N-bromosuccinimide (nbs)Puas yog tsib tus tswv cuab los ntawm Cyclic dicarboxylimide compound nrog nitrogen atom, nrog cov tshuaj siv tshuaj c4h4brno2, CAS 128-5. Cov tsos yog dawb rau milky dawb crystalline khoom lossis hmoov, nrog tus ntxhiab tsw me ntsis ntawm bromine. Soluble me ntsis hauv dej thiab acetic acid, soluble acid, soluble acid, soluble hauv acetone, tetrahydrofformamide, dimethyl sulfoxide. Rau methanol thiab acetone cov kuab tshuaj, lub solubility ntawm NBS nce nrog qhov kub. Nws yog cov tshuaj lom neeg cov khoom siv uas siv tau ntau zaus hauv kev lag luam, feem ntau yog siv los tswj hwm cov tshuaj tiv thaiv qis, thiab yog qhov zoo bromrinity reagent, uas tuaj yeem hloov hydrogen atom ntawm benzyl lossis allyl txoj hauj lwm. Nws kuj tseem siv tau ua tus oxidant rau oxidation ntawm cov cawv rau aldehydes thiab ketones, thiab rau oxidation ntawm aldehydes rau cov kua qaub.
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Tshuaj Cov Qauv |
C4H4BRNO2 |
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Muaj pes tsawg leej |
177 |
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Molecular hnyav |
178 |
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m/z |
177 (100.0%), 179 (97.3%), 178 (4.3%), 180 (4.2%) |
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Kev Ntsuam Xyuas |
C, 26.99; H, 2.27; Br, 44.89; N, 7.87; O, 17.98 |
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Nws yog ib feem siv reacht hauv cov organic. Xyoo tsis ntev los no, kev tshawb fawb tshiab tau ua nyob rau hauv daim ntawv thov NBS hauv ntau cov orgidant, xaiv brominating tus neeg sawv cev tshiab thiab cov txheej txheem polymerization hauv cov txheej txheem tshuaj tiv thaiv.
Daim ntawv thov ib txwm muajN-bromosuccinimide (nbs)Rov qab ua rau cov organic yog qhov bromination ntawm allyl hydrogen thiab carbonen Q - Hydrogen, uas yog Wohl ziesler cov tshuaj tiv thaiv. With the deepening of research, it is gradually found that NBS can also be used well as catalyst, oxidant and many other aspects, which shows the great application value and potential of NBS reagnt.
1. NBS ua catalyst:
Cov catalytic ntxiv ib qho ntawm cov amines organic thiab ofefins los tsim cov organic sib txuas yog qhov tseem ceeb rau kev tshawb fawb thiab tseem tseem ceeb heev rau kev tsim cov tshuaj. Txawm li cas los xij, cov tshuaj tiv thaiv ib txwm muaj feem ntau nyuaj rau kev sib txuas, kim, thiab siv hnyav. Sudalai thiab lwm tus siv NBS raws li catalystulfonamide thiab dej cawv ua nucleophilic reagent nyob rau hauv cov neeg mob me me kom tau amino alkoxy derivatives. Cov qoob loo ntawm ob hom kev tshua muaj siab heev, thiab 100% ntawm lawv yog Markov ntxiv
2. NBS AS Oxidant:
Oxidation ntawm cov dej cawv sib xyaw rau cov khoom siv dag zog yog ib qho tseem ceeb ntawm cov theem hauv hluav taws xob. Sharma thiab al tau qhia tias
NBS Oxidizes ntau cov dej cawv ob tog rau cov khoom siv dag zog. Cobalt complex ntawm acetylacetone tau siv los ua catalyst. Cov tshuaj tiv thaiv yog qhov mob me thiab cov txiaj ntsig yog qhov siab, tab sis cov qauv no tsis haum rau kev hloov pauv ntawm cov thawj dej cawv.
3. Green Chemistry kev taw qhia ntawm NBS kev tawm tsam:
Cov pa roj carbon tetrachloride feem ntau yog siv los ua cov kuab tshuaj rau cov tshuaj tiv thaiv dawb, tab sis carbon tetrachloride yog paub tias muaj kev puas tsuaj rau ozone txheej, uas txwv nws daim ntawv thov.
Yog li ntawd, nws yog qhov tsim nyog los tshawb txog cov xwm txheej ntawm bromination cov tshuaj tiv thaiv ntawm nbs thiab nrhiav ib qho hloov chaw rau carbonloride. Ntawm lawv, cov kuab tshuaj-dawb khoom theem tau kawm ntau yam.
5. Kev tshawb fawb kev vam meej ntawm NBS ntawm carbonyl orto hydrogen hloov chaw ntawm Ketones:
NBS yog lub carbony zoo heev a - thaj chaw ua haujlwm yooj yim ua haujlwm thiab siv dav nyob rau hauv cov tshuaj tiv thaiv kab mob thiab tawm los, ntau cov catalaltic tshuab tau tsim.
4. Daim ntawv thov ntawmkhoomHauv kev tshawb fawb polymer:
Nyob polymerization yog ib txoj kev tseem ceeb heev los npaj cov polymers nrog cov qauv tshwj xeeb thiab kev faib me me molecular. Vim tias n - Br tau nyiaj hauv NBS yog nquag heev, nws yog qhov yooj yim los ua kom muaj kev nquag ua kom tau txais cov khoom siv hluav taws xob ua kom nquag plawg dawb radicals los ntawm kev dawb radicals. Yog li no, yuav siv tau ua txoj saw pib hloov chaw rau kev pib ua ntej thiab Ticp2C12 ua catiator thiab Ticp2C12 ua catiator thiab ticp2c12 ua catiator thiab Ticp2C12 ua catiarator polymerization ntawm vinyl chloride.
6 lwm yam kev muaj feemN-bromosuccinimide (nbs):
Zoller li al. raug nplua txoj kev los hloov benzyl cawv rau benzyl bromide nyob rau hauv nruab nrab tej yam kev mob. Cov tshuaj tiv thaiv no tau ua ke nrog cov khoom siv theem khoom. Benzyl bromide yuav nyob rau ntawm cov tshuaj tiv thaiv, thiab ntau dhau saitants thiab lwm yam khoom (DMOPS thiab cov ntawv xa tawm nrog cov kuab tshuaj lom.
Daim ntawv thov ntawm NBS hauv cov organic ntau ntxiv thiab muaj ntau yam kev tshawb fawb ntawm cov kev siv hluav taws xob tshiab, thiab kev tshawb fawb ntawm cov kev txhim kho tseem ceeb ntawm cov organic cov tshuaj tiv thaiv.
Synthesis ntawmN-bromosuccinimide (nbs):
1. Nws tau los ntawm bromination ntawm succinimide. Sib tsoo succinimide thiab muab tso rau hauv lub lauj kaub uas tsis yooj yim, ntxiv cov dej khov dej thiab sodium hydroxide tov, do thiab yaj. Ntxiv cov sib tov ntawm bromine thiab carbon tetrachloride nyob rau hauv cov xwm txheej ntawm vigring stirring thiab txias, thiab lim nws sai sai tom qab nplawm li 2 feeb. Siab ntxuav nrog dej khov dej kom txog thaum tsis muaj xim, tom qab ntawd ntxuav nrog ib qho me me ntawm ethanol, thiab qhuav kom tau txais cov khoom tiav.
2. Ammonium succinate yog scadthesized los ntawm succinic acid thiab ammasdated los tsim succinimide, thiab tom qab ntawd brominated thiab refined kom tau cov khoom tiav.
3. Kev ua tiav yog npaj los ntawm reacting nrog Nabro2 nyob rau lub sijhawm HBR.
NBS yog crystalline nrog lub ntsej muag tsis hnov tsw. Melting taw tes 173-175℃(kev txiav txim siab me). Solubility (G / 100g Cov Hnyav, 25 Qib): Dej 1.47; acetone 14.40; carbon tetrachloride 0.02; glacial acetic acid 3.10. NBS tuaj yeem npaj los ntawm kev rov ua kom muaj dej khov nab kuab Nws yog tsuas yog siv nyob rau hauv cov synthic synthesis thiab raws li kev ntxiv rau cov khoom lag luam roj hmab. Nws yog qhov tshwj xeeb brominating tus neeg sawv cev rau chav kuaj mob ntawm Allylic Bromoolfins thiab lub npe rau kev txheeb xyuas tus thawj thawj, cov cawv thiab cov txiv ntoo.
N-bromosuccinimide (NBS) yog qhov sib txawv me me rov qab ua, uas haum rau brominthing cov tshuaj tiv thaiv ntawm allylic thiab benzyl haujlwm. Nws tsis tsuas yog muaj cov tshuaj tiv thaiv me me thiab yooj yim rau kev khiav lag luam, tab sis kuj muaj kev xaiv siab ntau thiab muaj ob peb sab kev ua haujlwm. Allyl thiab benzyl hydrogen atoms yog tus nquag. Bromination Rheated yog ib qho yooj yim rau tshwm sim hauv qab cov siab kub, lub teeb lossis lub xub ntiag ntawm dawb radical pib. Peroxides lossis AZO cov tebchaw tau siv ua cov thawj pib, thiab cov tshuaj ntau npaum li cas 5% rau 10%. Qhov ntsuas kub yog feem ntau siab. Rau allylic bromination, tsawg kub yog pab kom ntxiv reaction ntawm overle txwv; Rau benzylic bromination, dhau qhov ntsuas kub heev yuav ua rau muaj kev tsim ntawm Benzylic Dibrominates. Yog li ntawd, nws yog qhov tseem ceeb heev los xaiv qhov tsim nyog ntsuas kub. Feem ntau ntawm cov tshuaj ntsuam cov tshuaj pleev yog anhydrous tsis yog-polar inertor cov kuab tshuaj xws li carbon tetrachloride, benzene, thiab roj av kom tsis txhob muab cov tshuaj tiv thaiv kev tshem tawm thiab lwm yam kev phiv tshuaj.
NBS tuaj yeem ua rau muaj cov neeg muaj tswv yim tsis muaj neeg muaj tswv yim (m-anisole, -naphthyl metthyl ether, thiab lwm yam) kom bromine lub nplhaib Benzene. Tom qab, Benzene thiab Toluene kuj tseem tuaj yeem hnov cov kab mob Benmene, zoo li cov tshuaj txhuas, zinc chloride cataline, kom tau bromobenzene thiab p-bromotoluene, ntsig txog. Lub bromination cov tshuaj tiv thaiv ntawm m-toluene methyl ether thiab 6-methyl {{9} ithat naphthyl methyl ether nrog nbss {ittle yog:
Qhov kev tshuaj tiv thaiv ntawm n-bromosuccinimide rau Olefins nyob rau hauv cov acid catalysis yog ib txoj hauv kev tseem ceeb rau kev npaj -halohydrins. Hom qauv no muaj cov ua tau siab, cov txiaj ntsig siab, cov khoom ntshiab, realtion me me thiab kev ua haujlwm yooj yim. Cov txiaj ntsig yog 82%. Cov tshuaj reartion mis yog li nram qab no:
Dimethyl sulfoxide (DMOs) yog cov kuab tshuaj zoo heev. Daim ntawv thov nbs kom hnov mob nrog Olefins nyob rau aqueous nyob rau aqueous nyob rau aqueous dmo tuaj yeem tau txais txiaj ntsig siab thiab cov khoom lag luam zoo ntxiv nrog cov khoom muaj 92%. Cov tshuaj tiv thaiv cov tshuaj yog:
NBS yog ib tug heev carbonyl -Position bromination. Qhov kev ua kom yooj yim ua haujlwm thiab siv dav. Txhawm rau txhim kho cov realexion tus nqi thiab tawm los, ntau cov tshuab catalytic tau tsim. Yang li al. Siv mg (Clo4) 2 los ua kom muaj tseeb NBS rau kev ua pob sai ntawm 1,3-dicarbonyl compounds. Cov neeg rov qab ua tau cov me me hauv Ch3CN lossis ETOAC. Qhov kev tawm tsam muaj qhov zoo sereoselectivity thiab tuaj yeem yooj yim rau kev npaj-xbrominated 1,3-dicarbonyl sib txuas uas tseem ceeb heev hauv synthic.
Daim ntawv thov ib txwm muaj ntawm N-bromosuccinimide rov qab los ntawm cov organic rearter yog lub bromination ntawm allylic hydrogen thiab carbonyl -hydrogen. Nrog rau qhov tob tob ntawm kev tshawb fawb, nws yog muaj ntau cov ntawv thov hauv ntau yam xws li catalyst thiab oxidant.
Cim npe nrov: n-bromosuccinimide (NBS) CAS 128-08-5, cov chaw muag khoom, chaw tsim khoom, chaw tsim khoom, lag luam, yuav khoom, loj, rau muag