Shaanxi BLOOM Tech Co., Ltd. yog ib tug ntawm cov uas paub txog manufacturers thiab lwm tus neeg ntawm tetrahydrobiopterin (bh4) hmoov cas 17528-72-2 nyob rau hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo tetrahydrobiopterin (bh4) hmoov cas 17528-72-2 muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Tetrahydrobiopterin (BH4) hmoovyog ib tug natural compound nrog molecular mis C8H10N2O thiab CAS 17528-72-2. Nws kuj muaj qee yam cuam tshuam rau cov tshuaj tiv thaiv qaug zog. Nws tuaj yeem txhawb cov leeg nqaij metabolism thiab lub zog tsim, thaum inhibiting qhov tso tawm ntawm qhov qaug zog, yog li txhim kho lub cev endurance thiab tiv thaiv qaug zog. Tetrahydrobiopterin, raws li ib tug natural compound, kuj plays lub luag hauj lwm nyob rau hauv lub synthesis ntawm alkaloids raws li ib tug raw khoom. Nws tuaj yeem siv los ua ke ntau yam alkaloids, xws li ephedrine, vincristine, thiab lwm yam. Cov alkaloids no muaj cov nqi siv dav hauv cov chaw muag tshuaj, xws li tshuaj tiv thaiv qog, tiv thaiv kab mob, tshuaj tua kab mob, thiab lwm yam. Tetrahydrobiopterin muaj ntau yam teebmeem hauv cov khoom noj khoom haus, nrog rau kev ntxiv cov as-ham, txhawb kev tiv thaiv kab mob, muaj txiaj ntsig zoo, kev tiv thaiv kab mob antioxidant. Cov haujlwm no tseem ceeb heev rau kev tswj hwm tib neeg kev noj qab haus huv thiab tiv thaiv kab mob.
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tetrahydrobiopterin (BH4) hmoovyog ib qho tshwm sim enzyme cofactor nrog cov tshuaj formula C9H15N5O3 thiab molecular hnyav ntawm 241.25. Raws li ib qho tseem ceeb cofactor ntawm aromatic amino acid hydroxylase thiab nitric oxide synthase (NOS), BH4 plays lub luag hauj lwm tseem ceeb hauv physiological txheej txheem xws li neurotransmitter synthesis, vascular function regulation, tiv thaiv kab mob, thiab antioxidant tiv thaiv.
Kev Kho Mob: Kev kho cov kab mob genetic metabolic thiab neurotransmitter ntsig txog kab mob
Targeted therapy rau phenylketonuria (PKU)
Nws yog coenzyme ntawm phenylalanine hydroxylase (PAH), koom nrog hauv cov metabolism ntawm phenylalanine rau tyrosine. PKU cov neeg mob muaj kev tsis taus kev txawj ntse thiab kev puas hlwb puas tsuaj vim phenylalanine txuam nrog los ntawm PAH noob hloov. Kwv yees li 10% -15% ntawm cov neeg mob PKU tau nkag siab rau BH4 supplementation therapy (hu ua "BH4 reactive PKU"). Kev tswj qhov ncauj ntawm Sapropterin (BH4 dihydrochloride daim ntawv) tuaj yeem txo cov ntshav phenylalanine concentration, txo cov kev txwv kev noj haus, thiab txhim kho lub neej zoo. Hauv xyoo 2007, saxagliptin tau pom zoo los ntawm US FDA, dhau los ua thawj PKU hom tshuaj kho mob.
Pab tswj kev mob hyperphenylalaninemia (HPA)
BH4 deficiency (BH4D) yog ib pawg ntawm cov kab mob uas tsis tshua muaj caj ces, suav nrog 6-propanoyltetrahydropterin synthase deficiency (PTPS), dihydropteridine reductase deficiency (DHPR), thiab lwm yam, uas ua rau muaj kev cuam tshuam hauv BH4 synthesis lossis rov tsim dua tshiab, phenylalanine metabolism tsis zoo, thiab cov tshuaj neurotransmitter deficiency. BH4 supplementation therapy tuaj yeem kho qhov tsis sib xws ntawm cov neurotransmitter, txo cov tsos mob xws li cov leeg nqaij tsis zoo thiab convulsions, thiab tiv thaiv kev txhim kho neurodevelopmental qeeb.
Muaj peev xwm cuam tshuam rau kev puas siab puas ntsws thiab kev xav tsis txaus siab hyperactivity disorder (ADHD)
Cov kev tshawb fawb soj ntsuam tau pom tias qee cov neeg mob BH4 tsis muaj PKU muaj cov tsos mob ADHD, thiab BH4 ntxiv tuaj yeem txhim kho kev mloog thiab tswj tus cwj pwm. Tsis tas li ntawd, BH4 tuaj yeem muaj kev cuam tshuam zoo rau kev tsis sib haum xeeb thiab kev coj tus cwj pwm rov qab rau cov tib neeg uas muaj kev puas siab puas ntsws los ntawm kev tswj hwm serotonin synthesis, tab sis yuav tsum muaj kev lees paub ntxiv.
Neuroscience field: Tiv thaiv neurons thiab tswj kev paub txog kev ua haujlwm
Kev Tshawb Fawb Kev Kho Mob rau Cov Kab Mob Neurodegenerative
BH4 yog coenzyme ntawm tyrosine hydroxylase (TH) thiab tryptophan hydroxylase (TPH), koom nrog hauv dopamine thiab serotonin synthesis. Hauv Parkinson tus kab mob, BH4 txhim kho TH kev ua si, nce substantia nigra dopamine qib, thiab txo cov tsos mob ntawm lub cev muaj zog; Hauv Alzheimer's kab mob, BH4 yuav txo tau - amyloid protein induced neuronal puas los ntawm antioxidant teebmeem. Cov kev sim tsiaj tau pom tias BH4 ntxiv tuaj yeem txhim kho kev paub txog kev ua haujlwm hauv nas nrog cov qauv kev nco.
Kev tawg hauv Mechanism of Pain Management
Hauv xyoo 2013, kev tshawb fawb los ntawm Boston Children's Hospital pom tias BH4 yog tus tswj hwm tus mob neuropathic thiab mob inflammatory.tetrahydrobiopterin (BH4) hmoovtxhawb nqa mitochondrial hlau mov, txhim khu T cell ua, thiab intensifies mob teeb liab kis tau tus mob; Inhibiting BH4 synthesis tuaj yeem thaiv txoj kev mob. Qhov kev tshawb pom no muab lub hauv paus theoretical rau kev txhim kho cov tshuaj analgesic tshiab, xws li SPR antagonists.
Kev tiv thaiv ntawm cerebral ischemia thiab raug mob
BH4 txhim kho endothelial muaj nuj nqi tom qab cerebral ischemia los ntawm kev tswj cov nitric oxide (NO) synthesis, txo lub hlwb edema thiab neuronal tuag. Tsis tas li ntawd, BH4 tuaj yeem cuam tshuam oxidative kev nyuaj siab hauv ischemia-kev raug mob reperfusion, tiv thaiv lub hlwb tseem ceeb xws li hippocampus, thiab txhawb kev ua haujlwm ntawm lub paj hlwb.
Cov kab mob plawv: Tswj vascular muaj nuj nqi thiab tiv thaiv myocardial
Kev cuam tshuam rau vascular endothelial dysfunction
BH4 yog ib qho tseem ceeb cofactor ntawm endothelial nitric oxide synthase (eNOS), txhawb tsis muaj synthesis thiab tswj vasodilation muaj nuj nqi. Nyob rau hauv cov kab mob pathological xws li ntshav qab zib thiab ntshav siab, BH4 oxidation ua rau tsis muaj kev sib txuas ntawm eNOS, tsim cov superoxide es tsis yog NO, uas ua rau vascular endothelial tsis ua haujlwm. BH4 supplementation tuaj yeem kho cov bioavailability ntawm NO, txhim kho hemodynamics thiab txo qhov kev pheej hmoo ntawm atherosclerosis.
Muaj peev xwm kho rau pulmonary arterial hypertension (PAH)
Qib BH4 hauv cov hlab ntsha pulmonary ntawm PAH cov neeg mob txo qis, thiab eNOS kev ua haujlwm txo qis, ua rau pulmonary vasoconstriction thiab kho dua tshiab. Cov kev sim tsiaj tau pom tias BH4 supplementation tuaj yeem tiv thaiv kev loj hlob ntawm cov hlab ntsha hauv cov hlab ntsha ntawm cov leeg nqaij thiab txo cov tsos mob ntawm pulmonary arterial hypertension. Tsis tas li ntawd, BH4 ntxiv txo cov hlab ntsha hauv lub ntsws los ntawm kev tswj cov renin -angiotensin system.
Kev tiv thaiv ntawm myocardial hypertrophy thiab ischemia- raug mob reperfusion
Nyob rau hauv cov xwm txheej ntawm lub plawv ntau dhau los yog ischemia, BH4 txo qis myocardial hypertrophy thiab ua haujlwm tsis zoo los ntawm inhibiting mitochondrial oxidative stress thiab myocardial cell apoptosis. BH4 tseem tuaj yeem txhawb nqa myocardial cell ciaj sia thiab txo qhov chaw myocardial infarction los ntawm kev ua kom txoj hauv kev PI3K/Akt/mTOR.
Hauv kev tswj hwm kev tiv thaiv kab mob: txhim kho kev tiv thaiv- qog tiv thaiv kab mob
Cov txheej txheem metabolic ntawm T cell activation
Hauv 2018, Nature tau tshaj tawm tiastetrahydrobiopterin (BH4) hmoovtswj T cell proliferation thiab activation los ntawm regulating mitochondrial hlau tshuav nyiaj li cas. Kev ua kom T hlwb yuav tsum muaj ntau lub zog mitochondrial, thaum BH4 txhawb nqa hlau thiab txhawb nqa mitochondrial biosynthesis. Hauv cov qog microenvironment, qhov txo qis hauv BH4 qib tuaj yeem cuam tshuam T cell muaj nuj nqi thiab txhawb cov qog tiv thaiv kab mob. Ntxiv BH4 los yog overexpressing nws cov synthase (GCH1) tuaj yeem txhim kho kev tiv thaiv - qog ua haujlwm ntawm CD8 ⁺ T hlwb thiab inhibit qog loj hlob.
Kev cuam tshuam muaj peev xwm rau cov kab mob autoimmune
BH4 yuav muaj kev kho mob rau cov kab mob autoimmune xws li mob caj dab rheumatoid thiab ntau yam sclerosis los ntawm kev tswj hwm qhov sib npaug ntawm T cell subsets. Inhibiting BH4 synthesis tuaj yeem txo qhov kev loj hlob ntawm tus kheej reactive T hlwb thiab alleviate inflammatory reactions.
Muaj thiab Biotechnology Fields: Synthetic Intermediates thiab Environmental Applications
Pharmaceutical intermediates thiab hluavtaws biology
BH4 thiab nws cov derivatives yog siv los ua cov tshuaj pharmacophores tseem ceeb hauv kev tsim cov tshuaj tshiab xws li kinase inhibitors thiab G protein coupled receptor (GPCR) modulators. Tsis tas li ntawd, cov txheej txheem hluavtaws ntawm BH4, xws li GTP cyclohydrolase I catalytic kauj ruam, muab cov qauv rau biosynthesis ntawm siab - cov khoom muaj nqis.
Environmental Remediation thiab Agricultural Applications
BH4 analogues (xws li tetrahydropyrimidine) muaj kev ntxhov siab thiab tuaj yeem tiv thaiv kab mob thiab cov nroj tsuag los ntawm qhov chaw huab cua xws li ntsev alkali thiab dej qhuav. Hauv kev ua liaj ua teb, BH4 derivatives tau tshawb nrhiav los ua cov tswj kev loj hlob ntawm cov nroj tsuag lossis tshuaj biopesticides los txhawb cov qoob loo kev ntxhov siab.
Tshuaj pleev ib ce thiab cov khoom siv
BH4 analogs (xws li Ecidone) tau siv dav hauv kev tiv thaiv - cov khoom tu tawv nqaij laus thiab cov khoom tiv thaiv hnub ci vim lawv txoj haujlwm tiv thaiv cell zoo, uas tuaj yeem tiv thaiv ib puag ncig kev puas tsuaj xws li hluav taws xob ultraviolet thiab cov pa phem. Tsis tas li ntawd, cov khoom siv hluav taws xob ntawm BH4 ua rau nws muaj peev xwm ua rau cov khoom siv xws li cov khoom siv hluav taws xob thiab cov fluorescent probes.
BH4, raws li ib tug multifunctional cofactor, muaj cov ntawv thov dav thoob plaws hauv thaj chaw ntawm cov tshuaj, neuroscience, kev tiv thaiv kab mob plawv, kev tiv thaiv kab mob, thiab kev lag luam biotechnology.
Tetrahydrobiopterin (BH4) hmoov CAS NO 17528-72-2tsim los ntawm BLOOM TECH GMP polit Hoobkas.
Lus Cim: BLOOM TECH (Txij li xyoo 2008), ACHIEVE CHEM-TECH yog lub chaw pabcuam ntawm peb.
Tetrahydrobiopterin yog ib qho tseem ceeb coenzyme koom nrog hauv cov tshuaj lom neeg muaj xws li tryptophan thiab tyrosine hydroxylation. Nws biosynthesis feem ntau suav nrog peb lub ntsiab enzyme cov tshuaj tiv thaiv, uas yog catalyzed los ntawm GTP cyclase (GTPCH), 6-pyridone 2-carboxylate reductase (PCBD), thiab aldehyde dehydrogenase (SR).
Qhov no yog thawj kauj ruam hauv kev sib txuas ntawm tetrahydrobiopterin. GTP cyclase catalyzes cyclization thiab deamination cov tshuaj tiv thaiv ntawm GTP (guanosine triphosphate) los tsim 7,8-dihydroguanosine triphosphate.
GTP → (GTPCH) → 7,8-dihydropterin triphosphate
Hauv cov kauj ruam no, 7,8-dihydroguanylic acid yog tau los ntawm 6-Pyridone-5,6,7,8-tetrahydroguanylic acid los ntawm 6-Pyridone-2-carboxylate reductase.
Tom ntej: 7,8-dihydropterin triphosphate → (PCBD) → 6-pyruvyl-5,6,7,8-tetrahydropterin
Thaum kawg, 6-pyridone 5,6,7,8-tetrahydroguanylic acid generates tetrahydrobiopterin nyob rau hauv qhov kev txiav txim ntawm aldehyde dehydrogenase.
6-pyruvoyl-5,6,7,8-tetrahydropterin → (SR) → C9H17Cl2N5O3
Qhov no tsuas yog cov ntsiab lus tseem ceeb ntawm tetrahydrobiopterin biosynthesis. Txhua kauj ruam suav nrog cov txheej txheem enzymatic thiab tshuaj lom neeg, suav nrog kev ua enzyme, substrate tshwj xeeb, cov tshuaj tiv thaiv mechanisms, thiab lwm yam. Yog tias koj xav tau cov ntaub ntawv ntxaws ntxiv, kuv xav kom koj sab laj nrog cov ntaub ntawv tshaj lij lossis nrog cov kws tshaj lij biochemical.
FAQ
Lub luag haujlwm ntawm tetrahydrobiopterin yog dab tsi?
Tetrahydrobiopterin (BH4) yog ib qho tseem ceeb cofactor rau cov aromatic amino acid hydroxylases, uas yog qhov tseem ceeb hauv kev tsim cov neurotransmitters, thiab rau nitric oxide synthase. Nws yog tam sim no siv hauv kev kho mob los kho qee hom phenylketonuria (PKU) uas tuaj yeem kho tau los ntawm BH4 supplementation.
Dab tsi ntxiv BH4?
Ib lub tswv yim ntxiv yuav yog txhawm rau nce BH4 synthesis lossis txwv nws cov oxidative degradation. Raws li ib qho piv txwv, folic acid (vitamin B), thiab tshwj xeeb tshaj yog nws cov nquag metabolites 5-methyltetrahydrofolate, yuav txo tau BH4 oxidation thiab ua rau kom rov ua dua ntawm BH2 rau BH4 los ntawm kev ua DHFR.
BH4 ua li cas?
De Novo Txoj Kev ntawm BH4 Synthesis
Hauv txoj kev de novo, BH4 yog tsim los ntawm GTP los ntawm peb enzymes, uas yog GTP cyclohydrolase I (GCH1), 6-pyruvyl-tetrahydrobiopterin synthase (PTPS) thiab methotrexate reductase (SR).
Lub luag haujlwm ntawm BH4 hauv PKU yog dab tsi?
BH4 supplementation txhim kho qhov seem PAH enzyme kev ua haujlwm thiab nce cov metabolism hauv plasma Phe rau tyrosine hauv qee cov neeg mob PKU. Xyoo 1999, kev kho qhov ncauj BH4 tau pom los txo cov ntshav Phe hauv cov neeg mob PKU.
Cim npe nrov: tetrahydrobiopterin (bh4) hmoov cas 17528-72-2, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom