Ntshiab Fenbendazole hmoovYog ib qho dawb lossis tawm {- Hmoov dawb} hmoov hmoov {{1} Zoo li tshuaj lom neeg, tsw ntxhiab thiab tsis muaj qab hau thiab tsis muaj qab hau thiab tsis muaj qab hau thiab tsis muaj qab hau thiab tsis muaj qab hau thiab tsis muaj qab hau thiab tsis muaj qab hau thiab tsis muaj qab hau thiab tsis muaj qab hau thiab tsis muaj qab hau thiab tsis muaj qab hau thiab tsis muaj qab hau thiab tsis muaj qab hau. Cov lus qhia txog kev ua siab tseeb muaj xws li 99%, 99.99%, insoluble hauv dej, thiab solub hauv glacial acetic acid. Nws yuav tsum tau muab cia rau hauv ib lub teeb -} pov thawj, ntim ntim rau hauv qhov chaw qhuav kom ntseeg tau tias nws qhov ruaj khov.
Fenbendazole yog benimidazole Antworm. Nws cov kev ua tshuab ntawm kev ua yog los ua ke nrog cov microlotubule ntawm nematodes kom tau txais txiaj ntsig zoo tshaj plaws. Los ntawm inhibiting synthesis ntawm microlotubule hauv cab, nws ua rau lub cev meabolism tsis sib haum hauv cab thiab kev tuag. It not only has a high deworming activity against adult and larval nematodes in the animal gastrointestinal tract, but also has a good effect on nematodes nematodes, Trematodes caudatum, Trematodes procellatum and tapeworms.
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Cov ntaub ntawv ntxiv ntawm kev sib txuas lus:
Fenbendazole hmoovCoa
PUre fenbendazole hmoovyog qhov dav -} {{{{{1} {Toxicidazole Artinary Kev Xyaum thiab cov tsiaj ua kom zoo nkauj, raws li hauv qab no:
Kab pleev cov tshuaj lom zem
Broad -} spectrum kab tshuaj
Nematodes: Cov khoom no muaj cov txiaj ntsig tua tau zoo heev rau ntau yam Nematodes, thiab Vivotodes nematodes, thiab nematode ntawm Trichoderma, thiab lwm yam yaj nematodes, Cov duab liab, thiab lwm yam Thiab hookworms, roundweworms, plaub hau {{3} headed nematodes, thiab lwm yam ntawm dev thiab miv.
Tapeworms: Nws muaj qhov cuam tshuam zoo hauv kev tshem tawm ntau yam sib tw xws li txuas monitz tapworm thiab Bergii Monitz tapeworm.
Trematodes: Qhov koob tshuaj ntau dua yog xav tau rau cov khoom trematodes, xws li 20mg / kg rau 100% zoo li tus lej tawm {} kab noj ceg tawv. Kev siv tas mus li ntawm koob ntawm 15mg / kg rau 6 hnub yog ua tau zoo tiv thaiv daim siab tsis txaus ntseeg.
Inhibiting kev txhim kho ntawm parasite qe:Cov khoom no tsis tuaj yeem tsuas tua cov neeg laus thiab cov laus, tab sis kuj tseem ua rau kev txhim kho qe qe nyob hauv ib puag ncig.
Cov yam ntxwv ntawm cov chaw ua ke
Kev nqus:Ntshiab fenbendazole hmoov muaj cov solubility tsis muaj sia nyob thiab nqus tau tsawg heev tom qab kev tswj hwm qhov ncauj. Ruminants nqus qeeb, thaum cov tsiaj muaj monogastric nqus tau sai dua. Lub sijhawm siab ntawm cov ntshav hauv cov dev tom qab tswj cov ncauj yog 24 teev, thiab hauv yaj nws yog 2 mus rau 3 hnub.
Faib:Tom qab nqus, fenbendazole tau faib seem nyob rau hauv cov tsiaj thiab tuaj yeem ncav cuag cov chaw uas parasites parasitize.
Metabolism:Nws yog metabolized rau hauv sulfoxides (nquag ntawm kev ua haujlwm) thiab cov sulfones hauv lub cev tsiaj.
Excretion:Hauv cov nyuj, yaj thiab npua thiab npua, 44% mus rau 50% ntawm fenbendazole tau tawm hauv nws daim ntawv qub los ntawm cov quav, thiab tsawg dua 1% yog excreted los ntawm cov zis. Yog tias ib qho koob tshuaj yog qhov tsis muaj txiaj ntsig rau cov dev thiab miv, lawv yuav tsum tau saib xyuas 3 hnub.
Soj ntsuam daim ntawv thov
Cov khoom no yog ib qho tshuaj zoo rau kev kho nematode thiab pab kab mob sib kis hauv cov tsiaj txhu thiab nqaij qaib.
Cov tshuaj tiv thaiv: Nws tuaj yeem siv los ua cov tshuaj tiv thaiv kom txo cov kab mob ntawm cov tsiaj txhu hauv cov tsiaj txhu thiab txhim kho kev ua haujlwm ntawm kev yug me nyuam.
Kev Nyab Xeeb thiab Kev Ceev Faj
Cov kev tawm tsam
Feem ntau, tsis muaj kev cuam tshuam zoo yuav tshwm sim thaum siv ntawm cov tshuaj pom zoo. Txawm li cas los xij, vim kev tso tawm ntawm kev ua cab kuj tuag, cov kev tsis haum tshuaj ob tuaj yeem tshwm sim, tshwj xeeb tshaj yog thaum muaj koob tshuaj ntau. Nthuav yog qee zaum pom nyob rau hauv cov dev lossis miv thaum noj qhov ncauj. Tau muaj ib tsab ntawv ceeb toom ntawm ntau hom ntawm leukopenia hauv cov dev tom qab noj tshuaj.
Taboo
Txwv tsis pub siv nees rau cov zaub mov. Tsis muaj feem xyuam rau lactating mis nyuj thiab tsiaj nyob hauv thawj 45 hnub ntawm cev xeeb tub; Kev siv ntawm Fenbendazole nyob rau hauv lub sij hawm ntxov ntawm cev xeeb tub nyob rau hauv yaj thiab luav yuav nrog nrog Teratogenic thiab Embryoxic teebmeem.
Kev sib cuam tshuam yeeb tshuaj
Thaum siv ua ke nrog Fluer Killer Bromide, nws tuaj yeem ua rau muaj kev tuag ntawm yaj thiab nchuav menyuam ntawm cov tsiaj. Thaum siv Fenbendazole hauv cov tsiaj sib npaug, dichlorvos yuav tsum tsis txhob siv ua kev sib xyaw ua ke; Txwv tsis pub, cov tshuaj lom yuav tau txhim kho heev.
Rho tawm lub sijhawm
14 hnub rau nyuj thiab yaj, 3 hnub rau npua, thiab 28 hnub rau nqaij qaib. Cov mis tso tseg lub sij hawm yog 120 teev thiab lub qe tso tseg lub sijhawm yog 7 hnub.
Molecular qauv qauv
Cov qauv molecular ntawm Fenbendazole yog c₁₅h₁₃n₃o₂s, thiab nws cov molecular hnyav yog 299.348. Nws cov qauv tshuaj muaj benzimidazole rings thiab sulfide pawg. Lub nplhaib benzimidazole yog ib hom tshuaj uas muaj ntau yam tshuaj tiv thaiv ntau yam tshuaj tiv thaiv, uas tuaj yeem khi rau tubulin hauv cabulin thiab rhuav tshem Anthelmintic Cov teebmeem. Cov pab pawg sulfide muaj cov kev cuam tshuam tseem ceeb rau nws cov kev ua ub ntawm kev thiab tshuaj lom neeg.
Cov Khoom Siv Lub Cev
Zog:Ntshiab fenbendazole hmoov yog xim daj los yog tawm -}}}}}} Crystalline hmoov, tsw ntxhiab thiab tsis muaj qab.
Ntawj ntom:Kwv yees li 1.4 g / cm³. Qhov tseem ceeb no tus nqi qhia tau tias Fenbendazole muaj qee qhov ntom ntom ntom ntom ntom, uas yooj yim rau kev cia khoom thiab kev thauj mus los.
Melting taw tes:Lub taw tes melting yog 233℃(decomposition), uas txhais tau hais tias Fenbendazole yuav yauv tawm cov kev txiav txim siab ntau dua ntawm cov kev cuam tshuam ntau dua. Yog li ntawd, siab {{- qhov chaw ib puag ncig yuav tsum tau zam thaum lub sijhawm cia thiab siv.
Boiling taw tes:Qhov npau npau npau yog 541.4 ± 42.0℃(ntawm 760 mmHg). Ib qho siab dua boiling taw tes taw qhia tias Fenbendazole tsis yog volatile ntawm qhov kub thiab txias thiab siab.
Flash Toint:Kwv yees li ntawm 281.2 ± 27.9 degree, txuas ntxiv qhia nws tsis- cov cuab yeej siv.
Vapor siab:Nyob rau ntawm 25 degree, nws yog 0.0 ± 1.5 mmHg, qhia tias nws cov vapor siab yog qhov yooj yim thiab nws tsis yooj yim rau hauv huab cua ntawm qhov kub ib txwm muaj.
Refacking Index:1.679. Cov chaw ua haujlwm kom tsis pub muaj ib qho ntawm cov khoom siv kho tshiab ntawm cov tshuaj thiab tuaj yeem siv rau kev txheeb xyuas thiab tshuaj ntsuam ntawm cov tshuaj yeeb dej caw.
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So
Dej Solubility:Cov khoom no yog insoluble hauv dej. Cov cuab yeej no txwv nws daim ntawv thov hauv qee cov dej -}} Ua rau npaj cov ntaub ntawv kom haum rau lwm txoj hauv kev xws li kev ncua lossis emulsions.
Organic ntsuas cov solubility
Dimethyl Sulfoxide: Tsim kom yooj yim soluble hauv duethyl sulfoxide, ib feem siv organic kuab uas tuaj yeem ua haujlwm kom yaj ntau cov tshuaj insoluble.
Methanol: Nws yog soluble me ntsis hauv methanol. Cov cuab yeej soluble me ntsis ua rau nws yuav tsum tswj hwm cov nyiaj thiab cov xwm txheej ntawm cov kuab tshuaj thaum npaj qee yam kev npaj.
Glacial acetic acid: nws kuj muaj qee qhov solubility hauv glacial acetic acid. Glacial acetic acid tuaj yeem siv hauv qee cov tshuaj tshwj xeeb tshwj xeeb lossis kev npaj ntawm kev npaj.
Ruaj khov
Pa kev ruaj khov
Ntshiab fenbendazole hmoov yog ruaj khov nyob rau hauv cov chaw cia khoom seem (kaw, txias thiab qhuav), thiab yuav tsis decompose lossis tsis zoo.
Thermal ruaj khov
Vim nws lub ntsiab lus melted ntawm 233℃(decomposition), nws yuav dhau kev cuam tshuam kev cuam tshuam ntawm kev kub siab. Yog li ntawd, siab {{- qhov chaw ib puag ncig yuav tsum tau zam thaum lub sijhawm cia thiab siv.
Lub teeb ruaj khov
Rhiab rau lub teeb, prolonged raug rau lub teeb yuav ua rau muaj kev siv yeeb tshuaj. Yog li ntawd, lub teeb {- thaiv kev ntsuas yuav tsum tau coj thaum lub sijhawm cia thiab tsheb thauj mus los.
Tej Tshuaj Lom Zem
Khi rau tubulin:Lub ntsiab lus tseem ceeb ntawm kev ua ntawm Fenbendazole yog los khi rau tubulin hauv cabulin hauv cov microteububule thiab yog li nthuav tawm cov nyhuv anthelmintic. Cov nyhuv khi no muaj qib siab ntawm qhov tshwj xeeb thiab muaj kev sib xws, ua rau Fenbendazole kom ua kom zoo pab cab.
Cov tshuaj tiv thaiv metabolic:Hauv lub cev tsiaj, Fenbendazole yog metabolized rau hauv metabolized xws li sulfoxide (nquag ntawm kev ua haujlwm) thiab sulfone. Cov metabolites tseem muaj qee yam kev txiav txim siab thiab tuaj yeem tawm ntawm lub cev los ntawm cov zis thiab quav.
Kev sib cuam tshuam nrog lwm cov tshuaj:
Thaum Fenbendazole yog siv ua ke nrog Fluticide Bromide, nws tuaj yeem ua rau muaj kev phiv tsis zoo, xws li ua rau tuag ntawm cov tsiaj.
Thaum siv Fenbendazole hauv cov tsiaj sib npaug, dichlorvos yuav tsum tsis txhob siv ua kev sib xyaw ua ke; Txwv tsis pub, cov tshuaj lom yuav tau txhim kho heev.
Xam cov ntaub ntawv siv tshuaj
Kev siv qhov tseem ceeb rau hydrophobic parameter xam (Xlogp): tsis muaj cov ntaub ntawv cuam tshuam.
Tus naj npawb ntawm hydrogen bonderors: 2. Tus naj npawb ntawm cov nyiaj pab kasldogen hydrogen cuam tshuam cuam tshuam rau solubility ntawm molecules nyob rau cov kev daws teeb meem aqueous nyob rau aqueous nyob rau lwm yam kev daws teeb meem.
Tus naj npawb ntawm cov hydrogen beceptors: 4. Tus naj npawb ntawm cov neeg siv nyiaj txiag hydrogen breedors tseem cuam tshuam rau cov solubility thiab kev sib cuam tshuam ntawm cov lwg me me.
Tus naj npawb ntawm kev rotatable tshuaj lom neeg: 4. Tus naj npawb ntawm cov neeg sib tw tsis zoo cuam tshuam thiab kev yoog raws li cov molecule.
Tus naj npawb ntawm Tautomers: 5.
Topological Molecular Polar Nto Cheeb Tsam (TPSA): 92.3. Cov khoom siv sab hauv polar sab nrauv tuaj yeem siv tau los twv cov solubility, permeability thiab lwm yam kev ua si, thiab lwm yam.
Tus naj npawb ntawm cov atom hnyav: 21. Tus naj npawb ntawm cov atom hnyav yog hais txog tus naj npawb ntawm atoms hauv cov molecule uas tsis yog hydrogen atoms.
Tus nqi sib txawv: 0. Nto nqi cuam tshuam rau kev sib cuam tshuam ntawm cov lwg me me thiab lwm yam kev them nqi.
Kev nyuaj: 363. Cov nyom cuam tshuam txog qib ntawm cov qauv molecular.
Tus naj npawb ntawm IsoTope atoms yog 0, qhia tias Fenbendazole molecule tsis muaj isotope atoms.
Txiav txim siab tus naj npawb ntawm atomic steric chaw: 0. Stegic Chaw Xa Ntawv xa mus rau atoms hauv cov molecule uas muaj cov kev sib txawv vim kev sib txawv.
Tus naj npawb tsis meej ntawm atomic steric chaw: 0.
Txiav txim seb tus naj npawb ntawm constitutive cov chaw ntawm cov neeg siv tshuaj: 0.
Cov lej tsis meej ntawm cov khoom lag luam rau cov chaw tsim khoom: 0.
Tus naj npawb ntawm cov koog sib sib zog sib haum yog 1, qhia tias Fenbendazole Molecule yog ib txoj kev sib cog lus ywj pheej.
Kev Nyab Xeeb thiab Kev Lom Zem
Toxicity toxicity:Qhov ncauj LD50 ntawm cov nas yog siab dua 10,000 mg / kg, qhia tias qhov mob toxicity ntawm Fenbendazole yog tsawg. Txawm li cas los xij, thaum lub sijhawm siv kev siv, nws tseem tsim nyog kom ua raws li cov tswv yim kws kho mob thiab cov kev pom zoo muab rau cov lus qhia kom tsis txhob muaj kev cuam tshuam zoo los ntawm kev siv ntau dhau.
Ntev phalue:Ntev - sij hawm thiab siv ntau dhau yuav ua rau qee yam mob toxic mob rau tsiaj. Yog li ntawd, nws yog ib qho tsim nyog los saib xyuas kev noj qab haus huv ntawm cov tsiaj thiab kho cov tshuaj thiab tsis xav tau cov tshuaj raws li xav tau.
Taboos rau cov pab pawg tshwj xeeb thiab tsiaj:
Txwv tsis pub siv nees rau cov zaub mov.
Nws yuav tsum tsis txhob siv rau ntawm lactating mis mis nyuj thiab tsiaj nyob hauv thawj 45 hnub ntawm cev xeeb tub.
Kev siv ntawm Fenbendazole nyob rau hauv lub sij hawm ntxov ntawm cev xeeb tub nyob rau hauv yaj thiab luav yuav nrog nrog Teratogenic thiab Embryoxic teebmeem.
Cia thiab Tsheb Thauj Mus Los
Kev Cia
Nws yuav tsum muab cia rau hauv cov thawv ntim, hauv qhov chaw txias thiab qhuav, kom deb ntawm qhov kub thiab lub teeb. Lub teeb -} thaiv cov ntaub ntawv ntim tuaj yeem siv coj cov tshuaj rau hauv lub tsev rau khoom txias.
Kev Thauj Mus Los Yuav Tsum
Thaum lub sij hawm thauj mus los, ntim yuav tsum raug muab khaws cia kom tiv thaiv noo noo thiab qhov muag pom kev. Tsheb thauj mus los tuaj yeem nqa tawm hauv cov thawv ntim khoom thiab cov kev tiv thaiv tsim nyog yuav tsum tau ua.
Cim npe nrov: Ntshiab Fenbendazole Hmoov, Tuam Tshoj Chaw Tsim Tshuaj, Chaw Tsim Tshuaj, Hoobkas, lag luam Wholesale, Yuav, nqe, loj, rau muag