Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm cov tuam ntxhab thiab cov muag khoom ntawm fluconazole gel 0.5 hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo fluconazole gel 0.5 muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Fluconazole gel 0.5yog ib qho tshuaj pleev tshuaj tua kab mob tshuaj pleev, uas siv fluconazole ua cov khoom xyaw tseem ceeb los ua lub luag haujlwm bactericidal los ntawm inhibiting cov synthesis ntawm ergosterol ntawm fungal cell membrane. Daim ntawv tshuaj gel yog npaj nrog dej-soluble matrix (xws li carbomer, hydroxyethyl cellulose) lossis roj-raws li matrix (xws li polyethylene glycol, vaseline dawb), thiab tuaj yeem ua tiav kev nkag mus tas li los ntawm kev kho cov tshuaj tso tawm. Nws qhov txiaj ntsig yog nyob rau hauv nws lub peev xwm los ua ncaj qha rau ntawm qhov chaw ntawm tus kab mob, nce cov tshuaj hauv zos concentration, thaum txo qis kev nqus dej thiab txo qhov kev pheej hmoo ntawm cov kab mob tsis zoo xws li lub siab toxicity thiab gastrointestinal tshua. Piv txwv li, thaum kho qhov ncauj candidiasis, cov gel tuaj yeem sib npaug ntawm qhov ncauj mucosa, tsim cov yeeb yaj kiab tiv thaiv thiab maj mam tso tshuaj, ncua sijhawm ua haujlwm mus rau 4-6 teev.
Cov ntaub ntawv ntxiv ntawm chemical compound:
| Khoom npe | Fluconazole Gel | Fluconazole ntsiav tshuaj | Fluconazole Ncua tseg | Kev txhaj tshuaj Fluconazole | Fluconazole Capsule |
| Yam khoom | Gel | Cov ntsiav tshuaj | Ua kua | Txhaj tshuaj | Capsules |
| Khoom Purity | Ntau dua lossis sib npaug li 99% | Ntau dua lossis sib npaug li 99% | Ntau dua lossis sib npaug li 99% | Ntau dua lossis sib npaug li 99% | Ntau dua lossis sib npaug li 99% |
| Khoom Specifications | Customizable | Customizable | Customizable | Customizable | Customizable |
| Pob khoom | Customizable | Customizable | Customizable | Customizable | Customizable |
Peb cov khoom tsim
Fluconazole +. COA
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Certificate of Analysis |
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Compound npe |
Fluconazole | |
|
CAS Nr. |
86386-73-4 | |
|
Qib |
Pharmaceutical qib | |
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Ntau |
Customized | |
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Ntim txheem |
Customized | |
| Chaw tsim tshuaj paus | Shaanxi BLOOM TECH Co., Ltd | |
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Ntau No. |
20250109001 |
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MFG |
Jan 12th 2025 |
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EXP |
Jan 8th 2029 |
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Qauv |
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| TEST STANDARD | GB/T24768-2009 Kev lag luam. Stnndard | |
|
Yam khoom |
Enterprise txheem |
Kev txheeb xyuas qhov tshwm sim |
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Qhov tshwm sim |
Dawb los yog yuav luag dawb hmoov |
Ua raws |
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Cov ntsiab lus dej |
Tsawg dua lossis sib npaug li 4.5% |
0.30% |
| Poob rau ziab |
Tsawg dua lossis sib npaug li 1.0% |
0.15% |
|
Hnyav Hlau |
Pb Tsawg dua lossis sib npaug li 0.5ppm |
N.D. |
|
Tsawg dua lossis sib npaug li 0.5ppm |
N.D. | |
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Hg Tsawg dua lossis sib npaug li 0.5ppm |
N.D. | |
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Cd Tsawg dua lossis sib npaug li 0.5ppm |
N.D. | |
|
Purity (HPLC) |
Ntau dua lossis sib npaug li 99.0% |
99.5% |
|
Ib leeg impurity |
<0.8% |
0.48% |
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Residue ntawm ignition |
<0.20% |
0.064% |
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Tag nrho microbial suav |
Tsawg dua lossis sib npaug li 750cfu / g |
80 |
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E. Coli |
Tsawg dua lossis sib npaug li 2MPN / g |
N.D. |
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Salmonella |
N.D. | N.D. |
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Ethanol (los ntawm GC) |
Tsawg dua lossis sib npaug li 5000ppm |
400ppm ua |
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Cia |
Khaws rau hauv qhov chaw kaw, tsaus thiab qhuav ntawm -20 degrees |
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Cryptococcus kab mob yog ib tug kab mob sib sib zog nqus fungal tshwm sim los ntawm fungi ntawm Cryptococcus genus, uas tuaj yeem cuam tshuam rau ntau lub cev thiab lub cev hauv cov tsiaj, suav nrog meninges, ntsws, tawv nqaij, lub cev pob txha, thiab ntshav. Ntawm Cryptococcus genus, Cryptococcus neoformans thiab Cryptococcus graminearum yog cov kab mob tseem ceeb uas ua rau muaj kab mob, nthuav dav hauv cov av xws li av, pigeon quav, beehives, mis nyuj, txiv hmab txiv ntoo, thiab lwm yam. Tsiaj txhu feem ntau kis kab mob los ntawm kev nqus aerosolized Cryptococcus spores los ntawm ib puag ncig.Fluconazole gel 0.5Raws li ib qho tseem ceeb triazole tshuaj tiv thaiv kab mob, plays lub luag haujlwm tseem ceeb hauv kev kho mob ntawm cryptococcal kab mob.
Kev siv pa hauv kev kho tus kab mob Cryptococcus
1. Kev kho mob ntawm cryptococcal meningitis
(1) Induction therapy
Nyob rau hauv thawj theem kev kho mob ntawm cryptococcal meningitis, nws yog feem ntau siv raws li ib tug sequential kho tshuaj tom qab induction therapy nrog amphotericin B ua ke nrog flucytosine. Rau cov neeg mob HIV, 2010 IDSA Clinical Practice Guidelines for Cryptococcus pom zoo kom fluconzole (800 mg/d, qhov ncauj, tsawg kawg yog 8 lub lis piam) raws li kev kho mob tom qab 2 lub lis piam ntawm kev kho mob nrog amphotericin B (0.7-1.0 mg/(kg·d), intravenous flu0toine) / 8.
Kuj tseem muaj cov kev tshawb fawb qhia tias qhov siab - koob tshuaj fluconzole (800 mg, ib zaug ib hnub lossis 600 mg, ib zaug / 12 teev) ib leeg lossis ua ke nrog amphotericin B thiab flucytosine tuaj yeem ua tiav cov kab mob zoo thaum ntxov hauv kev kho mob HIV ntsig txog cryptococcal meningitis.
Lub Tsev Haujlwm Saib Xyuas Kev Noj Qab Haus Huv Malawi cov lus qhia dav dav rau cov menyuam yaus uas muaj tus kabmob HIV thiab cov neeg laus pom zoo kom fluconzole ua thawj - kab kev kho mob rau cov kab mob cryptococcal thib ob hauv cov neeg laus uas muaj tus kabmob HIV: 1200 mg / d rau 14 hnub, tom qab ntawd 400 mg / d rau 42 hnub, thiab tom qab ntawd 200 mg / d rau lub neej.
(2) Sib sau ua ke thiab tswj kev kho mob
Tom qab ua tiav lub sij hawm induction kev kho mob, nkag mus rau lub consolidation thiab txij nkawm kho theem. Rau cov neeg mob uas muaj kev sib xyaw ua ke zoo antifungal induction therapy rau 2 lub lis piam thiab lub raum ua haujlwm ib txwm muaj, 2010 IDSA Clinical Practice Guidelines for Cryptococcus Disease pom zoo kom noj cov tshuaj fluconzole 800 mg (12 mg / (kg · d)) ntawm qhov ncauj rau 8 lub lis piam. Tom qab ntawd, nyob ntawm tus neeg mob tus mob, fluconzole tuaj yeem siv rau kev sib sau ua ke thiab kev kho mob (400-800 mg / d, qhov ncauj, kev kho mob 6-18 lub hlis).
Txhawm rau tiv thaiv qhov rov tshwm sim ntawm cryptococcal meningitis hauv cov neeg mob AIDS, tom qab ua tiav cov kev kho mob yooj yim, nws tuaj yeem khaws cia ntawm 200 mg / zaug, ib hnub ib zaug, rau 10 mus rau 12 lub lis piam lossis tsis tas li.
2. Kev kho cov kab mob uas tsis yog hauv nruab nrab ntawm lub paj hlwb cryptococcal
(1) Pulmonary cryptococcosis
Rau cov neeg mob pulmonary cryptococcosis nrog lub cev tsis muaj zog, yog tias tsis muaj cov tsos mob tshwm sim tab sis lub ntsws cov ntaub so ntswg cryptococcosis kab lis kev cai yog qhov zoo, kev siv tshuaj tuaj yeem zam tau, kev soj ntsuam ze tuaj yeem ua, lossis fluconzole tuaj yeem siv rau 3-6 lub hlis. Rau cov neeg mob uas muaj cov tsos mob me mus rau nruab nrab thiab kab lis kev cai zoo, fluconzole lossis itraconazole yuav tsum tau siv rau 6-12 lub hlis. Yog tias kev tswj qhov ncauj tsis tuaj yeem ua tau, Amphotericin B tuaj yeem muab tau.
Rau cov neeg mob uas tsis muaj zog tiv thaiv kab mob thiab HIV tsis zoo pulmonary cryptococcosis, txoj kev npaj kho mob pom zoo yog tib yam rau cov neeg mob uas tsis muaj zog tiv thaiv kab mob. Cov neeg mob uas muaj tus kab mob HIV thiab muaj cov tsos mob ua pa me me yuav tsum siv fluconzole, itraconazole, lossis fluconzole ntxiv rau flucytosine rau lub neej; Rau cov neeg mob hnyav, lawv raug kho raws li lub hauv paus paj hlwb cryptococcal kab mob raws tu qauv.
(2) Kab mob Cryptococcus ntawm daim tawv nqaij
Thaum kis tus kab mob Cryptococcus, qhov ntau npaum li cas thiab kev kho mob tuaj yeem txiav txim siab raws li qhov hnyav thiab qhov ntev ntawm tus kab mob. Feem ntau, cov koob tshuaj tuaj yeem siv tau, xws li 200-400 mg ib hnub rau cov neeg laus. Cov kev kho mob tej zaum yuav raug kho raws li tus mob thiab yuav siv sij hawm ob peb lub lis piam los yog txawm lub hlis los xyuas kom meej tshem tawm tag nrho cov Cryptococcus thiab tiv thaiv rov tshwm sim.
3. Daim ntawv thov hauv kev tshawb fawb txog kab mob Cryptococcus hauv cov tsiaj sim
Hauv kev tshawb fawb tsiaj sim, nws tau siv dav los ntsuas nws cov txiaj ntsig kho mob ntawm tus kab mob Cryptococcus. Noj BALB / c nas qauv ntawm Cryptococcus neoformans kab mob ua piv txwv, cov kev sim cuam tshuam tau faib cov nas mus rau hauv ntau pab pawg thiab muab cov koob tshuaj sib txawv.Fluconazole gel 0.5, sertraline (ib yam tshuaj uas muaj cov tshuaj tiv thaiv Cryptococcus), thiab kev sib xyaw ntawm Fluconzole thiab sertraline.
Saib xyuas cov nyhuv inhibitory ntawm txhua pab pawg ntawm Cryptococcus neoformans los ntawm kev sim tshuaj vitro rhiab heev thiab kev sim tsiaj.Cov txiaj ntsig ntawm kev tshuaj ntsuam xyuas tshuaj vitro pom tau tias sertraline tuaj yeem txo cov colony loj ntawm Cryptococcus neoformans, thiab cov nyhuv antibacterial tseem ceeb dua thaum ua ke nrog nws.
Hauv kev sim tsiaj, nyob rau theem pib, ob qho tib si ntawm cov tshuaj sertraline (10 mg / mL thiab 20 mg / mL) tau pom tias txo qis cov kab mob suav nrog cryptococcus neoformans hauv lub hlwb thiab lub ntsws ntawm cov nas uas muaj kab mob. Txawm li cas los xij, nyob rau theem tom qab ntawm qhov kev sim, qhov tsis tshua muaj siab ntawm sertraline poob lawv cov tshuaj tua kab mob ntawm cov kab mob nas lub paj hlwb.Qhov sib txawv, nws cov tshuaj tua kab mob zoo dua rau cov sertraline hauv lub hlwb thiab lub ntsws cov ntaub so ntswg, thiab kev sib xyaw ntawm fluconzole thiab sertraline muaj zog tiv thaiv kab mob ntawm lub ntsws cov ntaub so ntswg ntawm nas nrog cryptococcus neotraline ntau dua li qhov no ib leeg.
Qhov no qhia tau hais tias nws ua lub luag haujlwm tseem ceeb hauv kev kho tus kab mob Cryptococcus hauv cov tsiaj sim, thiab nws cov kev sib xyaw ua ke nrog lwm cov tshuaj yuav muaj txiaj ntsig zoo, txhim kho cov txiaj ntsig kho.
Daim ntawv thov hauv kev tiv thaiv kab mob Cryptococcus
1. Tshuaj tiv thaiv rau cov neeg muaj kev pheej hmoo siab -
(1) Cov neeg mob AIDS
Cov neeg mob AIDS raug kev txom nyem los ntawm kev puas tsuaj loj ntawm cellular thiab humoral lub zog tiv thaiv kab mob vim yog kev puas tsuaj ntawm CD4+T lymphocytes los ntawm HIV, uas ua rau lawv muaj feem cuam tshuam rau cov kab mob kis tau zoo, ntawm cov kab mob cryptococcal yog ib qho tshwm sim thiab muaj peev xwm ua neej nyob - hem cov teeb meem. Cryptococcal kab mob feem ntau cuam tshuam nrog lub hauv nruab nrab lub paj hlwb, lub ntsws thiab lwm yam kabmob tseem ceeb, thiab thaum nws loj hlob mus rau hauv cryptococcal meningitis, tus neeg tuag yuav nce ntau yam tsis muaj kev cuam tshuam raws sijhawm.
Rau cov neeg mob AIDS uas muaj CD4+T lymphocyte suav qis dua 100 hlwb/μL- qhov pib tseem ceeb rau kev pheej hmoo kis kab mob siab - nws pom zoo ua thawj - cov tshuaj tiv thaiv kab mob. Cov koob tshuaj pom zoo yog feem ntau 200-400 mg ib hnub, muab tshuaj rau qhov ncauj. Lub sijhawm ntawm kev tiv thaiv kev kho mob yog hloov pauv thiab hloov kho raws li tus neeg mob lub cev tiv thaiv kab mob thiab kev kho mob: yog tias tus neeg mob tau txais kev kho tshuaj tiv thaiv kab mob zoo thiab CD4+T lymphocyte suav rov qab mus rau siab dua 200 hlwb / μL rau lub sijhawm ncua (feem ntau 3-6 lub hlis), cov tshuaj tiv thaiv tuaj yeem maj mam txiav mus rau kev kho mob; rau cov neeg mob uas muaj kev tiv thaiv tsis zoo, yuav tsum tau siv tshuaj kho mob ntev ntev. Cov ntaub ntawv kho mob qhia tau hais tias tus qauv tiv thaiv kab mob tuaj yeem txo qhov tshwm sim ntawm tus kab mob cryptococcal hauv cov neeg no ntau dua 70%.
(2) Cov neeg tau txais kev hloov cev
Cov neeg tau txais kev hloov pauv hauv lub cev yuav tsum tau siv sijhawm ntev - cov tshuaj tiv thaiv kab mob (xws li cyclosporine, tacrolimus) los tiv thaiv kev tsis lees paub ntawm lub cev hloov pauv. Txawm li cas los xij, cov tshuaj no yuav cuam tshuam lub cev tiv thaiv kab mob, ua rau muaj kev pheej hmoo ntawm kev kis kab mob ntau yam, suav nrog Cryptococcus. Tus kab mob Cryptococcal nyob rau hauv cov neeg tau txais kev hloov pauv muaj cov yam ntxwv ntawm qhov pib tsis zoo, kev loj hlob sai thiab kev tuag siab, thiab nws yog ib qho ntawm cov laj thawj tseem ceeb ntawm kev hloov pauv tom qab - teeb meem.
Rau cov neeg tau txais kev hloov pauv hauv nruab nrog cev, nws cov tshuaj tiv thaiv tuaj yeem siv tau raws li hom kev hloov pauv, qib ntawm kev tiv thaiv kab mob thiab kev pheej hmoo kis mob ntawm thaj av. Hauv kev kho mob, luv luv- lub sij hawm tiv thaiv kev tswj hwm feem ntau yog pib 1-2 lub lis piam ua ntej kev hloov pauv kom txo qis kev pheej hmoo ntawm kev kis kab mob perioperative; Tom qab hloov pauv, qhov ntau npaum li cas thiab cov kev kho mob tau txiav txim siab raws li tus neeg mob lub cev tiv thaiv kab mob thiab kev soj ntsuam kev ua haujlwm ntawm lub cev. Rau cov neeg tau txais kev pheej hmoo siab (xws li cov neeg uas muaj keeb kwm ntawm kev kis kab mob cryptococcal, lossis cov uas tau txais kev kho cov tshuaj tiv thaiv kab mob hnyav), kev noj tshuaj qis qis (feem ntau yog 100–200 mg / d) tuaj yeem siv rau 3-6 lub hlis tom qab hloov pauv. Lub hom phiaj tiv thaiv no tuaj yeem txo qis qhov tshwm sim tom qab- hloov pauv cryptococcal kab mob thiab txhim kho qhov ntev - lub sijhawm muaj sia nyob ntawm cov neeg tau txais kev hloov pauv.
2010 IDSA cov lus qhia pom zooFluconazole gel 0.5400-800 mg (6-12 mg / (kg · d)) qhov ncauj rau 8 lub lis piam, uas tuaj yeem siv rau kev sib sau ua ke tom qab 2 lub lis piam ntawm induction therapy nrog amphotericin B los tiv thaiv qhov tshwm sim ntawm tus kab mob cryptococcal.
2. Kev tiv thaiv hauv ib puag ncig tshwj xeeb lossis tom qab kis tau
Yog tias tsiaj lossis tib neeg nyob hauv qhov chaw muaj kev pheej hmoo siab rau tus kab mob Cryptococcus, xws li raug cov quav nquab ntau, kev ua haujlwm hauv thaj chaw uas muaj kab mob Cryptococcus ntau, lossis muaj keeb kwm meej ntawm Cryptococcus raug, lawv yuav txiav txim siab siv nws los tiv thaiv kev kho mob. Cov koob tshuaj tshwj xeeb thiab kev kho mob yuav tsum raug txiav txim raws li tus neeg mob thiab qib raug. Feem ntau, nws tuaj yeem siv tau sai tom qab kis tau thiab kav ntev li ob peb lub lis piam los tiv thaiv qhov tshwm sim ntawm tus kab mob Cryptococcus.
Qhov zoo ntawm kev kho tus kab mob Cryptococcus
Cryptococcosis yog ib qho tob -seated mycosis tshwm sim los ntawm cov kab mobCryptococcushom xws liCryptococcus neoformansMedlinePlus. Nws tuaj yeem koom nrog ntau qhov chaw xws li daim tawv nqaij, mucous daim nyias nyias, thiab lub hauv paus paj hlwb. Ntawm cov no, cutaneous thiab mucosal cryptococcosis yog ib hom kev kho mob, feem ntau tshwm sim hauv cov neeg uas muaj kev tiv thaiv kab mob, xws li cov neeg mob AIDS, cov neeg tau txais kev hloov hauv nruab nrog cev, thiab ntev -cov neeg siv ntawm glucocorticoidsMedlinePlus. Raws li kev npaj tshuaj tua kab mob, nws nthuav tawm qhov tshwj xeeb thiab tseem ceeb hauv kev kho cov kab mob ntawm daim tawv nqaij thiab mucosal cryptococcal. Piv nrog rau cov tshuaj tiv thaiv kab mob hauv qhov ncauj lossis cov hlab ntsha, nws yog qhov tsim nyog rau kev cuam tshuam ntawm cov kab mob hauv zos, nrog rau cov txiaj ntsig tshwj xeeb hauv qab no:
Cov tshuaj yeeb hauv zos siab siab, muaj zog lub hom phiaj, thiab qhov tseem ceeb ntawm kev ua haujlwm ntawm fungicidal
Cutaneous thiab mucosal lesions ntawm cryptococcosis feem ntau manifested li papules, nodules, ulcers, los yog plaques, nrog rau cov qhov chaw ntawm lub cheeb tsam. Los ntawm kev siv ncaj qha mus rau thaj chaw cuam tshuam, cov yeeb yaj kiab tiv thaiv tuaj yeem tsim rau ntawm daim tawv nqaij thiab cov mucous membranes. Cov khoom xyaw nquag tuaj yeem nkag mus rau hauv lub stratum corneum thiab cov dermis superficial, ua tiav cov tshuaj hauv zos ntau dua ntawm qhov chaw mob ntau dua li kev npaj ntawm qhov ncauj.
Lub mechanism ntawm kev txiav txim ntawm nws yog inhibit lub synthesis ntawm ergosterol nyob rau hauv lub fungal cell daim nyias nyias, rhuav tshem cov kev ncaj ncees ntawm Cryptococcus cell membrane, thiab yog li inhibit nws txoj kev loj hlob thiab kev loj hlob. Lub siab -kev ua yeeb yam hauv zos muaj zog tuaj yeem tsom ncaj qha rau Cryptococcus hauv qhov txhab, zam qhov teeb meem ntawm kev txo qis hauv zos concentration ntawm cov tshuaj hauv qhov ncauj tom qab cov metabolism hauv lub cev, thiab txhim kho kev ua tau zoo ntawm kev tua thiab inhibiting zos Cryptococcus. Cov ntaub ntawv kho mob qhia tau hais tias rau thaj chaw cutaneous cryptococcal nodules lossis plaques, kev siv nws li niaj zaus tuaj yeem ua rau maj mam txo qis thiab kev daws teeb meem ntawm qhov txhab feem ntau hauv 2 mus rau 4 lub lis piam, nrog rau cov tsos mob sai sai dua li kev kho mob nrog cov tshuaj hauv qhov ncauj ib leeg.
Kev nqus dej tsawg tsawg, muaj kev nyab xeeb siab, thiab qhov tshwm sim tsis tshua muaj tshwm sim
Tsis zoo li qhov ncauj lossis tso rau hauv nws, cov khoom lag luam yog cov tshuaj pleev ib ce, nrog kev nqus tsawg ntawm cov tshuaj mus rau hauv cov hlab ntsha los ntawm daim tawv nqaij thiab cov mucous membranes, uas ua rau muaj kev cuam tshuam tsis zoo rau cov kab mob hauv nruab nrog cev.
Ntawm ib sab, rau cov neeg mob uas muaj tus kab mob cryptococcal nyuaj los ntawm daim siab ua haujlwm tsis zoo, qhov ncauj nws tuaj yeem ua rau cov metabolism hauv lub siab thiab txawm tias ua rau lub siab enzymes siab, thaum cov tshuaj pleev gel kom zam qhov kev pheej hmoo no. Ntawm qhov tod tes, rau cov neeg tau txais kev hloov pauv hauv nruab nrog cev lossis cov neeg mob AIDS noj ntau yam tshuaj rau lub sijhawm ntev, cov tshuaj pleev ib ce tsis ua rau muaj kev cuam tshuam cov tshuaj nrog rau lwm cov tshuaj, tiv thaiv kev txo qis lossis kev cuam tshuam tsis zoo vim kev sib cuam tshuam tshuaj. Tsis tas li ntawd, cov kev phiv hauv zos ntawm cov gel feem ntau yog khaus ntawm daim tawv nqaij, xws li kev kub nyhiab thiab erythema, nrog qhov tshwm sim tsawg dua 3%, thiab cov tsos mob no feem ntau yog tus kheej - txwv. Piv nrog rau cov kab mob tsis zoo xws li kev mob plab hnyuv thiab mob taub hau uas yuav tshwm sim nrog kev npaj ntawm qhov ncauj, qhov txiaj ntsig kev nyab xeeb yog qhov tseem ceeb heev.
Kev siv ntau yam, tuaj yeem koom tes nrog kev kho mob txhawm rau txhim kho kev ua tau zoo tag nrho
Cov khoom siv tsis tau tsuas yog siv rau ib leeg rau cov mob me me, hauv cheeb tsam cutaneous thiab mucosal cryptococcal kab mob tab sis kuj yog ib qho ntxiv rau kev siv tshuaj tua kab mob rau kev tswj cov kab mob hauv zos hauv nruab nrab mus rau mob cryptococcosis.
Hauv kev kho mob, cov neeg mob uas muaj tus kab mob cryptococcal meningitis feem ntau xav tau ntev - lub sij hawm txhaj tshuaj ntawm nws los yog itraconazole rau kev kho mob, tab sis hauv zos cutaneous thiab mucosal lesions kho tau qeeb thiab muaj feem ua ib qhov chaw ntawm recurrent.Cryptococcuskev tshaj tawm. Lub sijhawm no, kev sib xyaw ua ke ntawm nws los siv rau cov kab mob ntawm daim tawv nqaij thiab cov mucosal tuaj yeem ua kom cov kab mob hauv zos, txo cov colonization.Cryptococcusnyob rau hauv ib cheeb tsam, thiab txo qhov kev pheej hmoo ntawm tus kab mob rov tshwm sim thaum lub sij hawm kev kho mob.
Lub caij no, rau cov neeg tshwj xeeb xws li cov me nyuam mos thiab cov neeg laus, kev hloov tshuaj ntawm qhov ncauj yog qhov nyuaj. Cov tshuaj pleev gel tuaj yeem tswj tau cov kab mob hauv zos tau zoo los ntawm kev tswj hwm hauv zos yam tsis muaj kev siv tshuaj ntau ntxiv, nthuav dav cov pej xeem siv rau kev kho mob cryptococcosis.
Cov kev txwv thiab kev daws teeb meem rau kev kho tus kab mob cryptococcal
Nrog rau kev siv dav hauv kev kho cov kab mob cryptococcal, qhov teeb meem ntawm cov tshuaj tiv thaiv tau maj mam dhau los ua qhov tseem ceeb. Cryptococcus tuaj yeem txhim kho nws txoj kev tiv thaiv los ntawm ntau lub tswv yim, xws li kev hloov pauv hauv ERG11 noob ua rau muaj kev hloov pauv hauv lub hom phiaj enzyme 14 - demethylase, txo nws txoj kev sib raug zoo rau lub hom phiaj enzyme; Overexpression ntawm efflux twj tso kua mis tsub kom cov tshuaj efflux, ua rau ib tug txo nyob rau hauv intracellular tshuaj concentration; Biofilm tsim tuaj yeem txo qhov rhiab heev ntawm Cryptococcus rau Fluconzole.
Txhawm rau daws qhov teeb meem ntawm kev tiv thaiv yeeb tshuaj, cov tswv yim hauv qab no tuaj yeem siv tau:
Ib qho yog siv cov tshuaj kom tsim nyog, tsis txhob saib xyuas cov tshuaj tiv thaiv kab mob thiab kev siv ntau dhau, ua raws li cov lus qhia thiab cov kev kho mob ntawm cov tshuaj, thiab txo cov kev xaiv ntawm cov tshuaj tiv thaiv- hom tshuaj tiv thaiv.
Qhov thib ob yog ua cov tshuaj rhiab heev rau cov tshuaj thiab xaiv cov tshuaj antifungal tsim nyog raws li cov tshuaj rhiab heev. Rau cov kab mob Fluconzole resistant Cryptococcus, lwm pawg ntawm cov tshuaj tiv thaiv kab mob xws li echinocandins (xws li caspofungin) lossis amphotericin B tuaj yeem txiav txim siab.
Qhov thib peb yog kev sib xyaw ua ke, uas tuaj yeem siv ua ke nrog lwm cov tshuaj tiv thaiv kab mob nrog cov txheej txheem sib txawv ntawm kev ua haujlwm los tsim cov teebmeem kev sib koom ua ke, txhim kho kev kho mob, thiab kov yeej cov tshuaj tiv thaiv. Piv txwv li, nws txoj kev kho ua ke nrog sertraline tau pom muaj kev sib koom ua ke tawm tsam Cryptococcus hauv kev sim tsiaj txhu, muab qee qhov kev siv rau kev kho mob.
FAQ
Yuav ua li cas yog tias kuv noj nws yam tsis muaj kab mob poov xab?
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Yog tias koj tsis muaj kab mob poov xab,antifungals yuav tsis pab koj kom zoo. Lawv tuaj yeem ncua qhov teeb meem vim tias qhov laj thawj tiag tiag yuav ua ntxiv mus ntxiv.
Puas muaj kev nyab xeeb thaum cev xeeb tub?
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Daim ntawv lo rau nws pom zoo cov poj niam cev xeeb tub tsis txhob siv cov tshuaj no tshwj tsis yog thaum muaj mob hnyav lossis muaj peev xwm ua neej nyob - hem cov kab mob fungal. Txawm li cas los xij, qhov txiaj ntsig ntawm kev siv nws yuav ua rau muaj kev pheej hmoo ntau dua.
Nws puas zoo rau daim tawv nqaij fungus?
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Nws kuj yogQee zaum siv los kho cov kab mob fungal lojuas pib hauv lub ntsws thiab tuaj yeem kis tau los ntawm lub cev thiab cov kab mob fungal ntawm lub qhov muag, tawv nqaij thiab rau tes.
Nws siv tau li cas?
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Cov lus teb hauv chaw kho mob pom tau tias 97% kho tom qab 14 hnub hauv kev kho nrog hauv situ gel. Hauv kev sib piv, pawg tswj hwm tau kho nrog nws cov ntsiav tshuaj pom 85% kev txhim kho hauv cov tsos mob ntawm qhov ncauj candidiasis.
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