Shaanxi BLOOM Tech Co., Ltd. yog ib tug ntawm cov uas paub txog manufacturers thiab lwm tus neeg ntawm tianeptine sulfate cas 1224690-84-9 nyob Suav teb. Txais tos rau cov lag luam wholesale bulk zoo tianeptine sulfate cas 1224690-84-9 muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Tianeptine sulfate, tseem hu ua 7- [(3-}chloro-6,11-dihydro-6-methyldibenzo [c,f] [1,2] - thiazepan-11-yl) - amino] heptanoic acid S, S-dioxide sulfate, molecular formula C21H25S24 CAS9-12O4 Nws feem ntau muaj nyob rau hauv daim ntawv ntawm cov khoom dawb los yog dawb crystalline hmoov thiab yog ib qho tseem ceeb ntawm cov tshuaj nruab nrab feem ntau siv rau kev kho mob ntawm kev nyuaj siab. Raws li cov khoom siv tshuaj tseem ceeb, nws siv yog tsom rau kev kho kev nyuaj siab thiab cuam tshuam txog kev mob hlwb. Nws cov tshuaj pharmacological tshwj xeeb, kev kho mob zoo, thiab kev nyab xeeb ua rau nws siv dav hauv kev kho mob. Tsis tas li ntawd, nws muaj ntau yam kev siv xws li kev tshawb fawb tshawb fawb thiab kev lag luam txawv teb chaws, ua qhov tseem ceeb hauv kev txhim kho kev lag luam tshuaj.
Peb cov khoom
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Tianeptine sulfate COA
Tianeptine sulfate, raws li cov khoom siv tshuaj tseem ceeb, feem ntau yog siv rau hauv kev kho mob, tshwj xeeb tshaj yog nyob rau hauv kev kho mob ntawm kev nyuaj siab thiab cuam tshuam txog kev mob hlwb.
Antidepressant nyhuv:
Nws feem ntau ua rau 5-hydroxytryptamine (5-HT) system, thiab tsis zoo li cov tshuaj tricyclic antidepressants (TCA), nws tuaj yeem ua rau rov ua dua ntawm 5-HT hauv synaptic cleft, uas yuav muaj kev cuam tshuam rau kev txhim kho 5-HT neuronal conduction. Cov txheej txheem tshwj xeeb no ua rau tianeptin ua kom pom cov txiaj ntsig zoo sib xws hauv kev kho mob ntshav qab zib raws li cov tshuaj ib txwm muaj, tab sis nrog kev zam tau zoo dua thiab kev nyab xeeb.
Tsis muaj kev sib raug zoo rau cholinergic lossis adrenergic receptors, yog li ntawd tsis ua rau muaj kev phiv cuam tshuam rau cov kab ke no, xws li cov tsos mob anticholinergic lossis cov kev mob plawv tsis zoo.
Qhov cuam tshuam rau kev xav tsis zoo:
Raws li kev faib tawm ntawm cov tshuaj tiv thaiv kev ntxhov siab, nws poob ntawm sedative antidepressants thiab excitatory antidepressants. Nws muaj qee yam cuam tshuam rau kev xav tsis zoo, tshwj xeeb tshaj yog hauv kev txhim kho plab hnyuv tsis xis nyob nrog rau kev ntxhov siab thiab kev xav tsis zoo.
Anti kev ntxhov siab vim:
Cov kev tshawb fawb soj ntsuam tau pom tias nws tseem muaj txiaj ntsig zoo hauv kev kho cov tsos mob ntxhov siab, thiab hauv qee qhov kev tshawb fawb, HAMA (Hamilton Anxiety Scale) tus qhab nia txo qis thaum kawg ntawm lub lim tiam 6 yog txawm tias me ntsis siab dua li cov tshuaj tiv thaiv kev ntxhov siab xws li amitriptyline. Qhov no qhia tau hais tias tianeptin muaj peev xwm zoo hauv kev kho cov neeg mob kev nyuaj siab nrog kev ntxhov siab.
Kev kho mob rau kev nyuaj siab:
Nws yog ib qho ntawm cov tshuaj tseem ceeb siv los kho kev nyuaj siab. Nws cov txheej txheem tshuaj tiv thaiv kev ntxhov siab tshwj xeeb tau pom tias muaj txiaj ntsig zoo thiab ua haujlwm ntev hauv kev kho mob, ua rau nws tsim nyog rau kev kho mob ntev -.
Kev kho cov tsos mob ntxhov siab:
Vim nws cov txiaj ntsig zoo hauv kev kho cov tsos mob ntxhov siab, nws feem ntau siv rau kev kho mob ntawm cov neeg mob kev nyuaj siab nrog kev ntxhov siab. Qhov kev cuam tshuam ob no ua rau cov neeg mob ib txhij txo cov tsos mob ntawm kev nyuaj siab thiab kev ntxhov siab thaum lub sijhawm kho, txhim kho lawv lub neej zoo.
Kev pab kho mob rau lwm yam teeb meem kev puas hlwb:
Nws kuj tseem yuav muaj qee yam cuam tshuam rau tus cwj pwm thiab kev coj tus cwj pwm tsis zoo uas tshwm sim hauv cov neeg haus dej cawv thaum lub sij hawm abstinence. Tsis tas li ntawd, cov kev tshawb fawb tau pom tias tianeptin kuj tseem muaj qee yam cuam tshuam rau kev txhim kho cov teeb meem kev puas siab puas ntsws xws li mob hawb pob thaum yau, tab sis cov ntawv thov no tseem xav tau kev tshawb fawb soj ntsuam ntxiv thiab siv tau.
Absorption thiab kev faib tawm:
Nws yog sai thiab tag absorbed thiab faib nyob rau hauv lub digestive ib ntsuj av, nrog ib tug plasma protein binding tus nqi (PPB) txog li 94%. Qhov no ua rau cov tshuaj nkag mus rau hauv cov hlab ntsha sai thiab ua rau lub cev lub cev.
Metabolism thiab excretion:
Metabolized tag nrho hauv daim siab los ntawm - oxidation thiab N-demethylation. Nws qhov kev tshem tawm ib nrab -lub neej (T1/2) luv luv, ntawm 2.5 teev. Cov tshuaj no tsuas yog tawm hauv daim ntawv ntawm metabolites los ntawm cov zis, tsuas yog ib qho me me (li 8%) ntawm cov tshuaj thawj zaug tawm ntawm lub raum. Ib nrab-Lub neej ntawm kev tshem tawm tshuaj nyob rau hauv cov neeg mob lub raum tsis txaus yuav ncua li ntawm 1 teev.
Raws li ib qho tseem ceeb kws tshuaj nruab nrab, nws txoj kev synthesis yog qhov tseem ceeb heev rau covTianeptine sulfatethiab kev tshawb fawb thiab kev tsim tshuaj. Kev sib xyaw ntawm sulfamethoxazole feem ntau muaj ntau cov kauj ruam, suav nrog kev xaiv cov khoom siv raw, kev sib txuas ntawm cov nruab nrab, thiab cov tshuaj ntsev kawg tsim. Cov kauj ruam no yuav tsum muaj kev ua haujlwm zoo thiab kev tswj xyuas nruj ntawm cov tshuaj tiv thaiv kom ntseeg tau tias qhov purity thiab tawm los ntawm cov khoom.
Cov txheej txheem synthesis tshwj xeeb
Kev sib xyaw ntawm sulfamethoxazole feem ntau pib los ntawm cov khoom siv tshwj xeeb, xws li 7-aminoheptanoate ethyl ester, 5,8-dichloro-10-dioxo-11-methyldibenzo [c, f] thiazepine, thiab lwm yam. Cov ntaub ntawv nyoos no yuav tsum tau ua kom huv thiab ua kom tau raws li qhov yuav tsum tau ua ntawm cov tshuaj tiv thaiv synthesis.
Nyob rau hauv tus txheej txheem ntawm synthesizing sulfamethoxazole sulfate, nws yog feem ntau tsim nyog los ua ke ib tug series ntawm intermediates. Cov kauj ruam synthesis ntawm cov intermediates yog complex thiab tseem ceeb, ncaj qha cuam tshuam rau qhov zoo thiab yield ntawm cov khoom kawg. Cov hauv qab no yog ib txoj hauv kev ua tau nruab nrab synthesis:
Kev daws zaum kawg
Kauj Ruam 1: Cov tshuaj tiv thaiv Esterification
React 7-aminoheptanoic acid ethyl ester nrog ib qho tsim nyog acylation reagent los tsim cov khoom sib xws esterification. Cov kauj ruam no feem ntau yog ua raws li acidic lossis alkaline tej yam kev mob thiab yuav tsum tau tswj cov tshuaj tiv thaiv kub thiab sijhawm.
Kauj Ruam 2: Cyclization cov tshuaj tiv thaiv
React cov khoom esterification tau nyob rau hauv cov kauj ruam dhau los nrog cyclization reagents xws li 5,8-dichloro-10-dioxo-11-methyldibenzo [c, f] thiazepine los tsim ib qho nruab nrab uas muaj cov pob txha ntawm tianeptin. Cov kauj ruam no yuav xav kom muaj cov catalyst thiab tswj cov tshuaj tiv thaiv kub, siab, thiab hnyav hnyav.
Kauj Ruam 3: Hydrolysis thiab acidification
Hydrolyze thiab acidify qhov nruab nrab tau txais los ntawm cov tshuaj tiv thaiv cyclization kom tshem tawm cov pab pawg tiv thaiv thiab qhia cov pab pawg xav tau. Cov kauj ruam no feem ntau yuav tsum tau siv cov tshuaj acidic thiab tswj cov tshuaj tiv thaiv kub thiab sijhawm.
Tom qab tau txais cov kua qaub ntawm tianeptin, nws yuav tsum tau hloov mus rau hauv daim ntawv sulfate. Cov kauj ruam no feem ntau yog ua tiav los ntawm kev tsim cov tshuaj ntsev, uas cuam tshuam nrog cov tshuaj tianeptin acid nrog sulfuric acid los yog sulfate los tsim tianeptin sulfate. Cov hauv qab no yog qhov ua tau ntsev tsim cov tshuaj tiv thaiv qib:
Kev daws zaum kawg
Kauj ruam 1: Dissolve thiab mix
Dissolve tianeptinic acid nyob rau hauv ib tug haum hnyav, xws li ethanol los yog methanol. Tom qab ntawd, ntxiv sulfuric acid los yog sulfate tov rau cov tshuaj thiab sib tov kom huv si.
Kauj Ruam 2: Cov tshuaj tiv thaiv thiab crystallization
Cia cov tshuaj tiv thaiv mus rau ib lub sij hawm nyob rau hauv qhov tsim nyog kub thiab nplawm tej yam kev mob. Raws li cov tshuaj tiv thaiv zuj zus, sulfamethoxazole sulfate yuav maj mam precipitate. Lub sijhawm no, cov txheej txheem crystallization tuaj yeem txhawb nqa los ntawm kev txias lossis ntxiv lwm cov kuab tshuaj.
Kauj Ruam 3: Lim thiab ziab
Lim thiab sau cov precipitated sulfamethoxazole sulfate, thiab ntxuav nws nrog ib qho hnyav hnyav kom tshem tawm impurities. Tom qab ntawd, qhuav cov khoom ntawm qhov kub thiab txias kom qhov hnyav tas li kom tau txais sulfamethoxazole sulfate ntshiab.
Optimization thiab txhim kho cov txheej txheem synthesis
Nyob rau hauv tus txheej txheem ntawm synthesizing sulfamethoxazole sulfate, cov kws tshawb fawb feem ntau optimize thiab txhim kho txoj kev synthesis thiaj li yuav txhim kho cov purity thiab tawm los ntawm cov khoom. Nov yog qee qhov kev ntsuas ua tau zoo:
Kev xaiv thiab ua cov khoom siv raw: Xaiv cov khoom siv siab-purity raw khoom thiab tau txais kev kho kom huv huv nruj kom txo tau qhov cuam tshuam ntawm impurities ntawm cov tshuaj tiv thaiv synthesis.
Kev tswj cov tshuaj tiv thaiv kab mob: Muaj tseeb tswj cov tshuaj tiv thaiv kub, siab, hom hnyav, thiab ntau npaum li cas los txhim kho cov txheej txheem tshuaj tiv thaiv thiab txhim kho cov khoom zoo
Kev siv cov catalysts: Siv cov catalysts tsim nyog hauv cov kauj ruam tseem ceeb kom nrawm cov tshuaj tiv thaiv thiab txhim kho cov khoom lag luam.
Purification ntawm intermediates: Purification ntawm intermediates generated thaum lub sij hawm synthesis txheej txheem kom tshem tawm impurities thiab txhim kho cov efficiency thiab cov khoom zoo ntawm cov kev tshwm sim tom ntej.
Optimization of Salt Formation Reaction: Xaiv cov ntsev tsim cov tshuaj reagents thiab cov tshuaj tiv thaiv kom ntseeg tau tias qhov kev ua tau zoo ntawm cov ntsev tsim cov tshuaj tiv thaiv thiab cov purity ntawm Tianeptine Sulfate.
Kev phiv tshuaj
Tianeptine sulfateyog ib qho kev sib xyaw nrog cov teebmeem tshuaj tshwj xeeb uas tau siv los kho qee yam kev puas hlwb thiab kev puas siab puas ntsws. Txawm li cas los xij, zoo li lwm yam tshuaj, nws kuj tseem tuaj yeem ua rau muaj kev cuam tshuam tsis zoo thaum siv tshuaj kho mob. Cov kev cuam tshuam tsis zoo no tsis tsuas yog cuam tshuam rau kev kho mob thiab kev ua neej zoo ntawm cov neeg mob, tab sis kuj tseem tuaj yeem ua rau muaj kev puas tsuaj rau lawv lub cev kev noj qab haus huv hauv cov mob hnyav.
Palpitations: Cov neeg mob yuav hnov lub plawv dhia ceev, palpitations, thiab qee zaum lub plawv dhia tsis xwm yeem. Qhov tshwm sim ntawm palpitations tuaj yeem yog vim Tianeptine Sulfate cuam tshuam rau kev tswj hwm lub paj hlwb ntawm lub plawv, ua rau muaj kev xav ntau ntxiv rau lub paj hlwb excitability thiab nce lub plawv dhia.
Ntshav siab hloov pauv: Qee tus neeg mob yuav muaj kev nce lossis txo cov ntshav siab. Kev nce ntshav siab tuaj yeem cuam tshuam nrog vasoconstriction lossis cov kua dej tuav los ntawm cov tshuaj;
Kev Phem Phem Loj
Arrhythmia: Muaj tsawg zaus, Tianeptine Sulfate tuaj yeem ua rau mob arrhythmias hnyav xws li ventricular premature beats, ventricular tachycardia, thiab lwm yam. Qhov tshwm sim ntawm arrhythmia tuaj yeem cuam tshuam rau lub cev ua haujlwm ntawm lub plawv, ua rau muaj kev hloov pauv hauv hemodynamics, thiab mob hnyav, txawm tias ua rau lub plawv nres, ua rau muaj kev phom sij rau lub neej.
Myocardial infarction: Txawm hais tias tsawg heev, muaj cov ntaub ntawv qhia tias Tianeptine Sulfate tuaj yeem cuam tshuam nrog qhov tshwm sim ntawm myocardial infarction. Qhov no tej zaum yuav yog vim cov tshuaj ua rau cov hlab ntsha coronary spasm lossis txhawb kev tsim cov thrombus, ua rau cov ntshav tsis txaus thiab ua rau myocardial infarction.
Qhov tshwm sim ntawm qhov tsis zoo tshwm sim nyob rau hauv cov hlab plawv system muaj feem xyuam rau qhov ncaj thiab tsis ncaj ntawm cov tshuaj ntawm cov hlab plawv system. Tianeptine Sulfate tuaj yeem cuam tshuam lub plawv dhia thiab ntshav siab los ntawm kev hloov pauv qhov sib npaug ntawm kev xav thiab parasympathetic paj hlwb los ntawm kev hloov pauv ntawm cov neurotransmitters hauv plawv plawv. Tsis tas li ntawd, cov tshuaj kuj tseem tuaj yeem cuam tshuam ncaj qha rau cov leeg nqaij leeg, ua rau vasoconstriction lossis dilation ntawm cov hlab ntsha.
Mechanism ntawm qhov tshwm sim thiab muaj feem cuam tshuam
Cov xwm txheej ntawm cov hlab plawv tus kheej, cov tshuaj sib xyaw ua ke, thiab lwm yam kuj tuaj yeem cuam tshuam qhov tshwm sim ntawm qhov tshwm sim tsis zoo. Piv txwv li, cov neeg mob uas muaj kab mob plawv xws li ntshav siab thiab kab mob plawv muaj peev xwm them nyiaj tsis zoo hauv lawv cov hlab plawv, thiab kev pheej hmoo ntawm kev mob plawv tsis zoo yuav nce ntxiv tom qab noj Tianeptine Sulfate; Lub caij no, thaum siv ua ke nrog lwm cov tshuaj hauv plawv, kev sib cuam tshuam ntawm cov tshuaj yuav tshwm sim, ntxiv qhov ua rau muaj qhov tsis zoo tshwm sim.
Cim npe nrov: Tianeptine sulfate CAS 1224690-84-9, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom