Ntshiab Candline HmoovPuas yog nitrogen -} muaj cov kua mis acid nrog cov tshuaj mis c4h9n3o2. Nws yog cov kua xim daj. Hauv Biochemistry, nws yog nitrogen - muaj cov egurbrates thiab tuaj yeem pab muab lub zog rau cov leeg nqaij thiab cov hlab ntsha. Michel Eug è ne chevreul thawj pom corsine hauv cov leeg pob txha hauv 1832, thiab tom qab ntawd yog nws "Creatine" raws li cov lus Greek "Kreas" (nqaij). Creatine yog tam sim no hauv cov zaub mov xws li ntses thiab nqaij, tab sis nws cov ntsiab lus yog tsawg heev (ib nrab ib phaus nqaij tsuas yog muab 1 gram ntawm creatine). Ib qho kev ua si endogenous amino acid metabolite uas ua lub luag haujlwm tseem ceeb hauv lub zog ntawm tes, tshwj xeeb tshaj yog nyob rau hauv cov leeg thiab lub hlwb. Nws tuaj yeem muab lub zog sai heev (ntau yam kev ua si ntawm tib neeg lub cev cia siab rau ATP, uas yog kev qoj ib ce, thiab muaj zog ntawm kev tawm dag zog, thiab muaj zog ntawm kev tawm dag zog, thiab muaj zog ntawm kev tawm dag zog, thiab muaj zog ntawm kev tawm dag zog, thiab muaj zog ntawm kev tawm dag zog, thiab lub zog tuaj yeem ua hluavtaws sai sai. Qhov cia ntawm Adenosine Triphosphate hauv tib neeg lub cev yog tsawg heev thiab yuav tsum tau txuas ntxiv hluav taws xob, tab sis lub cev synthesis ceev yog qeeb heev, uas ua rau qaug zog hauv lub cev. Yog li ntawd, txhawb ntxiv ntawm cov tsiaj muaj peev xwm ua tau zoo txhim kho cov leeg nqaij, nrawm, thiab kev ua siab ntev. Txhim kho kev tawm dag zog lub cev thiab qib kev kawm kom tiv thaiv kev qaug zog.
|
C.F |
C4H9N3O2 |
|
E.M |
131 |
|
M.W |
131 |
|
m/z |
131 (100.0%), 132 (4.3%), 132 (1.1%) |
|
E.A |
C, 73.97; H, 4.14; O, 21.89 |
Yog tsev neeg ib puag ncig tso cai, cov neeg mob nrog cov leeg nqaij ua kom muaj peev xwm coj cov kev coj ua kom tsis txhob muaj zog lossis tshuaj tiv thaiv los ntawm kev siv ntau dhau.Ntshiab Candline Hmoovyog lub zog hluav taws xob rau kev siv zog tawg. Yog li nws yog qhov zoo tshaj plaws los coj nws tom qab tawm dag zog thiab tawm dag zog. Tom qab qoj ib ce, muaj nyiaj ntau ntawm adenosine triphosphate tau noj. Kev coj Creatine tuaj yeem pab lub cev ua kom nrawm dua kev tsim khoom thiab ntxiv ntawm Adenosine Triphosphate, uas tuaj yeem txhim kho cov leeg nqaij, nrawm, thiab kev ua siab ntev. Yog tias ib qho tsis tawm dag zog, noj adenosine triphosphate ua ntej nws tau noj yuav tsis ua tiav cov nyhuv ntawm kev ntxiv, thiab cov nyhuv yuav mob heev dua. Qhov kev thov rau Adenosine Triphosphate thaum lub cev qoj ib ce yog ntau pua lub sijhawm ntau dua li thaum so. Qhov ntau dua cov kev tawm dag zog, ntau dua kev noj ntawm adenosine triphosphate. Qhov cia ntawm Adenosine Triphosphate hauv tib neeg lub cev yog tsawg heev thiab yuav tsum tau txuas ntxiv hluav taws xob, tab sis lub cev synthesis ceev yog qeeb heev, uas ua rau qaug zog hauv lub cev. Yog li ntawd, txhawb ntxiv ntawm cov tsiaj muaj peev xwm ua tau zoo txhim kho cov leeg nqaij, nrawm, thiab kev ua siab ntev. Txhim kho kev tawm dag zog lub cev thiab qib kev kawm kom tiv thaiv kev qaug zog.
Ua tus hloov chaw rau creatine
Hloov chaw rau creatine. Yog tias tsev neeg ib puag ncig tsis pub rau kev ua kom cov leeg nqaij uas muaj kev vam meej, cov neeg mob tuaj yeem siv ATP (Adenosine TripChosphate), ib yam khoom uas tsim los ntawm tus kws kho mob creatine. Nws txoj haujlwm zoo ib yam li cov creatine, uas muab lub zog rau cov hlwb hlwb thiab tuaj yeem pab cov leeg rov qab los ntawm kev qaug zog. Nws tseem yog cov tshuaj noj tsis muaj khoom noj, thiab nws yog qhov zoo tshaj plaws los coj nws tom qab tawm dag zog thiab tawm dag zog, vim li cas zoo ib yam li kev coj tus creatine. Thiab tus nqi pheej yig dua, nrog rau 100 daim feem ntau luv nqi hauv 30 yuaan. Yog tias ua ke nrog lwm cov zaub mov noj thiab tshuaj tiv thaiv ntawm tes, cov nyhuv yuav zoo dua. Tab sis nws yuav tsum tau coj raws li cov kev taw qhia ntawm tus kws kho mob tshaj lij. Piv txwv li, cov vitamin E uas tiv thaiv cell winpbranes, ATP, BT ntawd tu cov zog, thiab ntau coenzymes. Lub biphenyl liipid, uas txo cov enzymes, muaj cov kev ruaj khov ntawm cov leeg nqaij memrant, tiv thaiv cov leeg cell membrane los ntawm enzyme towage los ntawm kev puas tsuaj, thiab yog pheej yig. Txawm li cas los xij, vim cov kev mob tshwm sim, nws yuav tsum tau coj mus rau 20 hnub thiab nres rau 10 hnub, thiab nws yuav tsum tsis txhob ua xyoo {13 {13} round.
Yog tias muaj kev tawm dag zog thiab tawm dag zog thiab tawm dag zog, thiab cov khoom adenosine triphosphate tsis noj ua ntej kev tawm dag zog, nws yuav tsis ua tiav cov txiaj ntsig zoo ntxiv. Yog tias koj tuaj yeem taug kev thiab qoj ib ce, koj tuaj yeem siv nws. Yog tias koj tsis tuaj yeem taug kev, koj tuaj yeem siv ATP (Adenosine Triphosphate) ncaj qha, uas yog pheej yig dua. Creatine yog tshuaj noj khoom haus huv nrog kev siv tshuaj kho mob. Qhov no yuav tsum pom tseeb, thiab dej kub yuav tsum tsis txhob siv los ua nws tuaj yeem ua kev puas tsuaj creatin. Coj thiab sib tov cov dej txias ua ntej qoj ib ce kom muaj cov khoom noj muaj txiaj ntsig.
Txoj Kev Soj Ntsuam
Muaj peb cov txheej txheem sib txawv rau kev npajNtshiab Candline HmoovLos ntawm cov txiv qaub nitrogen:
01
Lorem ipsum dolor zaum amet consectetur elit.calcium nitrogen reacts nrog sodium sarcosine aque oce daws teeb meem ncaj qha.
02
Txiv qaub nitrogen reacts nrog methanol daws chlogen chloride roj kom tau txais o}}}}} Metyloride reacts nrog sarcosine kom tau creatine.
03
Cov kua qaub nitrogen thiab hydrochloric acid aqueous kev daws teeb meem chloroformamidine hauv qab huab cua, thiab tom qab ntawd hnov mob nrog sodium sarcosine kom tau creatine.
Txoj kev ua haujlwm yog raws li hauv qab no: Ntxiv 3.3Mol urea thiab 6Mol 50% rau hauv ib qho kev kub ntxhov, sib xyaw ua ke nyob rau hauv 30℃rau 2th tom qab pub 561.8g ntawm O {{13 {}} methylisourea sulfate tom qab txias. Ntxiv 61.7g ntawm 36% sodium sarcosine kua txob rau hauv ib qho kev sib tw, kho tus condenser, kho kom haum rau 30,0 21}}} Metylisoure-}} Kho cov pH txog li 11.0 nrog 25% NAOH daws thaum lub sijhawm poob cov txheej txheem. Tom qab kev poob ntxiv, txuas ntxiv mus do ntawm 40℃rau 2H, thiab tom qab ntawd txias qhov sib tov ntawm 0 ~ 5℃rau 2H, lim tawm ntawm cov xim tsis muaju tsim. Siv 2 × Ntxuav lub lim ncuav mog qab zib nrog 15ml dej khov kom tau txais cov ceg ntoo candied monohydrate. Tso cov khoom lag luam nyoos rau hauv ib lub beaker, ntxiv 7-8 lub sij hawm ntawm cov dej nyob hauv chav tsev, thiab qhuav kom tau ua tiav cov creatish monohydrate.
Creatine yog ib yam khoom siv los ntawm arginine, glycine thiab methionine. Nws tuaj yeem suav los ntawm tib neeg lub cev nws tus kheej lossis noj los ntawm cov zaub mov. Creatine, ib qho tshwm sim amino acid derivative hauv tib neeg lub cev, tuaj yeem nrawm nrawm cov leeg ua kom muaj zog, nrawm kev qaug zog rov qab thiab txhim kho lub zog tawg. Tus creatine ntau yog muab cia rau hauv lub cev, lub zog muaj zog dua thiab kev tawm dag zog. Nws tsis tuaj yeem muab lub zog sai sai (ntau yam kev ua si ntawm tib neeg lub cev cia siab rau thaum tawm dag zog, tab sis kev cia ntawm kev tawm dag zog thaum tawm dag zog, thiab muaj zog ntawm kev tawm dag zog, thiab muaj zog ntawm kev tawm dag zog, thiab muaj zog ntawm kev tawm dag zog, thiab muaj zog ntawm kev tawm dag zog, thiab muaj zog ntawm kev tawm dag zog, thiab muaj zog ntawm kev tawm dag zog, thiab creatine tuaj yeem nrawm nrawm rau hauv hluav taws xob). Nws tseem tuaj yeem nce lub zog, cov leeg thiab nkees rov qab. Qhov ntauNtshiab Candline HmoovCia nyob rau hauv tib neeg lub cev, qhov ntau dua cov khoom siv hluav taws xob yog, kev khiav qaug zog qeeb yog, thiab lub zog ua kom muaj zog dua yog.
Kev tshawb nrhiav ntawm cov creation tuaj yeem raug rov qab mus rau thaum ntxov 19th caug xyoo. Xyoo 1832, lub npe nrov Chemist Michel Eug è ne chevreul thawj zaug crystally ib tug crystaly) (muab tau los ntawm cov lus Greek "Kreas", lub ntsiab lus "nqaij"). Qhov kev tshawb pom no tau pib pib ntawm tib neeg kev tshawb fawb ntawm cov leeg zog metabolites.
Xyoo 1847, German Schologist Judus Jon LieBig ntxiv lees paub txog cov leeg nqaij tsiaj thiab pom nws cov mis mos thiab nrhiav tau nws cov mis mos noj raws li C ₄ N ₉ ₂. Nws tseem pom tias thaum ua noj ua noj, qee tus neeg cwm yog hloov mus ua vaj muaj kev ua si, uas yog breproductruct ntawm crepine metabolism.
Thaum pib ntawm lub xyoo pua 20, cov kws tshawb fawb pib kawm lub luag haujlwm ntawm kev muaj tswv yim hauv lub zog metabolism:
Xyoo 1926, Otto Folin thiab Willey Blothing Denis los ntawm tib neeg lub tsev kawm ntawv creatine, feem ntau yog khaws cia hauv cov leeg thiab tuaj yeem koom nrog kev siv hluav taws xob.
Xyoo 1927, fiske thiab subbarow pom phosphameath (PCR)
Xyoo 1930 thiab xyoo 1950, muaj tswv yim pib tshawb nrhiav siv rau hauv cov qauv ntawm cov tshuaj thiab cov kis las
Cov kws tshawb fawb soviet tau kawm qhov cuam tshuam ntawm kev ncaws pob ntawm cov neeg ncaws pob tom qab World War II thiab pom tias nws yuav nce lub zog loj.
Thaum xyoo 1960, kev tshawb fawb nrhiav tau tias muaj kev kho mob creally kab mob, tab sis vim nws cov nqi extraction Atrolople, nws tseem tsis tau siv tau dav.
Kev Tsim Kho Thaum Ntxov yog tsuas yog muab rho tawm los ntawm cov leeg tsiaj, uas yog qhov ua tsis tau zoo thiab muaj nuj nqis. Nyob rau lub xyoo pua 20th, tawg nyob rau hauv cov tshuaj synthesis cov qauv ua rau loj {2} kev tsim khoom ntawm creatin
Hauv xyoo 1970, German Cov kws tshawb fawb tau tsim qauv kev txo hwj txwv, uas tso cai rau kev lag luam synthesis ntawm kev muaj tswv yim.
Thaum xyoo 1990, cov sarcosine + Cyanamid synthesis tau siv dav, ua rau muaj kev coj dawb huv tshaj 99% rau creity.
Xyoo 1992, chaw kuaj mob luam tawm tau tshaj tawm tias ntxiv nrog Creatine tuaj yeem ua rau cov leeg nqaij phosochochochochochipy thiab txhim kho kev ua tau zoo. Tom qab, cov hmoov muaj tswv yim ntshiab sai sai sai sai no los ua cov neeg ncaws pob thiab tus neeg nyiam ua haujlwm:
Xyoo 1993, Asmeskas lub tuam txhab sim thiab ua tiav Sciences thiab thov kev tshawb fawb (Eas) tsim thawj cov lag luam tshuaj ntxiv, phosphaten.
Hauv xyoo 1996, Postredech tsim "tech tech", uas ua ke tsim kev tsim nrog carbohydrates ntxiv rau txhim kho tus nqi nqus dej.
Cim npe nrov: Ntshiab Candine hmoov uas 57-00-1, chaw tsim khoom, chaw tsim khoom, Hoobkas, lag luam, yuav, nqe, loj, rau muag