Shaanxi Bloom Tech Co., Ltd. yog ib qho ntawm cov neeg tsim khoom thiab cov chaw muag khoom ntawm Oxytocin hmoov yog 50-56-6 nyob hauv Suav teb. Txais tos rau kev lag luam wholesale loj zoo oxytocin hmoov npaum li 50-56-6 kev muag khoom ntawm no los ntawm peb lub hoobkas. Cov kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Oxytocin Hmoovyog ib qho tseem ceeb deev thiab precursor ntawm progesterone, uas ua ntau yam kev muaj zog ntawm lub cev hauv tib neeg lub cev. Oxytocin muaj nyob rau hauv daim ntawv ntawm daim ntawv dawb muaju lossis crystalline hmoov, nrog cov xeev muaj cov pob zeb ua tau zoo, kua, thiab gaseous. Muaj sib txawv ntawm cov solubility. Nyob rau hauv cov organic cov emvents xws li cawv, neeg muaj kev nyab xeeb, chlorinated hydrocarbons, thiab lwm yam, Oxytocin muaj siab solubility. Txawm li cas los xij, nws solubility hauv dej yog tus nqi tsawg. Tus mob nyob rau hauv cov kev mob uas ruaj khov, tab sis decomposition yuav tshwm sim nyob rau hauv cov acid muaj zog, alkali, lossis siab siab mob. Tshaj tawm los ntawm lub ntsej muag postary pilencatary caj pas thiab synthesized los ntawm cov paravesus thiab supraoptic nucleus ntawm hypothalamus, nws muaj 9 amino acids. Nws yog xa mus rau Neurohypophysis rau tso tawm ntawm tus nqi ntawm 2-3 millimeters ib hnub. Lub cysteine (CYS) cov seem ntawm txoj haujlwm "1" thiab "6 tus qauv ua ib tus qauv cyclic ntawm 6-peptide nyob rau hauv daim ntawv ntawm kev puas tsuaj. Oxytocin tuaj yeem txhawb cov khoom zais ntawm mis los ntawm lub mis los ntawm lub mis, txhawb nqa cov leeg ua ke ntawm cov menyuam yaus du, thiab txhawb nqa niam hlub. Ib qho ntxiv, nws kuj tseem tuaj yeem txo qis cov tshuaj hormones ntxhov siab xws li cov adrenal ketrium hauv tib neeg lub cev, yog li txo cov ntshav siab. Nws tsis yog tshwj xeeb rau cov poj niam, leej txiv neej thiab poj niam tuaj yeem tso nws.
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Tshuaj Cov Qauv |
C43H66N12O12S2 |
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Muaj pes tsawg leej |
1006 |
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Molecular hnyav |
1007 |
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m/z |
1006 (100.0%), 1007 (46.5%), 1008 (10.6%), 1008 (9.0%), 1007 (4.4%), 1009 (4.2%), 1008 (2.5%), 1008 (2.1%), 1007 (1.6%), 1009 (1.1%) |
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Kev Ntsuam Xyuas |
C, 51.28; H, 6.61; N, 16.69; O, 19.06; S, 6.37 |
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Cov kauj ruam hauv qab no yog cov ncauj lus kom ntxaws rau cov hluavtaws muaj peev xwm ntawmOxytocin Hmoov:
1. Khoom cua ntawm 7 {{{{- peptideute amide (3-9 ntu) los ntawm benzyloxalyloryl leucine P-nitrophenyfylen
1>Siv Benzylycarboryl leucine p - nitrophylyl eser (1) yog tau los ntawm cov kua qaub catalyzed tso tawm Benzyloxy pawg.
2>Compound (2) tau kho nrog chloroform thiab potassium carbonate kom tau txais cov khoom sib txuas tag nrho (3).
3>Kho cov compound (3) nrog rau cov dej ammonia, kho cov pH rau 8-}}}}}}}}}}}}
4>Dissolve compound (4) nyob rau hauv dilute hydrochloric acid, ntxiv sodium hydroxide kom tsa lub ph ntawm cov kev daws teeb meem rau 8-9, thiab hydryzing compound (4) kom tau txais compound (5).
5>Dissolve cov compound (5) hauv kev tshem tawm Naoh daws, ntxiv hydrochloric acid los tsa cov kev daws teeb meem rau 8-9, thiab hydryzing compound (5) kom tau txais cov compound (6).
6>Dissolve compound (6) nyob rau hauv ib tug durute nao tov, ntxiv hydrochloric acid los tsa cov kev daws teeb meem rau 8-9, thiab hydryzing compound (6) kom tau txais 7-peptide txoj cai.
2. Synthesis ntawm Benzylolycarbonyl - s benzylenleine · Tyzylaline (1-2 theem)
1>Do CBZ SE (t - bu) {{{2 {{{{{{2} Nyob rau hauv ib tug met4) {{2} -3-BenzyloxCarborianino-4-phenylalanine methyl ester (2) kom hnov mob nrog benzylmagnesium bromide kom tau cov khoom (3).
2>Reflux nyob rau hauv n, n- dimetylformamide muaj triethylorophenyl)} {}}}}}}}}}}}}}}}} {{9- n- (2,5 -}}} Alanine Methanesulfonate (5).
3>Reflux nyob rau hauv n, n- dimethylformamide muaj triethylorophine kom hnov mob (r)}
4>Reflux nyob rau hauv n, n- dimetylformamide muaj triethylorophenfonate (5) nrog benzyl magnesium bromide kom tau cov khoom (7).
5>Reflux nyob rau hauv n, n - dimethylformamide muaj triethylamine rau reaser cov khoom (7) nrog cov khoom siv trifluoroacetic kom tau txais cov khoom (8).
6>Reflux nyob rau hauv n, n - dimethylformamide muaj triethylamine kom hnov cov khoom (8) nrog sodium Azide kom tau txais cov khoom (9).
7>Reflux nyob rau hauv n, n- dimetylformamide muaj triethylamine kom hnov cov khoom (9) nrog hydrau hydrate kom tau txais cov khoom (10).
3. Khoom cua oxytocin
Reflux lub 7 {{{- peptideutionly ide (3-9 ntu)
Cov kauj ruam saum toj no tsuas yog ib txoj kev ua tau, tsis yog tus tsuas. Thaum cov txheej txheem kev siv tshwj xeeb, kev kho kom haum yuav tau ua raws li cov lus xws li kev kuaj mob, khoom siv, thiab muaj peev xwm muaj. Ib qho ntxiv, qee qhov kev ntsuas kev nyab xeeb thiab kev pheej hmoo yuav tsum tau ua rau lub sijhawm no txhawm rau paub txog qhov kev sim ntawm kev sim thiab kev ntseeg tau ntawm cov txiaj ntsig ntawm cov txiaj ntsig.
Daim Ntawv Thov Keeb Kwm:
Txij li xyoo 1911, Oxytocin tau siv hauv tsev kho mob los kho lub zog qeeb.
Xyoo 1927, nws tau siv los ntxias kev ua haujlwm, tab sis oxytocin los ntawm cov chaw nyob tau me me thiab kim.
Xyoo 1953, Asmeskas Biochemist Vincent Duvinho synthesized nws thawj zaug thiab yeej lub Nobel nqi zog xyoo 1955.
Tus qauv tshuaj:
Cov qauv tshuaj kho mob ntawm Oxytocin hauv tib neeg thiab cov tsiaj feem ntau yog raws li hauv qab no:
Cysteine tyrosine isoleucine glutamine aspartate cysteine proline leucine glycine nh2
Tus qauv ntawm Oxytocin yog qhov zoo heev rau qhov ntawd ntawm Antidiuretic Hormone (Cysteine Tyrosine Phenyylalanine Glarteine Proline Proline Proline Proline Proline Proline Glycine NH2).
Cov teebmeem Physiological:
(1) Cov nyhuv ntawm Mammary caj pas: Lactating Mammary caj pas Nrig tsis pub lwm tus neeg nyob rau hauv qhov kev txiav txim siab ntawm polactin thiab cov khw muag khoom hauv cov caj pas acini.Oxytocin Hmoovtuaj yeem ua rau myoepithelial hlwb nyob ib ncig ntawm Mascary Gland Acinus cog lus, thiab txhawb nqa cov kaus mom mammary nrog lactation ua haujlwm rau cov mis nyuj.
(2) Cov nyhuv rau lub tsev menyuam: Oxytocin muaj cov ntawv pov thawj zoo txhawb nqa rau lub tsev menyuam, tab sis lub cev xeeb tub yog rhiab. Cov tshuaj estrogen tuaj yeem nce qhov rhiab heev ntawm lub tsev menyuam mus rau oxytocin, thaum progesterone yog rov qab.
(3) Cov nyhuv ntawm kev txaj muag thiab kev tsis paub meej: Oxytocin tuaj yeem pab cov neeg uas tsis quav ntsej hauv kev sib raug zoo los kov yeej kev txaj muag. Tab sis oxytocin cov tshuaj tsuag oxytocin tsis ua haujlwm rau cov neeg uas twb ntseeg siab heev.
(4) Thaum koj muaj kev zoo siab lossis muaj lub siab muaj zog ntawm cov, hypothalamus synthesizin secretes oxytocin, thiab kev ntxhov siab kuj tau txais kev ntxhov siab. Nyob rau tib lub sijhawm, cov pa oxygen hauv lub cev nce ntau heev.
Lub luag hauj lwm tshwj xeeb:
Cuam tshuam rau kev sib raug zoo ntawm tus menyuam thiab leej niam
Qee qhov kev sim tau pom tias cov neeg uas tau tsim txoj kev sib raug zoo txuas nrog lawv hauv kev me nyuam yuav dhau los ua kev saib xyuas thiab txiav txim siab tom qab siv oxytocin; Txawm li cas los xij, rau cov neeg uas tsis pom zoo rau lawv cov niam hauv kev yug me nyuam, oxytocin sib sib zog nqus lawv cov kev nco tsis zoo.
Cov Kev Cai Tswj Secition:
Oxytocin tso zais pa taws yog feem ntau tswj hwm los ntawm neuroreflex. Thaum tus menyuam nqus lub txiv mis, cov ntaub ntawv kev txhawb nqa tau kis rau cov kev zais cia thiab ua rau muaj kev zais cia thiab ua rau lub ejaculation Ntawm lub hauv paus no, ib qho txias reflex tuaj yeem tsim, thiab tus menyuam quaj lossis kov tuaj yeem ua rau mis mos.
Thaum lub sij hawm ua zog, ncauj tsev menyuam thiab rub tawm thiab rub, uas tuaj yeem hloov kho oxytocin zais, uas muaj txiaj ntsig rau kev ua haujlwm. Oxytocin tuaj yeem txhawb kev txhawb nqa uterine, tab sis nws tsis yog qhov txiav txim siab txiav txim siab los pib uterine motion thaum lub sijhawm ua haujlwm. Tsis tas li ntawd, kev xav txog kev xav xws li kev ntshai thiab ntxhov siab tuaj yeem tiv thaiv oxytocin zais cia.
Cov qhov tseem ceeb ntawm kev hloov kho oxtrs
Kev sib hloov ntawm Oxtr (Oxytocin receptor) gene muaj kev cuam tshuam tseem ceeb. Los ntawm kev cuam tshuam kev ua haujlwm ntawm Oxytocin system, nws yog ze ze rau ntau yam neurological thiab kev mob hlwb nrog rau kev coj tus cwj pwm txawv txav. Cov kev ntsuas hauv qab no yog ua los ntawm peb yam: Koom xwm kab mob, kev coj cwj pwm, thiab kev kho mob.
Koom haum ntawm Oxtr hloov pauv thiab neuro -} psychodic tsis sib haum
Tsi hais lus spectrum tsis meej (asd)
Ntau cov kev tshawb fawb tau qhia tias Oxtr cov noob sib hloov yog qhov tseem ceeb rau kev ntseeg. Piv txwv li, cov polymorphisms ntawm Rs53576 thiab Rs2254298 Loci muaj feem xyuam nrog cov kev cuam tshuam tseem ceeb xws li kev coj tus cwj pwm thiab kev rov ua dua hauv cov neeg mob auticts. Cov kev sim tsiaj tau pom tias cov oxtrouts mice kev tshawb nrhiav hauv cov neeg mob auticistic nyob rau hauv qee thaj tsam ntawm lub hlwb yog txawv txav. Cov kev tshawb pom no qhia txog cov kev hloov tsheb khiav tawm Oxyr daws teeb meem
Schizophrenia thiab kev nyuaj siab
Oxtr hloov pauv kuj tseem cuam tshuam nrog cov tsos mob tsis zoo ntawm schizophrenia (xws li apathy (xws li kev tshem tawm ntawm kev ntxhov siab) thiab kev pheej hmoo ntawm kev nyuaj siab. Piv txwv li, qee yam Oxtr ib as nucleotide polymorphisms (snps) tej zaum yuav txo tau cov kev khi rau cov neeg ua haujlwm oxytocin, ua rau kev xav txog kev sib koom kev cai. Tsis tas li ntawd, cov qib Oxytocin hauv Cerebrospinal FRIDE cov neeg mob qis dua thaum hmo ntuj, ntxiv txhawb lub luag haujlwm ntawm OxTtr system nyob rau hauv kev xav ruaj khov.
Ntxhov siab vim muaj kev ntxhov siab
Oxytocin exerts ib anti - Ntxhov siab los ntawm inhibiting-}}}}}}}}} Lub Cev Anterior Cones Cortex (ACC) ntawm lub hlwb. Oxtr Gravations yuav ua rau cov tshuab hluav taws xob tsis muaj zog no, nce tus neeg mob siab rau mob mob ntev ntev {}}} kev ntxhov siab ntxhov siab (gad). Cov kev tshawb fawb soj ntsuam tau pom tias cov tib neeg muaj kev ntxhov siab qib qis uas cov neeg muaj kev ntxhov siab oxytocin vim yog vim muaj teeb meem oxytocin.
Kev coj txawv txav thiab kev sib raug zoo tshwm sim los ntawm oxtr hloov
Kev hloov pauv hloov pauv thiab kev zam kev sib raug zoo
OXTR cov kev sib hloov yuav ua rau muaj kev sib cav sib ceg, ua rau pom kev nyuaj siab, tsis muaj kev hlub tshua ntawm lub cev lossis tus cwj pwm sib chwv. Piv txwv li, cov tib neeg nqa tus -}}}}}}}}}}} ecele gene yuav muaj qhov txawv txav ntawm kev coj cwj pwm xws li khawm, nrog cov kev hloov pauv. Qhov kev coj cwj pwm no yuav raug pom tias yog huab kev qia dub heev thiab tsis quav ntsej rau lwm tus neeg txoj kev sib deev, muaj ntau dua kev pheej hmoo ntawm kev ua phem hauv tsev.
Kev sib cuam tshuam ntawm poj niam txiv neej thiab lub neej thaum ntxov
Cov kev tshawb fawb pom tau tias kev sib cuam tshuam ntawm Oxtr hloov thiab muaj kev ntxhov siab thaum ntxov thiab tsis saib xyuas menyuam yaus) yuav muaj teeb meem kev coj cwj pwm thaum yau Piv txwv li, poj niam oxtr mution yuav qhia kev pheej hmoo siab dua kev nyuaj siab thiab ntxhov siab hauv ib cheeb tsam muaj kev ntxhov siab, thaum cov txiv neej tej zaum yog tus cwj pwm tsis sib haum. Qhov sib txawv no yuav cuam tshuam nrog cov kev tswj hwm lub luag haujlwm ntawm Oxytocin nyob rau hauv poj niam txiv neej- txoj kev coj tus cwj pwm tshwj xeeb.
Cov kev sib tw thiab daws cov tswv yim hauv kev kho mob
Qhov sib txawv hauv cov lus teb Oxytocin
Txawm hais tias qhov ntswg ntawm cov thawj coj ntawm Oxytocin tau ua pov thawj rau cov tsos mob ntawm tus neeg mob tsis zoo, thiab lwm yam, Oxtr hloov pauv yuav ua rau Oxytocin hauv cov tib neeg. Piv txwv li, qee tus neeg mob auticts yuav tsis teb rau oxytocin kev kho vim yog cov xim oxtring ntawm lub receptor mus rau oxytocin lossis teeb liab transduction. Qhov no qhia kom pom tias kev soj ntsuam caj ces yuav dhau los ua qhov tseem ceeb ntawm kev kuaj xyuas cov neeg uas yuav tau txais txiaj ntsig los ntawm kev kho oxytocin.
Precision tshuaj thiab tus tswj hwm tus kheej
Rau cov tib neeg nrog Oxtr hloov, cov tswv yim kho mob yuav tsum tau tsim kho. Piv txwv li, los ntawm Gene Editing Technology los kho cov kev hloov pauv, lossis tsim cov neeg laus Oxtr tshiab los txhim kho cov teeb liab transdal. Ib qho ntxiv, ua ke cov profiles cov profiles thiab kev ua haujlwm kom ua haujlwm ntawm oxytocin, txhim kho kev txhim kho kev ua tau zoo thiab txo cov kev mob tshwm sim.
Kev Kho Mob Multalisodal Kev Kho Mob
Rau cov teeb meem kev coj cwj pwm nyuaj los ntawm oxtr hloov, kev kho tshuaj yuav tsis muaj kev cuam tshuam. Kev coj tus cwj pwm kev coj cwj pwm zoo, kev cob qhia kev txawj ntse, thiab ib puag ncig kev cuam tshuam tej zaum yuav ua tau zoo dua rau kev txhim kho cov neeg mob txoj haujlwm. Piv txwv li, hais txog Oxtr Mutation nyob rau hauv cov tib neeg uas muaj autism kev kho mob thiab kev kho tus cwj pwm kev txawj ntse tuaj yeem ua haujlwm txhim kho lawv cov kev sib raug zoo.
Cim npe nrov: Oxytocin Hmoov CAS 50-56, cov neeg muag khoom, chaw tsim khoom, Hoobkas, lag luam wholesale, yuav, nqe, loj, loj, rau muag