Pralidoxime Chloride Txhajyog ib qho tshuaj tua kab mob siv los kho organophosphate lom. Nws khi rau pawg phosphoryl hauv phosphorylated cholinesterase, tso cov cholinesterase thiab rov qab los rau hauv nws lub xeev qub, yog li siv nws cov nyhuv hauv rescuing organophosphate insecticide lom lom.
Nws muaj qhov sib txawv ntawm cov nyhuv reactivation ntawm cholinesterase kev ua haujlwm inhibited los ntawm cov kab mob organophosphate insecticides, tab sis muaj cov tshuaj lom tsis zoo ntawm malathion, dichlorvos, dichlorvos, dimethoate, mevalonate, propafenone, thiab octamethoxam. Nws tsis muaj qhov cuam tshuam txog kev ua haujlwm ntawm cholinesterase inhibited los ntawm carbamate insecticides. Feem ntau yog siv los cawm cov tshuaj lom los ntawm ntau yam organophosphate insecticides. Thaum siv ua ke nrog atropine, koob tshuaj atropine yuav tsum raug txo vim yog kev txhim kho lom ntawm chlorpromazine. Atropinization yuav tsum tau khaws cia rau 48 teev, maj mam txo cov koob tshuaj atropine lossis ncua sijhawm txhaj tshuaj tom qab ntawd.
Nyob rau tib lub sijhawm, peb lub tuam txhab tsis yog tsuas yog muab cov hmoov ntshiab, tab sis kuj muaj cov ntsiav tshuaj thiab tshuaj txhaj. Yog tias xav tau, thov koj xav tiv tauj peb txhua lub sijhawm.
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Cov ntaub ntawv ntxiv ntawm chemical compound:
Pralidoxime Chloride COA
Pralidoxime Chloride Txhajyog ib qho tshuaj tua kab mob siv los kho cov kab mob organophosphate lom, thiab nws cov koob tshuaj thiab kev tswj hwm yuav tsum tau ua tus kheej raws li yam xws li qib kev lom neeg, hnub nyoog ntawm tus neeg mob, thiab qhov hnyav. Cov hauv qab no yog cov ncauj lus kom ntxaws txog kev siv thiab ntau npaum li cas ntawm Pralidoxime Chloride:
Thaum cov neeg laus raug kev txom nyem los ntawm me me organophosphate tshuaj lom, feem ntau siv ntawm Chlorpromazine Txhaj yog 0.4g / zaug rau 0.5g / zaug. Feem ntau diluted nrog qabzib tov los yog physiological saline rau intravenous infusion los yog qeeb infusion. Yog tias tsim nyog, cov tshuaj tuaj yeem rov ua dua txhua 2 mus rau 4 teev, thiab qhov tshwj xeeb zaus yuav tsum tau hloov kho raws li tus neeg mob tus mob thiab qib cholinesterase ntshav; Thaum cov neeg laus raug kev txom nyem los ntawm kev lom organophosphate nruab nrab, thawj koob tshuaj feem ntau yog 0.8g rau 1.2g kom tswj tau cov tsos mob ntawm kev lom sai sai. Tom qab thawj zaug kev tswj hwm, 0.4g rau 0.8g tuaj yeem muab txhua 2 teev, rau tag nrho 2 mus rau 3 zaug; Xwb, cov tshuaj txhaj tshuaj tuaj yeem siv los tswj kev tswj hwm, nrog rau 0.4g ib teev twg rau tag nrho ntawm 4 mus rau 6 zaug; Thaum cov neeg laus raug kev txom nyem los ntawm organophosphate lom heev, thawj koob tshuaj yuav tsum tau nce mus rau 1g mus rau 1.2g kom rov qab tau cov tshuaj lom sai sai. Yog tias cov tsos mob tsis zoo tom qab 30 feeb, tuaj yeem muab ntxiv 0.8g rau 1.2g. Tom qab ntawd, 0.4 g yuav tsum tau muab txhua teev kom txog thaum tus mob stabilizes.
Pediatric siv thiab ntau npaum
Qhov ntau npaum ntawm Chlorpromazine Txhaj rau cov menyuam yaus feem ntau yog xam raws li lub cev hnyav, feem ntau yog 20mg / kg. Thaum cov me nyuam raug kev txom nyem los ntawm me me organophosphate tshuaj lom, chlorfenapyr txhaj tshuaj tuaj yeem siv tau ntawm ib koob ntawm 15mg / kg, thiab rov ua dua yuav tsum tau ua. Thaum raug kev txom nyem los ntawm kev lom nruab nrab, cov koob tshuaj tuaj yeem nce mus rau 20mg / kg txog 30mg / kg, thiab cov koob tshuaj tshwj xeeb yuav tsum tau kho raws li tus mob. Thaum mob hnyav heev, koob tshuaj tuaj yeem ncav cuag 30mg / kg kom tswj tau cov tsos mob ntawm kev lom sai sai. Txoj kev tswj hwm tuaj yeem ua rau cov dej tso rau hauv cov hlab ntsha lossis kev txhaj tshuaj maj mam.
Vim qhov txo qis ntawm cov khoom nruab nrog xws li lub plawv thiab lub raum, cov neeg laus tuaj yeem txo qhov ua siab ntev rauPralidoxime Chloride Txhaj. Yog li ntawd, nws yog ib qho tsim nyog yuav tsum tau txo cov koob tshuaj kom tsim nyog thiab ua kom qeeb ntawm kev txhaj tshuaj hauv cov hlab ntsha thaum siv. Tam sim no muaj pov thawj tsis txaus los ua pov thawj kev nyab xeeb ntawm chlorfenapyr rau kev txhaj tshuaj hauv cov poj niam cev xeeb tub thiab cov menyuam hauv plab. Yog li ntawd, cov poj niam cev xeeb tub thiab lactating poj niam yuav tsum tau siv nrog ceev faj thiab raws li kev qhia ntawm kws kho mob. Rau cov neeg mob uas muaj lub siab thiab lub raum tsis ua haujlwm, cov metabolism thiab kev tso tawm ntawm cov tshuaj chlorpromazine tuaj yeem cuam tshuam. Yog li, qhov ntau npaum li cas yuav tsum tau hloov kho raws li tus mob thaum siv, thiab tus neeg mob lub siab thiab lub raum kev ua haujlwm thiab cov ntshav tshuaj concentration yuav tsum tau saib xyuas kom zoo.
Kev sib tham nrog tshuaj
Pralidoxime Chloride Txhaj, raws li ib qho tshuaj tiv thaiv rau organophosphate lom, feem ntau cuam tshuam nrog tshuaj sib cuam tshuam nrog atropine thiab contraindications rau compatibility nrog lwm yam tshuaj. Hauv qab no yog cov lus qhia ntxaws:
Kev sib xyaw ua ke thiab kev hloov kho koob tshuaj nrog atropine
Chlorfenapyr, raws li ib tug acetylcholinesterase activator, tuaj yeem txo qis kev sib txuam ntawm acetylcholine thiab muaj kev cuam tshuam tseem ceeb ntawm kev sib tshuam ntawm cov leeg neuromuscular ntawm cov leeg pob txha; Atropine ncaj qha antagonizes lub tsub zuj zuj ntawm acetylcholine thiab muaj ib tug muaj zog nyhuv ntawm lub autonomic paj hlwb. Thaum ob qho tib si siv ua ke, lawv tuaj yeem sib koom ua ke ntawm cov txheej txheem pathological ntawm organophosphate lom los ntawm cov txheej txheem sib txawv, txhim kho kev kho mob zoo. Vim tias cov tshuaj lom neeg muaj txiaj ntsig zoo ntawm atropine los ntawm chlorpromazine, cov tshuaj atropine yuav tsum raug txo kom tsawg thaum siv ua ke kom tsis txhob muaj kev phiv los ntawm kev cuam tshuam ntau dhau ntawm acetylcholine receptors.
Atropine koob tshuaj hloov kho txoj kev npaj:
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Contraindications rau compatibility nrog alkaline tshuaj: Chlorfenapyr yog nquag rau hydrolysis cov tshuaj tiv thaiv hauv cov tshuaj alkaline, ua cov khoom tsis muaj zog decomposition uas ua rau txo qis kev ua tau zoo. Tsis txhob sib xyaw nrog cov tshuaj alkaline xws li sodium bicarbonate kom tsis txhob siv tshuaj degradation los ntawm kev hloov pH. Nws yuav tsum tau muab cais ua ke nrog Chlorfenapyr Txhaj Tshuaj kom tsis txhob sib koom cov tshuaj infusion nrog lwm cov tshuaj. Cov kuab tshuaj nruab nrab yuav tsum tau siv thaum lub sij hawm npaj cov txheej txheem los xyuas kom meej tias pH tus nqi ntawm cov tshuaj yog khaws cia nyob rau hauv thaj tsam ntawm 5-7.
Qhov sib txawv ntawm kev kho mob zoo piv rau cov tshuaj organophosphorus tshwj xeeb:Nws muaj kev kho mob tseem ceeb rau feem ntau ntawm cov tshuaj tua kab organophosphate xws li hauv cov phosphorus absorbed thiab parathion lom. Restore paj hlwb muaj nuj nqi los ntawm reviving inhibited cholinesterase kev ua.
Cov mob uas muaj kev kho mob tsawg. Nws muaj cov tshuaj lom tsis zoo rau malathion, dichlorvos, dichlorvos, dimethoate, mevalonate, propafenone, thiab octamethoxam. Tsis muaj cov nyhuv reactivation ntawm acetylcholinesterase inhibited los ntawm carbamate insecticides.
Kev sib cuam tshuam nrog lub xeev laus ntawm cholinesterase:Inhibition ntawm cholinesterase los ntawm organophosphate insecticides rau 36 teev ua rau muaj kev txhawb siab tseem ceeb. Lub tswv yim ntawm kev ua tau zoo attenuation yog tias tom qab ntau tshaj 36 teev, acetylcholinesterase tau dhau los ua "kev laus" tshwm sim, thiab cov phosphorylated pawg hauv nws qhov chaw ua haujlwm tsim cov ntawv cog lus ruaj khov nrog cov enzyme protein, ua rau tsis muaj txiaj ntsig ntawm kev sib khi ntawm chlorfenapyr. Tom qab kuaj pom tias muaj organophosphate lom, chlorfenapyr yuav tsum tau siv tam sim ntawd kom tsis txhob ncua kev kho mob. Yuav tsum tau kuaj ntshav cholinesterase tsis tu ncua. Thaum cov dej num rov qab mus rau 50% -60% ntawm tus nqi ib txwm muaj, kev hloov kho rau cov tshuaj noj yuav raug txiav txim siab.
Kev cuam tshuam nrog cov tsos mob ntawm lub hauv nruab nrab paj hlwb:Nws muaj kev txhim kho tseem ceeb ntawm nicotine zoo li cov tsos mob (xws li mob leeg thiab cov leeg tsis muaj zog), tab sis muaj kev txhim kho tsis muaj zog ntawm cov tsos mob muscarinic (xws li qaug dej qaug cawv thiab tawm hws) thiab cov tsos mob ntawm lub paj hlwb (xws li coma thiab convulsions). Raws li cov tsos mob tshwj xeeb ntawm tus neeg mob, atropine lossis lwm yam tshuaj txhawb nqa cov tsos mob yuav tsum tau siv ua ke. Tsim kom muaj kev ntsuas ntsuas ntsuas nrog rau cov tsos mob, kev ua cholinesterase, thiab cov cim tseem ceeb.
Kev sib raug zoo ntawm koob tshuaj nrog iodothyroxine:Cov ntsiab lus ntawm oxime tebchaw hauv chlorfenapyr yog 79.5%, ntau dua li 51.9% hauv iodothyroxine. Kev ua tau zoo ntawm 1g Chlorfenapyr yog sib npaug rau 1.5g Iodinapyr. Raws li tib txoj kev kho mob, qhov yuav tsum tau txhaj tshuaj ntawm chlorfenapyr yog me dua, uas tuaj yeem txo qhov txhaj tshuaj ntim thiab zaus. Cov koob tshuaj qis dua tuaj yeem pab txo qhov tshwm sim ntawm cov tshuaj - cuam tshuam txog kev phiv tshuaj.
Qhov sib txawv ntawm cov lus teb ntsig txog kev tswj xyuas ceev:Tus nqi txhaj tshuaj yuav tsum tau tswj tsis pub ntau tshaj 500mg ib feeb kom tsis txhob muaj kev phiv tshuaj. Kev txhaj tshuaj sai heev tuaj yeem ua rau muaj kev mob siab rau lub paj hlwb zoo li cov tsos mob xws li xeev siab, ntuav, thiab nce plawv dhia. Hauv cov xwm txheej hnyav, cov tsos mob hauv nruab nrab ntawm lub paj hlwb xws li kiv taub hau, mob taub hau, diplopia, qhov muag tsis pom kev, thiab kev txav tsis sib haum yuav tshwm sim. Nws raug nquahu kom siv cov tshuaj txhaj tshuaj rau thawj zaug kev tswj hwm, thiab cov dej tso dej tuaj yeem raug xaiv rau kev kho mob tom ntej. Siv lub twj tso kua mis infusion kom meej tswj tus nqi xa tshuaj thiab muab nws nrog cov khoom siv electrocardiogram saib xyuas tus neeg mob cov cim tseem ceeb hauv lub sijhawm.
Kev lom lom
Thawj koob tshuaj yog 2-4mg, muab txhua 10 feeb los ntawm kev txhaj tshuaj intramuscular lossis intravenously.
Mob hnyav heev
Thawj koob tshuaj yog 4-6mg, muab txhua 5-10 feeb los ntawm kev txhaj tshuaj intramuscular lossis intravenously.
Kev kho mob kho mob
Atropinization yuav tsum tau khaws cia rau 48 teev, tom qab ntawd cov koob tshuaj yuav tsum maj mam txo lossis ncua sijhawm txhaj tshuaj.
Kev sib raug zoo nrog cov lus qhia txog kev txiav tawm
Lub hauv paus tseem ceeb rau kev txiav cov tshuaj yog qhov ua tiav ntawm nicotine zoo li cov tsos mob (cov leeg tremors, cov leeg tsis muaj zog). Kev ua haujlwm ntawm cov ntshav cholinesterase yuav tsum tau khaws cia ntawm 50% -60% lossis siab dua ntawm tus nqi ib txwm muaj. Vim tias qhov nqus tau qeeb thiab lub voj voog ntev ntev ntawm cov organic phosphorus nyob rau hauv lub plab zom mov, kev kho mob yuav tsum tau khaws cia rau 48-72 teev. Kev ntsuam xyuas cov tsos mob thiab kev kuaj cholinesterase yuav tsum tau ua txhua 6 teev.
Synergistic nyhuv nrog compound npaj
Kev Txhaj Tshuaj Chlorfenapyr (Chlorfenapyr Txhaj) yog tsim los ntawm Chlorfenapyr, Benazepine Hydrochloride, thiab Atropine Sulfate. Chlorfenapyr revives acetylcholinesterase kev ua ub no, atropine antagonizes acetylcholine receptors, thiab benazepril txhim kho central anticholinergic teebmeem. Kev txhaj tshuaj ib zaug tuaj yeem ua tiav ntau lub hom phiaj kev kho mob thiab txo qhov zaus ntawm kev kho mob. Los ntawm kev sib txuas cov kev cuam tshuam nrog cov hom phiaj sib txawv, qhov ua tiav ntawm kev kho cov tshuaj lom organophosphate tuaj yeem txhim kho tau zoo.
Kev ceev faj rau cov neeg laus sivPralidoxime Chloride
Kev ceev faj tshwj xeeb rau cov neeg mob laus siv chlorpyrifos kom ntseeg tau tias cov tshuaj muaj kev nyab xeeb thiab ua tau zoo:
Kev ntsuam xyuas ua ntej - tswj hwm
Kev Ntsuam Xyuas Txog Kev Ua Phem Txhaum Cai: Ua ntej kev tswj hwm, nug kom meej seb tus neeg mob laus puas muaj keeb kwm ntawm kev tsis haum rau pralidoxime lossis organophosphate compounds. Yog tias muaj kev tsis haum tshuaj loj (xws li, laryngeal edema, dyspnea) tau tshwm sim, txwv tsis pub cov tshuaj no tiv thaiv kev poob siab anaphylactic.
Kev Ntsuas Kab Mob Ntshav Qab Zib thiab Cerebrovascular: Pralidoxime tuaj yeem ua rau muaj kev cuam tshuam ntawm cov hlab plawv xws li hypotension thiab tachycardia. Kev ceev faj thaum siv rau cov neeg laus uas muaj ntshav siab, kab mob plawv, myocarditis, arrhythmias, lossis peripheral circulatory disorders. Ua raws li cov lus qhia kev kho mob nruj me ntsis kom tiv thaiv kom tsis txhob muaj mob hnyav ntxiv.
Kev ntsuam xyuas lub siab thiab lub raum ua haujlwm: Chlorpyrifos yog metabolized los ntawm lub siab thiab tawm ntawm lub raum. Cov neeg mob uas muaj lub raum tsis ua haujlwm lossis lub raum tsis ua haujlwm tuaj yeem ntsib kev siv tshuaj ntau ntxiv. Ntsuas lub siab thiab lub raum ua haujlwm ua ntej kev tswj hwm. Kho cov koob tshuaj los yog ncua sij hawm noj tshuaj raws li qhov tsim nyog.
Kev Saib Xyuas Thaum Muaj Kev Tswj Xyuas
Kev soj ntsuam cov cim tseem ceeb: Ua tib zoo saib xyuas lub plawv dhia, ntshav siab, thiab kev ua pa ntawm lub ntsws kom tiv thaiv kev ua pa nyuaj lossis arrhythmias los ntawm kev siv tshuaj ntau dhau.
Yog tias muaj kev nyuaj siab ua pa tshwm sim, pib ua pa tawm tam sim ntawd thiab npaj cov tshuaj kho mob xwm txheej ceev xws li epinephrine.
Neurological Symptom Monitoring: Saib xyuas cov kev phiv xws li kiv taub hau, mob taub hau, tsis pom kev, pom ob lub qhov muag, lossis kev sib koom ua ke. Kho cov koob tshuaj lossis txiav tawm tam sim yog pom.
Kev siv tshuaj ntau lossis siv ntev yuav ua rau muaj kev cuam tshuam loj hauv lub paj hlwb, nrog rau qaug dab peg lossis tsis nco qab. Tam sim ntawd txiav cov tshuaj thiab nrhiav kev kho mob.
Kev soj ntsuam ntawm Serum Cholinesterase Kev Ua Haujlwm: Tsis tu ncua kuaj ntshav cholinesterase kev ua haujlwm raws li qhov ntsuas tshuaj xyuas, tswj qib siab tshaj 50% -60%.
Hauv cov mob hnyav hnyav, cov qib cholinesterase sib raug zoo nrog cov tsos mob hauv chaw kho mob. Kaw kev soj ntsuam ntawm qhov kev tshwm sim ntawm kev kho mob qhia tau hais tias rov noj tshuaj raws sij hawm.
Cov lus nug nquag
Dab tsi yog qhov txawv ntawm atropine thiab pralidoxime?
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Atropine yuav tsis ua rau cov kab mob neuromuscular hlws ris thiab tsis muaj kev cuam tshuam rau cov leeg nqaij leeg lossis tsis muaj zog, fasciculations lossis tremors; pralidoxime yog npaj los kho cov tsos mob no. Cov koob tshuaj ntawm atropine me ntsis nce systolic thiab qis diastolic siab thiab tuaj yeem ua rau muaj qhov tseem ceeb ntawm lub cev hypotension.
Kev txhaj tshuaj pralidoxime ua haujlwm sai npaum li cas?
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Lub sijhawm pib ntawm Pralidoxime Chloride nws txawv nyob ntawm txoj kev tswj hwm.Thaum muab intravenously, cov teebmeem tuaj yeem pom hauv feeb. Kev txhaj tshuaj intramuscular yuav siv sij hawm ntev me ntsis kom siv tau, feem ntau hauv 10 mus rau 20 feeb.
Vim li cas atropine tsis pom zoo?
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Cov menyuam yaus lossis cov hluas uas muaj lub plawv tsis zoo yuav tsis haum rau kev kho mob atropine, vim yognws lub peev xwm cuam tshuam rau lub plawv dhia. Atropine qhov muag tee tuaj yeem ua rau muaj kev phiv ntau ntxiv hauv cov menyuam yaus lossis cov tub ntxhais hluas noj cov tshuaj uas muaj cov txiaj ntsig zoo sib xws.
Leej twg tsis tuaj yeem noj atropine?
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Atropine feem ntau yog contraindicated rau cov neeg mobglaucoma, pyloric stenosis, thyrotoxicosis, kub taub hau, urinary obstruction thiab ileus.
Cim npe nrov: pralidoxime chloride txhaj, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom