Shaanxi BLOOM Tech Co., Ltd. yog ib tug ntawm cov uas paub txog manufacturers thiab lwm tus neeg ntawm rifampicin hmoov cas 13292-46-1 nyob rau hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo rifampicin hmoov cas 13292-46-1 muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Yog tiasrifampicin hmoovmuab tso rau hauv lub tshuab ntsuas hluav taws xob, nws tsis tshwm sim raws li cov khoom siv inert tag nrho, tab sis yog lub fortress loj heev. Nws qhov tshwj xeeb naphthoquinone core thiab piperazine choj saw tsim ib txoj hauv kev spatial, ib yam li tus yuam sij meticulously crafted. Nws cov kab mob tua kab mob muaj zog los ntawm qhov no - nws tuaj yeem nkag mus rau hauv lub hnab ntim cov kab mob ntawm cov kab mob RNA polymerase nrog yuav luag irreversible precision, zoo li tooj liab xauv tag xauv cov tub ntxhais iav ntawm lub tshuab luam ntawv, nres qhov txuas ntxiv ntawm RNA saw, thiab thaum kawg ua tiav qhov kev tawm tsam tuag tawm tsam Mycobacterium.
Txawm li cas los xij, lub fortress nws tus kheej kuj yog qhov kev sib ntaus sib tua: nws qhov zoo -paub hepatoprotective enzyme induction khoom yog tiag tiag tshwm sim los ntawm nws cov qauv molecular ua "dab ntxwg nyoog teeb liab", muaj zog ua rau tib neeg P450 enzyme system. Qhov kev coj cwj pwm no ntawm kev qhib txoj hauv kev rau nws tus kheej cov metabolism hauv kev npaj txhij txog ua rau kev puas tsuaj ntawm ntau cov tshuaj sib xyaw ua ke, dhau los ua teeb meem ob -edged ntaj hauv kev kho mob ua ke.
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| Tshuaj Formula | C43H58N4O12 |
| Exact Mass | 822.41 |
| Molecular Luj | 822.95 |
| m/z | 822.41 (100.0%), 823.41 (46.5%), 824.41 (10.6%), 824.41 (2.5%), 823.40 (1.5%), 825.41 (1.1%) |
| Elemental Analysis | C, 62.76; H, 7.10; N, 6.81; O, 23.33 |
Ntawm qib microscopic ntau dua, nws cov txiv kab ntxwv - xim liab tsis yog qhov yuam kev; Nws yog kev ntes thiab tso tawm cov teeb pom kev tshwj xeeb los ntawm nws cov quinone chromophore, thiab cov cuab yeej no kuj tau tshawb fawb hauv chav kuaj rau photodynamic antibacterial therapy, tso cai rau cov tshuaj tua kab mob qub no rov qab tau nws txoj kev tua hluav taws tua hluav taws hauv laser irradiation.
siv nyob rau hauv kev kho mob tuberculosis
Rifampicin hmoovexerts nws cov tshuaj tua kab mob los ntawm inhibiting cov DNA - nyob ntawm RNA polymerase, yog li thaiv cov synthesis ntawm mRNA thiab tom qab ntawd halting zus tau tej cov proteins uas yuav tsum tau rau cov kab mob loj hlob thiab replication. Cov txheej txheem no tshwj xeeb tshaj yog tiv thaiv Mycobacterium tuberculosis, tus neeg sawv cev ntawm tuberculosis.
Kev Kho Mob Ua Ke
Rifampicin feem ntau tsis yog siv ib leeg hauv kev kho mob tuberculosis vim muaj kev pheej hmoo ntawm kev tsim tshuaj tiv thaiv. Hloov chaw, nws tau ua ke nrog lwm cov tshuaj tiv thaiv kab mob -TB xws li isoniazid, ethambutol, pyrazinamide, thiab streptomycin. Qhov kev sib xyaw ua ke no, lub npe hu ua PIERS kev tswj hwm (Pyrazinamide, Isoniazid, Ethambutol, Rifampicin, thiab Streptomycin), muaj txiaj ntsig zoo nyob rau hauv ob qho tib si thawj zaug thiab thim rov qab theem ntawm tuberculosis, suav nrog tuberculous meningitis.
Dosage thiab Administration
Qhov ntau npaum ntawm rifampicin txawv nyob ntawm tus neeg mob lub hnub nyoog, qhov hnyav, thiab theem ntawm tus kab mob. Nws feem ntau yog siv los ntawm qhov ncauj, thiab cov ntshav siab tshaj plaws tau mus txog hauv 1.5 mus rau 4 teev tom qab noj. Lub sijhawm kho yuav kav li ntawm 6 lub hlis mus rau 2 xyoos lossis ntev dua, nyob ntawm qhov hnyav thiab qhov ua rau tus kab mob.
Qhov zoo
Rifampicin zoo heev tiv thaiv Mycobacterium tuberculosis.
Nws muaj qhov zoo ntawm qhov ncauj thiab kev faib tawm hauv feem ntau cov ntaub so ntswg thiab cov kua dej hauv lub cev, suav nrog cov kua dej cerebrospinal thaum lub sij hawm meningitis.
Nws tuaj yeem siv ua ke nrog lwm cov tshuaj tiv thaiv kab mob -TB los txhim kho tag nrho cov txiaj ntsig ntawm kev kho mob thiab ncua kev tshwm sim ntawm cov tshuaj tiv thaiv.
Kev txwv
Mycobacterium tuberculosis tuaj yeem tsim kev tiv thaiv rau rifampicin yog siv ib leeg rau lub sijhawm ntev.
Rifampicin tuaj yeem ua rau tsis muaj teeb meem liab - cov kua txiv kab ntxwv ntawm cov zis, uas yuav ua rau muaj kev txhawj xeeb ntawm cov neeg mob.
Nws muaj peev xwm cuam tshuam nrog lwm cov tshuaj, yog li cov neeg mob yuav tsum qhia lawv cov kws kho mob txog txhua yam tshuaj uas lawv noj.
daim ntawv thov nyob rau hauv lwm yam kab mob mycobacterial
Rifampicin ua los ntawm inhibiting cov kab mob DNA- nyob ntawm RNA polymerase, uas yog qhov tseem ceeb rau kev sau ntawv thiab, yog li ntawd, cov kab mob loj hlob. Qhov kev ua haujlwm no ua rau nws muaj txiaj ntsig zoo rau ntau yam ntawm mycobacteria, suav nrog NTM.
1. Mycobacterium szulgai Kab mob
Case Study: Nyob rau hauv ib qho xwm txheej ntawm kev kis kab mob ntawm daim tawv nqaij los ntawm Mycobacterium szulgai, ib tug hluas nkauj 7-xyoo tau nthuav tawm cov quav hniav ntawm sab laug ntawm nws lub ntsej muag. Tom qab cov ntaub so ntswg kab lis kev cai thiab kev txheeb xyuas, tus neeg mob tau kho nrog kev sib xyaw ntawm rifampicin, isoniazid, thiab ethambutol. Tus neeg mob tus mob tau zoo heev tom qab kev kho mob.
Kev ua tau zoo: Rifampicin lub peev xwm los inhibit mycobacterial kev loj hlob yog qhov tseem ceeb nyob rau hauv cov ntaub ntawv no, pab txhawb kev kho mob tau zoo.
Keeb kwm: CLGS yog kab mob ntawm daim tawv nqaij ntawm cov dev uas tshwm sim los ntawm ib hom NTM. Tus kab mob yog tus cwj pwm los ntawm kev tsim ntawm subcutaneous nodules, uas tuaj yeem sib txawv ntawm qhov loj thiab tshwm sim nyob qhov twg ntawm tus dev lub cev tab sis feem ntau tshwm sim ntawm lub taub hau thiab pob ntseg.
Kev kho mob: Txawm hais tias kab lis kev cai- raws li kev kuaj mob nyuaj rau CLGS, rifampicin tau siv los ua ib feem ntawm kev sib xyaw ua ke los kho tus kab mob no.
Cov kev kho mob pom zoo suav nrog kev sib xyaw ntawm rifampicin thiab clarithromycin, nrog rau cov tshuaj pleev ib ce uas muaj rifampicin thiab clofazimine kuj raug soj ntsuam.
Kev ua tau zoo: Rifampicin lub luag hauj lwm hauv kev kho mob ntawm CLGS yog inhibit qhov kev loj hlob ntawm lub causative NTM, yog li tso cai rau lub cev tiv thaiv kab mob thiab txhawb kev kho.
Rifampicin hmoovfeem ntau siv ua ke nrog lwm cov tshuaj tua kab mob los kho cov kab mob mycobacterial. Kev sib xyaw ua ke pab txhim kho kev ua tau zoo ntawm kev kho mob los ntawm kev tsom mus rau qhov sib txawv ntawm cov kab mob hauv lub neej thiab txo qhov kev pheej hmoo ntawm kev txhim kho kev tiv thaiv.
Kev sib xyaw ua ke: Rifampicin nquag ua ke nrog isoniazid, ethambutol, thiab pyrazinamide hauv kev kho mob tuberculosis. Rau cov kab mob NTM, nws tuaj yeem ua ke nrog clarithromycin, clofazimine, thiab lwm yam tshuaj tua kab mob nyob ntawm cov kab mob tshwj xeeb.
tiv thaiv & tawm - siv daim ntawv lo
Kev tiv thaiv zoo
Rifampicin yog siv rau prophylaxis nyob rau hauv siab - kev pheej hmoo nyob ze ntawm cov neeg mob uas muaj tus kab mob Neisseria meningitidis. Los ntawm inhibiting kev loj hlob ntawm meningococcus, Rifampicin tuaj yeem pab tiv thaiv kev kis tus kab mob meningococcal, uas tuaj yeem ua rau mob hnyav thiab tuag taus. Qhov kev tiv thaiv no yog qhov tseem ceeb tshwj xeeb hauv cov xwm txheej tshwm sim los yog hauv cov neeg uas muaj kev pheej hmoo siab kis tus kab mob meningococcus.
Tawm -Kev siv daim ntawv lo
Ntxiv nrog rau nws cov kev pom zoo, Rifampicin tau tshawb nrhiav rau ntau qhov kev siv - daim ntawv lo, suav nrog:
Mycobacterium avium intracellulare complex (MAC) kab mob
Rifampicin, feem ntau ua ke nrog lwm cov tshuaj tua kab mob, tau siv los kho cov kab mob MAC, uas tuaj yeem ua rau mob ntsws thiab lwm yam teeb meem hauv cov neeg mob uas muaj kev tiv thaiv kab mob.
Brucellosis
Rifampicin tau pom tias muaj txiaj ntsig zoo hauv kev kho mob brucellosis, kab mob kis los ntawm Brucella hom uas tuaj yeem cuam tshuam rau tib neeg thiab tsiaj txhu.
Cov pob txha staphylococcal hnyav thiab kab mob sib koom ua ke
Nyob rau hauv cov xwm txheej ntawm cov kab mob staphylococcal hnyav nrog rau cov pob txha thiab pob qij txha, Rifampicin tuaj yeem siv ua ke nrog lwm cov tshuaj tua kab mob txhawm rau txhim kho cov txiaj ntsig kev kho mob.
Prosthetic valve endocarditis tshwm sim los ntawm coagulase-negative staphylococci
Rifampicin tau raug siv tawm ntawm - daim ntawv lo los kho cov kab mob prosthetic valve endocarditis tshwm sim los ntawm coagulase- tsis zoo staphylococci, uas tuaj yeem nyuaj kho vim lawv tsis kam mus rau ntau yam tshuaj tua kab mob.
Autoimmune Cholestatic Liver Disease thiab Primary Biliary Cirrhosis (PBC)
Rifampicin tau tshaj tawm tias muaj kev txo qhov khaus khaus hauv cov neeg mob uas muaj kab mob autoimmune cholestatic daim siab thiab PBC. Txawm li cas los xij, nws yuav tsum tau muab sau tseg tias nws cov txheej txheem ntawm kev ua thiab kev ua tau zoo hauv cov xwm txheej no yuav tsum tau kuaj xyuas ntxiv.
Rifampicin hmoovyog ib qho tseem ceeb broad -spectrum antibiotic API, uas yog tsim los ntawm semi-synthetic method raws li natural rifamycin derivatives. Cov txheej txheem synthesis no ua ke nrog microbial fermentation precursor thiab tshuaj hloov kho, nrog cov tshuaj tiv thaiv me me thiab cov khoom lag luam siab, uas yog txoj hauv kev lag luam tseem ceeb tam sim no. Tag nrho cov txheej txheem tau muab faib ua peb kauj ruam tseem ceeb: ua ntej oxidation activation, formylation cyclization hloov kho thiab qhov kawg condensation purification.
Precursor Oxidation Activation
Lub ntsiab raw khoom rau synthesis yog rifamycin SV, ib tug natural metabolite tau los ntawm microbial fermentation. Ua ntej, rifamycin SV yog oxidized rau rifamycin S nrog oxidants xws li sodium hypochlorite nyob rau hauv ib puag ncig kub tswj ntawm 30-60 degree.
Cov kauj ruam no hloov cov hydroxyl active pab pawg ntawm precursor mus rau hauv ib pawg carbonyl, txhim kho cov tshuaj reactivity ntawm nruab nrab thiab nteg ib lub hauv paus rau kev hloov kho tom ntej.
Cov txheej txheem tshuaj tiv thaiv nruj me ntsis tswj cov reagent piv kom tsis txhob muaj oxidation ntau dhau ua rau los ntawm - cov khoom tsim, thiab oxidation efficiency ncaj qha txiav txim siab qhov kawg ntawm cov khoom yield.
Formylation thiab Cyclization Reaction
Lub tshuab txais rifamycin S tau txais cov tshuaj tiv thaiv formylation nrog formaldehyde thiab tert -butylamine hauv DMF hnyav system. Raws li qhov tsis muaj zog acid tswj ntawm acetic acid thiab molecular sieve auxiliary, cov tshuaj tiv thaiv cyclization tshwm sim ruaj khov los tsim 3-formyl tert-butylamine rifamycin S.
Cov kauj ruam no tsim cov yam ntxwv oxazine nplhaib qauv ntawm rifampicin, optimizes lub molecular steric configuration, thiab endows cov khoom nrog tshwj xeeb antibacterial kev ua si. Ib qho - thev naus laus zis thev naus laus zis feem ntau yog siv rau hauv kev tsim khoom, uas tshem tawm qhov nruab nrab ntawm kev sib cais thiab kev ua kom huv, ua kom cov txheej txheem yooj yim dua thiab txo cov khoom poob.
Txo, Condensation thiab Purification
Lub formylated intermediate yog thawj zaug txo los ntawm vitamin C los kho cov tshuaj tiv thaiv kab mob, tom qab ntawd nkag mus rau cov tshuaj tiv thaiv nucleophilic condensation nrog 1-methyl-4-aminopiperazine, qhov tseem ceeb amine reagent.
Tom qab cov tshuaj tiv thaiv tiav lawm, cov khoom nyoos rifampicin tau txais los ntawm kev ua kom txias crystallization thiab cawv hnyav elution. Thaum kawg, activated carbon decolorization, azeotropic distillation thiab recrystallization yog nqa tawm kom tshem tawm cov seem impurities thiab unreacted raw khoom.
Tom qab ziab thiab crushing, siab -purity rifampicin uas ua tau raws li cov qauv tshuaj tau npaj. Tag nrho cov txheej txheem muaj kev ruaj ntseg cov tshuaj tiv thaiv, thiab cov khoom purified muaj siab purity thiab zoo solubility, ua tau raws li kev kho mob daim ntawv thov kev thov.
Discovery ntawm Natural Rifamycin Scaffold (1957-1963)
Xyoo 1957, Piero Sensi pab neeg ntawm Ltalis lub Lepetit Laboratories cais Amycolatopsis Mediterranei (lub npe hu ua Streptomyces Mediterranei) los ntawm ntoo thuv hav zoov av raws Fabkis Riviera.
Fermentation ntawm cov kab mob no tau txais ib chav kawm tshiab ntawm cov tshuaj ansamycin tshuaj tua kab mob hu ua rifamycins, tom qab nrov Fabkis zaj duab xis Rififi. Lub ntuj sib xyaw muaj ntau yam khoom.
Rifamycin B tau nthuav tawm cov kev ua haujlwm tsis muaj zog tseem ua haujlwm raws li lub hauv paus rau kev hloov kho cov qauv. Kev hloov tshuaj lom neeg ua rau rifamycin SV, uas muaj kev tiv thaiv -tuberculosis kev ua haujlwm tab sis raug kev txom nyem los ntawm qhov ncauj tsis zoo; nws tsuas yog siv tau los ntawm kev txhaj tshuaj lossis tshuaj pleev ib ce, txwv nws qhov kev siv tshuaj kho mob.
Semisynthetic Modification thiab Yug ntawm Rifampicin (1963-1966)
Cov kws tshawb fawb tau ua ntau qhov kev tshuaj ntsuam xyuas raws li rifamycin core, aiming los txhim kho qhov ncauj bioavailability thiab nyob rau hauv vivo ib nrab -lub neej. Xyoo 1965, Maggi thiab cov npoj yaig tau condensed 3-formylrifamycin S nrog 1-amino-4-methylpiperazine kom tau rifampicin. Lawv qhov kev tshawb pom tau raug luam tawm hauv xyoo 1966, lees paub qhov zoo ntawm qhov ncauj thiab muaj zog tiv thaiv kab mob. Qhov kev ua txhaum ntawm semisynthetic no tau kov yeej cov kev txwv kev xa khoom ntawm rifamycins ua ntej thiab tau tsim lub hauv paus rau kev kho mob luv luv.
Clinical Adoption and Industrial Production (Post-1968)
Rifampicin tau nkag mus rau kev siv tshuaj kho mob hauv xyoo 1968. Ua ke nrog isoniazid thiab lwm yam tshuaj, nws txo qis cov pa 18-hloov kho tuberculosis mus rau 9 lub hlis thiab kho cov nqi kho tau zoo. Hauv Suav teb, Sichuan Industrial Institute of Antibiotics tau ua tiav kev tsim kho hluavtaws hauv xyoo 1972. Ntau lub chaw muag tshuaj tau ua tiav loj- nplai tsim hauv xyoo 1974, ua cib-liab crystalline rifampicin los txhawb kev tiv thaiv kab mob hauv lub tebchaws. Tom qab ntawd, rifampicin tau dhau los ua ib qho tseem ceeb ua ntej - kab tshuaj tiv thaiv kab mob -tuberculosis, thiab nws kuj yog siv rau kev mob ruas thiab kis kab mob los ntawm kev siv yeeb tshuaj- cov kab mob Gram-positive.
FAQ
Dab tsi yog rifampicin siv los kho?
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Rifampin, tseem hu ua rifampicin, belongs rau cov tshuaj tua kab mob. Cov tshuaj no yog siv los tswj thiab khoCov kab mob sib txawv ntawm cov kab mob mycobacterial thiab gram-cov kab mob zoo.
Dab tsi yog qhov feem ntau tshwm sim ntawm rifampin?
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Cov kev mob tshwm sim muaj xws lixeev siab, ntuav, raws plab, thiab mob plab. Rifampin tuaj yeem ua rau koj lub cev ua kua, xws li koj cov zis (pee), qaub ncaug, kua muag, thiab tawm hws, tig liab - xim txiv kab ntxwv. Qhov kev hloov xim no yog qhov qub thiab tsis muaj kev phom sij, tab sis nws tuaj yeem ua rau cov lo ntsiab muag lossis cov hniav hniav mus tas li.
Puas yog rifampin yog tshuaj tua kab mob muaj zog?
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Rifampin sawv tawm raws li cov tshuaj tua kab mob muaj zognrog rau ntau yam kev siv, los ntawm kev kho tuberculosis los tiv thaiv meningitis.
Thaum twg yog lub sijhawm zoo tshaj los noj rifampin?
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Rifampin ua haujlwm zoo tshaj plaws ntawm lub plab khoob; coj nws1 teev ua ntej lossis tsawg kawg 2 teev tom qab noj mov. Yog tias koj muaj teeb meem nqos cov tshuaj ntsiav, koj tuaj yeem tso nws cov ntsiab lus rau hauv applesauce lossis jelly. Noj rifampin raws nraim li qhia. Tsis txhob noj ntau lossis tsawg dua lossis noj ntau dua li koj tus kws kho mob tau sau tseg.
Cim npe nrov: Rifampicin hmoov CAS 13292-46-1, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom