Shaanxi BLOOM Tech Co., Ltd. yog ib tug ntawm cov uas paub txog manufacturers thiab lwm tus neeg ntawm decapeptide-12 qab zib nyob rau hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo decapeptide-12 qab zib rau muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Decapeptide-12 cream, raws li "tus nees tsaus" hauv thaj chaw ntawm cov khoom siv tshuaj pleev ib ce nyob rau xyoo tas los no, tau pom tias muaj txiaj ntsig zoo hauv kev ua kom dawb, tshem tawm qhov chaw, tiv thaiv- laus, thiab kho daim tawv nqaij vim nws cov qauv molecular tshwj xeeb thiab ntau - lub hom phiaj ntawm kev ua haujlwm. Nws ua tiav kev cuam tshuam los ntawm qib molecular mus rau qib ntawm cov ntaub so ntswg los ntawm kev tswj cov melanin tiam txoj hauv kev, ua kom cov tawv nqaij kho cov teeb liab network, thiab ua kom zoo dua cov khoom siv khoom xa tuaj, ua ib qho ntawm cov khoom tseem ceeb hauv siab - kawg cov qauv kev tu tawv nqaij.
DecaPeptide-12 COA
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| Certificate of Analysis | ||
| Compound npe | DecaPeptide-12 | |
| Qib | Pharmaceutical qib | |
| CAS Nr. | 137665-91-9 | |
| Ntau | 3 37,3kg | |
| Ntim txheem | 25kg / nruas | |
| Chaw tsim tshuaj paus | Shaanxi BLOOM TECH Co., Ltd | |
| Ntau No. | 202501090049 | |
| MFG | Peb 9, 2025 | |
| EXP | Peb 8, 2028 | |
| Qauv |
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| Yam khoom | Enterprise txheem | Kev txheeb xyuas qhov tshwm sim |
| Qhov tshwm sim | Dawb los yog yuav luag dawb hmoov | Ua raws |
| Cov ntsiab lus dej | Tsawg dua lossis sib npaug li 5.0% | 0.49% |
| Poob rau ziab | Tsawg dua lossis sib npaug li 1.0% | 0.32% |
| Hnyav Hlau | Pb Tsawg dua lossis sib npaug li 0.5ppm | N.D. |
| Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Hg Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Cd Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Purity (HPLC) | Ntau dua lossis sib npaug li 99.0% | 99.90% |
| Ib qho impurity | <0.8% | 0.47% |
| Tag nrho microbial suav | Tsawg dua lossis sib npaug li 750cfu / g | 80 |
| E. Coli | Tsawg dua lossis sib npaug li 2MPN / g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (los ntawm GC) | Tsawg dua lossis sib npaug li 5000ppm | 500ppm ua |
| Cia | Khaws rau hauv qhov chaw kaw, tsaus, thiab qhuav hauv qab 2-8 degree | |
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Molecular Properties thiab lub hauv paus ua haujlwm
Nws yog ib qho luv luv peptide saw tsim los ntawm 10 amino acids nrog ib qho hnyav molecular ntawm 1395.52 Da, uas sib txuas cov permeation zoo ntawm me me molecule peptides nrog rau lub hom phiaj cov khoom ntawm biologically active peptides. Nws cov qauv molecular muaj tyrosine (Tyr) thiab tryptophan (Trp) residues, uas tuaj yeem sib tw khi rau qhov chaw nquag ntawm tyrosinase los ntawm kev simulating benzene nplhaib qauv ntawm tyrosine, ncaj qha thaiv cov kauj ruam tseem ceeb ntawm melanin synthesis. Tsis tas li ntawd, qhov kev faib tawm thiab kev sib haum xeeb ua rau nws nkag mus rau hauv stratum corneum ntawm daim tawv nqaij, tsom melanocytes thiab fibroblasts, tso lub hauv paus rau nws cov haujlwm ua haujlwm ntau.
Core mechanism ntawm kev txiav txim: Dual pathway reshaping ntawm daim tawv nqaij noj qab haus huv
1. Lub hom phiaj inhibition ntawm melanin ntau lawm kom zoo whitening
Kev cuam tshuam ntawm melanin synthesis los ntawm ob txoj hauv kev ntawm "kev sib tw inhibition + teeb liab tswj":
Direct inhibition ntawm tyrosinase kev ua: Kev sim tau pom tias nws qhov inhibition tas li (Kd) yog 61.1 μ M, thiab ib nrab inhibitory concentration (IC50) yog 40 μ M. Ntawm qhov concentration ntawm 100 μ M,Decapeptide-12 creamtuaj yeem txo cov ntsiab lus melanin hauv melanocytes los ntawm 43% yam tsis muaj kev cuam tshuam cov cell proliferation.
Downregulation ntawm MITF qhia: Los ntawm inhibiting cov transcription yam cuam tshuam nrog microphthalmia (MITF), cov synthesis ntawm cov enzymes tseem ceeb xws li tyrosinase thiab TRP-1 yog indirectly txo, tsim ib tug ntev-ntev whitening mechanism.
Thaiv qhov - MSH teeb liab: inhibiting qhov khi ntawm melanocyte stimulating hormone (- MSH) rau melanocortin 1 receptor (MC1R), txiav tawm cov teeb liab melanin ntau lawm. Kev soj ntsuam xyuas pom tau tias nws cov nyhuv whitening yog sib npaug rau 4% hydroquinone, tab sis nws qhov kev chim siab yog txo qis.
2. Ua kom cov tsev neeg Sirtuins rov qab cov tawv nqaij laus
Los ntawm kev tswj hwm qhov kev qhia ntawm "ntev cov proteins" xws li SIRT1, SIRT3, thiab SIRT6, kev laus tuaj yeem ncua los ntawm peb yam: cellular metabolism, kho DNA, thiab collagen synthesis.
Txhawb nqa collagen synthesis: Hauv cov qauv ntawm daim tawv nqaij, nws nce cov ntsiab lus ntawm hom I thiab III collagen los ntawm 29% thiab nce qhov ceev ntawm elastic fibers los ntawm 18%.
Inhibition ntawm matrix metalloproteinases (MMPs): txo cov kev qhia ntawm collagenase (MMP-1) thiab tiv thaiv collagen degradation.
Txhim kho mitochondrial muaj nuj nqi: txhim kho cellular zog metabolism thiab txo oxidative kev nyuaj siab puas tsuaj los ntawm SIRT3 ua kom.
Cov ntaub ntawv kho mob qhia tau hais tias tom qab 12 lub lis piam ntawm kev siv, qhov muag cream muaj 0.01% Decapeptide-12 txo qhov tob ntawm wrinkles ib ncig ntawm lub qhov muag los ntawm 14% thiab txhim kho daim tawv nqaij firmness los ntawm 19%.
Technological breakthrough: Kev xa khoom thiab cov qauv kev ua kom zoo
Txhawm rau kov yeej cov kev txwv ntawm daim tawv nqaij barrier, liposome encapsulation, nanostructured lipid carriers (NLC), thiab microneedle patch technology yog feem ntau siv.
Liposome encapsulation: Transdermal absorption tus nqi nce 3.2 npaug, dermal retention tau nce 2.8 npaug, thiab tso tawm cov tshuaj nquag ua haujlwm ntev li 12 teev.
NLC thev naus laus zis: hauv kev ntsuas nrawm ntawm 40 degree, cov khoom siv khaws cia tau mus txog 92%, qhov tob nkag tau nce los ntawm 40%, thiab kev ruaj ntseg zoo dua li cov qab zib zoo tib yam.
Micro koob thaj: cov tshuaj nquag xa ncaj qha mus rau dermis, thiab kho cov nyhuv ntawm chloasma yog 39% siab dua li cov qab zib, thiab qhov tob ntawm qhov kev txiav txim tuaj yeem ncav cuag dermal papilla txheej.
Tsis tas li ntawd, nws feem ntau yog ua ke nrog nonapeptide-1 (thaiv alpha MSH signaling), chalcopeptide (txhim kho collagen), los yog antioxidants (xws li vitamin C) los tsim ib qho kev sib koom ua ke ntawm "whitening + anti-aging + kho". Cov kev kuaj mob tau pom tias nws cov txiaj ntsig zoo tau txhim kho ntau dua 40%.
Decapeptide-12 cream, raws li lub hnub qub muaj nyob rau hauv daim teb ntawm cov khoom siv tshuaj pleev ib ce, tau qhia qhov zoo ntawm kev ua kom dawb, tshem tawm cov quav, tiv thaiv - kev laus, thiab kho daim tawv nqaij vim nws qhov tshwj xeeb dual mechanism ntawm kev ua - tsom inhibition ntawm melanin ntau lawm thiab ua kom cov txheej txheem kho daim tawv nqaij. Nws cov txheej txheem ntawm kev ua haujlwm cuam tshuam nrog ntau theem xws li kev tswj hwm kev ua haujlwm enzyme, kev cuam tshuam ntawm cov noob caj ces, kev taw qhia ntawm tes, thiab kho cov qauv ntawm daim tawv nqaij, tsim kom muaj kev cuam tshuam ntau yam los ntawm cov molecules mus rau cov ntaub so ntswg.
1. Kev sib tw khi ntawm tyrosinase active site
Tyrosinase yog ib qho tseem ceeb ntawm kev txwv cov enzyme hauv melanin synthesis, thiab nws qhov chaw ua haujlwm muaj ob lub tooj liab ion (Cu ² ⁺) khi qhov chaw, lub luag haujlwm rau kev hloov pauv ntawm tyrosine rau dopaquinone. Los ntawm simulating benzene nplhaib qauv ntawm tyrosine los ntawm cov seem ntawm tyrosine (Tyr) thiab tryptophan (Trp) hauv nws cov qauv molecular, nws sib tw nrog C-terminal residue ntawm tyrosinase ncaj qha thaiv cov enzyme kev sib cuag nrog lub substrate. Cov ntaub ntawv sim tau pom tias qhov inhibition tas li (Kd) ntawm nceb tyrosinase yog 61.1 μ M, thiab ib nrab qhov siab tshaj plaws inhibitory concentration (IC50) yog 40 μ M, qhia tias nws muaj peev xwm inhibitory siab. Hauv kev sim tib neeg melanocyte, kev kho nrog Decapeptide-12 ntawm qhov concentration ntawm 100 μ M rau 7 hnub ua rau 43% txo cov ntsiab lus melanin yam tsis muaj kev cuam tshuam cov cell proliferation, paub meej tias nws muaj kev nyab xeeb thiab ua tau zoo.
2. Ntau lub hom phiaj inhibition ntawm melanin ntau lawm txoj kev
Ntxiv rau qhov ncaj qha inhibiting tyrosinase kev ua ub no, nws tseem tuaj yeem ua tiav ntev - ua kom dawb huv los ntawm kev tswj cov kev taw qhia txog kev tsim cov melanin. Kev tshawb fawb tau pom tias peptide no tuaj yeem txo qis qhov kev qhia ntawm microphthalmia ntsig txog kev hloov pauv hloov pauv (MITF), uas yog qhov tseem ceeb ntawm kev tswj hwm melanocyte sib txawv thiab tyrosinase noob qhia. Los ntawm inhibiting MITF, qhov kev qhia ntawm cov ntsiab lus melanin synthesis enzymes xws li tyrosinase thiab TRP-1 (tyrosinase ntsig txog cov protein 1) yog txo qis, ua rau "dual inhibition" mechanism. Tsis tas li ntawd, nws tuaj yeem cuam tshuam qhov kev sib txuas ntawm - MSH (melanocyte stimulating hormone) thiab MC1R (melanocortin 1 receptor), thaiv cov hluav taws xob hluav taws xob hloov pauv ntawm melanin ntau lawm, thiab ntxiv dag zog rau nws cov nyhuv whitening.
3. Clinical validation: Txhim kho melasma thiab photoaging
Hauv ob - qhov muag tsis pom kev sim rau 30 tus poj niam Asian, tom qab 8 lub lis piam ntawm kev siv cov tshuaj nplaum uas muaj 0.01% Decrepeptide-12, thaj tsam ntawm chloasma raug txo los ntawm 31% nyob rau nruab nrab, thiab cov xim ntawm cov xim tau txo los ntawm 27%. Cov nyhuv yog sib npaug ntawm 4% hydroquinone cream, tab sis qhov khaus khaus tau txo qis (15% ntawm pawg hydroquinone muaj erythema thiab scaling). Lwm qhov kev sim qhib rau cov neeg mob nrog kev yees duab pom tau tias tom qab siv cov tshuaj sib xyaw ua ke (muaj cov tshuaj antioxidants thiab cov txiv hmab txiv ntoo acids) rau 3 lub hlis, 38.5% ntawm cov neeg mob 'photoaging grading poob qis los ntawm qib III mus rau qib I, thiab kev npaj ntawm elastic fibers nyob rau hauv lub dermis txheej ho txhim kho, ua pov thawj tias nws muaj ob qho tib si whitening thiab anti-aging nyhuv.
Sirtuin tsev neeg ua kom: tus tsav tsheb tseem ceeb ntawm kev kho daim tawv nqaij thiab tiv thaiv -aging
1. Kev ua haujlwm lom neeg ntawm Sirtuins
Sirtuins (SIRT1-7) yog ib chav kawm ntawm NAD ⁺ - dependent histone deacetylases, hu ua "ntev cov proteins," uas ua lub luag haujlwm tseem ceeb hauv cellular metabolism, kho DNA, tswj kev mob, thiab kev laus. Ntawm lawv, SIRT1 tuaj yeem txhawb nqa collagen synthesis thiab inhibit qhov kev ua ntawm matrix metalloproteinases (MMPs), yog li txhim kho daim tawv nqaij elasticity; SIRT3 txo oxidative kev nyuaj siab thiab qeeb cellular laus los ntawm kev tswj mitochondrial muaj nuj nqi; SIRT6 koom nrog hauv DNA kev puas tsuaj kho thiab tswj cov genomic stability.
2. Kev tswj cov nyhuv ntawm Decapeptide-12 ntawm Sirtuins
Cov kev sim tau pom tias Decapeptide-12 (100 μ M, 72 teev kev kho mob) tuaj yeem txhim kho qib kev hloov pauv ntawm SIRT1, SIRT3, SIRT6, thiab SIRT7 hauv tib neeg cov keratinocytes uas tsis muaj cytotoxicity. Cov kev tshawb fawb ntxiv tau pom tias peptide tsis ncaj qha txhim kho Sirtuins kev ua haujlwm los ntawm kev ua kom lub AMPK (adenosine monophosphate activated protein kinase) qhia txoj hauv kev, nce intracellular NAD ⁺ qib. Hauv cov qauv ntawm daim tawv nqaij, Decapeptide-12 txhawb nqa kev tso tawm ntawm hom I thiab III collagen los ntawm fibroblasts, thaum inhibiting kev qhia ntawm MMP-1 (collagenase), uas ua rau 29% nce hauv cov ntsiab lus collagen thiab 18% nce hauv elastic fiber ntau, txhim kho daim tawv nqaij qauv.
3. Cov pov thawj kho mob ntawm kev tiv thaiv -aging
Ib qho randomized tswj mus sib hais nrog 60 yam qhia tau hais tias tom qab siv qhov muag cream uas muaj 0.01%Decapeptide-12 creamrau 12 lub lis piam, qhov tob ntawm wrinkles nyob ib ncig ntawm lub qhov muag txo los ntawm 14%, daim tawv nqaij nruj nce los ntawm 19%, thiab tsis muaj ib tug irritating tshuaj. Kev soj ntsuam ntawm lub koom haum qhia tau hais tias collagen fibers nyob rau hauv lub dermis yog teem nruj dua thiab elastic fiber network qauv yog ntau ua tiav, ua pov thawj tias nws reverses ntawm daim tawv nqaij laus ntawm lub cellular theem.
1. Liposome encapsulation technology
Qhov hnyav molecular yog 1395.52 Da, thiab txawm hais tias nws muaj peev xwm hloov pauv qee yam, nws cov bioavailability tuaj yeem txhim kho ntxiv los ntawm liposome encapsulation. Liposomes yog tsim los ntawm phospholipid bilayers, zoo ib yam li cov qauv ntawm daim tawv nqaij daim nyias nyias, thiab tuaj yeem xa cov tshuaj nquag mus rau keratinocytes lossis melanocytes los ntawm fusion. Qhov kev sim qhia tau hais tias qhov transdermal absorption tus nqi ntawm liposome coated cream yog 3.2 npaug ntau dua li cov qab zib zoo tib yam, thiab cov nyiaj khaws cia nyob rau hauv daim tawv nqaij stratum corneum yog 2.8 npaug ntau dua, thiab cov tshuaj nquag tso tawm tsis tu ncua rau 12 teev.
2. Nanostructured lipid carriers (NLC)
NLC siv cov matrix sib xyaw ntawm cov khoom thiab cov kua lipids txhawm rau txhim kho nws txoj kev ruaj khov. Hauv kev ntsuas 40℃nrawm, cov khoom siv khaws cia tus nqi (92%) ntawm pawg NLC formula tau siab dua li ntawm cov tshuaj nplaum zoo tib yam (78%), thiab qhov tob tob hauv daim tawv nqaij nce 40%. Tsis tas li ntawd, kev txhawb nqa - tso tawm cov khoom ntawm NLC tuaj yeem txo cov pov tseg ntawm cov khoom siv hauv cov txheej txheem epidermal thiab txo qhov kev pheej hmoo ntawm kev khaus.
3. Micro koob SMT tshuab
Rau kev sib sib zog nqus pigmentation (xws li melasma), microneedle thaj ua rau thaj tuaj yeem xa ncaj qha mus rau txheej dermis. Cov kev sim tsiaj tau pom tias daim tawv nqaij melanin cov ntsiab lus ntawm pawg microneedle yog 39% qis dua li ntawm pawg cream, thiab qhov tob ntawm qhov kev txiav txim tuaj yeem ncav cuag dermal papilla txheej. Cov thev naus laus zis no cuam tshuam los ntawm stratum corneum barrier los ntawm kev sib tsoo lub cev, tsim cov microchannels uas tso cai rau cov khoom siv los hla lub epidermal barrier thiab ncav cuag lub hom phiaj, txhim kho kev kho mob zoo.
Synergistic formula: Ntau lub hom phiaj sib koom ua ke kev cuam tshuam
1. Whitening Gold Combination: Decapeptide-12+Nine Peptide-1
Nonapeptide-1 thaiv cov kev taw qhia txog kev tsim cov melanin los ntawm inhibiting kev khi ntawm - MSH rau MC1R. Thaum ua ke nrog Decapeptide-12, ob qho tib si tsim muaj ob txoj hauv kev whitening mechanism ntawm inhibition blockade. Cov kev kuaj mob tau pom tias qhov kev sib xyaw ua ke no txhim kho kev ua kom tawv nqaij dawb los ntawm 47% thiab ua kom lub sijhawm pib mus txog 4 lub lis piam.
2. Anti aging composite system: Decapeptide-12+Blue Copper Peptide
GHK Cu tuaj yeem txhawb nqa collagen synthesis, tiv thaiv - cov teebmeem inflammatory, thiab kho cov tawv nqaij barrier.
Thaum ua ke nrog Decapeptide-12, tus qub yog lub luag haujlwm rau kho cov tawv nqaij puas tsuaj, thaum kawg inhibits melanin ntau lawm, tsim cov nyhuv synergistic ntawm "whitening + anti-aging". Hauv kev sim ntawm 60 cov ntsiab lus, qhov kev sib xyaw ua ke no ua rau cov tawv nqaij ci ntsa iab los ntawm 22%, txo qhov ntim ntawm 18%, thiab tau txais txiaj ntsig zoo.
3. Cov tshuaj tiv thaiv kev ruaj ntseg: Decapeptide-12+antioxidant
Antioxidants xws li vitamin C thiab vitamin E tuaj yeem tshem tawm cov dawb radicals, txo oxidative kev nyuaj siab ntawm melanocytes, thiab tiv thaiv lawv los ntawm lub teeb thiab kub degradation. Qhov kev sim pom tau hais tias qhov ua kom muaj zog ntawm cov kua nplaum uas muaj 1% vitamin C nce mus rau 95% thiab cov nyhuv whitening nce 30% hauv qhov kev ntsuas nrawm ntawm 40 degree.
Kev Nyab Xeeb thiab Kev Ua Siab ntev: Kev lees paub los ntawm Chav Ua Haujlwm mus rau Lub Ntiaj Teb tiag
1. Kev kuaj Cytotoxicity
Hauv 3T3 fibroblast qauv, IC50 tus nqi ntawmDecapeptide-12 creamyog ntau dua 1000 μ M, uas yog ntau dua li qhov ua tau zoo concentration (0.01-0.1 μ M), qhia tias nws tsis muaj cytotoxicity. Tsis tas li ntawd, peptide tsis pom muaj qhov mutagenicity lossis allergenicity, ua tau raws li cov qauv kev nyab xeeb rau cov khoom siv tshuaj pleev ib ce.
2. Tib neeg lub cev patch test
Kev kuaj 48 teev kaw tau ua rau 200 yam ntawm cov tawv nqaij sib txawv, thiab tsuas yog 1 rooj plaub pom tias mob erythema (0.5%), uas ploj mus nyob rau hauv 24 teev, lees paub tias nws haum rau txhua hom tawv nqaij, suav nrog cov tawv nqaij rhiab heev. Kev siv sijhawm ntev (12 lub lis piam) tsis ua rau muaj kev sib cuag dermatitis lossis pigmentation rebound.
Cim npe nrov: Decapeptide-12 qab zib, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom