Shaanxi BLOOM Tech Co., Ltd. yog ib tug ntawm cov uas paub txog manufacturers thiab lwm tus neeg ntawm buserelin acetate txhaj nyob rau hauv Suav teb. Txais tos rau kev lag luam wholesale bulk zoo buserelin acetate txhaj rau muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Buserelin acetate txhaj tshuajyog ib qho hluavtaws pergonal- tso tawm cov tshuaj hormones (GnRH) analogue, uas nws lub luag haujlwm ntawm kev ua haujlwm feem ntau cuam tshuam nrog kev hloov pauv cov tshuaj hormonal los ntawm kev ua raws li endogenous GnRH thiab stimulating hypothalamic pituitary gonadal axis (HPG axis). Hauv kev siv tshuaj kho mob, feem ntau yog siv los kho ntau yam kab mob gynecological los ntawm kev tswj hwm ntawm qib hormonal, tshwj xeeb tshaj yog cov kab mob uas cuam tshuam zoo heev los ntawm kev tswj hwm qib hormonal, xws li endometriosis, zes qe menyuam, uterine fibroids, thiab lwm yam.
Peb cov khoom tsim
buserelin acetate COA
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| Certificate of Analysis | ||
| Compound npe | Buserelin acetate hmoov | |
| Qib | Pharmaceutical qib | |
| CAS Nr. | 68630-75-1 | |
| Ntau | 50g | |
| Ntim txheem | PE hnab + Al foil hnab | |
| Chaw tsim tshuaj paus | Shaanxi BLOOM TECH Co., Ltd | |
| Ntau No. | 202601090088 | |
| MFG | Peb 9, 2026 | |
| EXP | Peb 8, 2029 | |
| Qauv |
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| Yam khoom | Enterprise txheem | Kev txheeb xyuas qhov tshwm sim |
| Qhov tshwm sim | Dawb los yog yuav luag dawb hmoov | Ua raws |
| Cov ntsiab lus dej | Tsawg dua lossis sib npaug li 5.0% | 0.45% |
| Poob rau ziab | Tsawg dua lossis sib npaug li 1.0% | 0.38% |
| Hnyav Hlau | Pb Tsawg dua lossis sib npaug li 0.5ppm | N.D. |
| Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Hg Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Cd Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Purity (HPLC) | Ntau dua lossis sib npaug li 99.0% | 99.80% |
| Ib leeg impurity | <0.8% | 0.67% |
| Tag nrho microbial suav | Tsawg dua lossis sib npaug li 750cfu / g | 420 |
| E. Coli | Tsawg dua lossis sib npaug li 2MPN / g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (los ntawm GC) | Tsawg dua lossis sib npaug li 5000ppm | 500ppm ua |
| Cia | Khaws rau hauv qhov chaw kaw, tsaus, thiab qhuav hauv qab -15 degree | |
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| Tshuaj Formula | C62H90N16O15 |
| Exact Mass | 1299 |
| Molecular Luj | 1299 |
| m/z | 1299 (100.0%), 1300 (67.1%), 1301 (22.1%), 1240 (5.9%), 1241 (3.6%), 1242 (3.5%), 1241 (2.7%), 1242 (1.7%), 1242 (1.2%) |
| Elemental Analysis | C, 57.31; H, 6.98; N, 17.25; O, 18.47 |
Therapeutic nyhuv ntawmbuserelin acetate txhaj tshuajyog raws li nws lub sijhawm ntev - ua kom lub sijhawm ntawm GnRH receptors, uas ua rau desensitization ntawm endogenous GnRH secretion, ua rau txo qis hauv qib pergonals (FSH thiab LH). Nyob rau hauv txoj kev no, lub zes qe menyuam hormonals (xws li estrogen thiab progesterone) hauv lub cev kuj txo, ua lub luag haujlwm hauv kev txo qis kev loj hlob ntawm cov kab mob hormonal dependent (xws li endomtriosis thiab uterine fibroids). Tsis tas li ntawd, Buserelin kuj tseem siv rau hauv kev pabcuam kev ua menyuam yaus los txhim kho kev xeeb menyuam los ntawm kev tswj hwm zes qe menyuam.
siv nyob rau hauv endometriosis
1. Txheej txheem cej luam ntawm endometriosis
Endometriosis yog ib qho kev mob tshwm sim hauv cov poj niam cev xeeb tub, uas yog hais txog cov tsos mob ntawm endometrial zoo li cov ntaub so ntswg hauv lwm qhov chaw sab nraum lub tsev me nyuam (xws li zes qe menyuam, hlab ntsha hauv plab, pelvic peritoneum, thiab lwm yam). Endomtriosis feem ntau yog nrog los ntawm cov tsos mob xws li kev coj khaub ncaws tsis xwm yeem, mob plab hauv plab, mob sib deev, thiab thaum mob hnyav, nws kuj tuaj yeem ua rau muaj menyuam tsis taus. Qhov tshwm sim ntawm qhov mob no yog ze ze rau qhov hloov pauv ntawm cov tshuaj hormones hauv lub cev, tshwj xeeb tshaj yog estrogen. Cov tshuaj estrogen txhawb kev loj hlob ntawm cov ntaub so ntswg endomtriosis, ua rau kev nthuav dav ntawm qhov txhab thiab ua rau cov tsos mob tsis zoo.
2. Mechanism ntawm kev ua
Los ntawm simulating qhov kev txiav txim ntawm GnRH, stimulating lub hypothalamic pituitary gonadal axis tuaj yeem pib txhawb kev tso tawm ntawm pergonals (LH thiab FSH). Txawm li cas los xij, kev siv sijhawm ntev - tuaj yeem ua rau desensitization ntawm GnRH receptors, maj mam ua kom tsis muaj zog ntawm lub caj pas pituitary los ntawm hypothalamus, yog li inhibiting qhov tso tawm ntawm pergonals thiab txo cov synthesis ntawm zes qe menyuam hormonals (xws li estrogen). Kev txo qis hauv cov tshuaj hormones pab txo qis kev loj hlob ntawm cov ntaub so ntswg endomtriosis thiab txo qhov mob thiab lwm yam tsos mob.
3. Kev siv tshuaj kho mob thiab ua tau zoo
Lub luag haujlwm tseem ceeb hauv kev kho mob endomtriosis yog txhawm rau txo cov tsos mob ntawm tus mob los ntawm kev txo qis cov tshuaj estrogen hauv lub cev. Cov kev tshawb fawb soj ntsuam tau pom tias kev kho mob endomtriosis tuaj yeem txo cov tsos mob xws li mob plab, mob sib deev, thiab mob khaub thuas hauv cov neeg mob. Tshwj xeeb tshaj yog nyob rau hauv cov neeg mob uas muaj mob me thiab nruab nrab endomtriosis, cov nyhuv kho mob tseem ceeb heev.
Tsis tas li ntawd, nws tseem tuaj yeem siv rau kev kho mob ua ntej, muab cov kev mob zoo dua rau kev kho mob phais los ntawm kev txo qhov loj ntawm qhov txhab thiab txo qhov tsim ntawm visceral adhesions. Rau qee tus neeg mob, kev kho phais tuaj yeem zam tau, tshwj xeeb tshaj yog nyob rau hauv cov mob me me lossis tsis haum rau kev phais.
4. Kev mob tshwm sim thiab kev nyab xeeb
Txawm hais tias muaj txiaj ntsig zoo hauv kev kho mob endomtriosis, kev siv sijhawm ntev - yuav ua rau qee qhov kev mob tshwm sim xws li kub kub, txo cov pob txha, thiab txo libido, uas feem ntau cuam tshuam nrog kev txo qis hauv cov tshuaj estrogen hauv lub cev. Txhawm rau txo cov kev mob tshwm sim no, lub voj voog kho feem ntau yog tswj tsis pub dhau 3 mus rau 6 lub hlis thiab tuaj yeem ua ke nrog lwm cov tshuaj (xws li cov tshuaj tiv thaiv pob txha) txhawm rau txo qhov kev pheej hmoo ntawm cov pob txha qis.
siv rau hauv kev ua haujlwm ntawm zes qe menyuam
1. Txheej txheem cej luam ntawm zes qe menyuam dysfunction
Ovarian dysfunction yog hais txog qhov tsis muaj peev xwm ntawm zes qe menyuam ua lawv lub cev ua haujlwm ib txwm ua, ua rau lub cev tsis muaj zog, ovulation tsis ua haujlwm, muaj menyuam tsis taus, thiab lwm yam tsos mob. Cov kab mob ntawm zes qe menyuam feem ntau muaj xws li polycystic zes qe menyuam syndrome (PCOS), zes qe menyuam ntxov ntxov tsis ua haujlwm (POI), thiab lwm yam. Qhov tsis txaus ntawm cov tshuaj hormones yog qhov tseem ceeb ntawm kev ua haujlwm ntawm zes qe menyuam, tshwj xeeb tshaj yog cov qib androgen siab thiab qis estrogen.
2. Mechanism ntawm kev ua
Buserelin acetate txhaj tshuajtxo qis ntawm zes qe menyuam hormonal secretion los ntawm inhibiting lub secretion ntawm GnRH, uas nyob rau hauv lem suppresses tso tawm pergonals (FSH thiab LH). Rau cov neeg mob uas muaj polycystic zes qe menyuam syndrome (PCOS), txo qis testosterone qib hauv lub cev tuaj yeem tswj hwm qib ntawm zes qe menyuam hormonal thiab pab rov ua haujlwm ntawm zes qe menyuam. Hauv cov neeg mob uas muaj lub zes qe menyuam ntxov ntxov (POI), kev tswj hwm ntawm zes qe menyuam muaj nuj nqi tuaj yeem ua rau qis qis ntawm zes qe menyuam thiab muab qhov chaw zoo hormonal rau kev loj hlob ntawm cov follicles.
3. Kev siv tshuaj kho mob thiab ua tau zoo
Hauv kev kho mob ntawm polycystic zes qe menyuam syndrome (PCOS), ovulation inducing tshuaj feem ntau yog siv ua ke los pab kho tus mob lub cev muaj nuj nqi ovulation. Los ntawm kev txo cov theem ntawm androgens nyob rau hauv lub cev thiab alleviating zes qe menyuam overreaction rau androgens, nws txhawb follicle maturation thiab ovulation. Kev tshawb fawb tau qhia txog kev kho mob tseem ceeb ntawm PCOS mob, tshwj xeeb tshaj yog nyob rau hauv kev tswj kev coj khaub ncaws thiab txhawb ovulation. Rau cov poj niam uas ntxov ntxov- pib zes qe menyuam tsis ua haujlwm (POI), inhibiting ntau dhau ntawm cov tshuaj hormones hloov pauv tuaj yeem ua rau qis qis ntawm zes qe menyuam thiab ua rau lub zes qe menyuam ua haujlwm ntev. Hauv kev kho mob, thaum siv rau hauv cov mob no, nws feem ntau txhim kho kev coj khaub ncaws thiab pab kho qee qhov fertility.
4. Kev mob tshwm sim thiab kev nyab xeeb
Thaum kho lub zes qe menyuam, nws yuav ua rau qee qhov kev mob tshwm sim, xws li kub hnyiab, txo cov pob txha ceev, kev xav hloov pauv, thiab lwm yam. Yuav kom txo tau cov kev mob tshwm sim no, feem ntau yuav tsum tau siv raws li kev qhia nruj ntawm tus kws kho mob, thiab tsis tu ncua xyuas cov tshuaj hormonal thiab cov pob txha ceev thaum kho kom muaj kev nyab xeeb ntawm kev kho.
siv nyob rau hauv uterine fibroids
1. Txheej txheem cej luam ntawm uterine fibroids
Uterine fibroids yog cov qog nqaij hlav hauv cov poj niam, feem ntau tshwm sim hauv cov nqaij mos ntawm lub tsev menyuam. Uterine fibroids tuaj yeem ua rau cov tsos mob xws li kev coj khaub ncaws tsis xwm yeem, ntshav ntshav, tso zis ntau zaus, thiab plab hnyuv, cuam tshuam rau lub neej zoo ntawm cov neeg mob. Kev tshawb fawb pom tau hais tias kev loj hlob ntawm uterine fibroids yog ze ze rau theem ntawm cov tshuaj estrogen hauv lub cev, tshwj xeeb tshaj yog nyob rau hauv cov poj niam ntawm cov me nyuam muaj hnub nyoog, qhov twg estrogen yog lub ntsiab txhawb rau lawv txoj kev loj hlob.
2. Mechanism ntawm kev ua
Los ntawm inhibiting qhov tso tawm ntawm GnRH, qhov tso tawm ntawm pergonals (FSH thiab LH) txo qis, ua rau muaj qhov txo qis hauv cov tshuaj estrogen hauv zes qe menyuam. Vim qhov kev txhawb nqa ntawm cov tshuaj estrogen ntawm kev loj hlob ntawm uterine fibroids, nws tuaj yeem ua rau qeeb lossis nres qhov kev loj hlob ntawm fibroids, thiab txawm ua rau qee cov fibroids ntsws. Kev siv lub sijhawm ntev tuaj yeem txhim kho cov tsos mob tshwm sim los ntawm uterine fibroids, xws li kev coj khaub ncaws ntau dhau, mob plab, thiab cov tsos mob compression.
3. Kev siv tshuaj kho mob thiab ua tau zoo
Hauv kev kho mob ntawm uterine fibroids, nws feem ntau yog siv los ua tshuaj kho mob, tshwj xeeb tshaj yog nyob rau hauv kev kho mob ua ntej, los ntawm kev txo qhov loj ntawm cov fibroids thiab txhim kho cov tsos mob, muab cov kev mob zoo rau kev kho mob phais. Kev tshawb fawb tau pom tias nws tuaj yeem txo qhov ntim ntawm cov uterine fibroids, txo qis kev coj khaub ncaws, thiab txo cov tsos mob xws li plab compression thiab nquag tso zis los ntawm fibroids.
Nws kuj tseem siv tau rau cov neeg mob uas tsis tuaj yeem kho qhov phais, tshwj xeeb tshaj yog rau cov poj niam uas tsis haum rau kev phais lossis xav kom tsis txhob phais. Los ntawm kev kho tshuaj, psickts tuaj yeem ua tiav cov txiaj ntsig ntawm kev txo cov tsos mob thiab tswj lawv tus mob.
4. Kev mob tshwm sim thiab kev nyab xeeb
Thaum kho uterine fibroids, nws yuav ua rau muaj qee yam kev mob tshwm sim, xws li kub flashes, txo libido, thiab txo cov pob txha ceev. These side effects are usually associated with a decrease in estrogen levels in the body, therefore, regular monitoring of sicks' bone density and hormonal levels is necessary during the cure process to ensure the safety of the cure.
Buserelin acetate txhaj tshuaj, raws li GnRH agonist, muaj qhov tseem ceeb siv tus nqi hauv gynecological morbids. Los ntawm kev tswj hwm cov qib hormonal hauv lub cev, nws tau ua lub luag haujlwm tseem ceeb hauv kev kho mob xws li endomtriosis, zes qe menyuam, thiab uterine fibroids. Hauv kev kho mob ntawm endomtriosis thiab uterine fibroids, kev loj hlob ntawm cov kab mob tuaj yeem qeeb los ntawm inhibiting qib estrogen; Hauv kev kho ntawm zes qe menyuam ua haujlwm tsis zoo, qib ntawm zes qe menyuam hormonal raug tswj los pab rov ua haujlwm ntawm zes qe menyuam.
Kev siv
1. Lunenfeld, B., & Tarlatzis, BC (2015). GnRH Agonists thiab antagonists nyob rau hauv pab kev yug me nyuam. Human Reproduction Update, 21(3), 271-285.
2. Sánchez, MJ, & Rodríguez, F. (2012). GnRH Agonists hauv Kev Kho Mob Endometriosis. European Journal of Obstetrics & Gynecology thiab Reproductive Biology, 175, 99-106.
3. Lombardi, S., & Ziegler, D. (2008). Buserelin hauv Kev Tswj Xyuas Uterine Fibroids. Fertility thiab Sterility, 90(3), 690-695.
4. Hwang, KJ, & Choi, JS (2010). Pharmacological Aspects ntawm Buserelin rau Ovarian Dysfunction. Obstetrics & Gynecology, 117(4), 798-805.
5. Fauser, BC, & Devroey, P. (2009). Clinical Aspects of Ovarian Stimulation in Assisted Reproductive Technology. Fertility and Sterility, 91(5), 1557-1567.
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