Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm cov tuam txhab kev paub ntau tshaj plaws thiab cov chaw muag khoom ntawm kisspeptin-10 txhaj tshuaj hauv Suav teb. Txais tos rau kev lag luam wholesale bulk zoo kisspeptin-10 txhaj tshuaj rau muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Kisspeptin-10 Txhaj(tseem hu ua Metastin 45-54) yog ib qho ntuj tsim neuropeptide encoded los ntawm endogenous KISS1 noob nyob rau hauv tib neeg lub cev. Nws muaj 10 amino acid residues thiab nws ua tiav ib ntus yog Tyr Asn Trp Asn Ser Phe Gly Leu Arg Phe NH ₂. Nws yog qhov tsawg tshaj plaws active fragment uas ua los ntawm proteolytic cleavage ntawm tag nrho-ntev Kisspeptin-145 thiab yog suav hais tias yog ib tug luv luv sequence nrog tag nrho intrinsic lom lom.
Tsev neeg Kisspeptin tau pom thawj zaug hauv xyoo 1996 los ntawm pab pawg tshawb fawb ntawm Hershey Medical Center hauv kev tshawb fawb melanoma metastasis inhibition, thiab yog li pib lub npe hu ua "Metastin" (metastasis suppressor). Txawm li cas los xij, kev tshawb fawb tom qab tau nthuav tawm nws txoj haujlwm tseem ceeb hauv kev ua tub ntxhais kawm endocrinology - tam sim no lub npe hu ua lub zog tshaj plaws lub cev ua haujlwm ntawm hypothalamic pituitary gonadal axis (HPG axis), hu ua "tus tswv hloov ntawm cov tshuaj hormones kev loj hlob".
Peb cov khoom Form
Kisspeptin-10 (tib neeg) COA
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| Certificate of Analysis | ||
| Compound npe | Kisspeptin 10 (tib neeg) | |
| Qib | Pharmaceutical qib | |
| CAS Nr. | 374675-21-5 | |
| Ntau | 50g | |
| Ntim txheem | PE hnab + Al foil hnab | |
| Chaw tsim tshuaj paus | Shaanxi BLOOM TECH Co., Ltd | |
| Ntau No. | 202601090064 | |
| MFG | Peb 9, 2026 | |
| EXP | Peb 8, 2029 | |
| Qauv |
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| Yam khoom | Enterprise txheem | Kev txheeb xyuas qhov tshwm sim |
| Qhov tshwm sim | Dawb los yog yuav luag dawb hmoov | Ua raws |
| Cov ntsiab lus dej | Tsawg dua lossis sib npaug li 5.0% | 0.56% |
| Poob rau ziab | Tsawg dua lossis sib npaug li 1.0% | 0.45% |
| Hnyav Hlau | Pb Tsawg dua lossis sib npaug li 0.5ppm | N.D. |
| Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Hg Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Cd Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Purity (HPLC) | Ntau dua lossis sib npaug li 99.0% | 99.98% |
| Ib qho impurity | <0.8% | 0.53% |
| Tag nrho microbial suav | Tsawg dua lossis sib npaug li 750cfu / g | 150 |
| E. Coli | Tsawg dua lossis sib npaug li 2MPN / g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (los ntawm GC) | Tsawg dua lossis sib npaug li 5000ppm | 500ppm ua |
| Cia | Khaws rau hauv qhov chaw kaw, tsaus, thiab qhuav hauv qab -20 degree | |
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| Chemical Formula: | C63H83N17O14 |
| Exact Mass: | 1301.63 |
| Molecular Luj: | 1302.46 |
| m/z: | 1301.63 (100.0%), 1302.63 (68.1%), 1303.64 (22.8%), 1302.63 (5.9%), 1304.64 (5.0%), 1303.63 (4.3%), 1303.63 (2.9%), 1304.64 (2.0%), 1304.63 (1.3%) |
| Elemental Analysis: | C, 58.10; H, 6.42; N, 18.28; O, 17.20 |
Kisspeptin-10 Txhaj(KP-10) yog ib qho active luv peptide muaj li ntawm 10 amino acids, uas yog qhov tsawg tshaj plaws functional fragment encoded los ntawm KISS1 noob. Nws tshwj xeeb activates KISSSR (GPR54) receptor nyob rau saum npoo ntawm GnRH neurons hauv hypothalamus, dhau los ua ib qho tseem ceeb ntawm kev tswj hwm ntawm HPG axis (hypothalamic pituitary gonadal axis). Kev txhaj tshuaj KP-10 tau pom tias muaj txiaj ntsig tseem ceeb hauv kev kho cov kab mob qog nqaij hlav hauv cov menyuam yaus, kev ua kom zoo ntawm cov cuab yeej siv me nyuam, kev tswj cov tub ntxhais hluas txoj kev loj hlob, kev tswj cov metabolic homeostasis, inhibition ntawm qog metastasis, thiab cov kev cai neuroendocrine, vim nws cov kev ua haujlwm siab, kev ua haujlwm luv luv, thiab cov khoom siv tshuaj.
Kev siv tshuaj kho mob ntawm cov kab mob qog nqaij hlav endocrine
Idiopathic hypogonadotropic hypogonadism (IHH)
IHH yog tshwm sim los ntawm kev hloov pauv hauv KISS1 / KISS1R noob lossis tsis txaus tso tawm ntawm endogenous Kisspeptin, ua rau GnRH mem tes tsis txaus thiab qib LH / FSH qis, tshwm sim raws li kev puberty agenesis, gonadal tsis ua haujlwm, thiab muaj menyuam tsis taus. Kev txhaj tshuaj KP-10 yog kev kho mob etiological.
Cov nyhuv: Kev txhaj tshuaj subcutaneous ntawm KP-10 (1-2 μ g / kg, 1-2 zaug hauv ib hnub) tuaj yeem kho LH pulse secretion, nce txiv neej LH mem tes zaus 2 zaug, thiab nce qib testosterone los ntawm<100ng/dL to 300-600ng/dL; Women resume their menstrual cycle and their estradiol levels normalize.
Cov txiaj ntsig kho mob: hloov cov twj paj nruag GnRH mem tes, kev tswj hwm yooj yim, thiab kev ua siab ntev; Natural activation ntawm HPG axis txhim kho phev ntau lawm thiab zes qe menyuam muaj nuj nqi, uas yog superior rau exogenous LH / FSH hloov kho.
Polycystic zes qe menyuam syndrome (PCOS)
Lub hauv paus pathology ntawm PCOS yog kev tsis sib haum xeeb ntawm HPG axis, siab LH secretion, polycystic zes qe menyuam zoo li kev hloov pauv, thiab ovulation teeb meem. KP-10 ua lub luag haujlwm kho mob los ntawm kev tswj hwm LH pulses, rov ua kom ovulation, thiab txhim kho insulin tsis kam.
Cov nyhuv: Tsawg koob KP-10 (0.5-1 μ g / kg) tuaj yeem txo qis LH, txhim kho LH / FSH piv, thiab txo qis ntawm zes qe menyuam androgen synthesis; Restore ovulation li niaj zaus, nce ovulation tus nqi los ntawm 40% -60%; Txhim kho cov tshuaj insulin rhiab heev, txo qis cov tshuaj insulin hauv cov ntshav, thiab txo qis PCOS cuam tshuam nrog cov metabolism.
Mechanism: Regulating hypothalamic GnRH mem tes atherosclerosis thiab inhibiting txawv txav LH siab secretion; Kev ua ncaj qha rau ntawm zes qe menyuam KISSSR, txhim kho follicular; Kev tswj hwm pancreatic beta cell ua haujlwm thiab txhawb nqa cov piam thaj nyob ntawm insulin secretion.
Central precocious puberty (CPP)
CPP, vim yog qhov tso tawm ntau dhau ntawm Kisspeptin hauv hypothalamus thiab ua kom ntxov ntxov ntawm HPG axis, ua rau muaj kev loj hlob ntxov ntawm cov yam ntxwv ntawm kev sib deev thiab kev kaw ntxov ntawm epiphyses hauv cov menyuam yaus. Kev txhaj tshuaj qis qis ntawm KP-10 tuaj yeem cuam tshuam qhov tso tawm ntau dhau ntawm Kisspeptin endogenous thiab ncua cov txheej txheem ntawm precocious puberty.
Cov nyhuv: Tsawg koob KP-10 (0.2-0.5 μ g / kg, ib zaug ib hnub) tuaj yeem txo qis kev qhia ntawm KISS1 hauv hypothalamus, inhibit qhov tso tawm ntau dhau ntawm GnRH, txo LH ncov, thiab ncua kev loj hlob ntawm cov yam ntxwv ntawm kev sib deev; ncua kev kaw epiphyseal thiab txhim kho cov neeg laus qhov siab.
Qhov zoo: Piv nrog rau GnRH agonists ib txwm muaj, nws muaj kev rov qab zoo dua, muaj kev phiv tsawg dua, thiab zam kev mob pob txha thiab metabolic abnormalities tshwm sim los ntawm ntev - lub sij hawm inhibition ntawm HPG axis.
Txiv neej hypogonadism (tsawg testosterone)
Txiv neej Testosterone deficiency (primary/secondary) yog tus cwj pwm los ntawm kev txo libido, erectile kawg, txo cov leeg nqaij, thiab infertility. KP-10 txhaj tshuaj activates HPG axis, txhawb endogenous testosterone synthesis, thiab ua tiav physiological testosterone supplementation.
Cov nyhuv: Kev txhaj tshuaj subcutaneous ntawm KP-10 (100-200 μ g / sijhawm, ib zaug ib hnub, 4-6 lub lis piam) tuaj yeem nce qib LH los ntawm 3-5 zaug thiab qib testosterone los ntawm<300ng/dL to 500-800ng/dL; Improving libido and erectile function, increasing sperm concentration and vitality, and increasing natural conception rate.
Daim ntawv thov scenario: Testosterone hloov kho (TRT) pab kho HPG axis muaj nuj nqi; Tom qab lub voj voog steroid, HPG axis rov pib dua, sai sai rov qab kho endogenous testosterone secretion, uas yog superior rau ib txwm SERMs (clomiphene, tamoxifen).
Qhov chaw siv:
- Kev sib txuas lus lom neeg. Txheej txheem cej luam: Kisspeptin isoforms: ntau yam hauv kev tsim tawm thiab lwm cov teb ob txhiab thiab nees nkaum-tsib
- Peptidex. Kisspeptin -10. 2026.
- Shanghai lub koom haum ntawm Materia Medica, Suav Academy ntawm Sciences. Hnia receptor ligand paub thiab downstream G protein recruitment mechanism ob txhiab thiab nees nkaum-plaub
- Cenexa Labs. Kisspeptin -10. 2026.
- Kev sib txuas lus lom neeg. Txheej txheem cej luam: Kisspeptin isoforms: ntau yam hauv kev tsim tawm thiab lwm cov teb ob txhiab thiab nees nkaum-tsib
- Peptide Initiative. Kisspeptin-10 Daim Ntawv Qhia Txhaj Tshuaj . 2026.
- British Dragon Pharma. Kisspeptin 10 mg . 2026.
Optimized siv cov cuab yeej pab kev yug me nyuam (ART)
Optimization of Ovulation Induction Protocol (IVF/ICSI)
Ib txwm ovulation induction tau yooj yim ua rau zes qe menyuam hyperstimulation syndrome (OHSS), asynchronous follicular kev loj hlob, thiab qe qe retrieval tus nqi qis.Kisspeptin-10 Txhajyog siv los ua lwm txoj hauv kev rau GnRH agonists kom raug tswj lub sijhawm ovulation thiab txhim kho follicle zoo.
Cov nyhuv: Thaum lub sij hawm IVF mus, ob koob tshuaj KP-10 (9.6nmol / kg, nrog rau 12 teev ib ntus) tuaj yeem synchronize follicular kev loj hlob thiab nce qe retrieval tus nqi ntawm 60%;
Ua rau endogenous LH ncov, ib txwm ua rau ovulation, thiab zam OHSS kev pheej hmoo los ntawm kev txhaj tshuaj HCG; Txhim kho qe kom loj hlob tuaj, nce siab -zoo embryo tus nqi los ntawm 30%, thiab nce qhov chaw kho mob cev xeeb tub los ntawm 20%.
Mechanism: Simulate physiological LH peaks los txhawb follicle maturation thiab ovulation; Tswj cov ntshav ntws hauv zos hauv zes qe menyuam thiab txhim kho cov khoom noj khoom haus follicle; Txo qhov ntau npaum ntawm ovulation inducing tshuaj thiab txo qis ntawm zes qe menyuam.
Txhim kho qhov kev vam meej ntawm embryo hloov thiab implantation
KP-10 txhim kho qhov kev kuaj mob cev xeeb tub thiab kev yug me nyuam ntawm ART los ntawm kev tswj hwm endometrial receptivity, txhawb embryo implantation, thiab txhim kho kev xeeb tub.
Cov nyhuv: Txhaj KP-10 (1 μ g / kg, ib hnub ib zaug) 3-5 hnub ua ntej embryo hloov mus rau upregulate endometrial receptivity markers (LIF, HOXA10), txhim kho endometrial thickness thiab cov ntshav khiav; Txhawb kev ntxeem tau ntawm trophoblast hlwb thiab nce embryo implantation tus nqi los ntawm 25%; Txo qhov nchuav menyuam thaum ntxov thiab txhim kho kev xeeb tub.
Qhov zoo: Muab piv rau cov kev txhawb nqa progesterone ib txwm muaj, nws tswj hwm ob qho tib si endocrine thiab endometrial functions, ua rau muaj kev vam meej ntawm kev cog qoob loo ntau dua thiab tsis muaj cov kev mob tshwm sim ntawm progesterone.
Kev kho tus txiv neej Infertility (Oligozoospermia)
KP-10 kho idiopathic oligozoospermia los ntawm kev ua kom HPG axis, txhawb cov phev ntau lawm, thiab txhim kho cov phev motility.
Cov nyhuv: Kev txhaj tshuaj subcutaneous ntawm KP-10 (150 μ g / zaug, ib zaug ib hnub, 8-12 lub lis piam) nce FSH qib los ntawm 2-3 zaug, nce phev concentration los ntawm<15 × 10 ⁶/mL to 30-60 × 10 ⁶/mL, and increases forward motility sperm rate to over 40%; Improve sperm DNA integrity, reduce sperm fragmentation rate, and increase natural conception rate.
Mechanism: FSH txhawb kev loj hlob ntawm seminiferous epithelium nyob rau hauv lub seminiferous tubules ntawm cov noob qes, txhim kho phev ntau lawm; Testosterone txhim kho epididymal muaj nuj nqi, txhim kho phev motility thiab kom loj hlob.
Qhov chaw siv:
- Kev sib txuas lus lom neeg. Txheej txheem cej luam: Kisspeptin isoforms: ntau yam hauv kev tsim tawm thiab lwm yam kev lag luam.2025
- Peptide- raws tu qauv. KissPeptin -10. 2026.
- Peptidex. Kisspeptin -10. 2026.
Cov lus nug nquag
Ntev npaum li cas nws txoj sia nyob hauv lub cev? --Molecular ib nrab-lub neej yog xam nyob rau hauv feeb lossis txawm vib nas this
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Kisspeptin-10 yog ib qho ntawm cov peptides nrog qhov luv tshaj ib nrab- lub neej hauv vivo, nrog kev tawg ib nrab ntawm lub neej tsuas yog li 1.7 feeb hauv ntshav ntawm lub cev kub.
Kev tshawb fawb tau pom tias nyob rau hauv ib puag ncig plasma ntawm 37℃C (xws li tib neeg lub cev kub), ib nrab -lub neej ntawm Kisspeptin-10 decomposition tsuas yog 1.7 feeb; Txawm tias nyob rau hauv lub tub yees ntawm 4℃C, nws ib nrab-lub neej tsuas yog 6.8 feeb. Qhov no txhais tau hais tias thaum nws raug thawb rau hauv lub cev, cov qauv molecular pib tawg yuav luag tam sim ntawd.
Cov txheej txheem tom qab nws stems los ntawm "fragility" ntawm N-terminal tyrosine - txoj hauv kev tseem ceeb ntawm kev degradation yog txiav nws ib qho los ntawm ib qho ntawm N-terminus, nrog tyrosine yog thawj zaug rau cleaved. Qhov no kuj yog vim li cas nws cov tshuaj pharmacological pom tau tias "pulse nyiam" es tsis yog "sustained" tshuaj keeb kwm.
Vim li cas ho tsis kuaj pom hauv cov ntshav sai li sai tau? --Ua 'noj' los ntawm lub cev, tsis yog degraded
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Ntxiv nrog rau molecular degradation, nws sai sai ploj hauv plasma kuj yog vim qhov nce sai thiab metabolic tshem tawm los ntawm cov ntaub so ntswg thiab cov kabmob.
Tom qab txhaj tshuaj, cov tshuaj tsis tshua muaj nanogram muaj peev xwm tsuas yog kuaj tau hauv ob peb feeb, thiab tom qab 30 feeb, lawv tsis tuaj yeem kuaj pom. Qhov kev cuam tshuam sai heev "kev pom tsis pom" tsis yog tsuas yog tshwm sim los ntawm cov tshuaj degradation, tab sis kuj yog qhov tshwm sim ntawm kev nqus sai thiab tshem tawm los ntawm cov ntaub so ntswg thoob plaws lub cev, tshwj xeeb tshaj yog cov kab mob metabolic xws li ob lub raum thiab daim siab. Hauv lwm lo lus, nws yog ob qho tib si tawg thiab tsis ua haujlwm hauv lub cev.
Vim li cas cov nyhuv "txo" thaum rov siv dua? --N-terminal deletion yog ob qho tib si metabolite thiab antagonist
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Thawj cov khoom degradation ntawm Kisspeptin-10- cov metabolite tsis muaj N-terminal tyrosine - tuaj yeem ua lub luag haujlwm ntawm lub ntuj "blocker".
Cov khoom lag luam degradation tseem ceeb txheeb xyuas los ntawm txoj kev tshawb fawb yog "Kisspeptin-10 tsis muaj N-terminal tyrosine". Txawm hais tias cov metabolite no tau poob nws qhov kev ua kom zoo siab, nws tseem tuaj yeem tuav GPR54 receptor. Qhov no txhais tau hais tias thaum lub sij hawm nruam infusion los yog rov ua hauj lwm, raws li cov niam cov tshuaj degrades thiab metabolites accumulates, tom kawg "nyob" cov nyhuv yuav ua rau tsis muaj zog ntawm cov kev ua tau zoo ntawm kev tswj xyuas tom ntej. Qhov no yog "tus kheej antagonistic" ntxiab uas yuav tsum tau xav txog hauv kev tsim qauv.
Cim npe nrov: kisspeptin-10 txhaj tshuaj, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom