Inj Glucagon 1 mg, Txhaj tshuaj glucagon 1mg yog peptide hormone tsim los ntawm 29 amino acid residues, nrog cov mis molecular ntawm C153H225N43O49S thiab molecular hnyav ntawm 3483. Cov tshuaj no feem ntau yog muab rau hauv daim ntawv ntawm sterile freeze-cov hmoov qhuav dawb, txhua qhov muaj 1 mg ntawm cov tshuaj txhaj tshuaj tuaj yeem ua rau glucagon. kev npaj tshuaj. Glucagon tsis ruaj khov hauv kev daws teeb meem, yog li nws yuav tsum tau siv tam sim tom qab kev npaj los xyuas kom meej nws cov txiaj ntsig thiab kev nyab xeeb. Glucagon feem ntau ua rau glycogen degrading enzymes hauv daim siab, txhawb kev tawg ntawm daim siab glycogen rau hauv cov piam thaj thiab tso tawm rau hauv cov hlab ntsha, yog li ua kom cov ntshav qab zib nce sai. Cov txheej txheem no yog ib qho tseem ceeb rau kev kho mob ntawm hypoglycemia hnyav (xws li hypoglycemic coma tshwm sim los ntawm insulin ntau dhau lossis kev noj zaub mov tsis txaus hauv cov neeg mob ntshav qab zib). Tsis tas li ntawd, glucagon tseem tuaj yeem cuam tshuam lub plab zom mov, uas ua rau nws yog ib qho tshuaj tiv thaiv kab mob hauv kev kuaj hluav taws xob, siv los cuam tshuam rau lub plab zom mov thiab txhim kho kev kuaj mob.
Peb cov khoom los ntawm
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| Glucagon hmoov | Kev txhaj tshuaj Glucagon | Glucagon ntsiav tshuaj |
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| Glucagon Cream | Glucagon Capsule |
Glucagon COA
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| Certificate of Analysis | ||
| Compound npe | Glucagon | |
| Qib | Pharmaceutical qib | |
| CAS Nr. | 16941-32-5 | |
| Ntau | 3 37,3kg | |
| Ntim txheem | 25kg / nruas | |
| Chaw tsim tshuaj paus | Shaanxi BLOOM TECH Co., Ltd | |
| Ntau No. | 202501090052 | |
| MFG | Peb 9, 2025 | |
| EXP | Peb 8, 2028 | |
| Qauv |
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| Yam khoom | Enterprise txheem | Kev txheeb xyuas qhov tshwm sim |
| Qhov tshwm sim | Dawb los yog yuav luag dawb hmoov | Ua raws |
| Cov ntsiab lus dej | Tsawg dua lossis sib npaug li 5.0% | 0.53% |
| Poob rau ziab | Tsawg dua lossis sib npaug li 1.0% | 0.36% |
| Hnyav Hlau | Pb Tsawg dua lossis sib npaug li 0.5ppm | N.D. |
| Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Hg Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Cd Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Purity (HPLC) | Ntau dua lossis sib npaug li 99.0% | 99.90% |
| Ib leeg impurity | <0.8% | 0.48% |
| Tag nrho microbial suav | Tsawg dua lossis sib npaug li 750cfu / g | 96 |
| E. Coli | Tsawg dua lossis sib npaug li 2MPN / g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (los ntawm GC) | Tsawg dua lossis sib npaug li 5000ppm | 500 ppm |
| Cia | Khaws rau hauv qhov chaw kaw, tsaus, thiab qhuav hauv qab 2-8 degree | |
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Kev siv cov tshuaj no nyob rau hauv overdose ntawm beta blockers thiab calcium channel blockers
Hauv kev kho mob xwm txheej ceev, kev siv tshuaj ntau dhau yog ib qho xwm txheej xwm txheej ceev, ntawm cov kev siv tshuaj ntau dhau ntawm beta blockers thiab calcium channel blockers yog qhov nyuaj tshwj xeeb. Kev siv ob qho tshuaj ntau dhau tuaj yeem ua rau mob plawv mob hnyav, ua rau muaj kev hem thawj rau tus neeg mob lub neej.Inj Glucagon 1 mg(tseem hu ua glucagon txhaj tshuaj 1 mg) yog peptide hormone uas ua lub luag haujlwm tseem ceeb hauv kev thim rov qab kev nyuaj siab los ntawm kev siv ntau dhau ntawm beta blockers thiab calcium channel blockers.
Pharmacological teebmeem thiab overdose manifestation ntawm beta blockers thiab calcium channel blockers
Beta blockers feem ntau ua los kho cov kab mob plawv xws li kub siab, kab mob plawv, thiab arrhythmia los ntawm kev thaiv cov beta adrenergic receptors ntawm cov leeg nqaij ntawm lub plawv thiab cov hlab ntsha, txo cov plawv dhia, myocardial contractility, thiab ntshav siab. Txawm li cas los xij, thaum beta blockers tau siv ntau dhau lawm, lawv cov teebmeem tshuaj muaj ntau dhau, ua rau mob bradycardia, hypotension, conduction block, thiab txawm tias cardiogenic poob siab. Tsis tas li ntawd, kev siv ntau dhau ntawm beta blockers kuj tseem tuaj yeem ua rau muaj kev cuam tshuam tsis zoo xws li bronchospasm, hypoglycemia, thiab kev cuam tshuam hauv nruab nrab ntawm lub paj hlwb.
Pharmacological cov teebmeem thiab kev tshwm sim ntau dhau ntawm calcium channel blockers
Calcium channel blockers feem ntau thaiv L- hom calcium channels ntawm daim nyias nyias ntawm myocardial thiab vascular smooth nqaij hlwb, inhibit qhov nkag ntawm cov calcium ions extracellular, yog li txo qis myocardial contractility, qeeb lub plawv dhia, thiab txo cov ntshav siab. Calcium channel blockers tuaj yeem muab faib ua dihydropyridine thiab tsis yog dihydropyridine raws li lawv cov kev xaiv ntawm cov hlab ntsha thiab lub plawv. Dihydropyridine tebchaw xws li nifedipine thiab amlodipine feem ntau ua rau vascular du leeg, ua rau peripheral vasodilation;
Tsis yog dihydropyridines xws li verapamil thiab diltiazem muaj zog inhibitory cuam tshuam rau lub plawv conduction system thiab myocardial contractility. Kev siv ntau dhau ntawm calcium channel blockers tuaj yeem ua rau mob hnyav heev, bradycardia, conduction block, plawv tsis ua haujlwm, thiab txawm tias mob plawv. Tsis tas li ntawd, kev siv ntau dhau ntawm calcium channel blockers tuaj yeem ua rau muaj teeb meem xws li hyperglycemia, metabolic acidosis, thiab pulmonary edema.
Nws cov teebmeem pharmacological thiab mechanisms
Ua kom ntshav qab zib ua haujlwm
Inj Glucagon yog peptide hormone secreted los ntawm pancreatic alpha hlwb, nws lub luag haujlwm tseem ceeb yog nce ntshav qab zib. Nws activates adenylate cyclase nyob rau hauv daim siab cell membrane, ua rau kom cov concentration ntawm intracellular cyclic adenosine monophosphate (cAMP), yog li ua kom phosphorylase, txhawb siab glycogen puas thiab gluconeogenesis, thiab ceev ceev cov ntshav qabzib. Cov txiaj ntsig no tseem ceeb heev rau kev thim rov qab hypoglycemia los ntawm kev siv ntau dhau ntawm beta blockers thiab calcium channel blockers.
Cov nyhuv inotropic zoo
Cov koob tshuaj ntau ntau Inj Glucagon muaj cov nyhuv plawv zoo ib yam li catecholamines, uas tuaj yeem txhim kho myocardial contractility, ua kom lub plawv dhia, ua rau lub plawv dhia thiab cov ntshav coronary, yog li nce ntshav siab thiab txhim kho atrioventricular conduction. Cov txheej txheem ntawm kev ua haujlwm no yuav cuam tshuam rau nws txoj kev ua haujlwm ntawm myocardial adenylate cyclase thiab nce cAMP concentration. Qhov zoo inotropic nyhuv yog lub luag haujlwm tseem ceeb ntawmInj Glucagon 1 mgHauv kev thim rov qab kev nyuaj siab plawv los ntawm kev siv ntau dhau ntawm beta blockers thiab calcium channel blockers.
Lwm cov haujlwm
Ntxiv nrog rau kev nce ntshav qab zib thiab txhawb cov leeg nqaij zoo, Inj Glucagon kuj muaj cov teebmeem xws li ua kom cov kua tsib thiab cov hnyuv tso tawm, inhibiting gastrointestinal peristalsis, thiab txo cov gallbladder nro. Txawm li cas los xij, cov teebmeem no tsis yog qhov tseem ceeb hauv kev thim rov qab siv ntau dhau ntawm beta blockers thiab calcium channel blockers.
Daim ntawv thov ntawm Inj Glucagon hauv kev kho mob ntawm beta blocker overdose
Inj Glucagon feem ntau yog siv los kho mob bradycardia hnyav, hypotension, conduction block, thiab cardiogenic poob siab los ntawm kev siv ntau dhau ntawm beta blockers. Hauv cov xwm txheej no, cov tshuaj siv tshuaj xws li dopamine thiab norepinephrine yuav tsis ua haujlwm zoo, thaum Inj Glucagon 1 mg tuaj yeem cuam tshuam cov hlab plawv inhibitory nyhuv ntawm beta blockers los ntawm nws cov txiaj ntsig zoo inotropic.
Rau kev noj tshuaj ntau dhau ntawm beta blockers, thawj koob tshuaj rau cov neeg laus feem ntau yog 5-10 milligrams txhaj tshuaj intravenously, uas feem ntau yuav siv sijhawm li 5-10 feeb thiab kav rau 15-30 feeb. Tom qab ntawd, kev saib xyuas tuaj yeem tswj hwm los ntawm kev txhaj tshuaj intravenously ntawm koob tshuaj 1-5 milligrams ib teev nyob ntawm tus neeg mob tus mob. Rau cov neeg mob me, thawj koob tshuaj yog 0.15 mg / kg intravenous infusion, ua raws li kev saib xyuas ntawm koob tshuaj 0.05-0.1 mg / kg ib teev ntawm kev tso dej.
Ntau qhov kev tshawb fawb soj ntsuam thiab kev xyaum ua tau pom tias Inj Glucagon muaj cov txiaj ntsig kho mob tseem ceeb hauv kev thim rov qab cov hlab plawv kev nyuaj siab los ntawm ntau cov beta blockers. Piv txwv li, tus neeg mob uas raug mob bradycardia, hypotension, thiab cardiogenic poob siab vim kev siv ntau heev ntawm metoprolol tau ntsib kev nce siab hauv plawv thiab ntshav siab thiab kev txhim kho tseem ceeb hauv cov tsos mob tom qab tau txais kev txhaj tshuaj ntawm Inj Glucagon.
Thaum siv Inj Glucagon los kho beta blocker overdose, cov ntsiab lus hauv qab no yuav tsum tau sau tseg: Cov neeg mob uas muaj pheochromocytoma yuav tsum tsis txhob siv Inj Glucagon vim nws yuav ua rau muaj kev kub ntxhov hnyav heev.Ib tug me me ntawm cov neeg mob yuav hnov mob ntuav, ntuav, ua npaws ntawm lub ntsej muag, thiab lwm yam kev phiv, uas yuav tshwm sim ntau dua thaum txhaj tshuaj. Kev ncua ntev ntawm cov tshuaj yuav yooj yim ua rau hypoglycemia.Inj Glucagon muaj cov nyhuv antagonistic nrog beta blockers xws li propranolol, tab sis muaj cov nyhuv hypoglycemic nrog cov tshuaj hypoglycemic, yog li yuav tsum tau them nyiaj rau kev kho cov tshuaj.
Daim ntawv thov ntawm Inj Glucagon hauv kev kho cov calcium channel blockers ntau dhau
Cov lus qhia
Inj Glucagon kuj tseem tuaj yeem siv los kho mob ntshav siab, bradycardia, kev ua haujlwm thaiv, thiab lub plawv tsis ua haujlwm tshwm sim los ntawm ntau cov calcium channel blockers. Hauv cov xwm txheej no, Inj Glucagon 1 mg tuaj yeem ua rau kom myocardial contractility, ua kom lub plawv dhia, thiab nce ntshav siab los ntawm nws cov txiaj ntsig zoo inotropic, yog li txhim kho tus neeg mob lub plawv ua haujlwm.
Cov ntaub ntawv thov kev kho mob
Hauv kev xyaum kho mob, Inj Glucagon 1 mg kuj tau ua tiav cov txiaj ntsig zoo hauv kev thim rov qab cov hlab plawv inhibition los ntawm ntau cov calcium channel blockers. Piv txwv li, tus neeg mob uas raug kev txom nyem los ntawm hypotension hnyav thiab bradycardia vim kev siv ntau dhau ntawm verapamil tau ntsib cov ntshav siab thiab lub plawv dhia nrawm tom qab tau txais kev txhaj tshuaj ntawm Inj Glucagon 1 mg, thiab cov tsos mob tau txo qis.
Kev sib xyaw ua ke
Hauv kev kho cov calcium channel blockers ntau dhau, Inj Glucagon feem ntau siv ua ke nrog lwm cov tshuaj los txhim kho kev ua tau zoo. Piv txwv li, cov tshuaj calcium (xws li calcium gluconate) tuaj yeem txhim kho myocardial contractility los ntawm kev nce ntxiv ntawm calcium ion concentration; Cov koob tshuaj ntau ntawm insulin thiab piam thaj tuaj yeem txhim kho myocardial kev ua haujlwm los ntawm kev txhawb nqa kev siv cov piam thaj thiab lub zog metabolism; Vasopressors xws li norepinephrine tuaj yeem ua rau ntshav siab los ntawm kev txwv cov hlab ntsha. Cov tshuaj no, thaum siv ua ke nrog Inj Glucagon 1 mg, tuaj yeem ua rau muaj kev sib koom ua ke thiab zoo dua rov qab cov hlab plawv kev nyuaj siab tshwm sim los ntawm ntau cov calcium channel blockers.
Cov kev ceev faj
Thaum sivInj Glucagon 1 mgTxhawm rau kho kev noj ntau dhau ntawm calcium channel blockers, kev saib xyuas yuav tsum tau them rau contraindications, kev phiv tshuaj, thiab kev cuam tshuam tshuaj. Tsis tas li ntawd, kev siv ntau dhau ntawm calcium channel blockers tuaj yeem ua rau cov kab mob metabolic xws li hyperglycemia. Yog li ntawd, kev soj ntsuam ze ntawm cov ntshav qabzib yog tsim nyog thaum siv Inj Glucagon 1 mg, thiab cov phiaj xwm kho mob yuav tsum tau kho raws li qhov xwm txheej.
Cov lus nug nquag
Yuav ua li cas rov tsim glucagon 1 mg?
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Siv lub syringe, tshem tag nrho cov Sterile Dej rau Txhaj Tshuaj (yog tias muab) los yog 1 mL Sterile Dej rau Txhaj thiab txhaj rau hauv Glucagon rau Txhaj vial. Co lub vial maj mam kom txog thaum cov hmoov yaj tag thiab tsis muaj cov khoom nyob hauv cov kua. Lub reconstituted kua yuav tsum ntshiab thiab tsis muaj xim.
Yuav ua li cas dilute glucagon rau infusion?
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Kev kho dua tshiab
Ntxiv 1.1mL dej rau kev txhaj tshuaj (muab) rau lub vial uas muaj cov hmoov los tsim cov tshuaj 1mg / 1mL.
Co maj mam kom txog thaum yaj tag.
Ib lub koob txhaj tshuaj nrog rab koob nyias nyias thiab kev kawm tiav zoo dua tuaj yeem tsim nyog hauv cov txheej txheem kuaj mob.
Koj thawb IV glucagon sai npaum li cas?
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Intravenous Administration
Yuav tsum tau tswj hwm los ntawm tus kws kho mob nkaus xwb. Tom qab rov kho dua, muab cov koob tshuaj IV ua ib qho bolus dhau lub sijhawm ntawm 1 feeb. Ib koob tshuaj bolus tshaj 1 mg IV tau ua rau xeev siab thiab ntuav thiab tsis pom zoo.
Cim npe nrov: inj glucagon 1 mg, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom