Shaanxi Bloom Tech Co., Ltd. yog ib qho ntawm cov neeg tsim khoom lag luam thiab cov chaw muag khoom ntawm nefiracetam tsiav tshuaj hauv Suav teb. Txais tos rau kev lag luam wholesale ntau cov nefiracetam capsules rau muag ntawm no los ntawm peb lub hoobkas. Cov kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Nefiracetam tsiav tshuajyog cov tshuaj noj ntawm qhov ncauj kom tau txais kev txawj ntse. Nws cov ntsiab lus yog hmoov dawb crystalline. Raws li dav -} spectrum pyrrolidone derrolidone derivative, nws tau nyiam ntau dua rau nws cov cim xeeb thiab muaj zog heev- kev siv cov nyhuv. Cov tshuaj no feem ntau yog txhim kho kev kawm thiab kev nco txog lub peev xwm los ntawm kev tswj hwm glutamatergic signing kev teeb tsa, tshwj xeeb yog los ntawm kev txhim kho tam sim no ntawm Ampa txais tam sim no. Nyob rau tib lub sijhawm, nws tuaj yeem txhawb cov cholinergic hlab ntsha kis thiab cuam tshuam ntau yam neurotransmitter, concentration, thiab cov ntaub ntawv ua ceev ntawm lub hlwb. Clinically, nws yog tsuas yog siv los kho hnub nyoog {{}}}}}}}}}}}}}}} Cov tsos mob ntsig txog Alzheimer Kev Puas Ntawm Ib puag ncig los ntawm ib puag ncig cov khoom siv xws li hypoxia. Nws cov tshuaj ntsiav tshuaj ntsiav tshuaj ua kom cov kev yooj yim ntawm kev tswj hwm thiab muaj qhov tseeb ntawm kev xaiv, kev xaiv tseem ceeb rau cov neeg mob uas muaj kev pheej hmoo.
Nyob rau tib lub sijhawm, peb lub tuam txhab tsis tsuas yog muab cov hmoov dawb, tab sis kuj cov ntsiav tshuaj thiab cov tshuaj. Yog tias xav tau, thov koj xav tiv tauj peb txhua lub sijhawm.
Cov ntaub ntawv ntau
Cov ntaub ntawv ntxiv ntawm kev sib txuas lus:
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Nefiracetam Hmoov Ca
Yuav ua li cas Nefiracetam reshapes hlwb zog thorostasis
Lub hlwb, raws li lub zog hluav taws xob zoo tshaj plaws hauv tib neeg lub cev, cov nyiaj rau tsuas yog 2% ntawm lub cev nyhav tab sis noj 20% ntawm lub cev qab zib. Kev Txij Nkawm Ntawm Nws Lub Zog Kev Lag Luam Kev Cai ntawm cov metabolism hauv cov metabolism, glutamine, lipid metabolism, thiab neurotransmitter. Txawm li cas los xij, cov kab mob neurodegenerative cov kab mob xws li Alzheimer muaj feem ntau nrog cov piam thaj tsis sib haum, muaj kev ntxhov siab oxidatance, thiab neurotransmitter tsis txaus.Nefiracetam tsiav tshuaj, raws li cov pyrrolidinone kev txawj ntse, tau pom tias txhim kho lub hlwb ua haujlwm los ntawm kev hloov kho cov neurotransmitter recepors thiab ion raws li ntau lub hom phiaj. Ntawm no yog cov ncauj lus piav qhia ntxaws ntxaws:
Cov Ncaws Pob thiab Homeostasis Imbalance ntawm Lub Hlwb Zog Hluav Taws Xob
Cov metabolism glucose: lub axis tseem ceeb ntawm kev siv zog
Cov piam thaj yog qhov tseem ceeb ntawm lub zog rau lub hlwb, thiab nws cov metabolism tau muab faib ua peb theem:
Glycolysis: cov piam thaj tau tawg rau hauv pyluvate, tsim cov tshuaj ATP me me thiab Nadh.
TricarboxLic acid voj voog (TCA): Acetoacetate tau hloov mus rau Acetyl COA thiab nkag mus rau hauv Madochondrial los tsim Nadh thiab FadH2.
Oxidatory phosphorylation: lub electron hloov saw siv nadh / fadh2 los tsim atp thaum noj oxygen.
Lub xeev cov neeg mob khov kho: Alzheimer tus kab mob tus mob muaj 30%-% txo qis glycolytic glluke, xws li hexolinase), ua rau tsis muaj qhov tsis txaus ntawm cov khoom noj.
Glutamine glutamate gaba voj voog: txuas ntawm neurotransmitters thiab lub zog
Glutamine synthesis: astrocytes hloov glutamate thiab ammonia rau hauv glutamine rau cov neurons kom synthesize glutamate lossis gaba dua.
Neurotransmitter tso tawm: Glutamate (txaus siab) thiab gaba (inhibitory (thiab lawv cov synthesis siv ntau npaum li cas ntawm ATP.
Qhov tshwm sim ntawm metabolic tsis txaus ntseeg: tom qab kev ua txhaum lub hlwb kev raug mob, ua rau muaj kev phom sij ntawm synthetase txo, thaum lub sij hawm txo ntawm Gaba Exacerebates Neuronal Overxcitation.
Lipid metabolism: Membrane qauv thiab txhawb rau teeb liab Transduction
Phospholipid metabolism: cov synthesis thiab kev tsis txaus siab ntawm neuronal membrane phosprane phosprane (xws li phosphatidylcholipids (xws li phosphatidylcholipids (xws li phosphatidylcholipids (xws li phosphatidylcholipids (xws li phosphatidylcholipids (xws li phosphatidylchod
Lipid Peroxidation: Oxidative Kev Nyuaj Siab Ua rau Peroxidation ntawm Phosphatidylylinositol (PI), cuam tshuam rau membrarane kev ntseeg siab.
Kev Tshawb Xyuas Kev Nyab Xeeb: Qib siab ntawm cov fatty fatty acids (FFA) Hauv Cerebrospinal Kua ntawm Alzheimer Tus Kab Mob Li CasBolism tsis sib xws.
Pharmacologism mechanism ntawm nefiracetam: mult - phiaj kev cai ntawm cov metabolic network
Txhim Kho Neurotransmitter Receptor Kev Ua Haujlwm: Txhim Kho Lub Zog Siv Hluav Taws Xob
AMPA / Kainate Receptor Txoj Cai: Nefiracetam, raws li ib qho isoform regulator, txhim kho receptor rhiab heev rau glutamate thiab txhawb synaptic plasticity. Txhim kho kev sib kis synaptic thiab txo kev siv zog rau kev rov ua dua tshiab rau cov teeb liab teeb liab transdal. Hauv cov nas hippocampal slices, Nefiracetam (10 μ m) nce ampa recenor {3}, thaum txo lub peev xwm tua hluav taws xob thiab txuag lub zog. NMDA Receptor kev ua haujlwm yog tiav los ntawm cov protein Kinase C (PKC) recwors los ntawm magnesium ions thiab txhim kho glutamatergic signaling. Kev ua kom ua kom muaj NMDA receptors txhawb nqa ntev {}}} Lub zog ua haujlwm, thiab zam kev siv zog ntawm kev rov ua dua ntawm- lub sij hawm nco. Nicotine Acetylcholine receptor (Nachr) Cov Kev Cai: NEFIRACETAM nce ntxiv Postsynaptic tam sim no (EPSC) piv rau kev sib kho los ntawm Nachr, txhim kho chotyergic kis. Acetylcholine yog ib qho tseem ceeb neurotransmitter rau kev txawj ntse, thiab nws cov efficiaitieve muaj ntau dua los ntawm kev ua haujlwm tsis sib xws.
Ionic Channel Cov Cai: Ntsuas Ntsuas Cov Kev Txaus Siab Thiab Cov Khoom Siv Metanolic
Kev ua kom muaj zog ntawm L / n - Hom calcium raws li cov calcium ntawm neurotrophic yam (xws li BDNF) los ntawm Nefiracetam. BDNF Induces Mitochondrial biosynthesis, nce atp ntau lawm, thaum ua kom haum ntawm lub xov tooj ntawm lub zog thiab txo lub zog khib nyiab. Qhov sib npaug ntawm cov paaquergic tuaj yeem tswj hwm los ntawm modulating Nyob rau hauv lub ro 5-4864 induced qaug dab peg qauv,Nefiracetam tsiav tshuajTxo seiVure zaus zaus los ntawm 67% thiab rov qab noj qab zib qab zib flucose (cmrglu) rau cov hauv paus qib.
Antioxidant kev ntxhov siab thiab kev neuroproction: tswj cov metabolic antostasis
Oxidative Kev Nyuaj Siab Inhibition: Nefiracetam txo cov tiam neeg ntawm cov khoom oxygen cov pa roj oxygen (Ros) thiab tiv thaiv mitochondrial muaj nuj nqi.
Cov pov thawj metabolic: hauv methamhetamine ua rau Neurotoxicity qauv, GSH) ntau ntau hauv lub hlwb ua ke (MDA) cov ntsiab lus los ntawm 35%.
Glutamine cycle repair: Nefiracetam alleviates glutamate excitotoxicity by promoting the expression of glutamine synthetase in astrocytes.
Tsiaj sim: Tom qab kho nrog Nefiracetam (10 Mg / Kg / D, 7 hnub) nyob rau hauv cov hippocampus rov qab mus rau 82% ntawm cov txiaj ntsig qub, thaum tus tswj hwm tau tsuas yog 55%.
Metabolomics Kev Kawm: Cov kev cai siv zog ntawm lub hlwb metabolites los ntawm nefiracetam
Kev Ntsuam Xyuas Quantitative ntawm cov metabolites
Arterial venous metabolite sib txawv: los ntawm kev sib tw tsis pom kev sib tw, nws tau pom tias nefiracetam nce net garcose uptake hauv lub hlwb los ntawm 18% (p<0.01), while reducing lactate release by 12%, indicating an improvement in glycolysis efficiency.
Tshaj Tawm enzyme qhia: Nefiracetam Upregulated Lub Hexokinase (HK) thiab PyRuvate Kinase (PyRuvate Kinase (PyRuvate Kinase (Py
Kev ua kom zoo ntawm glutamine glutamate gaba voj voog
Cov kev kho mob metabolic: nefiracetam kev kho txo qhov tso tawm ntawm glutamine hauv lub hlwb los ntawm 19%, xav txog kev txhim kho kev ua haujlwm ntawm kev ua haujlwm.
Txhim kho Gaba synthesis: theem ntawm Gaba hauv Cerebrospinal kua dej nce los ntawm 0.8 μ m ua ntej kev kho mob rau 1.2 μ m (p<0.05), which was significantly correlated with a decrease in anxiety behavior score (r=-0.72).
Reprogramming ntawm Lipid Metabolism
Kev hloov pauv hauv phospholipipid muaj kev sib xyaw: Nefiracetam txo cov ntsiab lus ntawm oxidized phosphatanolamine (ps) thiab kev txhim kho Membrane kev ruaj khov.
Pub Dawb Fatty Acid Kev Cai: Cov Pawg Kho Mob FFA theem hauv lub paj hlwb txo ntawm cov hauv paus 45 μ m rau 32 μ m (p<0.01), reducing mitochondrial damage caused by lipotoxicity.
Kev Tshawb Fawb thiab Chaw Tshawb Xyuas Tshawb Xyuas: Kev Hloov Los Ntawm Mechanial
Lub zog thoberasis rov qab hauv cov tsiaj tsiaj
Kev kho ntawm kev raug mob lub hlwb raug mob: Hauv kev tsim kho cortical raug mob (CCI) kev kho mob morris
Alzheimer Kev Cuam Tshuam: Tom qab kev kho mob nrog Nefiracetam (5 mg / teev / D, 3 hlis), app / Ps1 Transgenic Atp cov ntsiab lus thiab ib 35% tsawg hauv Amyloid Plaque thaj chaw.
Tib Neeg Cov Np pharmoMinetics thiab Kev Nyab Xeeb
Nqus thiab faib khoom: Tom qab kev tswj hwm ntawm qhov ncaujNefiracetam tsiav tshuajMus rau cov neeg ua haujlwm noj haus huv, lub sijhawm ua kom muaj ntshav lub hlwb (TMAX) yog li ntawm 65%
Cov metabolic licolic
Kev Nyab Xeeb: Theem I / II Cov chaw kuaj mob tau pom tias Nefiracetam tsis muaj kev cuam tshuam loj heev ntawm cov tshuaj lom neeg tsawg dua lossis sib npaug (12%) thiab insomnia (8%).
Cov Kev Sib Tw thiab Yav Tom Ntej
Heterogeneity ntawm cov lus teb metabolic
Cov hnub nyoog muaj txiaj ntsig: cov nas laus muaj cov lus teb metabolic tsis muaj zog, nrog tsuas yog muaj 10 pab cuam tshuam nrog MitochonderTs.
Cov poj niam sib txawv: Cov poj niam poj niam muaj kev nkag siab ntau ntxiv rau cov kev cuam tshuam antioxidant ntawm nefiracetam, nrog 22% nce hauv cov theem gsh ntau dua piv rau cov txivneej. Kev tshawb nrhiav ntxiv ntawm cov tshuaj hormones muaj kev cai tswj hwm.
Cov teeb meem metabolic synergistic ntawm kev kho kev kho
Ua ke nrog cov tshuaj yej qab zib muaj tshuaj yej: Nefiracetam (50 mg / kg) Tus kab mob lub hlwb ua kom ntsuas tau ntawm 38%, uas yog qhov zoo dua rau cov tshuaj kho ib leeg.
Synero nrog antioxidants: ua ke nrog n - acetylcysteine (NEX), nws tuaj yeem ntxiv cov teebmeem ntawm lub hlwb MDA los ntawm 45% thiab txhim kho kev cuam tshuam ntawm cov teebmeem.
Saib xyuas ntev -} lub sij hawm metabolic kev nyab xeeb
Lipid metabolism kev pheej hmoo: ntev lub sij hawm siab {{}} kev txhaj tshuaj me me (tg)
Qhov cuam tshuam rau cov plab me me: kev tshawb fawb ua ntej tau pom tias muaj kev sib xyaw ua ke ntawm AkkiSia), thiab nws cov peev txheej luv luv ntawm lub hlwb me me, uas yuav tsum tau tshawb pom ntxiv.
Cim npe nrov: Nefiracetam Capsules, cov chaw muag khoom, chaw tsim khoom, Hoobkas, lag luam wholesale, yuav, nqe, loj, loj, rau muag