Diethylaminosulfur Trifluoride CAS 38078-09-0

Diethylaminosulfur trifluoride, feem ntau yog cov xim av, 38078 -} 09-0, molecular cov mis c4h10f3ns, yog xim daj ua kua. Soluble nyob rau hauv feem ntau tsis-polar organic kuab tshuaj, feem ntau yog siv rau Ch2Cl2, Chcl3, thiab CCL4. Nws yog ib qho fluorinating reagent hauv synthic synthsis. Nws yog rau (Dialkylamino) Sulphur trifluoride tsev neeg. DAST yog nucleophilic fluorinating reagent uas tuaj yeem hloov ua liaj ua teb hydroxyl ntawm cov pab pawg ntawm carbonyls thiab cov pab pawg carboxylic thiab lawv cov derivatives.

N - (chimethylsilyl) diethylamine tau maj mam nqis mus rau cov kua txias ntau dhau sf4. Tom qab cov tshuaj tiv thaiv, seem seem sf4 thiab tus los ntawm {{3} Cov Khoom Tmsf tau raug tshem tawm, thiab Diethylamino Sulphur trifluoride nrog cov siab siab tau txais cov distillation. Cov txheej txheem tseem ceeb saum toj no yog kuaj cov teeb meem saum toj, tab sis yuav tsum tau siv cov zis ntau dua (kev tsim tawm siab dua)

Kev Siv 1:Diethylaminosulfur trifluoride(Dast), raws li muaj nucleophilic fluorination, yog qhov yooj yim siv rau hauv cov khoom siv hydroxyl, thiab lwm yam siv hauv cov organic tshuaj.

Kev Siv 2: Cov tshuaj fluoric fluoride muaj cov ntawv thov dav hauv biomedicine.

Kev Siv 3: Diethylamino Sulphur Trifluoride (dust) yog siv los ua fluorinating tus neeg sawv cev thiab fluorinating tus neeg sawv cev ntawm cov tshuaj anticancer. Piv txwv li, nws cuam tshuam nrog cawv kom tau txais cov tshuaj fluorozes; Cov tshuaj tiv thaiv nrog yl chloride kom tau txais cov tshuaj fluoride sib haum; Nws cuam tshuam nrog aldehyde lossis ketone kom tau txais ntxaib difluoride; Nrog sulfoxide {2} fluorosulfide yog oxidized nrog perchlorobenplenzoic acid kom tau txais {}} fluorosulfoxide.

Chlorination kev xav: Dust tuaj yeem hloov ua cov cawv ua ntej rau hauv cov tshuaj fluoride hauv qab cov xwm txheej me me. Feem ntau, pub ntawm - 78OC kom inhibit thawj txheej txheem exothermic, thiab tom qab ntawd cia cov tshuaj tiv thaiv cia li nce mus rau chav tsev kub rau ib pliag (kab zauv 1). Txawm hais tias kev haus dej cawv ob leeg tseem noj tau cov tshuaj tiv thaiv, nws feem ntau yuav tsum tau rhaub lossis refluxed hauv CH2CL2 ntev (Mis 2, Formula 3). Feem ntau, cov qoob loo ntawm cov tshuaj fluorinated yog nyob rau theem nrab, tab sis tsim nyog rau kev xaiv fluorination ntawm ntau}}} kev ua haujlwm molecules. Nyob rau hauv yuav luag tib yam mob uas fluorination dej cawv, dust tuaj yeem hloov aldehydes thiab ketones rau hauv cov tshuaj fluoride. Hauv kev sib piv, lawv cov tshuaj tiv thaiv kub yog siab dua li ntawm dej cawv; Cov tshuaj tiv thaiv ntawm aldehydes yog MILLER dua li Ketones. Piv txwv li, Aldehydes tuaj yeem kho nrog nthwv dej ntawm qhov kub tsawg lossis chav tsev kub kom tau txais cov tshuaj fluoride (mis mos). Txawm li cas los xij, Ketones yuav tsum tau muab rhaub nrog cov duab ntev rau lub sijhawm ntev los tsim cov lus sib piv (cov mis).

Diethylamine Sulphur trifluoride (dust), nrog tshuaj lom neeg c4h1010f3ns, yog cov tshuaj lom neeg tseem ceeb uas ua rau cov kev tshawb fawb organic, yog cov kws tshawb fawb thiab cov ntaub ntawv tshawb fawb.

1,

Organic Synthesis Teb

 

Cov tshuaj tiv thaiv fluorination
Cawv fluoride cawv
Dust tuaj yeem hloov pab pawg cawv rau cov pab pawg ua kom haum. Hauv cov synthic synthsis, cawv cov tebchaw muaj ntau dua. Los ntawm cov tshuaj fluorination muaj txiaj ntsig zoo, yog li hloov pauv cov molecule, yog li hloov nws lub cev thiab tshuaj lom neeg. Piv txwv li, hauv synthsis, qhia cov tshuaj fluorine atom rau hauv kev haus dej haus cawv tuaj yeem txhim kho cov khoom siv hluav taws xob, lossis hloov nws cov khoom siv tshuaj. Cov kev tawm tsam yog qhov ua ntej ua ntej cov ntaub ntawv nruab nrab nrog cov pab pawg cawv thiab tsim cov tshuaj fluoride hydrogule. Tom qab ntawd, cov tshuaj fluoride nucleophilically ntaus lub hydroxyl carbon ib los ntawm Sn1 lossis Sn2, tsim kom muaj kev sib txuas monoflluorinated. Cov cawv muaj rog thiab muaj ntxhiab, cov dej cawv txiv neej tuaj yeem hloov kho kom haum rau cov tshuaj fluorine. Cov tshuaj tiv thaiv feem ntau siv cov kuab tshuaj xws li dichhloromethane thiab monoflluorometiath, thiab cov pab pawg ntawm hydroxyl feem ntau tau nqa tawm ntawm qis dua kub (xws li qib qis (xws li -78 degree).

Fluorination ntawm aldehydes thiab ketones
Diethylaminosulfur trifluoridetuaj yeem hloov aldehydes thiab ketones rau hauv difluoro tebchaw. Aldehydes thiab cov pab pawg ua haujlwm tseem ceeb hauv pawg ua haujlwm tseem ceeb, thiab hloov lawv mus rau hauv cov lus sib txuas lus hauv nruab nrog cev muaj peev xwm sib xyaw ua ke nrog cov khoom tshwj xeeb.

 

Cov lus sib xyaw ua lus sib xyaw no yuav muaj cov ntawv thov muaj peev xwm hauv cov liaj teb xws li cov khoom siv science thiab kev tsim tshuaj. Piv txwv li, cov lus qhia ntawm diflluoro cov pab pawg tau tswj hwm cov qauv hluav taws xob thiab kev teeb tsa kev sib txuas lus thaum synthesizing cov ntaub ntawv nrog cov khoom siv hluav taws xob tshwj xeeb lossis hluav taws xob. Hauv cov tshuaj tiv thaiv, cov pab pawg carbonyl feem ntau tau nqa tawm ntawm 0 Degree -40 degree.

Fluorination ntawm lwm pab pawg ua haujlwm
Ntshaw tuaj yeem siv tau rau cov tshuaj cylror rau cov acyl fluorothal, thiab tom qab ntawd oxidize acid kom tau txais -} fluorosulfoxides. Cov khoom lag luam fluorinated no tuaj yeem ua cov khoom tseem ceeb hauv cov synmicynes hauv synthsis rau kev tsim cov nyom ntau cov olecules. Piv txwv li, Acyl fluoride tuaj yeem koom nrog kev noj haus kev coj noj coj ua kom synesize kev sib txuas lus ntau ntxiv; Alpha fluorothioethers and alpha fluorosulfoxides can be used to synthesize sulfur-containing fluorine-containing compounds with special biological activity.

Kws tshawb nrhiav thiab kev txhim kho kev txhim kho

 

Synthesis ntawm cov tshuaj intermediates
Tsua tuaj yeem pab ua ib qho tseem ceeb hauv nruab nrab hauv Synthsis. Nyob rau hauv cov txheej txheem kev tsim tshuaj, nws yog ib qho tsim nyog los synthesize ntau yam nruab nrab nrog cov txheej txheem tshwj xeeb thiab kev tsim cov hom phiaj yeeb tshuaj los ntawm kev ntsuas kev tshuaj ntxiv. Ntse yuav muab txoj hauv kev zoo rau cov synthsis ntawm cov tshuaj nruab nrab los ntawm nws cov tshuaj fluorination, thiab lwm yam kev tawm tsam. Piv txwv li, hauv synthsis ntawm qee yam anti {- cov tshuaj artras thiab tsim tau cov tshuaj lom neeg ua haujlwm los txhawb cov tshuaj nruab nrab nrog kev ua haujlwm roj ntsha. Cov nruab nrab no tuaj yeem tsim kho ntxiv rau cov qauv thiab tshuaj ntsuam rau kev ua yeeb yam nrog kev ua tau zoo thiab kev nyab xeeb.

 

Fluorinated anticancer tshuaj
Dust yog siv los ua cov tshuaj fluorinating rau tshuaj tiv thaiv tshuaj tiv thaiv tshuaj. Hauv kev txhim kho cov tshuaj tiv thaiv tshuaj tiv thaiv tshuaj, kev qhia cov tshuaj tua tsiaj kom zoo rau cov tshuaj molecules tuaj yeem hloov cov tshuaj tua hluav taws xob, thiab kev ua yeeb yam ntawm cov tshuaj. Cov lus qhia txog fluorine atoms yuav txhim kho txoj hlua khi ntawm cov tshuaj thiab cov hom phiaj, txhim kho kev siv tshuaj sati- Cancer kev ua tshuaj. Piv txwv li, qee cov tshuaj fluorine - muaj cov tshuaj anticancer tau qhia tau txiaj ntsig zoo dua thiab qis toxicity hauv kev sim tshuaj. DETASS tuaj yeem qhia cov tshuaj fluorine atoms rau hauv ov- Cov cuab yeej muaj txiaj ntsig rau kev txhim kho cov tshuaj tiv thaiv kab mob.

Cov ntaub ntawv kawm txuj ci

 

Synthesis ntawm Optoelectronic cov ntaub ntawv
Cov qauv molecular ntawm dast muaj tshwj xeeb optical thiab hluav taws xob cov khoom, ua rau nws muaj feem siv nyob hauv thaj chaw Optoelectronic cov ntaub ntawv. Organic Optoelectronic cov ntaub ntawv nrog tshwj xeeb optical thiab cov hluav taws xob tuaj yeem ua ke los ntawm synthic synthsis cov kev cuam tshuam nrog dast. Piv txwv li, organic molecules nrog fluoruminescescence, lossis nonlinear optical cov khoom siv xws li organic teeb organic (oleds), organic solar hlwb, thiab hloov kho tshiab. Hauv OLED cov khoom siv oled, fluorinated organic molecules nrog cov qauv txheej txheem lossis cov khoom siv thauj khoom los txhim kho cov cuab yeej los txhim kho cov cuab yeej luminescent txuag, ci ntsa iab, thiab ruaj khov.

 

Cov Khoom Siv Khoom Hloov Ua Haujlwm
Dust kuj tuaj yeem siv los hloov cov ntaub ntawv uas twb muaj lawm. Los ntawm kev qhia txog fluorine atoms lossis fluorine {{1} muaj cov khoom siv ua haujlwm, hydrophobicity, tshuaj lom neeg ruaj khov, thiab lwm yam khoom ntawm cov ntaub ntawv tuaj yeem hloov. Piv txwv li, hauv kev hloov kho cov ntaub ntawv polymer, cov lus qhia txog cov tshuaj fluorine tuaj yeem txhim kho tus kheej ua kom zoo dua qub-}}}}}}}}}}}} {uti adhesion khoom. Cov ntaub ntawv hloov kho no muaj cov ntaub ntawv ua haujlwm dav hauv cov chaw xws li aerospace, kev tsim khoom lag luam, thiab ntim tshuab hluav taws xob.

Lwm daim teb

 

Tshuaj Tshuaj Xuav
Hauv cov tshuaj tua kab synthsis, dust tuaj yeem siv los ua cov tshuaj tua tsiaj fluorinated fluicinated fluicides nrog kev ua tshwj xeeb. Cov lus qhia txog cov tshuaj fluorine atoms tuaj yeem hloov cov qauv ntawm cov kab tsuag, ua rau lawv cov tshuaj lom, thaum muaj peev xwm txo lawv cov kuab lom rau cov khoom muaj sia. Piv txwv li, qee cov tshuaj fluorine {{3} muaj cov tshuaj tua kab thiab cov fungicides hauv kev tiv thaiv zoo dua thiab kev tiv thaiv ib puag ncig thiab kev nyab xeeb. DAST muab cov tshuaj zoo txhais tau tias rau synthesizing cov tshuaj tua tsiaj tshiab no.

 

Kev Tshawb Fawb Kev Kawm
Dast yog qhov tseem ceeb reagent hauv kev tshawb fawb kawm. Cov kws tshawb nrhiav tuaj yeem siv cov tshuaj tiv thaiv ntau ntawm kev sib tw ntawm kev tshawb fawb los ua cov kev tshawb fawb urthis enlechology thiab tshawb xyuas cov kab mob tshiab thiab kev hloov pauv. Los ntawm kev kawm cov kev tawm tsam kawg, peb tuaj yeem nce kev nkag siab tob txog cov kev sib cav sib ceg thiab kev xaiv ntawm cov organic molecules, muab kev txhim kho lub hauv paus rau kev txhim kho cov organic chemistry. Lub caij no,Diethylaminosulfur trifluorideKuj tseem siv tau los ua ke cov organic molecules nrog cov qauv tshwj xeeb thiab cov qauv sib txuas rau kev tshawb fawb hauv kev ua haujlwm ntawm lub cev thiab biochemistry.

Diethylaminosulfur trifluorideyog ib qho tseem ceeb nucleophilic fluorinating reagent. Nws cov tub ntxhais muaj nuj nqi yog hloov pauv cov pab pawg ua haujlwm xws li cov tshuaj lom neeg fluorinated los ntawm kev xaiv cov tshuaj fluorination ntawm kev xaiv cov tshuaj, tshuaj tua kab, thiab cov khoom siv tshuaj ntsuam. Cov hauv qab no yuav raug piav qhia los ntawm plaub yam: hom tshuaj tiv thaiv, kev ua haujlwm, daim ntawv thov, thiab kev tswj hwm kev nyab xeeb.

Cov Cheeb Tsam Thov thiab Piv Txwv

01

Tshuaj Nruab Nrab Nruab Nrab Synthesis

DAST yog cov khoom siv hluavtaws tseem ceeb rau cov tshuaj fluorinated:

Cov tshuaj tiv thaiv kab mob siab: Cov saw hlau fluorination ntawm cov dej qab zib los txhim kho cov tshuaj lom ntses los txhim kho cov tshuaj fluorine los txhim kho cov tshuaj fluorine los txhim kho cov tshuaj fluorine los txhim kho cov tshuaj fluorine los txhim kho cov tshuaj fluorine los txhim kho cov tshuaj fluorine los txhim kho cov tshuaj fluorine los txhim kho cov tshuaj fluorine los txhim kho cov tshuaj fluorine los txhim kho cov tshuaj fluorine los txhim kho cov tshuaj fluorine los txhim kho cov tshuaj fluorine los txhim kho cov tshuaj fluorine los txhim kho cov tshuaj fluorine los txhim kho cov tshuaj fluorine los txhim kho cov tshuaj fluorine los txhim kho cov tshuaj fluorinity los txhim kho cov tshuaj fluorine thiab cov ntshav} Nplooj tshuaj nkag siab lub hlwb.

Cov tshuaj tiv thaiv kab mob: dast yog siv rau kev siv tshuaj ketones hauv synthesis ntawm Lopinaver ntawm Lopinavir, txhim kho qhov ruaj ntseg ntawm lub molecule.

02

Kev hloov kho ntawm cov khoom siv nquag ntawm cov tshuaj tua kab

Cov lus qhia txog cov tshuaj roj fluorine tuaj yeem txhim kho kev ua haujlwm roj ntsha ua tau zoo tshaj plaws ntawm cov tshuaj tua kab:

Tshuaj ntsuab: Hloov cov pab pawg hauv hydoxyacyacyic acid

Cov tshuaj tua kab: dast {{{- Medorination fluorinated pyrethroids thiab ketones tuaj yeem tsim cov tshuaj lom neeg uas yog 30%.

03

Ua haujlwm nyob rau hauv cov ntaub ntawv kev kawm txuj ci

Dust yog siv los npaj fluorinated cov ntaub ntawv fluorinated:

Cov ntaub ntawv ua kua siv fuorinating: los ntawm fluorinating cyclohexane derivatives, theem hloov ntsuas kub thiab dielotrotropy ntawm cov kua muaju tuaj yeem tswj tau.

Surfactants: Cov lus qhia ntawm fluorinated alkyling alkyl chains tuaj yeem txo qis thaj av nro thiab txhim kho cov khoom ntub dej.

Cim npe nrov: Diethylaminosulfur Trifluoride CAS 38078-09-0, tus neeg muag khoom, chaw tsim khoom, chaw tsim khoom, yuav khoom, nqi, loj, rau muag