Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm cov kws tshaj lij kev lag luam thiab cov neeg muag khoom ntawm levamisole txhaj tshuaj hauv Suav teb. Txais tos rau kev lag luam wholesale bulk zoo levamisole txhaj rau muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Kev txhaj tshuaj Levamisoleyog ib qho tshuaj tua tsiaj uas muaj levamisole, feem ntau yog siv los tua cov kab mob nematode hauv cov tsiaj thiab tswj kev tiv thaiv kab mob. Lub active ingredient levamisol yog ib tug dawb mus rau tawm dawb crystalline hmoov uas inhibits cov kev ua ntawm succinate dehydrogenase nyob rau hauv kab cov leeg, ua rau cov leeg leeg tuag tes tuag taw, ua tiav cov nyhuv deworming. Tib lub sijhawm, cov tshuaj tuaj yeem txhim kho tsiaj tiv thaiv kab mob thiab txhim kho kev tiv thaiv kab mob thiab kis kab mob.
Scope ntawm kev siv:
Qhov kev txhaj tshuaj no tsim nyog rau kev kho cov kab mob nematode hauv cov tsiaj nyeg xws li dev, miv, nyuj, yaj, npua, thiab nqaij qaib, nrog rau cov kab mob sib kis, kab ntsig, kab mob ntsws, kab mob plab, thiab plab hnyuv nematodes (xws li Metastrongylus thiab Strongylus parasites). Txwv tsis pub rau nees vim nws yuav ua rau muaj kev phiv loj heev.
Txoj kev siv:
Kev tswj hwm los ntawm kev txhaj tshuaj subcutaneous lossis intramuscular, qhov ntau npaum li cas yuav tsum tau hloov kho raws li hom tsiaj thiab lub cev hnyav. Piv txwv li, dev thiab miv tau txhaj tshuaj 10mg ib 1kg ntawm lub cev hnyav; nyuj, yaj, thiab npua tau txhaj tshuaj 7.5mg ib 1kg ntawm lub cev hnyav; thiab nqaij qaib yog txhaj nrog 25mg ib 1 kg ntawm lub cev hnyav. Cov koob tshuaj tshwj xeeb yuav tsum ua raws li cov kws kho tsiaj cov lus qhia.
Cov ntaub ntawv ntxiv ntawm chemical compound:
Peb Cov Khoom
Levamisole COA
Kev txhaj tshuaj Levamisole, raws li qhov dav -spectrum anthelmintic ntawm chav kawm imidazole thiazole, tau dhau los ua kev txhim kho hauv kev kawm txog nws cov txheej txheem ntawm kev ua los ntawm ib qho tshuaj tua kab mob rau kev tswj hwm kev tiv thaiv txij li nws thawj daim ntawv thov kev kho mob hauv xyoo 1966.
Mechanism ntawm deworming nyhuv: synergistic nyhuv ntawm neuromuscular blockade thiab lub zog metabolism cuam tshuam
1. Nicotine zoo li receptor agonistic nyhuv
Levamisol xaiv activates nicotinic acetylcholine receptor (nAChR) ntawm lub neuromuscular hlws ris ntawm nematodes, ua rau cov leeg nqaij contractions. Cov txheej txheem no muaj cov yam ntxwv hauv qab no:
Receptor tshwj xeeb: Piv nrog rau cov tsiaj nyeg nAChR, levamisol muaj 10-100 npaug ntau dua affinity rau nematode receptors, ua kom muaj kev nyab xeeb kev kho mob.
Dose dependence: Low concentrations (0.1-1 μ M) can cause muscle tremors in the parasite, while high concentrations (>10 μ M) tuaj yeem ua rau tuag tes tuag taw.
Neurotransmitter kev sib tw: Sib tw nrog acetylcholine los khi rau receptors, ncua lub sij hawm depolarization ntawm postsynaptic membrane thiab tsim "depolarization block" xeev.
2. Lub zog metabolic blockade mechanism
Nyob rau hauv siab concentration tej yam kev mob, levamisol cuam tshuam nrog nematode zog metabolism los ntawm ob txoj kev:
Succinate dehydrogenase inhibition: thaiv kev hloov pauv ntawm succinic acid rau fumarate nyob rau hauv lub voj voog tricarboxylic acid, ua rau txo qis hauv ATP ntau lawm. Qhov kev sim tau pom tias ATP cov ntsiab lus ntawm npua roundworms txo qis dua 80% tom qab kho.
Oxidative phosphorylation mediated uncoupling: cuam tshuam cov electron thauj saw nyob rau hauv lub mitochondrial membrane, ua rau lub zog mus rau dissipate nyob rau hauv daim ntawv ntawm thermal zog. Kev soj ntsuam electron microscopy pom tau hais tias lub mitochondrial crest qauv ntawm cov txheej txheem twisted ntshav lance nematode tau tawg.
3. Dynamics ntawm kev tshem tawm kab
Cov leeg tuag tes tuag taw sij hawm: Tom qab 15-30 feeb ntawm kev tswj hwm, canine hookworm qhia tias tsis muaj zog ntawm lub qhov ncauj capsule, thiab ua tiav tuag tes tuag taw tshwm sim hauv 60-90 feeb.
Tus tswv tsev plab hnyuv propulsion: Koom tes nrog tus tswv tsev plab hnyuv peristaltic nthwv dej (3-5 zaug / feeb) kom ua tiav kev tshem tawm cov kab mob tuag hauv 24-48 teev.
Mechanism of drug resistance: Qee hom kab kab txo cov tshuaj tsub zuj zuj los ntawm upregulating P-glycoprotein qhia (3-5 quav ntxiv), los yog mutating nAChR qauv kom txo binding affinity.
Immne regulatory mechanism: reprogramming ntawm multi-level immne network
1. Rov ua haujlwm ntawm T lymphocyte
Th1/Th2 balance regulation:
Txhawb IL-12 tso tawm thiab txhim kho Th1 immne teb (ntxiv IFN - qib los ntawm 2-3 zaug)
Inhibit IL-4 ntau lawm thiab downregulate Th2 hom teb (IgE qib txo los ntawm 40-60%)
Cov ntaub ntawv kho mob: Hauv kev kho tus kab mob canine parvovirus, CD4+/CD8+ qhov sib piv hauv kev sib xyaw ua ke kho tau zoo los ntawm 0.8 txog 1.5
Treg cell kev cai:
Inhibit FOXP3+ tswj kev ua haujlwm T cell thiab txo nws qhov inhibition ntawm effector T hlwb
Hauv feline infectious peritonitis qauv, qhov feem ntawm IFN - +CD8+T hlwb tau ntxiv los ntawm 12% mus rau 28%
2. Ua kom lub cev tsis muaj zog
Enhanced macrophage muaj nuj nqi:
Nce phagocytic Performance index (los ntawm 1.2 txog 3.5)
Txhawb ROS / RNS ntau lawm (ntxiv NO qib los ntawm 4-6 zaug)
Txhim khu kev nthuav qhia antigen muaj peev xwm (upregulation ntawm MHC-II qhia los ntawm 30-50%)
NK cell stimulation:
Nce kev qhia ntawm perforin thiab granzyme B (mRNA qib ntxiv 2-3 zaug)
Nyob rau hauv porcine circovirus hom 2 kab mob, kev tua ntawm NK hlwb ntxiv los ntawm 35% mus rau 68%
4. Txhim khu kev nco
B cell antibody ntau lawm:
Txhim kho cov tshuaj tiv thaiv kab mob (ntxiv Brucella tshuaj tiv thaiv kab mob muaj zog los ntawm 2-4 zaug)
Txhawb kev tsim ntawm lub cim xeeb B hlwb (ntxiv qhov feem ntawm CD27+B hlwb los ntawm 30%)
Mucosal immne activation:
Nce cov ntsiab lus ntawm plab hnyuv secretory IgA (sIgA) los ntawm 12 μ g / mL mus rau 35 μ g / mL
Hauv cov tshuaj tiv thaiv kab mob kis kab mob avian, qhov zoo ntawm kev ua pa sIgA tau ntxiv los ntawm 60% mus rau 85%
1. Tshwj xeeb ntawm cov tsiaj ruminant
Kev cuam tshuam ntawm rumen microbiota:
Tus nqi degradation ntawm levamisol hauv rumen nce mus txog 30-50%
Kev nthuav tawm cov qauv ntxiv tuaj yeem ntxiv qhov tseeb ntawm lub plab nqus mus rau ntau dua 75%
Ntau yam rhiab heev txawv:
Holstein nyuj yuav tsum tau hloov koob tshuaj (8.5mg / kg vs 7.5mg / kg rau cov nyuj tsis tu ncua)
Yaj muaj 20-30% muaj zog tiv thaiv kab mob teb ntau dua li tshis
2. Cov yam ntxwv ntawm cov tsiaj txhu monogastric
Metabolic sib txawv ntawm dev thiab miv:
Ib nrab- lub neej ntawm dev (3.2 teev) luv dua li miv (4.8 teev)
Miv yog feem ntau ua rau neurotoxicity (nrog 15% qhov tshwm sim ntau dua li dev)
Mechanism optimization cov tswv yim hauv kev siv tshuaj kho mob
Combination therapy plan
Cov tshuaj tua kab thiab kev ua tau zoo txhawb kev sib xyaw ua ke:
Ua ke nrog ivermectin (nrog rau lub sijhawm 7-hnub), lub deworming spectrum txuas mus rau 98% ntawm cov tsiaj txhu thiab nqaij qaib parasites
Hauv cov kab mob sib xyaw ntawm npua roundworm thiab whipworm, qhov txo qis ntawm cov qe qe ntxiv los ntawm 85% mus rau 99%
Immne regulation synergy:
Ua ke nrog Huangqi polysaccharide, antibody potency ntawm canine distemper tshuaj tiv thaiv yog ntxiv peb zaug.
Ua kom ceev tus nqi rov qab los ntawm CD4+/CD8+ piv los ntawm 50% hauv tus kab mob feline leukemia
Precision tshuaj xa khoom technology
Nanoformulation kev loj hlob:
Poly (lactic acid glycolic acid) copolymer (PLGA) nanoparticles ntxiv cov tshuaj enrichment hauv cov ntaub so ntswg lymphoid los ntawm 10 npaug
Nyob rau hauv porcine circovirus hom 2 kab mob, tus kab mob load yog txo los ntawm 2 logarithmic txiav txim ntawm magnitude.
Pulse tswj:
Ob zaug kev noj tshuaj txhua lub lim tiam txhim kho kev tiv thaiv kab mob los ntawm 40% piv rau kev noj txhua hnub
Txo qhov tshwm sim ntawm granulocyte deficiency (los ntawm 5% mus rau 0.8%)
Cov lus qhia kev tshawb fawb yav tom ntej
Epigenetic tswj mechanism:
Tshawb nrhiav cov nyhuv ntawm levamisol ntawm histone acetylation /methylation
Kev sib cuam tshuam ntawm plab microbiota:
Kawm txog kev tswj hwm cov tshuaj ntawm cov saw luv fatty acid uas tsim cov kab mob
Nanoantibody kev loj hlob:
Tsim ib qho tshuaj tiv thaiv ib leeg tsom rau levamisol receptors los txhim kho lub peev xwm
AI assisted drug delivery system:
Tsim kom muaj tus qauv kev kwv yees koob tshuaj tus kheej raws li kev kawm tshuab
Kev txhaj tshuaj Levamisole sawv cev rau cov txheej txheem kho kom zoo uas ua haujlwm los ntawm kev ua haujlwm ntawm ob lub tswv yim, ua haujlwm tau zoo ntawm qhov sib txawv ntawm kev cuam tshuam ncaj qha parasitological thiab kev tiv thaiv kab mob. Ntawm qhov tseem ceeb ntawm nws cov tshuaj tiv thaiv kab mob yog lub peev xwm los ntxias cov kab mob neuromuscular blockade hauv cov kab mob helminths raug mob - tau ua tiav los ntawm kev xaiv agonism ntawm nicotinic acetylcholine receptors ntawm nematode cov leeg hlwb, ua rau tsis tu ncua depolarization, spastic tuag tes tuag taw, thiab qhov kawg tshem tawm ntawm cov kab mob parasites. Qhov kev cuam tshuam sai thiab tsom rau cov neeg tuag tes tuag taw no ua kom muaj txiaj ntsig zoo ntawm cov kab mob cab cab thaum txo qis lub sijhawm ntawm tus tswv tsev raug rau cov kab mob pathogenic.
Ua kom tiav nws cov kev ua haujlwm ncaj qha anthelmintic, levamisole nthuav tawm cov khoom siv tshuaj tiv thaiv kab mob uas ua rau kom muaj peev xwm tiv thaiv tus tswv tsev. Los ntawm kev ua raws li cov tshuaj hormones thymic-zoo li kev ua ub no, cov khoom sib xyaw ua rau T-kev sib txawv ntawm tes, txhim kho macrophage tsiv teb tsaws thiab phagocytic kev ua haujlwm, thiab rov ua kom muaj kev nyuaj siab ntawm tes- cov tshuaj tiv thaiv kab mob sib kis hauv cov tshuaj tiv thaiv kab mob. Cov nyhuv immunorestorative tsis yog tsuas yog ua kom rov qab los ntawm cov kab mob cab, tab sis kuj txhawb kev tiv thaiv cov kab mob microbial thib ob, yog li tsim kom muaj kev kho mob holistic uas hais txog ob qho tib si tus neeg sawv cev thiab qhov tsis zoo ntawm tus tswv tsev tiv thaiv kab mob.
Nws yog cov tshuaj kws kho tsiaj nrog ob qho tib si deworming thiab immne tswj kev ua haujlwm, suav nrog ntau theem ntawm kev sib cuam tshuam tshuaj xws li kev txhim kho kev ua tau zoo, ntxiv toxicity, lossis cuam tshuam nrog cov txheej txheem ntawm kev ua.
1. Synergistic effect nrog cov tshuaj tiv thaiv
Levamisol tuaj yeem txhim kho kev tiv thaiv kab mob ntawm cov tshuaj tiv thaiv Brucella, tshuaj tiv thaiv kab mob khaub thuas avian, thiab lwm yam tshuaj tiv thaiv los ntawm kev txhawb nqa T lymphocyte proliferation thiab antibody ntau lawm, yog li txhim kho cov tshuaj tiv thaiv. Piv txwv li, hauv kev txhaj tshuaj tiv thaiv kab mob porcine circovirus hom 2, kev siv levamisol ua ke tuaj yeem ntxiv cov tshuaj tiv thaiv kab mob los ntawm 2-4 zaug, txo qhov kev pheej hmoo ntawm cov kab mob qus.
2. Kev sib xyaw ua ke nrog cov tshuaj tiv thaiv kab mob
Hauv kev kho tus kab mob canine parvovirus, kev sib xyaw ntawm levamisol thiab interferon tuaj yeem ua rau luv luv ntawm cov kab mob los ntawm 3-5 hnub. Lub tshuab yog tias levamisol restores NK cell kev ua, txhim khu interferon induced antiviral xeev, thiab tsim ib tug dual tiv thaiv kab ntawm "immne clearance direct inhibition".
3. Synergistic daim ntawv thov nrog tshuaj tua kab mob
Kev tshawb fawb ntawm cov tshuaj -tus qauv tiv thaiv Escherichia coli kab mob tau pom tias kev sib xyaw ntawm levamisol thiab enrofloxacin tuaj yeem txo qis qhov tsawg kawg nkaus inhibitory concentration (MIC) los ntawm 50%. Qhov no tuaj yeem cuam tshuam txog kev txo qis ntawm cov noob qhia ntsig txog cov kab mob biofilm tsim los ntawm levamisol.
Cov nyhuv antagonistic ntawm cholinesterase inhibitors
Thaum cov tshuaj tua kab organophosphate (xws li dichlorvos) ua ke nrog levamisol, yav dhau los exacerbates nicotine zoo li cov tsos mob los ntawm inhibiting acetylcholinesterase, ua rau muaj tshuaj lom xws li salivation thiab tshee tshee hauv cov tsiaj. Qhov kev sim tau pom tias qhov kev tuag ntawm pawg ua ke yog 30% siab dua li ntawm pawg levamisol ib leeg.
Kev sib tw inhibition ntawm cov tshuaj tiv thaiv helminth
Thaum ua ke nrog albendazole, ob leeg sib tw rau P-glycoprotein transporters, ua rau 40% txo qis hauv plab hnyuv nqus ntawm levamisol. Nws raug nquahu kom siv cov kev kho mob ua ntu zus (thawj levamisol thiab tom qab ntawd albendazole) hauv kev kho deworming kom tsis txhob muaj qhov ua tau zoo.
3. Cov nyhuv antagonistic ntawm immunosuppressants
Cov nyhuv antagonistic ntawm immunosuppressants
Dexamethasone tuaj yeem thaiv kev ua kom CD4+T hlwb raug ntxias los ntawm levamisol, ua rau 80% txo qis hauv IFN - zais cia. Hauv kev kho mob qog noj ntshav hauv canine, yog tias yuav tsum tau txhaj tshuaj tiv thaiv kab mob sib xyaw ua ke, lawv yuav tsum tau siv sijhawm tsawg kawg 72 teev kom tswj tau qhov ua tau zoo.
Cov nyhuv synergistic ntawm cov tshuaj neurotoxic.Thaum siv ua ke nrog thiacloprid, ob qho tib si ua rau nAChR, ua rau muaj kev phiv loj xws li cov leeg tremors thiab ua pa nyuaj siab hauv miv. Cov kws kho mob tau pom tias qhov tshwm sim ntawm neurotoxicity hauv pawg ua ke yog 25%, thaum nyob rau hauv pawg monotherapy nws tsuas yog 3%.Metabolic cuam tshuam ntawm daim siab enzyme inducers.Phenobarbital tuaj yeem ua kom cov hydroxylation metabolism ntawm levamisol, txo nws ib nrab -lub neej los ntawm 4.8 teev mus rau 1.2 teev. Hauv kev mob qaug dab peg kho tsiaj, cov tshuaj ntshav ntshav yuav tsum tau saib xyuas thiab cov koob tshuaj tau hloov mus rau 1.5 npaug ntawm tus qauv koob tshuaj.Instability ntawm cov tshuaj electrolyte.
Kev txhaj tshuaj LevamisoleNws yooj yim rau crystallize hauv 0.9% sodium chloride txhaj, ua rau cov kab mob sib kis. Cov tshuaj pharmacopoeia tau hais tias cov kuab tshuaj yuav tsum tau ua kom tsis muaj dej txhaj tshuaj thiab yuav tsum siv li ntawm 6 teev.
Cim npe nrov: levamisole txhaj, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom