Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm cov tuam ntxhab thiab cov muag khoom ntawm lotilaner hmoov hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo lotilaner hmoov rau muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Lotilaner hmoovyog ib qho kev sib xyaw nrog cov qauv tshuaj ntshiab, nrog rau CAS tus lej ntawm 1369852-71-0, ib qho qauv molecular ntawm C20H14Cl3F6N3O3S, thiab qhov tseeb molecular hnyav ntawm 596.76. Cov tshuaj no tshwm sim nyob rau hauv ib daim ntawv uas muaj xws li dawb mus rau dawb nyob rau hauv lub chav tsev kub thiab muaj ib tug tshwj xeeb lub cev thiab tshuaj. Kev kwv yees qhov ceev yog 1.66 ± 0.1 g / cm³, thiab acidity coefficient (pKa) yog 12.52 ± 0.46, qhia txog qee yam kua qaub-puag. Nyob rau hauv cov nqe lus ntawm solubility, lotilana muaj siab heev solubility nyob rau hauv dimethyl sulfoxide (DMSO), mus txog ntau tshaj los yog sib npaug zos rau 100 mg / mL (167.57 mM), uas muab kev yooj yim rau nws daim ntawv thov nyob rau hauv kev tshawb fawb soj ntsuam thiab tshuaj formulations. Thaum khaws cia, nws yuav tsum tau muab tso rau hauv qhov chaw qis qis ntawm -20 ° C kom nws ruaj khov thiab ua haujlwm.
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Daim ntawv thov kev kho mob: los ntawm ib qho deworming mus rau kev tiv thaiv thiab kev tswj hwm
1.1 Tiv thaiv thiab tswj cov kab mob sab nraud
Flea tiv thaiv thiab tswj:
Killing adult insects: The killing rate is>99% hauv 8 teev tom qab kev tswj hwm thiab nce mus txog 100% hauv 24 teev.
Blocking reproduction: Inhibiting txoj kev loj hlob ntawm qe thiab larvae, txiav tawm lub neej voj voog ntawm fleas.
Cov ntaub ntawv kho mob: Kev tshawb fawb hauv Tebchaws Meskas tau pom tias tom qab siv tas li rau 3 lub hlis, cov dev mub hauv tsev ib puag ncig txo qis los ntawm 99.5% -100%, thiab cov tsos mob ntawm cov tsiaj tawv nqaij (erythema, desquamation) zoo dua.
Tick Control:
Kev ua haujlwm dav dav: Siv tau rau cov zuam hom xws li cov zuam dub thiab cov zuam Asmeskas dev, nrog rau hom zuam ntshav.
Kev pib sai: Kev tua pib 4 teev tom qab kev tswj hwm, nrog kev tua tus nqi ntau dua lossis sib npaug li 97% hauv 48 teev.
Kev tiv thaiv kab mob: Los ntawm kev thaiv cov zuam tom, txo qhov kev pheej hmoo ntawm zuam yug kab mob xws li Lyme kab mob thiab Babesia.
1.2 Tiv thaiv thiab tswj cov kab mob sab hauv (compound npaj)
Noj Credelio Quattro (cov tshuaj ntawm Lopinal / Moxibustin / Praziquantel / Thiamethoxam) ua piv txwv:
Kev tiv thaiv kab mob plawv: 100% tiv thaiv kab mob canine heartworm, thaiv kev txhim kho ntawm L3 theem larvae.
Kev kho mob plab hnyuv parasites:
Ascaris lumbricoides (lub taub hau roundworm, tsov ntxhuav roundworm): ua tau zoo dua los yog sib npaug rau 97%.
Hookworm (qaub taub hau nuv lub qhov ncauj nematode): tua tus nqi ntau dua los yog sib npaug rau 97%.
Taenia (Taenia solium, Taenia solium): 100% tua cov neeg laus worms.
2 Daim Ntawv Thov Tshwj Xeeb Scenario
2.1 Kev tiv thaiv cov menyuam dev thiab cov laus dev
Lub hnub nyoog tsim nyog: Puppies tshaj 8 lub lis piam tuaj yeem siv taulotilaner hmoov, nrog qhov tsawg kawg nkaus qhov hnyav ntawm 1.5 kg.
Kev nyab xeeb dev laus: Tsis muaj kev pheej hmoo ntawm daim siab thiab lub raum toxicity txuam nrog, haum rau cov tsiaj uas muaj kab mob comorbidities.
2.2 Kev tswj lub sij hawm yug me nyuam
Cev xeeb tub: Txawm hais tias kev nyab xeeb tsis tau raug soj ntsuam, tsis muaj qhov cuam tshuam teratogenic tau pom nyob rau hauv kev tshuaj xyuas.
Lub sij hawm pub niam mis: Tus nqi ntawm cov tshuaj secreted los ntawm cov mis nyuj yog tsawg heev thiab tsis cuam tshuam rau kev noj qab haus huv ntawm cov me nyuam.
2.3 Kev Tiv Thaiv thiab Tswj Ntawm Ntau Tsev Neeg Tsiaj
Hla kev tiv thaiv: Txo cov kab mob sib kis ntawm cov tsiaj los ntawm kev tswj kab tsuag ib puag ncig.
Cov tshuaj sib koom ua ke: tuaj yeem siv ua ke nrog cov tshuaj tiv thaiv, tshuaj tua kab mob, thiab lwm yam, yam tsis muaj kev cuam tshuam cov tshuaj tseem ceeb.
Cov khoom lag luam: Txhim kho los ntawm ib tus neeg cov khoom mus rau kev daws teeb meem
3.1 Unilateral formulations (Credelio series)
Credelio CAT: Cov tshuaj tiv thaiv kab mob hauv qhov ncauj / zuam thiab nqaij nyug flavored chewable ntsiav tshuaj rau miv los txhim kho palatability.
Credelio DOG: ib tus neeg sawv cev rau cov dev, tsom rau kev tiv thaiv thiab tswj cov kab mob sab nraud.
3.2 Kev npaj ua ke (Credelio Quattro)
Plaub qhov cuam tshuam hauv ib qho:
Lothilana: Ceev ceev tua hma / zuam.
Moxibustin: Tiv thaiv kab mob plawv thiab tswj cov kab mob.
Praziquantel: dav -spectrum anti tapeworm.
Thiamethoxam: Ceev ceev tua kab kab kab / kab nuv ntses.
Clinical zoo:
Txo cov tshuaj noj ntau zaus: Hloov ntau yam tshuaj ib hlis ib zaug.
Txhim kho kev ua raws: Nqaij nyuj flavored chewable ntsiav tshuaj muaj palatability ntawm 92%.
Txo qhov kev pheej hmoo ntawm cov tshuaj tiv thaiv: ntau- lub hom phiaj ua kom qeeb cov tshuaj tiv thaiv kab mob.
Hauv cov cuab yeej technology uas twb muaj lawm, PCT patents WO2022020585A1 thiab WO2014090918A1 nthuav tawm txoj kev hluavtaws raulotilaner hmoov. Tshwj xeeb tshaj yog, ua ntej tsim lub nplhaib imidazole, halogen lossis carboxyl pawg tau nkag mus rau hauv lub nplhaib thiophene ua ntej, thiab tom qab ntawd cov chains sab tau qhia kom tau txais lotilan. Txawm li cas los xij, tus neeg tsim khoom pom los ntawm kev tshawb fawb pom tias nyob rau hauv cov txheej txheem synthesis ntawm lotilana nyob rau hauv cov ntaub ntawv hais txog patent, txoj kev qhia halogens lossis carboxyl pawg ntawm lub nplhaib thiophene ua ntej tsim lub nplhaib imidazole, thiab tom qab ntawd qhia cov saw hlau, yog qhov nyuaj kom tau txais cov ntaub ntawv raw, kim, thiab muaj qhov tsis zoo ntawm kev txo cov molecular. Nyob rau tib lub sijhawm, hauv kev tshaj tawm - ua tiav cov tshuaj tiv thaiv cyclization tom ntej, muaj ntau yam impurities hauv cov khoom tiav uas nyuaj rau purify. Cov impurities tau yooj yim nkag mus rau hauv cov khoom tiav, ua rau nws nyuaj rau kev ua kom zoo dua. Kev kho kom huv ntau yam yuav tsum tau ua, ua rau kev tsim khoom nyuaj, siv zog, thiab kim, ua rau nws nyuaj rau kev ua lag luam. Yog li ntawd, kov yeej qhov tsis txaus ntseeg hauv cov txheej txheem synthesis ntawm lotilana hauv cov thev naus laus zis uas twb muaj lawm thiab txhim kho txoj kev sib txuas tsim nyog rau kev tsim khoom lag luam yog qhov tseem ceeb tshwj xeeb rau kev ua tiav kev lag luam ntawm lotilana.
Synthetic method
1. Ntxiv 140g (1.0mol) ntawm 2-acetyl-4-methylthiophene thiab 277g (1.0mol) ntawm 2,2,2-trifluoro-1- (3,4,5-trichlorophenyl) acetophenone, txhua tus muaj 700mL ntawm methyl tert butyl necked peb, Tom qab nplawm thiab yaj, ntxiv 50g ntawm triethylamine thiab hnov mob ntawm 50℃rau 2 teev kom tau txais cov tshuaj tiv thaiv. Tom qab txias cov tshuaj tiv thaiv kom qis dua 5 degree, maj mam ntxiv 50g ntawm thionyl chloride thiab kub nws mus txog 40℃rau 3 teev. Tom qab txias, tshem tawm nrog 200mL ntawm saturated sodium bicarbonate tov thiab 200mL ntawm purified dej feem. Extract lub aqueous theem ob zaug nrog 100mL ntawm methyl tert butyl ether, muab cov organic theem thiab ntxuav ib zaug nrog 200mL ntawm purified dej. Qhuav nrog anhydrous sodium sulfate, lim, thiab mloog zoo rau cov filtrate nyob rau hauv txo siab ntawm 50℃kom tau ib tug concentrate. Cov concentrate yog recrystallized los ntawm ib qho ethanol / dej (ntim piv 1: 1) tov kom tau 351g ntawm nruab nrab kuv nrog ib tug yield ntawm 87.8%.
2. Ntxiv 350g ntawm intermediate I (0.876mol) thiab 1000mL ntawm ethanol rau hauv cov tshuaj tiv thaiv lub raj mis, do kom yaj, txias kom qis dua 5 degree, ces ntxiv 60.9g ntawm hydroxylamine hydrochloride (0.876mol), maj mam ntxiv 116g ntawm 30wt% sodium reactor 30 teev, thiab ntxiv 60.9g ntawm hydroxylamine hydrochloride (0.876mol), maj mam ntxiv 116g ntawm 30wt% sodium reactor 30 teev, thiab Tom qab ntawd ntxiv 1000mL dej deionized, do rau 2 teev, lim, ntxuav lub ncuav mog qab zib lim nrog dej deionized, qhuav kom txog thaum tsis muaj qhov hnyav, thiab tau 313g ntawm nruab nrab II nrog cov txiaj ntsig ntawm 86.2%.
3. Ntxiv 50g (0.12mol) ntawm intermediate II thiab 100mL ntawm LDMF rau hauv cov tshuaj tiv thaiv hwj. Ntxiv phosphorus oxychloride (24.5, 0.16mol) dropwise ntawm 0 degree. Tom qab qhov sib ntxiv ntawm dropwise tiav, hnov mob ntawm 0℃rau 10 teev. Tom qab cov tshuaj tiv thaiv tiav, ncuav cov tshuaj tiv thaiv rau hauv 1000mL ntawm dej khov dej, cia nws sawv ntsug rau 15 feeb, ces dilute nws ntxiv nrog 300mL dej thiab 100mL saturated NaHCO3, thiab do rau 1 teev; Tom qab ntawd tshem tawm peb zaug nrog 50mL ntawm ethyl acetate, muab cov organic theem, qhuav nrog anhydrous sodium sulfate, lim, thiab mloog zoo rau cov filtrate nyob rau hauv txo siab ntawm 50℃kom txog thaum tag nrho cov ntim yog txo los ntawm 1/3 kom tau ib tug concentrate. Tom qab ntawd, nyob rau hauv ib qho kev nplawm, 500mL ntawm n-hexane tau ntxiv dropwise rau cov concentrate, thiab tso cai rau crystallize kom txog thaum tsis muaj nag lossis daus. Cov khoom tau lim thiab qhuav kom txog thaum tsis muaj qhov hloov pauv hauv qhov hnyav, ua rau 48g dawb crystalline intermediate III nrog cov txiaj ntsig ntawm 90.3%.
4. CuSO4 · 5H2O (1.25g, 5mmol), 2-amino-N - (2,2,2-trifluoroethyl) acetamide hydrochloride (19.3g, 0.1mol), triethylamine (20.2 g, CO 30 mol1), 1 Ca 200mL acetonitrile tau ntxiv rau lub khob tshuaj tiv thaiv. Intermediate III (44.3g, 0.1mol) thiab tert butanol hydroperoxide (70% aqueous tov, 16mL, 0.11mol) tau ntxiv rau hauv cov cua nitrogen. Cov tshuaj tiv thaiv tau nplawm ntawm 20-30℃rau 6 teev, thiab tom qab ntawd ua kom muaj zog nyob rau hauv qhov txo qis ntawm 50℃kom tau txais cov tshuaj concentrated. Cov tshuaj concentrated crystallized siv n-hexane / ethyl acetate (ntim piv 1: 5) kom tau 55.7g ntawmlotilaner hmoovnrog cov txiaj ntsig ntawm . 93.3%, HPLC purity 99.90%.
Cov lus nug nquag
1.Product Specifications thiab Technical Requirements
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Khoom npe: Lotilaner
CAS Nr .: 1369852-71-0
Cov roj formula: C20H14Cl3F6N3O3S
Molecular Luj: 596.76 g / mol
Purity Requirements: Qhia qhov tsawg kawg nkaus purity theem (piv txwv li, Ntau tshaj los yog sib npaug rau 98%).
Daim ntawv lub cev: Qhia txog lub cev uas xav tau (piv txwv li, hmoov, crystalline).
Ntim Cov Lus Qhia: nthuav dav hom ntim thiab qhov loj me (piv txwv li, 1 kg fwj, 25 kg nruas).
2.Quality Standards thiab Certifications
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Pharmacopoeia Standards: Yuav tsum tau ua raws li cov qauv tshuaj pharmacopoeia (xws li USP, EP).
Cov ntawv pov thawj: Thov luam cov ntawv pov thawj zoo (piv txwv li, GMP, ISO).
Batch Documentation: Yuav tsum tau batch-cov ntaub ntawv tshwj xeeb, suav nrog Daim Ntawv Pov Thawj Kev Ntsuam Xyuas (CoA).
3.Quantity thiab Pricing Requirements
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Order Quantities: Muab ntau qhov kev txiav txim kom muaj nuj nqis rau tus nqi (piv txwv li, 100g, 500g, 1kg, 5kg).
Tus nqi Table: suav nrog ib lub rooj rau cov neeg muag khoom los sau rau hauv ib -unit pricing rau txhua qhov ntau.
Cov Nqi Ntxiv: Thov tus nqi rau cov nqi ntxiv, xws li kev xa khoom, kev lis kev cai, lossis tus nqi tuav.
4.Delivery thiab Logistics
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Delivery Schedule: Qhia lub sijhawm xa khoom xav tau lossis lub sijhawm ua haujlwm.
Shipping Terms: Txhais cov nqe lus shipping (xws li, FOB, CIF) thiab lub ntsiab lus ntawm lub hauv paus chiv keeb.
Cia Tej yam kev mob: Qhia tej yam tshwj xeeb cia tej yam kev mob uas yuav tsum tau thaum lub sij hawm kev thauj mus los (piv txwv li, kub tswj).
5.Kev Tsim Nyog thiab Cov Cai
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Cov Ntaub Ntawv Lub Tuam Txhab: Thov tus neeg muag khoom lub tuam txhab daim ntawv qhia, daim ntawv tso cai ua lag luam, thiab cov ntaub ntawv tiv tauj.
Kev Muaj Peev Xwm: Nug txog tus neeg muag khoom qhov kev txiav txim yam tsawg kawg nkaus (MOQ) thiab ntau tshaj qhov muaj peev xwm txhua hli.
Cov ntsiab lus them nqi: Qhia koj cov nqe lus them nqi uas koj nyiam (piv txwv li, 30% tso nyiaj, 70% tom qab kuaj xyuas zaum kawg thiab ua ntej xa khoom) thiab thov tus neeg xa khoom yooj yim.
Kev ua raws cai thiab kev tswj hwm: Xyuas kom tus neeg muag khoom ua raws li tag nrho cov kev cai tswj hwm rau kev xa tawm thiab xa tawm ntawm Lotilaner.
Cim npe nrov: lotilaner hmoov, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom