muaj cov iodine, lawv tuaj yeem cuam tshuam rau cov thyroid ua haujlwm. Cov neeg mob hyperthyroidism tuaj yeem ua rau cov thyroid cua daj cua dub ntau dua tom qab tau txais cov tshuaj no.
Hauv kev xaus, cov neeg sawv cev sib txawv yog cov cuab yeej tseem ceeb hauv kev kho mob, ua rau cov kws kho mob kom tau txais cov duab meej thiab cov ncauj lus kom ntxaws ntawm lub cev sab hauv. Txawm li cas los xij, lawv cov kev siv yuav tsum tau ua tib zoo tswj kom txo tau qhov kev pheej hmoo ntawm kev tsis zoo.
Tshiab indocyanine ntsuab(IR-820) yog qhov tseem ceeb nyob ze -infrared dye nrog dav siv hauv kev tshawb fawb txog lub neej thiab kev tshawb fawb txog biomedical. Raws li tus nqi-zoo imaging tus neeg saib xyuas nrog qis cytotoxicity, nws tau pom muaj peev xwm zoo kawg li hauv ntau qhov kev tshawb fawb.
Ib qho piv txwv kev tshawb fawb tseem ceeb suav nrog nws siv hauv kev phais laparoscopic, tshwj xeeb tshaj yog nyob rau hauv kev phais mob. Hauv tsab ntawv ceeb toom, nws tau ua haujlwm ua tus saib xyuas fluorescent los txheeb xyuas thiab nrhiav cov lymphoceles thaum lub sijhawm laparoscopic. Los ntawm kev txhaj tshuaj ICG rau hauv lymphocele, cov kws phais tuaj yeem pom cov qauv sab hauv ntawm cov lymphocele lobes nyob ze ntawm -infrared fluorescence imaging. Cov txheej txheem no tso cai rau kev txiav txim siab meej ntawm cov phab ntsa lymphocele thiab aspiration ntawm serous kua, txo qhov kev pheej hmoo ntawm kev puas tsuaj rau cov zis thaum phais. Daim ntawv thov ua tiav ntawm ICG hauv qhov piv txwv no qhia txog nws cov txiaj ntsig raws li lub cuab yeej rau kev txhim kho kev phais mob thiab cov txiaj ntsig ntawm tus neeg mob.
Tsis tas li ntawd, nws tau siv rau hauv kev tshawb nrhiav cov kab mob qog nqaij hlav hauv plab hnyuv. Nws muaj peev xwm muab tau tiag tiag - sijhawm, tsis yog - kev kuaj pom ua rau nws yog qhov kev xaiv zoo rau kev zam qhov tsis tsim nyog resection thiab txhim kho qhov raug phais. Tsis tas li ntawd, ICG tau tshawb nrhiav los ua tus neeg sawv cev sib txawv rau kev tshawb nrhiav thiab ntsuas cov ntaub so ntswg muaj kab mob hauv cov tsiaj, ntxiv rau nws qhov kev siv dav dav.
Hauv cov ntsiab lus, IR-820 tau pom cov txiaj ntsig tau zoo hauv ntau qhov kev tshawb fawb, suav nrog kev phais laparoscopic thiab kev kuaj mob qog noj ntshav. Nws cov khoom tshwj xeeb ze-infrared fluorescence ua rau nws muaj ntau yam cuab yeej rau kev txhim kho kev pom thiab kev ua tau zoo hauv kev tshawb fawb kho mob thiab kev kho mob.
FAQ
Dab tsi yog indocyanine ntsuab?
Indocyanine ntsuab (ICG) yogcov kws kho mob zas xim siv los nrhiav thiab pab kho cov teeb meem hauv qee qhov ntawm lub cev. Cov zas xim hloov txoj hauv kev ntawm lub cev saib hauv lub teeb tshwj xeeb kom cov kws kho mob pom lawv yooj yim dua. ICG siv sijhawm luv luv thiab muaj kev nyab xeeb rau menyuam yaus.
Dab tsi yog indocyanine ntsuab ua los ntawm?
Idocyanine ntsuab yog ibdej soluble, tricarbocyanine dyenrog ncov spectral absorption ntawm 800 nm. Lub npe tshuaj rau Indocyanine Green yog 1 H-Benz[e]indolium,2-[7[1,3-dihydro-1,1-dimethyl-3-(-4-) sulfobutyl)-2H-benz[e]indo-2-ylidene]-1,3,5-heptatrienyl]-1,1-dimethyl-3-(4-sulfobutyl)-, hydroxide, innersalt, sodium.
Puas yog indocyanine ntsuab yog tshuaj?
Indocyanine ntsuab (ICG) yogLwm qhov tsawg dua -cov tshuaj tsis paub uas sawv hauv kev kho mob rau 60 xyoo. Cov yam ntxwv kho qhov muag fluorescence ntawm ICG ua nws thawj zaug hauv kev kho mob. Raws li cov txheej txheem imaging nce mus rau hauv emerges.
Puas yog indocyanine ntsuab radioactive?
Indocyanine ntsuab yog ib qho xim tshwj xeeb uas yogtsis yog radioactive, tuaj yeem pom nrog lub koob yees duab yooj yim uas tsis tas yuav muaj hluav taws xob, thiab tsim los mus rau cov qog hlwb thaum tswj hwm.
Cim npe nrov: tshiab indocyanine ntsuab cas 172616-80-7, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom