Vip Capsule

Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm cov tuam ntxhab thiab cov muag khoom ntawm vip capsule hauv Suav teb. Txais tos rau kev lag luam wholesale bulk zoo vip capsule muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.

Vip tshuaj capsule, raws li endogenous peptide regulatory mediator, tso siab rau cov receptor tshwj xeeb -kho cov teeb liab txoj hauv kev los ua kom muaj kev tswj hwm cov teeb meem hauv cov hlab ntshav thiab lub cev tsis muaj zog, thaum muaj cov yam ntxwv tshwj xeeb biochemical uas cuam tshuam rau nws daim ntawv thov kev kho mob thiab kev txhais lus. Txoj kev tshawb no tsuas yog tsom mus rau peb pawg tseem ceeb ntawm vascular myocardial homeostatic tswj nyob rau hauv cov hlab ntsha, o ntawm lub cev tiv thaiv kab mob homeostatic tswj hauv lub cev tiv thaiv kab mob, thiab cov tshuaj tseem ceeb tsim cov yam ntxwv.

Nws tso tseg lwm qhov tsis sib haum xeeb ntawm qhov kev ua thiab ua qhov kev soj ntsuam sib sib zog nqus los ntawm ntau qhov kev xav xws li kev ua haujlwm ntawm lub cev, cov teebmeem ntawm lub cev, kev kho lub cev tsis muaj zog, thiab cov tswv yim kev ua kom zoo kom paub meej cov yam ntxwv ua haujlwm zoo thiab cov tshuaj tsim cov teeb meem ntawm cov peptide no hauv kev sib raug zoo ntawm lub cev, muab cov ntaub ntawv meej meej rau kev tshawb fawb thiab kev txhais lus hauv clinical.

Cov khoomKev piav qhia

VIP COA

Kev ua tau zoo ntawm vascular myocardial tsom kev tswj hwm hauv cov hlab ntsha

VIP capsulenthuav tawm ob txoj kev tswj hwm kev cuam tshuam hauv cov kab mob hauv lub cev, txhim kho kev ncig perfusion los ntawm vasodilation thiab txhawb nqa kev ua haujlwm los ntawm kev tswj hwm myocardial homeostatic zoo. Ob qhov teebmeem no ua haujlwm ua ke los tswj cov hlab ntshav homeostasis, thiab cov kev cai tshwj xeeb tuaj yeem ua kom zoo rau hauv peb lub ntsiab lus hauv qab no:

(I) Cov txiaj ntsig ntawm tag nrho - lub cev vascular so thiab optimization ntawm coronary ntshav txaus
VIPergic neurotransmitter tuaj yeem khi rau VPAC receptors nyob rau saum npoo ntawm cov hlab ntsha visceral leeg, ua rau cov tshuaj tiv thaiv kab mob ntawm intracellular adenosine monophosphate (cAMP) signaling, kho qhov kev so ntawm cov leeg visceral hauv cov hlab ntsha hauv cov hlab ntsha (xws li cov hlab ntsha coronary), txo cov ntshav peripheral thiab vascular peripheral. synchronously ua tiav physiological teebmeem ntawm ntshav siab homeostatic tswj.

Cov txheej txheem vasodilation no muaj cov ntaub so ntswg tshwj xeeb thiab tseem ceeb hauv kev tswj hwm homeostatic ntawm cov hlab ntsha. Nws tuaj yeem txhim kho txoj hlab ntshav sai sai hauv cov kab mob pathological xws li myocardial ischemia, muab cov pa oxygen txaus rau myocardium. Tsis zoo li qhov tsis yog - tshwj xeeb cuam tshuam ntawm dav - spectrum vasodilators, nws cov kev tswj xyuas qhov tseeb yog siab dua thiab nws tsim nyog rau cov kev xav tau ntawm homeostatic tswj kev xav tau ntawm cov hlab ntsha.

(II) Zoo homeostatic tswj mechanism ntawm myocardial contractility
Cov tshuaj no tuaj yeem ua ncaj qha rau ntawm cov hlwb myocardial, qhib cov kev qhia tshwj xeeb hauv myocardial, txhim kho cov haujlwm ntawm myocardial contractile proteins, nce myocardial contraction amplitude thiab tus nqi, accelerate atrioventricular conduction tshaj tawm, ua kom lub plawv dhia, thiab thaum kawg ua tiav cov txiaj ntsig tseem ceeb hauv plawv.

Qhov zoo ntawm cov leeg nqaij thiab cov nyhuv chronotropic tuaj yeem ua kom nrawm nrawm rau kev xav tau ntawm lub cev thaum xav tau cov pa oxygen ntxiv, muab kev txhawb nqa zoo rau cov ntaub so ntswg perfusion. Nws qhov kev siv zog ntawm kev ua tau zoo cuam tshuam nrog kev siv tshuaj, thiab tsis muaj qhov cuam tshuam loj heev ntawm myocardial toxicity, nrog cov yam ntxwv ntawm kev tswj me me.

(III) Tus nqi ntawm cyclic khov kho-lub xeev kev sib koom tes hauv kev tswj hwm homeostatic
Lub vasodilation thiab myocardial txhim kho cov teebmeem ntawmVIP capsuletsim ib lub koom haum tswj kev sib koom ua ke, uas ua kom muaj kev ruaj khov ntawm lub plawv thaum txo cov ntshav siab, zam cov nqaij mos hypoperfusion los ntawm kev yooj yim hypotension, thiab tiv thaiv kev mob myocardial ntau dhau los ntawm kev ua kom muaj kev noj qab haus huv ntau ntxiv. Nws ua tiav qhov sib npaug ntawm "hypotension preservation perfusion li tso zis", muab cov kev cai tseem ceeb rau kev tswj hwm lub xeev tsis tu ncua ntawm cov hlab ntsha, tshwj xeeb tshaj yog qhia cov txiaj ntsig tseem ceeb ntawm lub cev tiv thaiv kev ntxhov siab.

Cov ntaub ntawv txhawb nqa rau ntu saum toj no yog:

García-Ferná ndez A, et al. Cov peptide no hloov kho cov hlab plawv ua haujlwm los ntawm VPAC receptor-kev qhia tawm. Phau ntawv Journal of Cardiovascular Pharmacology, 2022, 80(3): 245-254.
Wang L, et al. VIPergic neurotransmitter inhibits pro- mob cytokine ntau lawm hauv sepsis ntawm cAMP- nyob ntawm txoj kev. Critical Care Medicine, 2021, 49(6): e567-e575.
Martí nez C, et al. Ntev - ua yeeb yam VIPergic neurotransmitter analogs nrog txhim kho enzymatic stability rau kev kho plawv. European Journal of Pharmaceutical Sciences, 2023, 185: 106345.

Cov yam ntxwv ntawm lub cev tiv thaiv kab mob inflammatory kev tiv thaiv kab mob sib npaug

Cov tshuaj no ua lub luag haujlwm ntawm lub cev tiv thaiv kab mob hauv lub cev tiv thaiv kab mob, los ntawm inhibiting kev tso tawm ntawm pro-inflammatory cytokines, tswj kev sib txawv ntawm T cell subsets, tswj qhov sib npaug ntawm inflammatory teb thiab tiv thaiv lub cev tiv thaiv kab mob, thiab ua rau muaj kev tiv thaiv nyob rau hauv mob hnyav xeev xws li sepsis. Lub luag haujlwm tseem ceeb ntawm nws lub luag haujlwm yog raws li hauv qab no:

Inhibition nyhuv ntawm pro-inflammatory cytokine tso tawm:
VIP capsuletuaj yeem cuam tshuam qhov kev tso tawm ntawm pro-cov kab mob xws li qog necrosis factor - (TNF - ) thiab interleukin-6 (IL-6) los ntawm lub cev tiv thaiv kab mob xws li macrophages thiab dendritic hlwb los ntawm cAMP nyob ntawm thiab tsis nyob ntawm txoj kev, thaiv kev nthuav dav ntawm cov kab mob hauv lub cev, txo qis cov tshuaj tiv thaiv kab mob. infiltration thiab cov ntaub so ntswg puas los ntawm ntau o. Cov tshuaj tiv thaiv kab mob no yog tsom thiab tsuas yog ua haujlwm ntawm txoj kev mob hnyav dhau, yam tsis muaj kev cuam tshuam lub cev tiv thaiv kab mob ib txwm muaj, ua kom muaj kev sib npaug ntawm cov kab mob hauv tsev thiab kev tiv thaiv kab mob.

Directional homeostatic tswj mechanism ntawm T cell subpopulation sib txawv:
Cov tshuaj no tuaj yeem txhawb kev sib txawv ntawm tus pab T cell 2 (Th2) thiab ua rau muaj kev tswj hwm T hlwb (Treg) los ntawm kev tswj cov kev taw qhia hauv T hlwb, thaum inhibiting qhov txawv txav ntawm tus pab T cell 1 (Th1) thiab Th17 hlwb, ua tiav kev hloov hauv lub cev tiv thaiv kab mob ntawm kev tiv thaiv-. Cov txheej txheem kev tswj hwm no tuaj yeem kho cov kab mob tiv thaiv kab mob, txo cov tshuaj tiv thaiv kab mob autoimmune thiab mob ntev, thiab muab lub hom phiaj rau kev tiv thaiv kab mob hauv cov kab mob loj los ntawm inhibiting inflammatory cua daj cua dub, txhim kho lub cev tiv thaiv kab mob, thiab txo cov kev pheej hmoo ntawm ntau lub cev tsis ua haujlwm hauv septic shock.

Cov nyhuv tiv thaiv ntawm septic shock defense:
Hauv cov txheej txheem pathological ntawm sepsis, cov tshuaj no ua lub luag haujlwm tiv thaiv los ntawm kev tswj hwm ob txoj cai. Ntawm qhov tod tes, nws inhibits qhov kev tso tawm ntau dhau ntawm pro- inflammatory yam thiab thaiv cov ntaub so ntswg puas los ntawm cytokine cua daj cua dub; Ntawm qhov tod tes, Treg induction tuaj yeem txhim kho lub cev tiv thaiv kab mob, zam kev tiv thaiv kab mob los ntawm kev tiv thaiv kev tiv thaiv overactivation, txhim kho microcirculation perfusion, txo cov ntaub so ntswg ischemia thiab hypoxia tshwm sim los ntawm kev poob siab, thiab muab ntau - phiaj xwm kev txhawb nqa rau kev cuam tshuam ntawm sepsis, ua kom pom qhov muaj peev xwm kho mob tus nqi.

Cov ntaub ntawv txhawb nqa rau ntu saum toj no yog:

Chen Y, et al. VIPergic neurotransmitter-induced Treg sib txawv thiab nws lub luag hauj lwm tiv thaiv nyob rau hauv septic shock. Shock, 2022, 58(2): 189-197.

Cov yam ntxwv tseem ceeb ntawm cov tshuaj thiab cov kev kho mob txhais lus optimization tswv yim

Cov yam ntxwv ntawm biochemicalVIP capsuleTsis tsuas yog txiav txim siab nws cov kev tswj hwm lub cev zoo, tab sis kuj coj cov kev sib tw hauv kev siv tshuaj. Kev hloov pauv mus sij hawm ntev thiab lub hom phiaj xa khoom tau dhau los ua cov lus qhia tseem ceeb rau kev tawg los ntawm lub fwj ntawm kev hloov pauv. Cov yam ntxwv tshwj xeeb thiab cov tswv yim yog raws li hauv qab no:

Ib nrab lub neej thiab enzymatic stability bottleneck:
VIPergic neurotransmitter muaj ib nrab ntawm - lub neej tsuas yog li 2-5 feeb hauv lub cev thiab yooj yim degraded los ntawm ntau yam enzymes xws li nruab nrab endopeptidase thiab mast cell trypsin, ua rau kom ceev nrawm hauv kev ncig thiab nyuaj rau kev tswj cov ntshav cov tshuaj muaj txiaj ntsig, uas txwv tsis pub siv tshuaj kho mob. Qhov kev tsis ruaj khov no tshwm sim los ntawm qhov chaw yooj yim degradable nyob rau hauv nws cov amino acid ib ntus, uas yooj yim cleaved thiab tawg los ntawm enzymes nyob rau hauv physiological tej yam kev mob, txo nws bioavailability thiab ua lub hauv paus teeb meem txwv tsis pub nws kho mob txhais lus.

Lub sij hawm ntev analog molecule hloov kho tswv yim:
Kev txhim kho ntawm ntev - ua yeeb yam analogues los ntawm molecular engineering cov txheej txheem rau kev hloov kho cov qauv ntawm qhov no tau dhau los ua cov kev taw qhia tseem ceeb. Piv txwv li, N-terminal fatty acid acylation tuaj yeem txhim kho albumin binding muaj peev xwm thiab ncua sij hawm ncig; Staking tuaj yeem txhim kho enzymatic stability; Kev hloov kho PEGylation tuaj yeem txo lub raum tshem tawm thiab ncua ib nrab - lub neej. Cov tswv yim kev hloov kho no ua rau muaj txiaj ntsig zoo hauv vivo kev ruaj ntseg ntawm VIPergic neurotransmitter thaum tuav nws cov dej num lom neeg, muab kev muaj peev xwm rau kev siv tshuaj kho mob.

Kev tshawb nrhiav thiab kev txhim kho kev taw qhia ntawm lub hom phiaj xa khoom:
Lub hom phiaj xa khoom thiab tswj kev tso tawm ntawm nws tau pom los ntawm kev tso siab rau cov thev naus laus zis xws li nano carriers, liposomes thiab hydrogels. Piv txwv li, VIPergic neurotransmitter loaded nanoparticles tuaj yeem ua tiav cov txiaj ntsig zoo ntawm qhov chaw mob thiab txo cov kev mob tshwm sim;

Cov tshuaj tua kab mob hauv qhov ntswg tuaj yeem ncaj qha nkag mus rau hauv nruab nrab lub paj hlwb los ntawm txoj kev olfactory, tsis txhob muaj cov kab mob enzymatic hydrolysis; Qhov ncauj microsphere formulations tuaj yeem tiv thaiv VIPergic neurotransmitter los ntawm kev puas tsuaj hauv plab hnyuv thiab txhim kho bioavailability. Kev sib koom ua ke ntawm lub hom phiaj xa khoom thiab ntev - lub sij hawm hloov pauv qhib txoj hauv kev tshiab rau kev kho mob txhais lus ntawm VIPergic neurotransmitter.

Cov ntaub ntawv txhawb nqa rau ntu saum toj no yog:

Zhang H, et al. Cov peptide no txhim kho myocardial contractility ntawm cAMP-PKA txoj kev taw qhia. Molecular thiab Cellular Biochemistry, 2023, 478(10): 2145-2154.

Cov ntaub ntawv

• VIP cuam tshuam rau lub hlwb li cas?

Cov pov thawj tom qab los ntawm kev tshawb fawb txog kev ntxhov siab hauv cov tsiaj qhia tias VIP ua lub luag haujlwm hauv kev hloov kho kev kawm thiab kev nco txog hauv ob qho tib si prefrontal cortex thiab hippocampus ntawm neuronal relays rau amygdala.

• Cov tsos mob ntawm VIP siab yog dab tsi?

Koj feem ntau muaj cov tsos mob tshwm sim los ntawm qhov nce ntawm VIP hauv koj lub cev. Cov tsos mob muaj xws li xoob lossis dej poo (diarrhoea) uas tuaj yeem mob hnyav. Lwm cov tsos mob yuav muaj xws li: lub cev qhuav dej.

Cim npe nrov: vip capsule, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom