Tom ntej: Trimethylsilyl Trifluoromethanesulfonate CAS 27607-77-8

Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm cov tuam txhab kev paub tshaj plaws thiab cov chaw muag khoom ntawm trimethylsilyl trifluoromethanesulfonate cas 27607-77-8 hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo trimethylsilyl trifluoromethanesulfonate cas 27607-77-8 muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.

Trimethylsilyl trifluoromethanesulfonatelub npe hu ua1-(2,6-chlorophenyl)-2-indolinone (diclofenac), yog ib qho khoom siv nrog lub cev tshwj xeeb. Nws yog xim tsis muaj xim rau lub teeb xim av pob tshab kua nrog me ntsis irritating tsw. Qhov ceev yog 1.228g / mL, CAS 27607-77-8, thiab qhov hnyav molecular yog 222.26. Nws cov qauv molecular muaj peb pawg methyl (CH3) thiab ib pawg trifluoromethyl (CF3), nrog rau ib lub atom silicon thiab ib pawg sulfonic acid. Nws tuaj yeem yaj hauv cov kuab tshuaj organic xws li cov tshuaj tsw qab hydrocarbons, halogenated hydrocarbons, thiab tetrahydrofuran, tab sis tsis nyob hauv dej. Qhov muaj zog polarity ntawm cov compound no muab nws zoo solubility hauv cov kuab tshuaj organic. Nws muaj qhov tseem ceeb Lewis acidity thiab muaj zog hygroscopicity. Nyob rau hauv qhov chaw ntub dej, qhov sib xyaw no yog qhov ua rau muaj tshuaj lom neeg muaj zog nrog dej thiab deteriorate.

Yog li ntawd, nws yog ib qho tsim nyog yuav tsum khaws cia rau hauv qhov chaw qhuav kom nws ruaj khov. Nws yog ib qho zoo silanization reagent, muaj zog Lewis acid catalyst, thiab feem ntau siv silicon -raws li kev tiv thaiv reagent. Nws muaj ntau yam kev siv hauv kev tshawb fawb thiab kev tsim kho cov txheej txheem thiab tshuaj thiab tshuaj ntau lawm, feem ntau yog siv rau kev tiv thaiv hydroxyl hauv kev hloov tshuaj lom neeg thiab kev npaj ntawm enol silanes. Tsis tas li ntawd, qhov sib xyaw no kuj tseem siv los ua ke rau lwm yam tseem ceeb silicon thiab fluorine compounds. Clinically siv rau rheumatoid mob caj dab, nplaum spondylitis, non-inflammatory mob caj dab, mob caj dab, mob los ntawm tsis sib koom rheumatism thiab tsis sib koom o, ntau hom neuralgia, mob cancer, post- mob, thiab kub taub hau los ntawm ntau yam mob. Nws yog tshuaj lom rau qee yam tsiaj, xws li eagles taub. Diclofenac hmoov yog siv nyob rau hauv chemistry, tab sis diclofenac tov yog tsuas yog siv nyob rau hauv cov tsiaj, xws li nyob rau hauv lub qhov muag ntawm dev los yog miv thaum lawv mob.

melting point 25 degree, boiling point 77℃/ 80 mmHg (lit.), Ceev 1.228 g / mL ntawm 25℃C (lit.), Vapor siab 4.7 hPa (20℃C), Refractive index n20 / D 1.36 (lit, cia point, 7 degree) + 30℃C., Solubility sol aliphatic thiab aromatic hydrocarbons, haloalkanes, ethers. , Morphology Fuming Liquid, Proportion 1.15, Colour Clear colorless to light brown, Water solubility REACTS, Sensitive Moisture-Sensitive, Hydrolysis rhiab heev 8: cov tshuaj tiv thaiv sai nrog cov dej noo, dej, cov kuab tshuaj protic.

Trimethylsilyl trifluoromethanesulfonate(TMSOTf, CAS naj npawb 27607-77-8) yog cov organic silicon compounds uas muaj cov qauv tseem ceeb uas muaj trimethylsilyl (- Si (CH ∝) ∝) thiab trifluoromethanesulfonate (- SO ∝ CF ∝) pawg. Nws cov qauv molecular yog C ₄ H ₉ F ∝ O ∝ SSi, nrog rau qhov hnyav molecular ntawm 222.26. Nws zoo nkaus li tsis muaj xim rau daj ntseg daj pob tshab kua thiab muaj zog hygroscopicity, flammability, thiab corrosiveness. Raws li ib qho tseem ceeb reagent nyob rau hauv lub tshav pob ntawm cov organic synthesis, TMSOTf tau nthuav dav daim ntawv thov tus nqi nyob rau hauv ntau yam xws li tshuaj, cov ntaub ntawv, lub zog, thiab ntsuab chemistry vim nws cov cim Lewis acid catalytic zog thiab siliconization muaj peev xwm.

Synthesis of pharmaceutical intermediates: ib qho cuab yeej tseem ceeb rau kev tswj xyuas cov qauv molecular

 

1. Kev tiv thaiv thiab tiv thaiv cov piam thaj derivatives
TMSOTf yog ib qho kev xaiv zoo tiv thaiv reagent nyob rau hauv glycochemistry, tshwj xeeb tshaj yog haum rau siliconization tiv thaiv hydroxyl pawg xws li qabzib thiab nucleotides. Nws cov tshuaj tiv thaiv kev ua tau zoo yog qhov zoo dua li cov tshuaj reagents (xws li trimethylchlorosilane, TMSCl), thiab nws tuaj yeem ua kom tiav cov kev hloov pauv ntawm hydroxyl pawg mus rau silicon ethers hauv cov mob me (0-10 degree) nrog tsawg dua los ntawm - khoom. Piv txwv li, nyob rau hauv cov synthesis ntawm nucleoside derivatives, TMSOTf tuaj yeem xaiv tiv thaiv 2 '- lossis 3' - hydroxyl pawg ntawm lub nplhaib ribose, muab lub hauv paus rau kev hloov kho stereoselective tom ntej.

 

Kev sim cov ntaub ntawv qhia tau hais tias thaum TMSOTf yog siv los tiv thaiv pawg hydroxyl ntawm qabzib, cov tshuaj tiv thaiv tuaj yeem ncav cuag ntau dua 95%, thiab pab pawg tiv thaiv tuaj yeem raug tshem tawm tau zoo nyob rau hauv acidic tej yam kev mob, nrog rau tus nqi rov qab ntau dua 90%.

2. Kev tsim kho ntawm heterocyclic compounds
TMSOTf, raws li lub zog Lewis acid catalyst, tuaj yeem ua kom nrawm nrawm ntawm alkylation, acylation, thiab cyclization ntawm cov tshuaj heterocyclic xws li indole thiab pyridine. Piv txwv li, nyob rau hauv 3-site xaiv acylation cov tshuaj tiv thaiv ntawm indole, qhov sib ntxiv ntawm TMSOTf tuaj yeem txo cov sijhawm tshuaj tiv thaiv los ntawm 12 teev hauv cov txheej txheem ib txwm siv mus rau 2 teev, thiab txhim kho qhov purity ntawm cov khoom mus rau 98%.

 

Tsis tas li ntawd, nws muaj peev xwm catalyze Dieckmann zoo li cyclization cov tshuaj tiv thaiv ntawm ester imides thiab cov neeg tuag, ua tau zoo tsim tsib - los yog rau tus tswv cuab cyclic qauv, muab cov kauj ruam tseem ceeb rau kev sib txuas ntawm cov khoom ntuj tsim xws li alkaloids.

3. Synthesis ntawm tshuaj tua kab mob thiab tshuaj tua kab mob
TMSOTf feem ntau yog siv rau kev tsim kho ntawm cov intermediates tseem ceeb hauv synthesis ntawm cov tshuaj tua kab mob (xws li macrolides) thiab tshuaj tiv thaiv kab mob (xws li nucleoside analogues). Piv txwv li, nyob rau hauv cov synthesis ntawm erythromycin derivatives, TMSOTf catalyzes tsim glycosidic bonds, nce cov tshuaj tiv thaiv tawm los ntawm 60% mus rau 85% thaum txo cov tiam ntawm cov khoom los ntawm - khoom. Nws siab reactivity thiab selectivity ua rau cov tshuaj synthesis cov kauj ruam yooj yim dua thiab qis dua tus nqi.

Kev hloov kho cov khoom siv polymer: cov ntsiab lus ntxiv uas ua rau cov khoom siv nrog kev ua haujlwm siab

 

1. Silicone roj hmab crosslinking tus neeg saib xyuas
Trimethylsilyl trifluoromethanesulfonateyog tus neeg saib xyuas kev sib txuas ua tau zoo rau chav kub vulcanized (RTV) silicone roj hmab, uas tuaj yeem txo lub sijhawm kho thiab txhim kho cov khoom siv. Ib txwm siv silicone roj hmab curing yuav tsum tau kub siab (120-}}150 degree) los yog ntev (ntau tshaj 24 teev), thaum ntxiv TMSOTf tuaj yeem txo lub sijhawm kho ntawm chav sov mus rau 20-60 feeb, thiab lub zog tensile ntawm kho silicone roj hmab yog nce li 30%, nrog rau qhov kub thiab txias tsis kam (txog 20). Nws cov txheej txheem ntawm kev ua yog: TMSOTf catalyzes cov tshuaj tiv thaiv condensation ntawm silanol pawg (- Si OH) thiab silane coupling cov neeg ua haujlwm (xws li methyltrimethoxysilane), tsim cov qauv peb sab.

 

2. Synthesis ntawm Optoelectronic Materials
Hauv kev npaj ntawm OLED (organic light-emitting diode) cov ntaub ntawv, TMSOTf yog siv los ua ke lub qhov thauj cov ntaub ntawv txheej (xws li TPD derivatives), uas txhim kho cov molecular cab kuj los ntawm kev hloov kho siliconization. Piv txwv li, nyob rau hauv silicon -raws li kev hloov kho ntawm TPD, TMSOTf catalyzes hloov dua siab tshiab ntawm hydroxyl pab pawg neeg ntawm benzene nplhaib rau silicon ethers, ua kom lub photoluminescence efficiency ntawm cov khoom los ntawm 20% thiab ncua lub neej ntawm cov cuab yeej mus rau 1.5 npaug ntawm cov ntaub ntawv ib txwm siv. Tsis tas li ntawd, nws tseem tuaj yeem siv rau kev hloov kho lub qhov thauj txheej hauv perovskite hnub ci hlwb txhawm rau txhim kho cov kev hloov pauv photoelectric ntawm tes.

 

3. Nto functionalization ntawm nanomaterials
TMSOTf tuaj yeem siv rau kev hloov pauv ntawm qhov chaw siliconization ntawm nanoparticles (xws li silica thiab quantum dots) los txhim kho lawv cov dispersibility thiab biocompatibility. Piv txwv li, nyob rau hauv kev hloov kho saum npoo ntawm silica nanoparticles, TMSOTf catalyzes hloov dua siab tshiab ntawm hydroxyl pawg rau silicon ethers, ho txhim kho cov dispersibility ntawm hais nyob rau hauv cov organic solvents thiab muab ib tug ruaj khov cab kuj rau cov tshuaj xa systems.

Organic synthesis catalysis: "chemical engine" uas accelerates cov txheej txheem tshuaj tiv thaiv

 

1. Friedel Crafts acylation cov tshuaj tiv thaiv
TMSOTf, raws li lub zog Lewis acid catalyst, tuaj yeem ua kom zoo rau Friedel Crafts acylation cov tshuaj tiv thaiv ntawm cov tshuaj tsw qab thiab tsim cov pa roj carbon monoxide. Piv txwv li, nyob rau hauv cov tshuaj tiv thaiv acylation ntawm benzene nrog acetyl chloride, qhov sib ntxiv ntawm TMSOTf nce cov tshuaj tiv thaiv tawm los ntawm 70% ntawm cov tshuaj catalysts (xws li AlCl3) mus rau 90%, thiab cov tshuaj tiv thaiv mob me dua (chav kub vs . 80℃), txo cov tiam ntawm - khoom.

2. Diels Alder cycloaddition tshuaj tiv thaiv
TMSOTf tuaj yeem txo lub zog ua kom muaj zog thiab ua kom cov tshuaj tiv thaiv ntau ntxiv hauv cov tshuaj tiv thaiv cycloaddition ntawm dienes thiab dienophiles.

 

Piv txwv li, nyob rau hauv cov tshuaj tiv thaiv ntawm cyclopentadiene thiab acrylic acid, cov tshuaj tiv thaiv lub sij hawm luv luv los ntawm 24 teev mus rau 2 teev nyob rau hauv TMSOTf catalysis, thiab cis selectivity ntawm cov khoom mus txog 95%, muab ib tug npaum txoj kev rau lub synthesis ntawm tej yam ntuj tso khoom xws li terpenes.

3. Lub cev qhuav dej thiab etherification ntawm cawv
TMSOTf tuaj yeem ua kom lub cev qhuav dej ntawm cov dej cawv los tsim cov olefins, lossis cov dej tsis huv los tsim cov ethers. Piv txwv li, nyob rau hauv lub cev qhuav dej cov tshuaj tiv thaiv ntawm n-butanol, cov tshuaj tiv thaiv tawm los nyob rau hauv TMSOTf catalysis nce mus txog 90%, thiab qhov feem ntawm trans olefins nyob rau hauv cov khoom tshaj 95%, uas yog zoo dua li ib txwm sulfuric acid catalytic txoj kev (yield 60%, trans proportions 70%).

Green Chemistry Applications: Innovative Directions in Accordance with Sustainable Development Trends

 

1. Microwave pab synthesis
TMSOTf tuaj yeem ua kom ceev cov txheej txheem tshuaj tiv thaiv thiab txo qis kev siv hluav taws xob hauv microwave hluav taws xob. Piv txwv li, nyob rau hauv kev tiv thaiv siliconization ntawm qab zib derivatives, lub sij hawm cov tshuaj tiv thaiv tau luv luv los ntawm 5 teev nyob rau hauv ib txwm txoj kev mus rau 30 feeb nyob rau hauv microwave-pab tej yam kev mob, thiab cov yield tau nce mus rau 98%.

2. Dawb synthesis ntawm cov kuab tshuaj
TMSOTf tuaj yeem ua rau cov tshuaj tiv thaiv nyob rau hauv cov kuab tshuaj -cov xwm txheej pub dawb, txo kev siv cov kuab tshuaj organic thiab pov tseg.

 

Piv txwv li, hauv kev hloov kho siliconization ntawm esters, cov txiaj ntsig ntawm TMSOTf catalyzed cov tshuaj tiv thaiv nyob rau hauv cov kuab tshuaj-dawb tej yam kev mob mus txog 95%, thiab kev khiav hauj lwm yog yooj yim, raws li txoj cai ntawm ntsuab chemistry.

3. Nanoparticle catalyzed synthesis
Trimethylsilyl trifluoromethanesulfonateHloov kho nanoparticles, xws li silicon-raws li kub nanoparticles, tuaj yeem ua cov khoom siv tshiab los txhim kho kev xaiv cov tshuaj tiv thaiv. Piv txwv li, nyob rau hauv cov tshuaj tiv thaiv epoxidation ntawm styrene, qhov kev xaiv ntawm cov khoom catalyzed los ntawm silicon -raws li kub nanoparticles nce mus txog 90%, thiab cov catalyst tuaj yeem rov qab siv ntau dua 5 zaug yam tsis muaj qhov txo qis hauv kev ua haujlwm.

Analytical Chemistry Assistance: A "Chemical Amplifier" txhawm rau txhim kho kev tshawb pom rhiab heev

 

1. Compound derivatization
TMSOTf tuaj yeem hloov cov pab pawg nquag xws li hydroxyl thiab amino pawg mus rau hauv silicon ethers lossis silicon amine derivatives, txhim kho kev tshawb pom rhiab heev ntawm cov tebchaw hauv roj chromatography (GC) lossis kua chromatography (HPLC). Piv txwv li, hauv kev tshuaj xyuas amino acid, silicon-raws li derivatization tuaj yeem txo qhov kev kuaj pom qhov txwv mus rau qib picomolar (pmol), ua tau raws li qhov yuav tsum tau muaj ntawm kev tshuaj xyuas kab.

2. Mass spectrometry tsom xam txhim kho
TMSOTf hloov cov tebchaw yog nquag tsim cov cations ruaj khov nyob rau hauv huab hwm coj spectrometry tsom, txhim kho teeb liab siv. Piv txwv li, nyob rau hauv huab hwm coj spectrometry tsom xam ntawm carbohydrate tebchaw, siliconization kev hloov kho tsub kom lub ncov siv ntawm molecular ions los ntawm 10 lub sij hawm, ua kom yooj yim rau kev txheeb xyuas cov qauv.

Kev Tshawb Fawb Hauv Kev Siv Hluav Taws Xob: Cov Lus Qhia Muaj Peev Xwm rau Cov Kev Siv Hluav Taws Xob

 

1. Electrolyte additives rau lithium-ion roj teeb
TMSOTf tuaj yeem siv los ua ib zaj duab xis- tsim cov khoom ntxiv rau lithium- ion roj teeb electrolytes, tsim cov yeeb yaj kiab SEI ruaj khov ntawm qhov chaw tsis zoo electrode, inhibiting electrolyte decomposition, thiab txhim kho lub roj teeb lub neej. Cov kev sim ua ntej tau pom tias ntxiv 1% TMSOTf electrolyte tuaj yeem ua rau cov roj teeb ntau dua 500 thiab ua kom muaj peev xwm tuav tau ntawm 85%.

2. Proton exchange membrane hloov kho rau roj hlwb
TMSOTf tuaj yeem siv rau kev hloov pauv ntawm siliconization ntawm proton pauv daim nyias nyias los txhim kho proton conductivity thiab tshuaj stability. Piv txwv li, nyob rau hauv kev hloov kho ntawm perfluorosulfonic acid daim nyias nyias, siliconization kev kho mob nce proton conductivity los ntawm 20% thiab ho txhim khu kev ruaj ntseg ntawm daim nyias nyias ntawm qhov kub thiab txias (120 degree).

Trifluoromethanesulfonate trimethylsilyl ester tau dhau los ua ib qho tseem ceeb reagent hauv thaj chaw ntawm cov organic synthesis, tshuaj, cov ntaub ntawv, thiab lub zog vim nws cov qauv tshuaj tshwj xeeb thiab ntau yam kev ua haujlwm. Nws cov ntawv thov suav nrog ntau qhov xwm txheej los ntawm cov tshuaj tiv thaiv catalysis mus rau siab -kev npaj cov ntaub ntawv kawg, thiab nrog kev ua tiav hauv ntsuab chemistry thiab cov thev naus laus zis ntau lawm, nws lub peev xwm ua lag luam tseem raug tso tawm. Nyob rau hauv lub neej yav tom ntej, nrog rau kev thov kom siab -purity (Ntau dua los yog sib npaug rau 99.9%) cov khoom thiab kev txhim kho cov kev pabcuam customized, TMSOTf yuav tsum ua kom tiav cov ntawv thov dav dua hauv cov haujlwm tshiab xws li perovskite solar cells thiab lithium- ion roj teeb, txhawb kev txhim kho ntawm cov kev lag luam muaj feem xyuam rau kev ua haujlwm siab thiab ruaj khov.

Peb yog cov chaw tsim khoom ntawm cov khoom.

Lus Cim: BLOOM TECH (Txij li xyoo 2008), ACHIEVE CHEM-TECH yog peb lub koom haum ntawm peb.

SyntheticTrimethylsilyl trifluoromethanesulfonate :

Nws tau tsim los ntawm trifluoromethanesulfonic acid thiab trimethylchlorosilane. Los ntawm kev tshuaj xyuas qhov cuam tshuam xws li qhov kub, lub sijhawm, qhov sib piv ntawm cov khoom siv raw thiab lub siab distillation, qhov kev pom zoo ntawm cov tshuaj tiv thaiv tau txiav txim siab raws li hauv qab no: kub 20 - 30 C, lub sijhawm tshuaj tiv thaiv 8 h, raw khoom molar ratio 1: 1.40, thiab lub tshuab nqus tsev distillation siab - 0.090 MPa. NMR spectra ( 'H, 'p, 'Si NMR) thiab chemical titration method tau siv rau kev txheeb xyuas ntau yam ntawm cov khoom lag luam. Cov txiaj ntsig ntawm cov khoom tuaj yeem ncav cuag ntau dua 98% thiab purity tuaj yeem ncav cuag ntau dua 99%.

Cim npe nrov: Trimethylsilyl trifluoromethanesulfonate cas 27607-77-8, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom