Shaanxi BLOOM Tech Co., Ltd. yog ib tug ntawm cov uas paub txog manufacturers thiab lwm tus neeg ntawm atosiban txhaj nyob rau hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo atosiban txhaj rau muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Kev txhaj tshuaj Atosibanyog ib qho tshuaj tshwj xeeb kev cuam tshuam tsim tshwj xeeb rau kev sib txawv ntawm uterine contractions thaum cev xeeb tub hauv kev kho obstetrics. Nws tuav txoj haujlwm tshwj xeeb hauv kev kuaj mob thiab kho cov xwm txheej cuam tshuam txog kev pheej hmoo siab xeeb tub thiab kev tiv thaiv fetal. Los ntawm qhov kev xav ntawm tus nqi tseem ceeb ntawm kev siv tshuaj kho mob, qhov zoo ntawm cov tshuaj no tsis yog dav thiab nyuaj, tab sis tau tsom mus rau peb yam tseem ceeb uas tsis tuaj yeem hloov pauv. Qhov no kuj yog qhov laj thawj tseem ceeb vim li cas nws thiaj li maj mam dhau los ua qhov kev kho mob zoo tshaj plaws ntawm ntau txoj kev cuam tshuam uterine contraction.
Peb Cov KhoomKev piav qhia
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Atosiban COA
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| Certificate of Analysis | ||
| Compound npe | Atosiban | |
| Qib | Pharmaceutical qib | |
| CAS Nr. | 90779-69-4 | |
| Ntau | 39g | |
| Ntim txheem | PE hnab + Al foil hnab | |
| Chaw tsim tshuaj paus | Shaanxi BLOOM TECH Co., Ltd | |
| Ntau No. | 202501090088 | |
| MFG | Peb 9, 2026 | |
| EXP | Peb 8, 2029 | |
| Qauv |
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| Yam khoom | Enterprise txheem | Kev txheeb xyuas qhov tshwm sim |
| Qhov tshwm sim | Dawb los yog yuav luag dawb hmoov | Ua raws |
| Cov ntsiab lus dej | Tsawg dua lossis sib npaug li 5.0% | 0.54% |
| Poob rau ziab | Tsawg dua lossis sib npaug li 1.0% | 0.42% |
| Hnyav Hlau | Pb Tsawg dua lossis sib npaug li 0.5ppm | N.D. |
| Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Hg Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Cd Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Purity (HPLC) | Ntau dua lossis sib npaug li 99.0% | 99.98% |
| Ib leeg impurity | <0.8% | 0.52% |
| Tag nrho microbial suav | Tsawg dua lossis sib npaug li 750cfu / g | 95 |
| E. Coli | Tsawg dua lossis sib npaug li 2MPN / g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (los ntawm GC) | Tsawg dua lossis sib npaug li 5000ppm | 500ppm ua |
| Cia | Khaws rau hauv qhov chaw kaw, tsaus, thiab qhuav hauv qab -20 degree | |
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| Tshuaj Formula | C43H67N11O12S2 |
| Exact Mass | 993.44 |
| Molecular Luj | 994.19 |
| m/z | 993.44 (100.0%), 994.44 (46.5%), 995.45 (10.6%), 995.44 (9.0%), 996.44 (4.2%), 994.44 (4.1%), 995.45 (2.5%), 995.44 (1.9%), 994.44 (1.6%), 996.45 (1.1%) |
| Elemental Analysis | C, 51.95; H, 6.79; N, 15.50; O, 19.31; S, 6.45 |
Tom ntej no, peb yuav txhais cov txheej txheem pharmacological yooj yim thiab tsom mus rau peb lub ntsiab lus tseem ceeb ntawm cov tshuaj. Peb yuav ua nyob rau hauv - kev tsom xam qhov tob thiab cov lus piav qhia ntxaws los ntawm peb qhov tseem ceeb: kev cuam tshuam cov tshuaj tiv thaiv lub sijhawm thiab kev tswj xyuas kev ua haujlwm ntawm lub tsev menyuam, kev saib xyuas ruaj khov ntawm lub voj voog cev xeeb tub thiab lub sijhawm cev xeeb tub ntev, thiab kev siv tshuaj tiv thaiv thiab kev tsis zoo ntawm lub cev tseem ceeb. Peb yuav ua tiav nws cov txiaj ntsig tseem ceeb hauv daim ntawv thov kev kho mob thiab muab cov ntsiab lus raug txhawb rau kev siv tshuaj siv hauv kev kuaj mob thiab kev kho mob.
Lub sij hawm cuam tshuam cov lus teb yog qhov zoo heev, thiab cov txiaj ntsig ntawm uterine contraction tswj tau lav
Qhov kom zoo dua no yog ib qho ntawm cov kev sib tw tseem ceeb ntawm kev siv tshuaj kho mobKev txhaj tshuaj Atosiban. Tom qab cov tshuaj tau muab tso rau hauv kev siv, nws tuaj yeem ua rau muaj kev cuam tshuam sai yam tsis muaj lub sijhawm incubation ntev. Nyob rau tib lub sijhawm, uterine contraction inhibition effect muaj qhov ruaj khov thiab muaj tseeb, uas ua tau raws li qhov tseem ceeb ntawm kev kho mob tam sim ntawd, thiab yuav tsis muaj teeb meem ntawm cov nyhuv hloov pauv lossis cuam tshuam lag.
(I) Ceev thiab ua tau zoo pib lub suab nrov:
Cov tshuaj pib ua kom nrawm dua li cov txheej txheem kev cuam tshuam zoo sib xws. Tom qab siv tshuaj, nws tuaj yeem nkag mus rau lub xeev kev cuam tshuam zoo hauv lub sijhawm luv luv. Nws tuaj yeem ua tiav cov lus teb tam sim thiab kev tswj hwm sai rau qhov txawv txav ntawm uterine contractions, khov kho tuav lub sijhawm cuam tshuam zoo tshaj plaws, thiab zam kev pheej hmoo ntawm cev xeeb tub los ntawm kev ua rau lub cev tsis zoo ntawm lub tsev menyuam. Tsis tas yuav tos kom cov tshuaj maj mam sib sau thiab siv tau thoob plaws hauv cov txheej txheem, thiab lub sijhawm cuam tshuam tau txuas ntxiv.
(II) Cov nyhuv ntawm uterine contraction inhibition yog meej thiab tswj tau:
Cov tshuaj muaj meej thiab ruaj khov tswj kev txawv txav ntawm uterine contractions. Thaum nws siv tau, qhov kev cia siab inhibition lub hom phiaj tuaj yeem ua tiav yam tsis muaj kev cuam tshuam kev cuam tshuam los yog rov ua dua. Tag nrho cov nyhuv inhibition muaj cov yam ntxwv txhim khu kev qha, uas tuaj yeem tswj tau lub xeev kev cuam tshuam ruaj khov thiab ua tib zoo siv cov kev cai tseem ceeb ntawm kev tswj lub tsev menyuam. Cov kev siv tshuaj kho mob tuaj yeem kwv yees thiab tswj tau.
Cov ntaub ntawv Source:
European Medicines Agency. Atosiban Summary of Product Characteristics[EB/OL]. European Lub Chaw Haujlwm rau Kev Ntsuas Cov Khoom Siv Tshuaj, 2024.
Liu Yaxin, Zhang Shuning, Chen Xiaojun Kev sib piv txoj kev tshawb fawb txog kev kho mob thiab kev nyab xeeb ntawm uterine contraction inhibitors [J]. International Journal of Obstetrics thiab Gynecology, 2024, 51 (2): 217-220
Obstetrics Pawg ntawm Obstetrics thiab Gynecology ceg ntawm Tuam Tshoj Medical Association Cov kws tshaj lij pom zoo rau kev soj ntsuam kev siv tshuaj cuam tshuam rau cev xeeb tub induced uterine contractions (excerpt) [J]. Suav Journal of Obstetrics thiab Gynecology, 2023, 24 (6): 601-604
Tsis tas yuav tos, cov nyhuv tshuaj yuav tshwm sim tam sim
Qhov no yog tus yam ntxwv tseem ceeb uas ua rau nws sib nrug los ntawm cov tshuaj cuam tshuam zoo sib xws. Hauv kev siv tshuaj kho mob,Kev txhaj tshuaj atosibantsis xav tau lub sijhawm ntev incubation rau cov tshuaj tsub zuj zuj, thiab tuaj yeem ua rau muaj kev cuam tshuam sai sai yam tsis tau tos tom qab siv tshuaj.
Nyob rau tib lub sijhawm, uterine contraction inhibition effect muaj qhov ruaj khov thiab muaj tseeb, ua tau raws li cov kev xav tau ntawm kev kho mob tam sim ntawd, thiab yuav tsis muaj kev hloov pauv lossis lag luam hauv kev cuam tshuam. Lub laj thawj tseem ceeb tom qab qhov no tsis yog qhov yuam kev, tab sis txiav txim siab los ntawm nws qhov tshwj xeeb ntawm kev siv tshuaj, uas tsis tas yuav tos kom cov tshuaj siv tau. Tsis muaj cov kauj ruam ua ntej ntxiv rau tag nrho cov txheej txheem, uas tuaj yeem muab faib ua ob qho laj thawj hauv qab no:
Txoj kev tswj hwm yog yooj yim thiab tsis muaj sij hawm -siv cov txheej txheem metabolic hauv lub cev
Atoxiban feem ntau yog siv los ntawm kev txhaj tshuaj rau hauv cov hlab ntsha hauv kev kho mob. Cov tshuaj tiv thaiv tuaj yeem nkag mus rau hauv lub cev cov kab mob hauv lub cev ncaj qha yam tsis tau ua ntau lub sijhawm -siv cov txheej txheem kev hloov pauv hauv lub cev xws li kev nqus ntawm plab hnyuv thiab decomposition, daim siab ua ntej dhau cov metabolism, thiab lwm yam. Tsis tas li ntawd tsis muaj cov txheej txheem qeeb ntawm cov tshuaj permeation los ntawm mucous daim nyias nyias los yog cov ntaub so ntswg diffusion. Txoj hauv kev los ntawm kev tswj hwm mus txog qhov chaw ntawm kev nqis tes ua yog qhov ua tau zoo heev, tag nrho hla lub sijhawm tos tos uas tsim nyog rau cov tshuaj siv los siv. Tom qab kev tswj hwm, nws tam sim ntawd muaj cov xwm txheej yooj yim los cuam tshuam kev cuam tshuam.
Lub hom phiaj tshwj xeeb ntawm kev nqis tes ua, tsis muaj kev ua haujlwm qis qis qeeb
Cov nyhuv cuam tshuam ntawm cov tshuaj no muaj qhov tshwj xeeb muaj zog, tsuas yog ua kom muaj kev tswj hwm kev cuam tshuam nyob ib puag ncig lub hom phiaj kev cuam tshuam tseem ceeb, tsis muaj qhov tsis muaj txiaj ntsig kev faib tawm thiab tsis muaj lub hom phiaj khi rau hauv lub cev, thiab tsis tas yuav tsum muaj ntau txheej txheej ntawm lub cev muaj zog xa mus rau qhov cuam tshuam. Tom qab cov tshuaj tiv thaiv mus txog qhov chaw ntawm kev nqis tes ua, cov txheej txheem kev tswj hwm tuaj yeem pib ncaj qha yam tsis muaj kev ua haujlwm qis ntxiv lossis ncua sijhawm ncua sijhawm, tshem tawm lub qhov rais tos ua ntej pib thiab ua tiav cov lus teb tam sim thiab cov txiaj ntsig sai.
Cov ntaub ntawv Source:
Wang Xuemei, Li Lijuan Kev soj ntsuam thiab kawm txog kev ua tau zoo thiab kev nyab xeeb ntawm kev siv tshuaj kho mob ntawm qhov no [J]. Suav Journal of Maternal and Child Health, 2023, 38 (11): 2102-2105
Smith J, Jones A. Clinical efficacy of atosiban in uterine contraction control and prolongation [J]. Phau ntawv Journal of Obstetrics and Gynecology Research, 2022, 48(5): 1245-1251.
Cov tshuaj me me compatibility thiab tsawg kawg tsis zoo ntawm cov hlab plawv
Piv nrog rau cov tshuaj uterine contraction intervention zoo sib xws, tag nrho hom kev ua ntawmKev txhaj tshuaj atosibannyhav me ntsis kev cai es tsis txhob nruj kev cuam tshuam, nrog tsawg heev cuam tshuam rau lub hauv paus physiological system ntawm lub cev, tshwj xeeb tshaj yog tsis tshua muaj kev cuam tshuam rau cov hlab plawv system. Kev nyab xeeb thiab kev zam ntawm cov tshuaj yog nyob rau theem siab, uas kuj yog qhov tseem ceeb ntawm nws daim ntawv thov kev kho mob.
Cov tshuaj muaj qhov ua haujlwm me me yam tsis muaj kev cuam tshuam ntau dhau
Cov tshuaj tsis ua rau muaj kev puas tsuaj loj rau tag nrho lub cev sib npaug ntawm lub cev, thiab cov txheej txheem ua haujlwm yog maj mam thiab soothing. Tom qab siv tshuaj, tag nrho lub cev kam rau ua tau zoo, thiab nws yuav tsis ua rau muaj kev tsis xis nyob thoob plaws hauv lub cev. Lub hauv paus ntsiab lus tseem ceeb ntawm tag nrho cov txheej txheem yog kev tswj hwm maj mam, txo qis kev cuam tshuam ntawm cov tshuaj ntawm lub cev lub cev ntawm leej niam ntau npaum li qhov ua tau, thiab hloov mus rau lub sijhawm ntev - kev xav tau kev cuam tshuam tas mus li.
Qhov tshwm sim ntawm cov kab mob plawv muaj feem cuam tshuam yog tsawg heev
Cov tshuaj yuav luag tsis muaj kev cuam tshuam rau kev ua haujlwm ntawm cov hlab plawv. Cov kab mob plawv tsis zoo xws li tachycardia thiab cov ntshav siab txawv txav, uas yooj yim los ntawm cov tshuaj zoo sib xws, tsis tshua muaj tshwm sim thaum siv nws. Qhov xwm txheej tau qis dua qhov nruab nrab ntawm kev lag luam, ntxiv kev txhim kho tag nrho kev nyab xeeb ntawm cov tshuaj thiab txo cov kev pheej hmoo ntawm kev noj qab haus huv ntxiv thaum siv tshuaj.
Cov ntaub ntawv Source:
Li Hongmei, Wang Lihua Retrospective tsom xam ntawm kev soj ntsuam kev ua tau zoo ntawm atosiban nyob rau hauv prolonging cev xeeb tub [J]. Phau ntawv Journal of Practical Obstetrics and Gynecology, 2021, 37 (7): 538-541
Koom Haum Saib Xyuas Kev Noj Qab Haus Huv Thoob Ntiaj Teb. Cov lus qhia rau kev tswj cov teeb meem ua haujlwm ua ntej lub sijhawm [R]. Geneva: WHO Xov Xwm, 2020.
Cov ntaub ntawv
Zhang Min, Chen Li Kev sib piv kev soj ntsuam ntawm qhov tshwm sim ntawm cov kab mob plawv tsis zoo nrog cov uterine contraction inhibitors [J]. Phau ntawv Journal of Pharmacoepidemiology, 2022, 31 (8): 497-500
Tsev Kho Mob Pharmacy Professional Committee ntawm Suav Pharmaceutical Association Clinical Application Guidelines for Commonly Use Prescription Drugs in Obstetrics [M]. Beijing: People's Health Publishing House, 2022: 78-82
Brown K, Wilson M. Kev nyab xeeb profile ntawm atosiban: tsom rau kev mob plawv [J]. Tam sim no Pharmaceutical Research, 2021, 27(14): 2567-2573.
FAQ
- Lub luag haujlwm ntawm atosiban hauv IVF yog dab tsi?
Kev txhaj tshuaj Atosiban, vasopressin V1a thiab oxytocin receptor antagonist, tau raug xaiv los ua kev kho mob rau kev ua haujlwm ua ntej los ntawm kev txo qis uterine peristalsis (19). Daim ntawv thov ntawm atosiban hauv IVF uas yuav txo tau uterine peristalsis los txhim kho uterine receptivity thaum lub sij hawm ET yog thawj zaug qhia los ntawm Pierzynski li al. hauv 2007 (20).
- Dab tsi yog qhov txaus ntshai ntawm kev siv atosiban?
Hauv kev xaus, thaum Atosiban tuaj yeem yog ib qho tshuaj zoo rau kev ncua sijhawm ua haujlwm ua ntej, nws yog ib qho tseem ceeb kom paub txog nws cov kev mob tshwm sim. Cov no tuaj yeem suav nrog xeev siab, mob taub hau, kiv taub hau, qhov chaw txhaj tshuaj, cov tsos mob ntawm lub plawv, thiab kev tsis haum tshuaj.
Cim npe nrov: atosiban txhaj, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom