Shaanxi BLOOM Tech Co., Ltd. yog ib tug ntawm cov uas paub txog manufacturers thiab lwm tus neeg ntawm l-tryptophan hmoov cas 73-22-3 nyob rau hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo l-tryptophan hmoov cas 73-22-3 muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
L-Tryptophan hmoov, tseem hu ua - Aminoindolylpropionic acid, molecular mis: C11H12N2O2, dawb mus rau yellowish dawb crystalline hmoov los yog crystalline hmoov. Nws tsis muaj ntxhiab tsw lossis tsw ntxhiab me ntsis, thiab nws yuav muaj xim thaum pom lub teeb rau lub sijhawm ntev. Nws ruaj khov rau cua sov nrog acid nyob rau hauv qhov chaw tsaus. Nws yooj yim rau decompose thaum coexist nrog lwm cov amino acids, suab thaj thiab aldehydes. Siv ua zaub mov fortifier thiab antioxidant. Nws kuj yog siv hauv tshuaj. Nws yog tsim los ntawm indolealdehyde. Nws tuaj yeem npaj tau los ntawm trypsin decomposition thiab synthesis.
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Tshuaj Formula |
C11H12N2O2 |
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Exact Mass |
204 |
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Molecular Luj |
204 |
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m/z |
204 (100.0%), 205 (11.9%) |
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Elemental Analysis |
C, 64.69; H, 5.92; N, 13.72; O, 15.67 |
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L-Tryptophan hmoovyog ib qho tseem ceeb amino acid uas tib neeg lub cev tsis tuaj yeem tsim los ntawm nws tus kheej thiab yuav tsum tau txais los ntawm kev noj sab nraud. Nws koom nrog ntau txoj hauv kev metabolic hauv lub cev, tsim cov tshuaj nquag nrog cov haujlwm tseem ceeb hauv lub cev xws li serotonin (5-hydroxytryptamine), melatonin, niacin, thiab lwm yam. Raws li nws cov khoom siv tshwj xeeb thiab cov yam ntxwv metabolic, nws tau nthuav tawm ntau daim ntawv thov tus nqi hauv tshuaj, zaub mov, pub, tshuaj pleev ib ce, thiab cov chaw tawm tshiab.
1. Cov tshuaj tiv thaiv kev ntxhov siab thiab kev tswj kev xav
Nws yog tus precursor ntawm serotonin, uas yog tus tseem ceeb neurotransmitter nyob rau hauv lub hauv paus paj hlwb system tswj kev xav, pw tsaug zog thiab kev txawj ntse muaj nuj nqi. Ntxiv nws tuaj yeem nce qib serotonin hauv lub hlwb, yog li txo cov tsos mob ntawm kev nyuaj siab. Cov kev tshawb fawb soj ntsuam tau pom tias kev sib xyaw nrog cov vitamin B6 tuaj yeem txhim kho kev xav tsis zoo, tshwj xeeb tshaj yog hauv kev kho mob me me mus rau nruab nrab kev nyuaj siab. Tsis tas li ntawd, nws cov metabolite melatonin ntxiv pab txhim kho kev xav hloov pauv los ntawm kev tswj cov circadian rhythms.
2. Kev pab pw tsaug zog thiab kev tswj lub moos lom neeg
Los ntawm kev hloov mus rau hauv melatonin, nws koom nrog tswj kev pw tsaug zog.
Melatonin secretion nce thaum hmo ntuj, uas tuaj yeem txo lub sijhawm pw tsaug zog, ncua sijhawm pw tsaug zog, thiab txo qhov zaus ntawm kev pw tsaug zog hmo ntuj. Cov tshuaj ntxiv tau raug pov thawj los txhim kho kev pw tsaug zog zoo rau cov neeg mob insomnia, jet lag syndrome, thiab pw tsaug zog atherosclerosis. Piv txwv li, hauv cov neeg laus, kev siv nrog magnesium tuaj yeem txhim kho kev pw tsaug zog zoo.
3. Txhim khu kev tiv thaiv kab mob
Nws cov metabolites, xws li serotonin thiab melatonin, muaj cov tshuaj tiv thaiv antioxidant thiab tiv thaiv - mob thiab tuaj yeem tswj hwm lub cev tiv thaiv kab mob. Kev tshawb fawb tau pom tias los ntawm kev txhawb nqa kev sib txawv ntawm lymphocytes thiab txhim kho kev ua haujlwm ntawm cov neeg tua neeg lub cev (NK hlwb), lub cev tiv thaiv kab mob tuaj yeem txhim kho.
Hauv kev sim tsiaj, qhov sib ntxiv ntawm cov khoom noj tuaj yeem ua rau cov thymus Performance index thiab immunoglobulin G (IgG) qib hauv cov nqaij qaib, txo qhov kev pheej hmoo ntawm kev kis kab mob.
4. Kev Tswj Kev Mob thiab Kev Tiv Thaiv Neuroprotection
Los ntawm nce serotonin synthesis, nws inhibits qhov mob teeb liab kis tau tus mob. Cov kev tshawb fawb soj ntsuam tau pom tias cov metabolite 5-hydroxyindoleacetic acid (5-HIAA) tau qis dua hauv cov neeg mob uas mob neuropathic. Ntxiv nrog rau L-tryptophan tuaj yeem txo qhov mob pob qij txha, mob leeg, thiab mob migraine. Tsis tas li ntawd, nws muaj peev xwm tiv thaiv cov kab mob neurodegenerative xws li ntshav qab zib neuropathy thiab Parkinson's kab mob, thiab nws cov txheej txheem yuav cuam tshuam rau kev ntxhov siab antioxidant thiab mitochondrial muaj nuj nqi tu.
5. Lwm lub hom phiaj kho mob
Kev tiv thaiv thiab kev kho mob ntawm pellagra: Nws tuaj yeem hloov mus rau niacin (vitamin B3) los tiv thaiv pellagra los ntawm niacin deficiency.
Kev noj qab haus huv ntawm plab hnyuv: Los ntawm kev ua kom cov serotonin receptors nyob rau hauv txoj hnyuv, txhawb kev ua kua dej hauv plab thiab plab hnyuv peristalsis, txhim kho cov tsos mob ntawm gastric acid reflux, gastritis, thiab peptic ulcers.
Kev cuam tshuam ntawm metabolic syndrome: nws koom nrog kev tswj hwm ntawm insulin secretion thiab tej zaum yuav muaj kev pabcuam kho mob rau cov kab mob metabolic xws li rog thiab ntshav qab zib.
1. Nutrient fortifier
Raws li ib qho tseem ceeb amino acid, nws yog feem ntau ntxiv rau cov mis mos, cov khoom noj khoom haus kev ua si, thiab cov khoom noj tshwj xeeb los them rau qhov tsis txaus ntawm tryptophan hauv cov nroj tsuag protein. Piv txwv li, qhov tsis muaj tryptophan nyob rau hauv cov kua protein tuaj yeem ua rau lub iab saj thiab tsis muaj zog satiety. NtxivL-tryptophan hmoovtuaj yeem txhim kho tsw thiab nce kev siv cov protein. Raws li Suav lub teb chaws tus qauv (GB 14880-2015), cov zaub mov qib purity yuav tsum siab tshaj los yog sib npaug rau 98.5%, thiab hnyav hlau thiab microbiological ntsuas yuav tsum nruj me ntsis raws li cov qauv kev nyab xeeb.
2. Kev tsim khoom noj khoom haus muaj nuj nqi
Vim nws cov sedative thiab hypnotic zog, nws yog siv los tsim cov khoom noj xws li pw tsaug zog pab dej qab zib thiab kev ntxhov siab relieving khoom noj txom ncauj.
Piv txwv li, cov dej haus kis las uas muaj cov tshuaj no tuaj yeem txo qis kev ntxhov siab tom qab qoj ib ce thiab txhawb cov leeg nqaij; Ntxiv cov tshuaj no rau yogurt tsis ncaj qha txhim kho lub siab lub ntsws los ntawm kev tswj lub plab microbiota.
3. Kev txuag zaub mov thiab khaws cia
Nws cov qauv indole muaj hlau chelate muaj peev xwm thiab tuaj yeem cuam tshuam kev loj hlob ntawm microbial. Ntxiv cov mis rau mis hmoov tuaj yeem ua rau nws lub neej txee; Hauv kev khaws ntses, nws ua ke nrog tshuaj yej polyphenols tuaj yeem txo qis kev loj hlob ntawm cov kab mob.
1. Txhawb tsiaj kom loj hlob
Nws yog qhov thib peb feem ntau txwv cov amino acid tom qab methionine thiab lysine, thiab tseem ceeb heev rau kev loj hlob ntawm cov tsiaj nyeg thiab nqaij qaib. Ntxiv rau kev pub noj tuaj yeem ua kom qhov hnyav txhua hnub, txhim kho kev hloov pauv hloov pauv, txo cov rog rog, thiab nce cov nqaij ntshiv feem pua. Piv txwv li, ntxiv 0.05% rau piglet pub tuaj yeem nce qhov hnyav txhua hnub los ntawm 12% thiab txo tus nqi pub los ntawm 8%.
2. Txhim khu kev tiv thaiv thiab kev ntxhov siab
Los ntawm kev tswj hwm immunoglobulin secretion thiab antioxidant enzyme kev ua haujlwm, tsiaj cov kab mob tuaj yeem txhim kho.
Ntxiv rau qhov pub ntawm nteg hens tuaj yeem ua rau lub qe ntau lawm thiab txo cov neeg tuag los ntawm kev kub ntxhov. Tsis tas li ntawd, nws cov metabolite 5-hydroxytryptamine tuaj yeem txo tus cwj pwm nruj hauv cov tsiaj nyeg thiab txhim kho qhov chaw yug me nyuam.
3. Txhim kho kev ua me nyuam
Koom nrog hauv kev sib txuas ntawm hemoglobin thiab cov tshuaj hormones poj niam txiv neej, uas muaj kev txhawb nqa ntawm cov tsiaj yug tsiaj. Ntxiv pub rau cev xeeb tub sows tuaj yeem nce litter loj; Ntxiv cov mis nyuj rau nyuj pub tuaj yeem ua rau cov kua mis ntau ntxiv thiab txhim kho cov kua mis zoo.
1. Antioxidant thiab tiv thaiv -aging
Nws cov qauv indole tuaj yeem ntes cov dawb radicals, inhibit lipid peroxidation, thiab yog li ncua kev laus ntawm daim tawv nqaij. Nws cov metabolite melatonin muaj zog antioxidant muaj peev xwm thiab tuaj yeem txo UV induced DNA puas. Cov khoom siv tawv nqaij uas muaj cov tshuaj no tuaj yeem txhim kho daim tawv nqaij elasticity thiab txo qhov tob ntawm wrinkles.
2. Kev tswj kom dawb thiab xim xim
Los ntawm inhibiting tyrosinase kev ua ub no thiab txo melanin synthesis, nws exerts ib tug whitening nyhuv. Qhov kev sim tshuaj ntsuam xyuas qhia tau hais tias cov kua essence uas muaj nws tuaj yeem txo qhov chaw stain los ntawm 23% thiab ua kom cov tawv nqaij sib xws li 18%.
Cov ntawv thov hauv thaj chaw tshiab
1. Kev tswj kab tsuag ua liaj ua teb
Cov tshuaj no thiab nws cov derivatives tuaj yeem siv los ua biopesticides los cuam tshuam rau lub paj hlwb kev ua haujlwm ntawm cov kab tsuag. Piv txwv li, nws tuaj yeem ua rau cov kab ntsig yav qab teb tsis kam noj thiab tuag, thiab nws cov kev sib xyaw nrog salicylic acid tuaj yeem txhim kho cov tshuaj tua kab.
2. Kev saib xyuas ib puag ncig
Nws cov khoom fluorescence ua rau nws yog ib qho kev sojntsuam lom neeg rau kev kuaj xyuas cov hlau hnyav. Nws lub nplhaib indole tuaj yeem khi nrog cov hlau ions xws li txhuas thiab mercury, ua rau fluorescence quenching, yog li ua tiav kev tshuaj ntsuam xyuas ntawm ib puag ncig cov co toxins.
3. Kev tsim kho biomaterial
Nws cov qauv aromatic ua rau nws muaj peev xwm monomer rau synthesizing biodegradable plastics. Piv txwv li, cov ntaub ntawv polyester npaj los ntawmL-Tryptophan hmoovtuaj yeem degraded tag nrho hauv av hauv 6 lub hlis yam tsis muaj kev phiv tshuaj lom.
Kev tsim tawm ntawmL-tryptophan hmoovFeem ntau tso siab rau cov tshuaj synthesis thiab protein hydrolysis thaum ntxov. Nrog rau kev txhim kho txuas ntxiv ntawm kev tshawb fawb ntawm tryptophan ntau lawm los ntawm txoj kev microbial, tib neeg pib siv microbial fermentation los tsim tryptophan. Tam sim no nws yog tswv yim thiab tseem ceeb. Txoj kev microbial feem ntau tuaj yeem muab faib ua microbial fermentation method thiab enzymatic conversion method. Nyob rau hauv xyoo tas los no, kuj tseem muaj kev tshawb fawb txog kev tsim cov tryptophan los ntawm kev ncaj qha fermentation thiab tshuaj synthesis, thiab kev sib xyaw ua ke ntawm kev ncaj qha fermentation thiab kev hloov pauv. Tsis tas li ntawd, daim ntawv thov ntawm genetic engineering, enzyme immobilization thiab siab -cov kab lis kev cai ceev technologies nyob rau hauv microbial yug me nyuam thiab enzyme kev lag luam tau zoo heev txhawb txoj kev lag luam ntawm tryptophan ntau lawm los ntawm ncaj qha fermentation thiab enzymatic txoj kev.
1. Protein hydrolysis:
Kev tsim cov L-tryptophan tsuas yog tso siab rau cov protein hydrolysis thiab tshuaj synthesis.
Txoj kev protein hydrolysis siv cov proteins xws li cov plaub hau, ntshav hmoov thiab khib nyiab lo lo ntxhuav ua tsev neeg qub, thiab tsim L-tryptophan los ntawm alkaline hydrolysis thiab enzymatic hydrolysis. Nrog rau kev tsim cov tshuab tsim cov amino acid, txoj kev no tsis tshua muaj siv los tsim L-tryptophan.
Chemical synthesis yog ib txoj hauv kev los tsim lossis npaj cov amino acids los ntawm kev sib txuas cov organic synthesis nrog tshuaj engineering. Cov tshuaj synthesis ntawm DL tryptophan tuaj yeem muab faib ua ob hom: kev sib xyaw nrog indole ua raw khoom thiab cov khoom sib xyaw nrog phenylhydrazine ua raw khoom. Snydcr thiab MacDonald tau tsim ib txoj hauv kev yooj yim rau kev sib txuas ntawm DL tryptophan, uas yog, siv indole thiab acetic anhydride nyob rau hauv lub xub ntiag ntawm acetic acid thiab acetic anhydride - N-ethylphthalide- DL-tryptophan yog tau los ntawm licacetylyacid acid nyob rau hauv sodium direct condensation. hydroxide tov kom tau DL tryptophan hauv 57.7% tawm los. Moe thiab MacDonald tau tshaj tawm tias tryptophan tau tsim los ntawm phenylhydrazine, uas yog, nyob rau hauv muaj sodium acetate, acrolein thiab diethyl acetaminomalonate tau condensed, thiab cov condensate reacted nrog phenylhydrazine los tsim phenylhydrazone. Cov phenylhydrazone tau hydrolyzed nyob rau hauv H2S04 los yog BF3 aqueous tov nyob rau hauv reflux, thiab cyclized kom tau cov compound 3-indolyl-methyl-acetylaminomalonate diethyl ester. Lub compound yog hydrolyzed thiab decarboxylated kom tau DL tryptophan.
2. Enzymatic transformation:
Txoj kev Enzymatic siv cov catalytic muaj nuj nqi ntawm L-tryptophan biosynthetic enzyme system hauv cov kab mob los tsim L-tryptophan. Nws tuaj yeem siv lub precursor ntawm tshuaj synthesis ua raw khoom. Nws tsis tsuas yog muab tag nrho cov kev ua si rau qhov zoo ntawm cov organic synthesis technology, tab sis kuj muaj qhov zoo ntawm cov khoom siab concentration, siab yield, siab purity, ob peb los ntawm - khoom, thiab yooj yim refining lag luam. Nws yog tus nqi qis - tus nqi tsim khoom siv los tsim tryptophan. Nws yog dav siv nyob rau hauv zus tau tej cov L-tryptophan.
Kuj tseem muaj kev tshawb fawb txog kev tsim cov enzymatic ntawmL-tryptophan hmoovlos ntawm L-cysteine thiab indole. Weipinghe et al. siv tryptophanase genetic engineering strain WWW-4 los catalyze cov synthesis ntawm L-tryptophan los ntawm L-cysteine thiab indole, nrog rau tag nrho cov nyiaj rov qab ntawm 70%. Tsis tas li ntawd, nws kuj tau tshaj tawm tias L-tryptophan tuaj yeem hloov pauv los ntawm cov kab mob uas muaj cov txiaj ntsig zoo ntawm pyruvate thiab kev ua haujlwm siab ntawm tryptophanase.
Kev hloov pauv enzymatic tuaj yeem siv ncaj qha siv tryptophan synthetase, tryptophan enzyme, lossis ib lub xovtooj ntawm tes nrog tryptophan synthetase los yog tryptophan enzyme los catalyze cov synthesis ntawm L-tryptophan, lossis immobilize lub enzyme lossis cell los ua ke L{{1}tryptophan. Cov kab mob immobilized thiab enzyme muaj qhov zoo ntawm kev txhim kho kev ruaj ntseg ntawm enzyme, ua kom yooj yim siv dua, paub txog kev tsim khoom tas mus li thiab automation.
3. Microbial fermentation:
Microbial fermentation txoj kev muaj xws li ncaj qha fermentation txoj kev thiab ntxiv precursor fermentation txoj kev.
Txoj kev fermentation ncaj qha siv cov piam thaj, qab zib qab zib molasses thiab lwm yam khoom siv pheej yig raws li cov pa roj carbon monoxide, siv cov tshuaj tryptophan zoo heev, thiab ncaj qha ferments tryptophan raws li qhov tsim nyog fermentation. Qhov teeb meem tseem ceeb ntawm kev fermentation ncaj qha yog xaiv cov high thiab ruaj khov tryptophan ua hom.
Txoj kev no tseem hu ua microbial transformation method. Nws siv cov piam thaj los ua cov pa roj carbon monoxide, thiab ib txhij ntxiv cov precursors (xws li o-aminobenzoic acid, indole, L-serine, thiab lwm yam) xav tau rau cov synthesis ntawm tryptophan. Nws siv lub tryptophan synthetase system ntawm cov kab mob los hloov cov precursors mus synthesize L-tryptophan. Txoj kev no tau muab tso rau hauv kev lag luam ntau lawm ntev. Nyiv lub Showa Electric Co., Ltd., lub ntiaj teb no tus loj tshaj plaws tryptophan chaw tsim tshuaj paus, siv o-aminobenzoic acid ua precursor thiab Hansenula los yog Bacillus hom los hloov nws mus rau hauv tryptophan.
Qhov tsis zoo ntawm txoj kev hloov pauv microbial yog tias thaum cov concentration ntawm precursor nyob rau hauv cov kev hloov pauv yog siab, qhov hloov pauv tau txo qis, tab sis nws qhov inhibition tuaj yeem txo los ntawm kev ntxiv me me ntawm precursor hauv batch. Tsis tas li ntawd, lub precursor yog kim, uas yog tsis conducive rau txo nqi. Yog li ntawd, nws tau kawm los muab ib qho pheej yig precursor los ntawm fermentation, thiab tom qab ntawd muab cov txiaj ntsig ntawm lwm txoj hauv kev los tsim tryptophan. Hajimu Morikota et al. siv Brevibacterium flavum P390 ncaj qha ferment L-glutamic acid- - Semialdehyde (GSA) mus txog 13.2g/L, thiab tom qab ntawd cov fermentation broth tau diluted kom zoo thiab ntxiv rau hauv 1mol/L H2S04 tov ntawm phenylhydrazine rau cua sov thiab refluxing. Tom qab ntawd, 48% ntawm GSA tuaj yeem hloov mus rau hauvL-tryptophan hmoov. SMgeru oita et al. siv cov lipoic acid thiab thiamine ob yam kab mob tsis zoo Enterobacter aetogene LT-94 los tsim pyruvate 30g / L hauv kab lis kev cai nrog 5% qabzib, thiab tom qab ntawd ntxiv indole thiab ammonium chloride los ua kom muaj kev hloov pauv ntawm L-tryptophan mus rau 16.7% los ntawm tryptophanase.
FAQ
L-tryptophan zoo rau dab tsi?
L-tryptophan tuaj yeem ua rau koj tsaug zog. Nws tau siv los kho insomnia. Tej zaum nws yuav yog ib qho tshuaj tiv thaiv kev nyuaj siab thiab kev ntxhov siab. Nws tuaj yeem pab kho hyperactivity hauv cov menyuam yaus.
Koj puas tuaj yeem noj L-tryptophan rau pw?
L-tryptophan tau siv ua tiav rau cov neeg uas pw tsaug zog hauv ntau qhov kev tshawb fawb, suav nrog ob - qhov muag tsis pom kev sim. Ntau. Cov amino acid, L-tryptophan, serotonin precursor, noj nyob rau hauv cov nyiaj ntawm 1 mus rau 4 grams thaum mus pw, tau siv tau zoo rau cov neeg uas insomnia nyob rau hauv ntau yam kev tshawb fawb, nrog rau ob - qhov muag tsis pom kev sim.
Kuv puas tuaj yeem noj L-tryptophan txhua hnub?
Dosing. L- cov tshuaj tryptophan feem ntau tau siv los ntawm cov neeg laus hauv koob tshuaj 60 mg ntawm qhov ncauj txhua hnub rau 16 lub lis piam. Tham nrog tus kws kho mob kom paub seb qhov koob tshuaj twg yuav zoo tshaj rau ib tus mob tshwj xeeb. Nco ntsoov tias qee cov khoom noj khoom haus yuav tsis sau L-tryptophan cais ntawm daim ntawv lo.
Koj puas tuaj yeem noj tryptophan nrog tshuaj tua kab mob?
Tsis txhob noj L-tryptophan yog tias koj nyob rau ntawm cov tshuaj tiv thaiv kev nyuaj siab hu ua selective serotonin reuptake inhibitors (SSRIs), MAO inhibitors, tricyclic antidepressants thiab atypical antidepressants. Ua li no yuav ua rau lub neej muaj kev hem thawj hu ua serotonin syndrome. Cov tsos mob ntawm serotonin syndrome yog: Kev ntxhov siab heev.
Cim npe nrov: l-tryptophan hmoov cas 73-22-3, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom