Shaanxi Bloom Tech Co., Ltd. yog ib qho ntawm cov neeg tsim khoom lag luam thiab cov khoom lag luam ntawm cov tub lag luam hydrochloride CAS 51-05-8 nyob hauv Suav teb. Txais tos rau kev lag luam wholesale loj zoo probotide CAS 51-05-8 Kev muag khoom ntawm no los ntawm peb lub hoobkas. Cov kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Caraine Hydrochloride CAS 51-05-8tuaj yeem siv los ua cov khoom siv raw, cov khoom siv tshuaj lom neeg hauv chav kuaj. Nws yog qhov sib luag ruaj khov ntsev, feem ntau yog cov hmoov dawb huv, hmoov dawb lossis xim tsis muaj crystal. Nws cov xim yog feem ntau cuam tshuam los ntawm cov tshuaj purity thiab ntau lawm cov txheej txheem. Lub solubility hauv dej yog heev. Nws kuj tseem tuaj yeem ua kom yaj lossis tawg hauv qee cov kuab tshuaj organic, xws li ethanol, ether, thiab benzene. Lub ntsiab lus melting ntawm yog 154-158 degree. Qhov taw tes melting no tuaj yeem siv ua ib qho ntawm cov qauv rau kev kuaj xyuas nws cov khoom zoo. Nws yog ib qho kev ua kom zoo nkauj. Nws tuaj yeem khaws cia rau hauv chav tsev kub. Nws tseem tuaj yeem tiv taus oxidation hauv huab cua thiab tsis cuam tshuam los ntawm lub teeb.
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Tshuaj Cov Qauv |
C13h2cln2o2 |
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Muaj pes tsawg leej |
272.13 |
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Molecular hnyav |
272.77 |
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m/z |
272.13 (100.0%), 274.13 (32.0%), 273.13 (14.1%), 275.13 (4.5%) |
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Kev Ntsuam Xyuas |
C, 57.24; H, 7.76; Cl, 13.00; N, 10.27; O, 11.73 |
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Nws yog tshuaj loog hauv zos thiab tseem siv los ua ib qho dhau - {1} {1} {1} {1} {1} {1} {1} {1} {1}- Kev Ntsuas Mob Me Me, xws li mob hniav. Nws yog dav siv nyob rau hauv kev lag luam kho mob vim tias nws yog kev nyab xeeb thiab ua tau zoo hauv cheeb tsam. Ntawm no peb yuav tham txog ntau txoj hauv kev rau synthesizing nws.
1. Cov kev tawm tsam ntawm para aminobenzoic acid (Kaba) thiab Diethylamine ether
Qhov kawg kev npaj cov khoom lag luam yog txhawm rau txhawm rau txhawm rau kab ntsig xov tooj thiab diethylamine ua kom tiav cov khoom ua haujlwm hauv Alkaline. Cov qauv no tau pom los ntawm Ernest Fourneau thiab Pierre Refain xyoo 1905.
Firstly yog acidrifated nrog cov sulfuric acid los tsim cov kev coj mus sib luag nrog ethinediamine nyob rau hauv qhov kev txiav txim ntawm sodium hydroxide los ua ib lub hauv paus. Thaum kawg, tus painte puag yog neutralized nrog hydrochloric acid daws tau rau cov khoom.
2. Cov tshuaj tiv thaiv ntawm protamamide thiab paba
Printamide yog cov tshuaj tshaj lij ntawm cov tshuaj muaj txiaj ntsig los ntawm sulfation kev tshwm sim ntawm procaine. Therefore, procaine reacts with p-Toluenesulfonic acid and H2SO4 to produce procaine mide methylated at position 14, and reacts with PABA to produce HCL salt.
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Ntshiab API (nquag tshawb xyuas cov khoom xyaw) rau kev tshawb fawb txog kev tshawb fawb nkaus xwb, kev tshawb xyuas cov tshuaj, kev kuaj tshuaj ua tshuaj, cov receptor tiv thaiv thiab lwm yam.Caraine hydrochloride, white crystalline or crystalline powder is local anesthetic with strong effect but less toxicity and short time-effective. Cov chaw kho mob feem ntau yog sivLub HCRaine HCL, Tus Hnyav HCLAse HCL HmoovRau infiltration antesthatesia thiab conduction antesthesia. Vim tias nws cov kev tsis zoo, nws feem ntau tsis siv rau kev ua kom loog ntev.
Cov cuab yeej siv tshuaj:
(a) stability:
Nws tuaj yeem khaws cia rau hauv chav sov thiab siab. Txawm li cas los xij, nws yuav hloov xim, decompose, thiab poob nws cov yam ntxwv hauv tshav ntuj thiab huab cua.
(b) solubility:
Nws yog yooj yim soluble hauv dej thiab muaj volatility tsis tshua muaj. Nws kuj tseem tuaj yeem ua rau soluble hauv qee cov kuab tshuaj organic xws li Methanol thiab ethanol. Thaum lub solubility yog 25 degree, muaj 8.8g ntawm cov khoom hauv txhua 100ml dej.
(c) PHEEJ:
Cov aqueous kev daws teeb meem yog cov qaug zog acidic, nrog tus nqi ntawm tus nqi ntawm kwv yees li 3.0-5.0.
(d) oxidation -} kev txo cov khoom:
Nws zoo li lub xub ntiag ntawm cov nroog xws li fe 3+ thiab cu {} Nws tseem tuaj yeem ua ib qho tshuaj tsw qab ntawm alkaline los ua ib qho tshuaj yeeb.
(e) dilution:
Qhov kev ua kom muaj kev phom sij maj mam nce, tab sis nws tsis tuaj yeem rhuav tshem.
(f) alkalinity:
Nws tsis muaj zog acidic thiab tuaj yeem decompose rau hauv hydrogen ions thiab ruaj khov hydrochloric acid molecules nrog sib npaug moles.
(g) tsis khov:
Nws muaj cov cai nruj yuav tsum muaj kev ruaj khov. Nws yuav tsum muab khaws cia rau hauv ib lub cim, noo - Cov ntaub ntawv pov thawj, thiab kev sib cuag nrog cov kuab tshuaj alkaline, thiab oxidants.
kuaj xyuas
Acidity:
Noj 0.40g ntawm cov khoom no, yaj nws nyob rau hauv 10ml dej, thiab ntxiv 1 tee methyl liab qhov ntsuas kev daws teeb meem. Yog tias nws hloov xim liab, ntxiv 0.20ml ntawm sodium hydroxide sterrant (0.02mol / l), thiab lub lim yuav tig txiv kab ntxwv.
Clarity ntawm kev daws:
Nqa 2.0g ntawm cov khoom no thiab yaj nws hauv 10ml dej. Kev daws yuav tsum muaj tseeb.
Aminobenzhoic acid:
Txiav txim siab los ntawm high - Kev ua kua chromatography (txoj cai dav dav 0512).
Ntsuas cov lus:
Siv cov khoom no, ntsuas nws raug, yaj nws hauv dej, thiab ua rau nws ntau tau los npaj kev daws teeb meem uas muaj 0.2mg ib 1mL.
Kev daws teeb meem:
Nqa cov nyiaj uas tsim nyog
Cov Txheej Txheem Kev Siv:
Nqa 1ML ntawm kev ntsuas daws thiab 9ML ntawm cov kev daws teeb meem, sib xyaw kom zoo.
Kev Ntsuas Txuj Ci:
Kev ntsuas ntsuas qhov ntsuas daws thiab tswj cov kev daws teeb meem, tshuaj tiv thaiv lawv mus rau hauv cov kua chromatograph cais, thiab sau cov chromatogram.
Lub cev yuag yuag:
Nqa cov khoom no thiab qhuav nws ntawm 105℃C txog qhov hnyav tas li, nrog txoj cai yuag tsis pub dhau 0.5% (cov cai dav dav 0831).
Hlawv Cov Khoom Noj:
Siv 1.0g ntawm cov khoom no thiab xyuas raws li Txoj Cai Kev Cai (cov cai dav dav 0841). Cov seem uas tsis pub dhau 0.1%.
Txwv:
Yog tias muaj chromatographic peaks nyob rau hauv cov chromatogram ntawm cov kev ntsuas ntsuas uas muaj tib lub sijhawm khaws cia, lub ntsej muag tshaj plaws yuav tsum tsis pub tshaj 0.5%, suav raws li tus qauv sab nraud.
24H Kev Pab Online
Convente Posuere Morbi urna Molestie keeb Pulvinar Odio ESIAM.
Ntiaj Teb Shipping
Urna condimentum mattis pellentesque nibh. Integer Vitae Meso Eget Magna
Chromatographic mob:
Octadecylsilane sib khi ua silica gel tau siv los ua tus muab tub lim, thiab 0.05Mol / L Potassium DiSulor) {}} methanol (68:32) tau siv raws li mobile theem. Kev nrhiav hluav taws xob yog 279nm, thiab kev txhaj tshuaj ntim yog 10 μ L.
Qhov system haum yuav tsum muaj:
Nyob rau hauv lub chromatogram ntawm lub kaw lus haum kev daws teeb meem, cov phiaj xwm theoretical tsis muaj tsawg dua 2000, thiab kev sib cais ntawm lub ncov siab thiab lub ntsej muag muaj acid tsawg dua 2.0.
Cov Ntsev Ntsev:
Coj cov seem tso rau hauv qab qhov chaw nres tsheb tseem ceeb, ntxiv 2ml ntawm cov kev tswj dej, thiab kos raws li cov dej tsis sib xws, thiab kos rau ntawm cov dej hlau ua kua, nws yuav tsum tsis txhob ntxaum (0.001%).
Caraine hydrochlorideBelongs rau ester cov tshuaj loog hauv zos, uas muaj tshuaj loog hauv zos, anti {{ Nws yog tsuas yog siv hauv kev sim tshuaj rau Infiltration Actionhesia, thaiv tshuaj loog, lumbar txha caj qaum, thiab lwm yam.
Toding mus rau ester Hauv Zej Zog Kev Ntsuas Hauv Nroog, nws muaj qhov ua kom zoo nrawm thiab muaj cov nyhuv thaiv ntawm cov leeg ntswg hauv ntau qhov chaw. Yog li ntawd, nws yog feem ntau siv hauv kev tshawb nrhiav kev Infiltration Actionhesia, kev ua kom lub loog, tus txha caj qaum, thiab lwm yam.
Toding mus rau ester Hauv Zej Zog Kev Ntsuas Hauv Zos, nws muaj anti {{{incammatory cuam tshuam thiab tuaj yeem thaiv cov tshuaj tiv thaiv. Nws yog feem ntau siv tau daws cov tsos mob xws li mob hniav, mob taub hau, neuralgia, thiab mob pob txha qhov mob.
Nws tseem muaj cov kev cuam tshuam tiv thaiv rheumatic cuam tshuam, uas tuaj yeem cuam tshuam cov tsos mob hauv tus neeg mob lub cev, yog li kev mob sib koom tes xws li mob pob txha caj dab.
Nws tuaj yeem ncaj qha rau ntawm cov leeg ntshav, ua kom cov ntshav tawm los kho cov kab mob khaus thiab mob taub hau cereblovascular, thiab kab mob percarasal, thiab lwm yam ntshav, thiab lwm yam ntshav, thiab lwm yam ntshav, thiab lwm yam ntshav, thiab lwm yam ntshav, thiab lwm yam ntshav, thiab lwm yam ntshav, thiab lwm yam ntshav, thiab lwm yam ntshav, thiab lwm yam ntshav, thiab lwm yam ntshav, thiab lwm yam ntshav, thiab lwm yam ntshav, thiab lwm yam ntshav, thiab lwm yam ntshav, thiab lwm yam ntshav, thiab lwm yam ntshav, thiab lwm yam ntshav
Nws tseem muaj cov nyhuv tiv thaiv arrhythmic, uas tuaj yeem cuam tshuam lub nruab nrab ntawm cov leeg ntshav thiab daws cov tsos mob caj dab, thiab kiv taub hau los ntawm arrhythmia.
Nws yuav tsum raug sau tseg tias cov tshuaj saum toj no yuav tsum tau siv nyob rau hauv tus kws kho mob thiab yuav tsum tsis txhob siv dig muag rau kev tsis txaus siab thiab kev puas tsuaj rau lub cev. Tsis tas li ntawd, nws yuav tsum yog contraindicated rau cov neeg mob loog hauv zos ua xua, nplooj siab thiab raum tsis sib xws, thiab lwm yam.
Caraine hydrochloride, raws li ib qho kev ua yeeb yam classic actesthetic, muaj cov txheej txheem thiab meej meej ntawm kev ua ntau yam kev cuam tshuam nrog ntau lub cev thiab kev sib txuas lus molecular.
Raws li qhov ester foresthetic, nws cov nyhuv tshuaj loog hauv zos yog tsuas yog ua tiav los ntawm kev thaiv cov conduction ntawm cov hlab ntsha conduction. Cov txheej txheem tshwj xeeb yog raws li hauv qab no:
(1) Memonal Membrane nkag mus: Gradaine molecules cia siab rau eliffuse gradients los ntawm neuronal membrane, uas yog thawj kauj ruam hauv lawv cov nyhuv tshuaj loog.
(2) Sodium ion channel blockade: Tom qab nkag mus rau cov leeg hlab ntsha Sodium ions yog qhov tseem ceeb ions rau tiam thiab kev tshaj tawm ntawm kev ua kom muaj kev ntxhov siab ntawm cov hlab ntsha thiab qhov tsis muaj peev xwm thiab kev coj ua.
(3) Cov ntaub ntawv kis tau: raws li cov paj hlwb thiab kev tawm tsam ntawm cov hlab ntshav ntawm sodium ion channel, ua tiav cov txiaj ntsig tshuaj loog hauv cheeb tsam.
Central Ntshav Qhov Cuam Tshuam
Qhov cuam tshuam rau hauv nruab nrab cov leeg ntshav yog ze rau kev noj tshuaj haus, tshwj xeeb yog:
(1) Inhibition nyhuv: ntawm cov tshuaj tiv thaiv kab mob, propaine tsuas yog txo qis inhibitos cuam tshuam ntawm lub nruab nrab ntawm cov leeg ntshav. Cov neeg mob tuaj yeem ua kom muaj kev poob qis, nce qhov ntsuas qhov pib, thiab txawm tias coma lossis coma. Lub chaw inhibitia cov nyhuv no pab kom cov neeg mob ntxhov siab thiab mob, thiab txhim kho kev nplij siab lossis kev kho mob.
(2) Cov nyhuv zoo: Nrog rau kev nce tshuaj noj, cov nyhuv ntawm procaine ntawm lub plawv nruab nrab yuav maj mam tsis muaj zog, thiab txawm hloov mus rau qhov kev ntxhov siab. Cov neeg mob tuaj yeem paub cov lus hais txog kev zoo siab, Mania, thiab muaj cov xwm txheej hnyav, tej zaum yuav ua rau muaj kev tawm tsam zoo li qaug dab peg. Yog li ntawd, thaum siv cov txiv neej, cov nqi yuav tsum tau nruj me ntsis kom tsis txhob siv ntau dhau.
Qhov cuam tshuam rau cov hlab plawv kuj cuam tshuam nrog kev noj tshuaj ntau npaum li cas ntawm cov tshuaj, tshwj xeeb yog:
(1) hloov pauv ntawm lub plawv dhia thiab ntshav siab: Yuav tsim kom muaj kev mob siab rau lub siab xav, ua rau muaj kev nce siab thiab ntshav siab. Txawm li cas los xij, raws li cov tshuaj noj muaj txiaj ntsig ntau, nws yuav txwv tsis pub muaj kev sib tw ua ke, ua rau txo cov ntshav siab. Qhov no nyuaj - teb cov kws kho mob yuav tsum saib xyuas cov neeg mob lub plawv dhia thaum siv cov npawg.
(2) Antiarrhythhiav cov nyhuv: nws tseem muaj cov nyhuv Antiarrhythmic. Nws tuaj yeem txo qhov tshwm sim ntawm arrhythmia los ntawm kev thaiv cov kev sib kis ntawm cov hlab ntsha impulses thiab inhibiting qhov kev txaus siab ntawm mousitabial cell. Txawm li cas los xij, txoj haujlwm no yuav tsum tau siv rau kev coj tus kws kho mob hauv tus kws kho mob kom zam dhau qhov tshwm sim ntawm kev tsis zoo.
Neuromuscular blockade effect
Kev sib tw inhibition ntawm acetylcholine receptors ntawm lub cev muaj zog ua rau muaj kev sib kis ntawm cov hlab ntsha ntawm cov hlab ntsha Cov nyhuv no pab txo cov leeg nruj thiab qhov mob thaum phais mob, thiab txhim kho qhov kev phais mob sminness. Txawm li cas los xij, nws yuav tsum tau sau tseg tias cov neuromuscular thaiv cov nyhuv ntawm cov nqaij tsis muaj zog lossis tuag tes tuag taw kev hloov pauv ntawm cov leeg ua haujlwm thaum siv.
Cov tshuaj tiv thaiv tsis zoo
Caraine hydrochloride, raws li tus qauv eter ester hauv zos anesthetic, tau siv dav hauv Infiltration Tshuaj loog, thiab Epidural kev ua yeeb yam thaum pib ua haujlwm 20 xyoo. Txawm li cas los xij, cov nyom uas yuav tshwm sim thaum nws siv tau ntau yam xws li cov hlab plawv, ua pa hauv nruab nrab, cov pa taws plab, thiab kev ua xua.
Cov tshuaj tiv thaiv kab mob plawv tsis zoo
Kho Mob Ua Haujlwm
Arrhythmia: ProCaine hydrochloride tuaj yeem ua rau Sinus Tachycardia, Atrolular ua ntej Beats, thiab txawm Ventricular Tachycardia. Cov ntaub ntawv kuaj mob qhia tau tias qhov tshwm sim ntawm Arthythmia hauv epidgural kev ua kom zoo nkauj yog li 2%, uas muaj ntau dua thaum cov tswj hwm nrawm nrawm lossis cov nqi ntau heev.
Ntshav siab hloov pauv: Qee tus neeg mob yuav muaj kev hypotension transient lossis kub siab. Cov kev hypotension feem ntau tshwm sim los ntawm vasodilation lossis myocardial inhibition, thaum kev kub siab tuaj yeem cuam tshuam nrog cov kev xav paub txog kev xav paub lossis kev mob siab.
Ntsej muag flushing: txog 10% -15% ntawm cov neeg mob lub ntsej muag rov qab tom qab txhaj tshuaj, uas yog qhov ua rau cov ntshav tawm lossis ua rau cov histamine tso tawm.
Mechanism ntawm qhov tshwm sim
Sodium channel blockade: fydaine hydrochloride inhibels nyob rau hauv myochlorial cells - sawv thiab qeeb qeeb, uas yuav ua rau rov qab reedrant arhythmia.
Calcium cov kev cuam tshuam: kev ua kom muaj ntau cov tshuaj tuaj yeem txwv tsis pub muaj, txo cov kev ua haujlwm hauv cov tshuaj calcium calcium, thiab ua rau mob siab.
Cov Kev Tso Tawm Tawm Tsam: Eser Hauv Cheeb Tsam Kev Ntsuas Hauv Cheeb Tsam tuaj yeem yooj yim Cov Kev Tso Tawm, ua rau muaj kev cuam tshuam nrog hluav taws xob, ua rau cov kab mob uas muaj kev sib xyaw thiab hypotension.
Kev tiv thaiv kev ntsuas
Tswj Xyuas Kev Tswj Xyuas Ceev: Thaum Infiltration Actionhesia, 0.25% -0.5% daws tsis pub tshaj 1.5g toj ib teev; Thaum lub sij hawm thaiv kev ua kom loog, qhov 1% -2% kev daws teeb meem yuav tsum tsis pub tshaj 1.0g ib teev.
Saib xyuas cov cim tseem ceeb: txuas ntxiv saib xyuas hluav taws xob thiab cov ntshav siab thaum phais mob kom pom kev sai sai.
Zam txhob nkag mus rau cov hlab ntsha los ntawm kev yuam kev: Rub rov qab ua ntej txhaj tshuaj kom paub tseeb tias koob tsis nyob hauv cov hlab ntsha tsis nyob hauv cov hlab ntsha thiab txo cov hlab ntsha.
Central Ntshav Qhov Kev Ruaj Ntseg
Kho Mob Ua Haujlwm
Kev zam txim siab: Cov tsos mob thaum ntxov, tinnitus, kiv cua, cov leeg tshee, thiab txawm tias epileptic qaug dab peg yuav tshwm sim. Qhov tshwm sim tshwm sim yog hais txog 0.1% -0.5%, uas muaj ntau dua thaum cov tshuaj hauv ntshav ntau tshaj 5 μ G / ML.
Central inhibition: tsawg tsawg ntawm cov neeg mob yuav muaj kev mob siab rau thiab muaj feem cuam tshuam nrog ncaj qha inhibition ntawm central system los ntawm cov tshuaj.
Neurotoxicity: Lub sij hawm ntev lossis ntau dhau yuav ua rau peripheral neuropathy, manifested as sensory tsis zoo lossis muaj zog tsawg dua.
Mechanism ntawm qhov tshwm sim
Cov ntshav lub hlwb lub hlwb
Gamma aminobutyric acid (gaba) receptor inhibition: yuav inhibit gaba recepride ion Incluct, thiab txo cov neuronal inhibition.
Kev ntxiv ntawm cov metabolites: cov metabolites xws li para aminobenzoic acid (kabla) yuav muaj neurotoxicity, tshwj xeeb tshaj yog thaum muaj kev sib sau ua ke ntawm daim siab ua haujlwm tsis sib xws.
Kev tiv thaiv kev ntsuas
Kev tswj cov tshuaj: yuav tsum tsis pub tshaj 1.0G, tau suav raws li lub cev hnyav, thiab kev txhaj tshuaj hauv zos yuav tsum tsis pub tshaj 20mg ib kg.
Kev zam kev tshaib nqhis: cov neeg mob uas muaj kev tshaib plab yog ntau dua cov tshuaj lom thiab tsis zoo ua ntej.
Npaj cov khoom siv thaum muaj xwm ceev: xws li diazepam (xws li diazepam) thiab sodium thiopin thiopawv muaj nyob rau hauv txoj kev ua haujlwm los tswj kev qaug dab peg epileptic.
Cim npe nrov: Caraine Hydrochloride CAS 51-05-8, cov neeg muag khoom, chaw tsim khoom, chaw tsim khoom, lag luam, yuav, nqe, loj, rau muag