Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm cov tuam ntxhab thiab cov muag khoom ntawm mu-conotoxin hauv Suav teb. Txais tos rau cov lag luam wholesale tej khoom zoo mu-conotoxin muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Mu-conotoxinyog cov tshuaj pleev ib ce -qib biomimetic peptide uas lub hom phiaj voltage-gated sodium channels (Nav1.4) los so lub ntsej muag cov leeg nqaij thiab txo cov tsos ntawm dynamic wrinkles - nrog rau hauv pliaj kab, kab laug sab ko taw, thiab nasolabial folds. Raws li cov kws tshaj lij peptide chaw tsim khoom, Bloomtechz muab siab -purity Mu-conotoxin rov qab los ntawm cov ntaub ntawv ua tiav, kev txhawb nqa kev loj hlob rau kev tsim qauv, thiab ib qho - ntawm- ib qho kev muag khoom muag - los ntawm me me -batch sampling rau kilogram{11}} nplai mov.
Peb Cov Khoom Muag Khoom
Mu-conotoxin COA
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| Certificate of Analysis | ||
| Compound npe | Mu-conotoxin | |
| Qib | Pharmaceutical qib | |
| CAS Nr. | 936616-33-0 | |
| Ntau | 20g | |
| Ntim txheem | PE hnab + Al foil hnab | |
| Chaw tsim tshuaj paus | Shaanxi BLOOM TECH Co., Ltd | |
| Ntau No. | 202601090059 | |
| MFG | Peb 9, 2026 | |
| EXP | Peb 8, 2029 | |
| Qauv |
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| Yam khoom | Enterprise txheem | Kev txheeb xyuas qhov tshwm sim |
| Qhov tshwm sim | Dawb los yog yuav luag dawb hmoov | Ua raws |
| Cov ntsiab lus dej | Tsawg dua lossis sib npaug li 5.0% | 0.39% |
| Poob rau ziab | Tsawg dua lossis sib npaug li 1.0% | 0.80% |
| Hnyav Hlau | Pb Tsawg dua lossis sib npaug li 0.5ppm | N.D. |
| Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Hg Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Cd Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Purity (HPLC) | Ntau dua lossis sib npaug li 99.0% | 99.5% |
| Ib qho impurity | <0.8% | 0.73% |
| Tag nrho microbial suav | Tsawg dua lossis sib npaug li 750cfu / g | 80 |
| E. Coli | Tsawg dua lossis sib npaug li 2MPN / g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (los ntawm GC) | Tsawg dua lossis sib npaug li 5000ppm | 500ppm ua |
| Cia | Khaws rau hauv qhov chaw kaw, tsaus, thiab qhuav hauv qab -20 degree | |
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Mu-conotoxinyog ib chav kawm ntawm cov khoom xyaw peptide uas tau txais kev saib xyuas thoob plaws hauv cov tshuaj pleev ib ce los tiv thaiv- kev laus hauv xyoo tas los no. Nws lub npe muab los ntawm lub ntuj μ-conotoxins pom nyob rau hauv cov venom ntawm marine cone snails - ntuj co toxins uas so cov nqaij ntshiv los ntawm thaiv voltage-gated sodium channels. Mu-conotoxin siv hauv cov tshuaj pleev ib ce tsis yog ncaj qha muab rho tawm los ntawm lub khob hliav qab ntuj, tab sis yog biomimetic peptide tsim los ntawm cov khoom siv hluavtaws uas ua rau cov qauv tsim thiab cov txheej txheem ntawm ntuj μ-conotoxins.Cov khoom feem ntau tshwm li dawb los yog tawm -dawb powdery khoom uas tsis muaj pichys.
Raws li cov peptide folded heev, Mu-conotoxin muaj ntau yam disulfide bonds hauv nws cov molecule. Cov ntawv cog lus no tuav cov saw peptide qhov kev sib cog lus peb - qhov sib txawv ntawm qhov sib txawv, ua rau nws muaj kev ruaj ntseg zoo thiab lub hom phiaj kev sib khi muaj peev xwm. Ua ntej nkag mus rau kev tsim cov tshuaj pleev ib ce, Mu-conotoxin raw khoom muaj nyob rau hauv daim ntawv ntawm refined lyophilized hmoov.Qhov no yog cov khoom siv zoo tshaj plaws raws li - cov ntaub ntawv raw ntawm peptide. khov- txheej txheem ziab, dej hauv cov tshuaj peptide raug tshem tawm ntawm sublimation nyob rau hauv qis- qhov kub ntawm lub tshuab nqus tsev, yielding xoob, ntxeem tau dawb hmoov.
Daim ntawv lyophilized hmoov zoo tshaj plaws khaws cia cov peptide kev ua haujlwm lom neeg, tsis txhob degradation, oxidation, thiab microbial paug uas yuav tshwm sim thaum lub sij hawm ua kua.Hais txog physicochemical zog, Mu-conotoxin lyophilized hmoov nthuav tawm cov yam ntxwv hauv qab no: Ua ntej, hais txog kev solubility, cov peptide no yog soluble2} dej thiab soluble raws li glycerin, butylene glycol, thiab propylene glycol), thiab tuaj yeem yaj sai sai hauv cov txheej txheem aqueous yam tsis tas yuav muaj cov tshuaj solubilizer tshwj xeeb.
Thib ob, hais txog pH stability, peptide kuj tseem ruaj khov nyob rau hauv nruab nrab rau qhov tsis muaj zog acidic ib puag ncig (pH 5.0-7.0), thaum peptide daim ntawv cog lus hydrolysis los yog kev hloov pauv yuav tshwm sim nyob rau hauv cov kua qaub lossis alkaline. Yog li ntawd, yuav tsum tau them nyiaj rau kev tswj lub cev pH thaum lub sij hawm tsim. Thib peb, hais txog thermal stability, Mu-conotoxin ruaj khov nyob rau hauv chav tsev kub rau lub sij hawm luv luv, tab sis ntev - lub sij hawm raug rau siab - qhov kub thiab txias tej zaum yuav ua rau kom muaj kev puas tsuaj. Kev cia nyob rau hauv lub tub yees ntawm 2-8℃yog pom zoo, thiab rov khov dua -thaw cycles yuav tsum tau zam.
Plaub, hais txog hygroscopicity, lyophilized hmoov muaj qee yam dej noo-absorbing zog. Tom qab qhib, nws yuav tsum tau siv sai li sai tau thiab khaws cia thiab qhuav kom tsis txhob muaj kab mob thiab kab mob microbial.
Nyob rau hauv qhov tseeb ntau lawm dosing,Mu-conotoxinlyophilized hmoov feem ntau yog ua ntej-solved nyob rau hauv ib tug me me ntawm cov dej purified los yog polyol los npaj ib qho kev daws teeb meem ntawm ib tug tej yam concentration, uas yog ntxiv mus rau lub aqueous theem system ntawm ib tug tsawg- kub theem (feem ntau hauv qab 40 degree) thiab stirred tusyees.
Txoj kev sib cais ua ntej no pab kom tsis txhob muaj teeb meem xws li kev sib cais tsis sib xws thiab cov caking hauv zos uas tuaj yeem tshwm sim thaum cov hmoov raug txhaj ncaj qha, kom ntseeg tau tias cov khoom xyaw nquag raug muab faib rau hauv cov khoom.Hais txog kev ua haujlwm, cov haujlwm tseem ceeb ntawm Mu-conotoxin nyob rau hauv nws lub hom phiaj blockade ntawm voltage-gated sodium subtalvele tshwj xeeb tshaj yog 4 channels. cov leeg. Lub ntsej muag ntsej muag muaj feem cuam tshuam nrog kev rov ua dua ntawm cov leeg ntawm lub ntsej muag: cov hlab ntsha impulses raug xa mus rau cov leeg los ntawm cov neurotransmitters xws li acetylcholine, ua rau sodium ion influx thiab muaj peev xwm ua tau, thaum kawg ua rau cov leeg nqaij.
Los ntawm occluding lub sodium channel pore, Mu-conotoxin txo sodium ion influx, yog li inhibiting cov leeg nqaij contraction thiab ua tiav cov teebmeem ntawm so kom txaus cov nqaij ntshiv thiab diminishing dynamic wrinkles. Tsis zoo li txhaj tshuaj botulinum toxin, Mu-conotoxin, raws li cov khoom siv tshuaj pleev ib ce, ua rau cov leeg nqaij ion hauv cov txheej txheem ntawm daim tawv nqaij yam tsis nkag mus rau hauv cov hlab ntsha sib sib zog nqus, ua rau nws txoj kev siv softer thiab yooj yim dua.
Raws li ib lub tuam txhab, Bloomtechz tshwj xeeb hauv R&D thiab tsim cov khoom siv peptide raw khoom, Bloomtechz tso siab rau cov khoom lag luam paub tab -theem peptide synthesis txheej txheem thiab oxidative folding thev naus laus zis los muab siab -purity cosmetic- qib Mu-conotoxin raw khoom. Lub tuam txhab tau sau cov kev tsim khoom nplua nuj nyob rau hauv kev sib xyaw thiab folding ntawm disulfide- muaj cov peptides, thiab tuaj yeem tswj tau qhov sib raug zoo ntawm disulfide daim ntawv cog lus, ua kom cov khoom ruaj khov thiab batch - rau -batch sib xws kom tau raws li qhov yuav tsum tau ua ntawm cov tswv lag luam tshuaj pleev ib ce thiab cov kws tsim qauv tsim.
Qhov tseem ceeb ntawm kev sivMu-conotoxinnyob rau hauv cov tshuaj pleev ib ce yog anti-wrinkle, tshwj xeeb tshaj yog lub hom phiaj dynamic wrinkles tsim los ntawm rov ua contraction ntawm lub ntsej muag qhia cov leeg nqaij, xws li hauv pliaj kab, glabellar kab, crow's ko taw, thiab nasolabial folds. Los ntawm inhibiting cov leeg nqaij ntau dhau, Mu-conotoxin tuaj yeem ua kom cov leeg nqaij hauv lub xeev so, yog li txo cov kab mob los ntawm cov leeg rub thiab ua rau daim tawv nqaij zoo dua. Ntau qhov kev tshawb fawb hauv vitro thiab preclinical tau pom tias Mu-conotoxin tuaj yeem ua rau cov leeg nqaij- so kom txaus nyob rau lub sijhawm luv luv, thiab qee cov neeg siv tau tshaj tawm tias qhov txo qis ntawm daim tawv nqaij nruj thiab fading ntawm cov kab hauv ob peb teev tom qab thov.
Nws yuav tsum tau muab sau tseg tias qhov transdermal absorption qhov tob thiab qhov kev siv ntawm cov tshuaj peptides raug txwv, thiab lawv cov teebmeem txawv los ntawm kev txhaj tshuaj botulinum toxin; cov neeg siv khoom yuav tsum tuav cov kev cia siab tsim nyog.
Hauv cov qauv tsim tiag tiag, Mu-conotoxin feem ntau yog siv ua ke nrog lwm cov tshuaj tiv thaiv -wrinkle nquag peptides kom ua tiav ntau- lub hom phiaj, tag nrho - saw anti-wrinkle los. Cov khoom xyaw ua ke muaj xws li Acetyl Hexapeptide-8 (ib botox-zoo li peptide), Syn-Ake (Dipeptide Diaminobutyroyl Benzylamide Diacetate), thiab Carnosine.
Cov khoom xyaw no ua rau cov kev sib txuas sib txawv hauv cov paj hlwb xa mus: Mu-conotoxin feem ntau blocks sodium channels, Acetyl Hexapeptide-8 inhibits neurotransmitter tso tawm, thiab Syn-Ake sib tw khi rau cov leeg acetylcholine receptors. Los ntawm kev sib xyaw ua ke, cov leeg nqaij tuaj yeem ua rau muaj kev cuam tshuam los ntawm ntau lub pob ntawm cov teeb liab conduction, yog li txhim kho tag nrho cov tshuaj tiv thaiv -wrinkle effect. Tsis tas li ntawd, Mu-conotoxin tuaj yeem ua ke nrog cov teeb liab peptides xws li Palmitoyl Pentapeptide-4 thiab Palmitoyl Tripeptide-1 los txhawb collagen synthesis thaum so cov leeg, hais txog ob qho tib si dynamic thiab zoo li qub wrinkles.
Raws li cov dej -soluble peptide raw khoom, Mu-conotoxin tuaj yeem siv dav hauv ntau hom tshuaj pleev ib ce, suav nrog cov tshuaj pleev ib ce, tshuaj pleev qhov muag, tshuaj pleev ntsej muag, tshuaj pleev ib ce, qhov ncauj qhov ntswg, thiab ampoules. Nyob rau hauv cov formulations, Mu-conotoxin feem ntau yog ntxiv thaum lub sij hawm aqueous theem los yog qis-kub theem kom tsis txhob peptide kev ua poob los ntawm kub kub. Qhov pom zoo ntxiv tus nqi sib txawv nyob ntawm cov khoom muag thiab kev tsim cov txheej txheem, feem ntau nyob rau hauv thaj tsam ntawm 0.01% mus rau 0.5%.
Txij li thaum peptide raw cov ntaub ntawv kuj tseem rhiab heev rau pH thiab kub, yuav tsum tau them nyiaj rau compatibility nrog rau lwm cov khoom xyaw thaum lub sij hawm tsim formulation, tsis txhob sib cuag ncaj qha nrog cov acids, muaj zog alkalis, los yog muaj zog oxidizing cov khoom xyaw, los xyuas kom meej lub stability ntawm cov khoom nyob rau hauv nws lub neej txee.Cosmetic-qibMu-conotoxinyog ib qho qis -kev ua peptide uas tau dhau los ua cov khoom siv dag zog thiab kev hloov kho cov qauv, qhov txawv ntawm cov tshuaj lom neeg muaj txiaj ntsig zoo.
Ntuj conotoxins muaj zog neurotoxicity thiab tsis tuaj yeem siv ncaj qha rau ntawm daim tawv nqaij; cov tshuaj pleev ib ce- qib hluavtaws peptides, txawm li cas los xij, tau dhau los ua qhov hloov pauv molecular thiab kev ntsuas kev nyab xeeb, thiab lawv txoj kev nyab xeeb nyob rau hauv kev pom zoo siv ntau yam tau txais kev txhawb nqa los ntawm ntau qhov kev sim hauv vitro thiab kev kuaj tib neeg. Cov ntaub ntawv tshaj tawm kev sim qhia tau hais tias ntawm kev siv ntau npaum li cas, Mu-conotoxin tsis muaj cytotoxicity tseem ceeb, khaus tawv nqaij, lossis rhiab heev.Ib tug me me ntawm cov tawv nqaij tsis muaj zog los yog cov tawv nqaij rhiab tuaj yeem ua rau mob me me, liab, lossis khaus tom qab siv cov khoom uas muaj Mu-conotoxin.
Qhov no tej zaum yuav muaj feem xyuam rau kev nkag mus ntawm cov khoom xyaw peptide ntawm daim tawv nqaij los yog kev sib koom ua ke ntawm lwm cov khoom xyaw hauv cov qauv (xws li cov tshuaj tua kab mob, tshuaj tsw qab, cawv). Nws feem ntau daws nws tus kheej tom qab txiav tawm.Txawm hais tias Mu-conotoxin nws tus kheej muaj peev xwm ua kom tsis muaj zog, qhov sib txawv ntawm tus kheej yuav ua rau cov neeg siv tsawg heev los tsim cov tshuaj tsis haum rau peptide lossis lwm cov khoom xyaw hauv kev tsim, tshwm sim raws li erythema, o, papules, thiab lwm yam. Ib qho kev soj ntsuam ntawm ob lub pob ntseg tom qab siv los yog pom zoo. 24-48 teev yam tsis muaj qhov txawv txav ua ntej siv rau lub ntsej muag.
Nyob rau hauv cov ntaub ntawv ntawm kev siv siab concentration los yog ntau tshaj daim ntawv thov, qee cov neeg siv yuav hnov cov tawv nqaij nruj los yog lub ntsej muag tsis zoo, xws li ib qho tawv nqaij me ntsis thaum luag ntxhi. Cov mob no feem ntau yog ib ntus thiab tuaj yeem maj mam rov zoo li cov khoom lag luam metabolized thiab absorbed. Nws raug nquahu kom siv cov khoom raws li cov lus pom zoo hauv cov lus qhia thiab tsis txhob siv ntau dhau.f cov khoom ua yuam kev nkag mus rau hauv lub qhov muag, nws yuav ua rau lub qhov muag stinging, tearing, thiab lwm yam kev mob tshwm sim. Cov tshuaj pleev qhov muag lossis cov tshuaj uas muaj Mu-conotoxin yuav tsum tau siv kom tsis txhob muaj kab mob; yog tias qhov muag tsis pom kev tshwm sim, yaug tam sim nrog dej ntau.
Ntawm cov khoom siv raw khoom, Bloomtechz muab daim ntawv qhia ua tiav zoo rau txhua pawg ntawm Mu- cov khoom lag luam conotoxin, npog cov cim tseem ceeb xws li HPLC purity testing, mass spectrometry molecular weight verification, tsos thiab solubility inspection, thiab microbial limit test, kom ntseeg tau tias txhua pawg ntawm cov khoom siv raw cov ntaub ntawv tau txais los ntawm cov neeg siv khoom zoo, cov ntaub ntawv raw khoom tau txais los ntawm cov neeg siv khoom. kev ua tau zoo thov ntawm cov khoom kom zoo nkauj.
siv
1.Conus Venom Peptide Pharmacology
2.Structure thiab Function ntawm μ-Conotoxins, Peptide-Based Sodium Channel Blockers nrog Kev Ua Txhaum Cai
3.µ-Conotoxins ua Tus Thawj Coj hauv Kev Txhim Kho Kev Kho Mob Tshiab
4.Neuropharmacology ntawm Voltage-Gated Sodium Channel Inhibition los ntawm µ-Conotoxins
5.Sustainable Dynamic Wrinkle Efficacy: Tsis yog -Invasive Peptides li yav tom ntej ntawm Botox lwm txoj
FAQ
Q1: Puas yog Mu-conotoxin muaj kev nyab xeeb hauv kev tu tawv nqaij?
Yog lawm. Tshuaj pleev ib ce-qib Mu-conotoxin yog ib qho hluavtaws, qis-peptide kev ua haujlwm uas tsuas yog ua rau ntawm daim tawv nqaij cov leeg nqaij xwb - tsis zoo li cov tshuaj lom neeg lub cev. Ntawm 0.01% – 0.5%, kev ntsuam xyuas tsis muaj qhov ua kom khaus lossis hnov qab. Bloomtechz muab COA thiab MSDS nrog txhua pawg rau kev ua raws cai thiab tshuaj xyuas.
Q2: Nws ua haujlwm zoo npaum li cas thiab Botox?
Nws relaxes qhia cov nqaij ntshiv ntawm Nav1.4 channel thaiv, txo cov wrinkles zoo li hauv pliaj kab thiab crow's ko taw. Qee cov neeg siv pom cov kab sib dua hauv cov xuab moos. Txawm li cas los xij, raws li cov tshuaj pleev peptide nws qhov tob thiab kev siv zog yog txwv - nws tsis tuaj yeem phim cov tshuaj Botox. Qhov zoo tshaj plaws rau kev ua siab mos, tsis yog - tawm tsam tiv thaiv -wrinkle care. Bloomtechz muab cov khoom siv cov ntaub ntawv yooj yim rau kev siv.
Q3: Nws puas ruaj khov hauv kev khaws cia thiab kev tsim khoom?
Yog lawm. Shipped raws li lyophilized hmoov; tsis qhib lub txee lub neej yog 24 lub hlis ntawm 2-8 degree, kaw thiab deb ntawm lub teeb. Nws yaj yooj yim hauv dej / polyols; Ntxiv hauv qab 40℃ntawm pH 5.0-7.0, tsis txhob muaj cov kua qaub / alkali. Bloomtechz suav nrog cov lus qhia khaws cia thiab MSDS nrog rau txhua qhov khoom xa tuaj.
Cim npe nrov: mu-conotoxin, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom