4-Butylresorcinol hmoovyog ib qho organic compound nrog CAS 18979-61-8 thiab tshuaj formula C10H13O3. Kuj hu ua Rucinol, yog ib qho khoom muaj nyob rau hauv ntau yam tshuaj pleev ib ce. Nws yog dawb mus rau lub teeb daj hmoov los yog siv lead ua uas yog opaque nyob rau hauv nws cov khoom muaj zog. Lub nplhaib benzene thiab hydroxyl pawg hauv nws cov qauv molecular txiav txim siab nws cov polarity siab thiab hydrophilicity. Cov tshuaj no tuaj yeem soluble hauv cov kuab tshuaj organic xws li ethanol, ether, thiab chloroform, tab sis tsis nyob hauv dej. Qhov no qhia tau hais tias nws muaj zoo solubility nyob rau hauv cov organic solvents, thaum nws yuav luag insoluble nyob rau hauv dej. Cov yam ntxwv no yog tshwm sim los ntawm benzene nplhaib thiab hydroxyl pawg hauv nws cov qauv molecular. Lub refractive index yog ib qho kev ntsuas ntawm ib yam khoom muaj peev xwm rau refract lub teeb, thiab qhov siab dua qhov refractive index, qhov muaj zog ntawm cov khoom muaj peev xwm rau refract lub teeb. Siv los ua ib qho tshuaj dawb thiab freckle tshem tawm hauv cov tshuaj pleev ib ce, nws tuaj yeem inhibit qhov tsim ntawm melanin, yog li fading me ntsis thiab txhim kho cov xim ntawm daim tawv nqaij. Nws muaj cov teebmeem antioxidant thiab tuaj yeem tiv thaiv cov hlwb ntawm daim tawv nqaij los ntawm kev puas tsuaj los ntawm cov dawb radicals, yog li ncua kev laus ntawm daim tawv nqaij. Nws tuaj yeem siv los ua cov tshuaj tua kab mob thiab cov pigment dispersant los txhim kho kev ua haujlwm thiab kev ruaj ntseg ntawm cov txheej.
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Tshuaj Formula |
C10H14O2 |
|
Exact Mass |
166.22 |
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Molecular Luj |
166.10 |
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m/z |
166.10 (100.0%), 167.10 (10.8%) |
|
Elemental Analysis |
C, 72.26; H, 8.49; O, 19.25 |
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Morphological |
hmoov |
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Xim |
dawb mus daj daj hmoov. |
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Melting point |
50.0 txog 55.0 degree |
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Boiling point |
166℃C / 7mmHg (lit.) |
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Qhov ntom |
1.092 ± 0.06 g / cm3 (Kev kwv yees) |
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Cia tej yam kev mob |
Inert cua |
|
solubility cawv |
soluble soluble 40 feem ntawm cov kuab tshuaj |
|
Acidity coefficient (pKa) |
9.95 ± 0.18 (Kev kwv yees) |
|
|
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Tam sim no, muaj ob txoj hauv kev tseem ceeb rau kev sib txuas ntawm4-Butylresorcinol hmoov:
Txoj Kev 1:
4-Butyl resorcinol raug txo nrog palladium carbon hauv methanol. Catalytic hydrogenation yog cov kua roj ib txwm muaj peb-theem heterogeneous cov tshuaj tiv thaiv. Txhawm rau kom ua tiav qhov kev sib cuag ntawm peb theem, qhov kub thiab txias siab (15atm) yuav tsum tau ua, uas tsis yog tsuas yog muaj lub zog siv hluav taws xob xwb, tab sis kuj muaj cov nplaim hluav taws kub thiab tawg ntawm H2 hauv lub cev. Nyob rau hauv cov ntaub ntawv ntawm to, muaj kev nyab xeeb loj heev, thiab tus nqi ntawm kev siv palladium carbon yog siab heev.
Txoj Kev 2:
Nyob rau hauv tej yam kev mob, 4-butyl resorcinol raug txo nrog zinc amalgam ntawm 120℃C. Vim hais tias cov tshuaj tiv thaiv yog nqa tawm nyob rau saum npoo ntawm active zinc, tshiab zinc amalgam yog xav tau rau txhua kauj ruam; Cov tshuaj tiv thaiv kub siab ua rau poob loj ntawm hydrochloric acid concentration, thiab concentrated hydrochloric acid yuav tsum tau ntxiv kom muaj acidity; Tsim ib tug loj npaum li cas ntawm cov pa phem zinc amalgam.
Zoo li cov qauv kev qhia tam sim no, ob txoj hauv kev saum toj no muaj qhov tsis xws luag hauv cov txheej txheem amplification. Tsis tas li ntawd, cov tshuaj reactor ib txwm siv thiab pub cov tshuaj tiv thaiv tso tawm cua sov thiab tsim cov roj ntau, uas muaj peev xwm ua rau muaj kev nyab xeeb zoo thiab ua rau muaj kev nyuaj ntawm cov txheej txheem amplification.
Cov txheej txheem ntawm kev sib txuas 4-n-butyl resorcinol tau txais los ntawm peb lub tuam txhab yog:
Qhov hnyav 100g ntawm 4-n-butyryl resorcinol thiab yaj nws hauv toluene, dej khov rau 0 degree, tom qab ntawd maj mam ntxiv 32g (1.5eq) sodium borohydride hauv cov khoom, thiab hnov mob ntawm chav tsev kub rau 12h tom qab ntxiv; Tom qab ntawd txhaj nws rau hauv preheating module 1 thiab preheat nws mus rau 80 degree; Sib tov 67g Raney nickel thiab isopropanol rau hauv preheating module 2 thiab preheat rau 80 degree. Tom qab ntawd ntxiv ob qho khoom siv preheated saum toj no rau hauv cov tshuaj tiv thaiv, thiab lub sijhawm nyob yog tswj ntawm 200s. Sau cov tshuaj tiv thaiv tawm, ncuav rau hauv dej khov kom tua, lim tawm cov khoom, evaporate feem ntau ntawm cov toluene, ntxiv 330ml ntawm dichloromethane rau extraction, evaporate dichloromethane, thiab tau 82G ntawm dawb khoom 4-n-butyl resorcinol, nrog ib tug yield ntawm 89%.
4-Butylresorcinol hmoovmuaj ntau yam kev siv hauv kev lag luam tshuaj.
1. Cov tshuaj tiv thaiv kab mob:
4 Butylresorcinol yog ib qho tshuaj tua kab mob uas siv tau los kho cov kab mob fungal ntawm daim tawv nqaij. Nws cov txheej txheem ntawm kev ua yog tsuas yog los ntawm kev cuam tshuam kev ncaj ncees ntawm cov kab mob fungal cell membranes, yog li inhibiting fungal kev loj hlob thiab kev loj hlob. Cov tshuaj no tau dav siv los kho cov kab mob fungal xws li dermatophytosis thiab kis las ko taw. Piv nrog rau lwm cov tshuaj tiv thaiv kab mob, 4 Butylresorcinol muaj zog tiv thaiv kab mob thiab muaj kev cuam tshuam tsawg dua, ua rau nws suav tias yog tshuaj tiv thaiv kab mob zoo heev.
2. Cov tshuaj tiv thaiv inflammatory:
4 Butylresorcinol kuj muaj cov tshuaj tiv thaiv - mob thiab tuaj yeem siv los kho cov kab mob inflammatory xws li mob caj dab thiab mob caj dab rheumatoid. Nws cov tshuaj tiv thaiv - cov nyhuv inflammatory yog ua tiav los ntawm inhibiting kev tso tawm ntawm cov neeg kho mob inflammatory thiab inhibiting cov synthesis ntawm prostaglandins. Piv nrog rau lwm cov tshuaj tiv thaiv kab mob, 4 Butylresorcinol muaj zog tiv thaiv - cov teebmeem inflammatory thiab tsawg dua cov tshuaj tiv thaiv, ua rau nws yog ib qho kev xaiv thawj zaug rau cov tshuaj tiv thaiv {- inflammatory.
3. Antitumor tshuaj:
Nyob rau hauv xyoo tas los no, cov tshuaj tiv thaiv -cov nyhuv ntawm 4 Butylresorcinol tau maj mam tau txais kev saib xyuas. Kev tshawb fawb tau pom tias qhov sib xyaw no tuaj yeem cuam tshuam kev loj hlob thiab nthuav tawm ntawm cov qog hlwb thiab ua rau apoptosis ntawm cov qog hlwb. Nws cov tshuaj tiv thaiv -cov nyhuv qog tuaj yeem cuam tshuam nrog inhibition ntawm cov teeb liab transduction txoj hauv kev qog hlwb. Yog li ntawd, 4 Butylresorcinol tuaj yeem dhau los ua ib hom tshuaj tiv thaiv qog noj ntshav tshiab rau kev kho mob qog noj ntshav ntau yam.
4. Kev kho mob ntshav qab zib ko taw:
Mob ntshav qab zib ko taw yog ib qho teeb meem loj ntawm ntshav qab zib, uas feem ntau xav tau kev txiav tawm. Kev tshawb fawb qhia tias 4 Butylresorcinol tuaj yeem txhim kho cov tsos mob ntawm cov mob ntshav qab zib ko taw, txhawb kev kho qhov txhab, thiab txhim kho lub neej zoo ntawm cov neeg mob. Nws cov txheej txheem ntawm kev ua haujlwm tuaj yeem cuam tshuam txog kev txhawb nqa angiogenesis, txhawb nqa cell proliferation, thiab inhibiting inflammatory reactions. Yog li, 4 Butylresorcinol tuaj yeem dhau los ua cov tshuaj tshiab rau kev kho mob ntshav qab zib ko taw.
5. Lwm yam kev siv:
Ntxiv nrog rau cov lus hais saum toj no, 4 Butylresorcinol kuj muaj lwm yam kev siv tshuaj. Piv txwv li, nws tuaj yeem ua cov tshuaj tiv thaiv rau cov kab mob plawv, nrog rau cov teebmeem xws li txo cov ntshav siab, txo cov ntshav lipids, thiab tiv thaiv platelet aggregation. Tsis tas li ntawd, nws tseem tuaj yeem siv los kho qee yam kab mob hauv lub paj hlwb, xws li Alzheimer's disease, Parkinson's disease, thiab lwm yam. Kev tshawb fawb ntxiv thiab kev siv tau los txiav txim siab txog kev nyab xeeb thiab kev ua tau zoo ntawm cov kev siv no.
Feem ntau, 4-Butylresorcinol muaj ntau yam kev siv hauv kev kho mob, los ntawm cov tshuaj tiv thaiv kab mob mus rau cov tshuaj tiv thaiv- cov tshuaj tiv thaiv kab mob, tshuaj tiv thaiv qog thiab kho mob ntshav qab zib ko taw. Txawm li cas los xij, nws yuav tsum raug sau tseg tias cov kev siv no yuav tsum muaj kev lees paub ntxiv thiab kev lees paub ntawm lawv txoj kev nyab xeeb thiab kev ua tau zoo hauv kev sim tshuaj. Tsis tas li ntawd, rau txhua qhov kev siv tshiab lossis daim ntawv thov kev lag luam, kev tshawb fawb thiab kev sim txaus yuav tsum tau ua kom ntseeg tau tias nws muaj kev nyab xeeb thiab ua haujlwm tau zoo.
4-Butylresorcinol hmoovyog ib qho derivative ntawm resorcinol, uas feem ntau tsis yog - tshuaj lom thiab tsis muaj mob rau daim tawv nqaij tom qab hloov cov qauv. Txawm li cas los xij, vim muaj qhov tsis haum ntawm cov khoom xyaw no, kev kuaj kev tsis haum yuav tsum tau ua ua ntej siv kom tsis txhob muaj tawv nqaij intolerance. Tsis tas li ntawd, nws yog me ntsis soluble hauv dej thiab nws yooj yim rau oxidation thiab discoloration raws li phenolic tshuaj. Nws kuj yog nquag chelation nrog hlau ions, uas txwv nws daim ntawv thov hauv tshuaj pleev ib ce.
(1) Inhibition ntawm melanin ntau lawm thiab hloov pauv: Nws tuaj yeem nkag mus tob rau hauv cov txheej txheem ntawm daim tawv nqaij thiab inhibit qhov tsim thiab hloov ntawm melanin. Nws txhim kho lub peev xwm degradation ntawm tyrosinase, pab kom zom thiab tshem tawm melanin precipitates uas twb muaj lawm, yog li ua tiav cov teebmeem ntawm kev tshem tawm daj, ci, whitening thiab lightening me ntsis.
(2) Cov nyhuv whitening muaj zog: Raws li kev tshawb fawb, nws muaj qhov cuam tshuam tseem ceeb ntawm kev ua haujlwm tyrosinase. Nyob rau hauv vitro human tyrosinase assay, nws cov nyhuv inhibitory yog 5 npaug ntawm hexylresorcinol, 6 npaug ntawm phenethyl resorcinol (377), 25 npaug ntawm quercetin, 325 npaug ntawm arbutin, thiab 220 npaug ntawm hydroquinone. Piv rau 377577, nws muaj qhov nkag tau zoo dua, muaj zog ua kom tawv nqaij tawv dua, thiab ua kom pom tseeb dua.
(3) Dimming hnub nyoog me ntsis thiab pob txuv nti: siv lub sij hawm ntev tuaj yeem ploj cov hnub nyoog melanin thiab pob txuv nti tshwm sim los ntawm melanin deposition, ua rau daim tawv nqaij brighter thiab smoother.
2. Antioxidant nyhuv
(1) Tshem tawm cov dawb radicals: Nws muaj zog antioxidant muaj peev xwm thiab tuaj yeem tshem tawm cov dawb radicals hauv lub cev, tiv thaiv kev laus ntawm daim tawv nqaij.
(2) Tiv thaiv UV puas: Nws tuaj yeem tiv thaiv daim tawv nqaij los ntawm UV puas thiab tiv thaiv kev tsim ntawm tshav ntuj thiab wrinkles.
(3) Txo cov tawv nqaij o: Nws muaj kev tiv thaiv - cov teebmeem inflammatory thiab tuaj yeem txo cov tawv nqaij o thiab liab.
(4) Txhawb kev kho qhov txhab: Nws tuaj yeem txhawb kev kho qhov txhab thiab txo qis kev caws pliav.
(1) Inhibition ntawm cov kab mob thiab fungi: Nws muaj inhibitory cuam tshuam rau ntau yam kab mob thiab fungi, thiab tuaj yeem tiv thaiv thiab kho kab mob ntawm daim tawv nqaij.
(2) Ua kom cov tawv nqaij noo noo: Nws tuaj yeem ua kom cov dej noo ntawm daim tawv nqaij, txhim kho dryness thiab flaking ntawm daim tawv nqaij.
(3) Xauv hauv cov dej noo: Nws tuaj yeem kaw cov dej noo ntawm daim tawv nqaij, ua kom nws mos thiab du.
(1) Ntxiv piv: feem ntau yog ntxiv rau cov khoom tu tawv nqaij xws li cov tshuaj pleev xim dawb, xws li cov tshuaj pleev xim dawb, pleev xim rau lub ntsej muag, thiab lwm yam. Qhov sib ntxiv yuav tsum tau kho raws li cov khoom tsim tawm thiab kev ua siab ntev ntawm daim tawv nqaij.
(2) Cov nyhuv siv: Siv cov khoom siv tawv nqaij tuaj yeem txhim kho daim tawv nqaij dullness, pigmentation, thiab lwm yam teeb meem, ua rau cov tawv nqaij ci dua thiab ntau dua.
Cov kev mob tshwm sim ntawm cov tshuaj no yog dab tsi?
Kab mob
Cov tawv nqaij liab thiab o: Thaum daim tawv nqaij los rau hauv kev sib cuag nrog 4-butylresorcinol hmoov, stimulating nyhuv ntawm cov tshuaj tej zaum yuav ua rau cov hlab ntsha hauv zos dilation, ua rau daim tawv nqaij liab thiab o.
Khaus khaus: Cov tshuaj lom neeg ua rau cov hlab ntsha xaus ntawm daim tawv nqaij, uas yuav ua rau khaus thiab ua rau tus neeg mob tas li khawb, ua rau cov tawv nqaij puas tsuaj ntxiv.
Mob: Qee zaum, 4-butylresorcinol hmoov tuaj yeem ua rau mob los yog kub hnyiab ntawm daim tawv nqaij, feem ntau yog vim kev puas tsuaj rau cov tawv nqaij los ntawm cov tshuaj lom neeg.
Kev puas tsuaj rau plab hnyuv
Mob plab: 4-Butylresorcinol txhawb lub plab mucosa, uas yuav ua rau mob lossis tsis xis nyob hauv plab.
Kev xeev siab thiab ntuav: Tom qab noj cov tshuaj no, cov neeg mob yuav hnov cov tsos mob xws li xeev siab thiab ntuav vim nws ua rau mob plab hnyuv.
Acid reflux: Qee zaum, 4-butylresorcinol tuaj yeem ua rau cov kua qaub ntau dhau ntawm cov plab hnyuv siab raum, ua rau cov tsos mob tsis zoo xws li acid reflux thiab kub siab.
Ua pa puas
Kev ua pa ua pa: ntev ntev rau 4-butylresorcinol tuaj yeem ua rau cov tsos mob xws li congestion thiab edema ntawm cov pa mucosa, ua rau tsis xis nyob xws li hnoos thiab ua pa nyuaj.
Tachycardia thiab ntshav siab poob: Qee zaum, cov tshuaj no tuaj yeem cuam tshuam rau cov hlab plawv, ua rau cov cim tseem ceeb xws li tachycardia thiab ntshav siab poob.
Dyspnea: Kev ua pa hnyav tuaj yeem ua rau muaj sia nyob - cov tsos mob hem xws li ua pa nyuaj thiab ua tsis taus pa hauv cov neeg mob.
Lwm yam kev pheej hmoo
Kev tsis haum tshuaj: Qee tus neeg mob yuav muaj kev fab tshuaj rau cov tshuaj, tshwm sim ua pob liab liab, urticaria, ua pa nyuaj, thiab lwm yam tsos mob. Rau cov neeg mob zoo li no, kev siv cov tshuaj pleev ib ce uas muaj cov tshuaj no yuav tsum tau nres tam sim ntawd thiab lawv yuav tsum nrhiav kev kho mob rau kev kho mob los tiv thaiv kev tsis haum.
Photosensitivity: Cov kev tshawb fawb tau pom tias 4-butylresorcinol tuaj yeem ua rau cov tawv nqaij rhiab heev rau lub teeb. Yog li ntawd, tom qab siv tshuaj pleev ib ce uas muaj cov tshuaj no, ntev raug rau lub hnub ci yuav tsum tau zam kom ntau li ntau tau kom txo tau qhov tshwm sim ntawm photosensitive tshwm sim.
Endocrine cuam tshuam cov teebmeem: Qee cov tshuaj muaj qhov cuam tshuam endocrine cuam tshuam thiab tuaj yeem cuam tshuam rau tib neeg endocrine system. Txawm hais tias tam sim no tsis muaj pov thawj txaus los qhia tias 4-butylresorcinol muaj cov nyhuv no, nws tseem yuav tsum tau ceev faj thiab saib xyuas cov kev tshawb fawb txog kev ua tiav.
Cov lus nug nquag
Puas yog 4-butylresorcinol zoo dua li hydroquinone?
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4-n-Butylresorcinol, tus neeg sawv cev hypopigmenting tshiab, inhibits tyrosinase thiab TRP-1. Superior human tyrosinase inhibitory kev ua haujlwm ntawm 4-n-butylresorcinol tiv thaiv hydroquinone, arbutin, thiab kojic acid tau tsim nyob rau hauv kev tshuaj ntsuam biochemical.
Cov kev phiv ntawm 4 Butylresorcinol yog dab tsi?
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Tsis tas li ntawd, kev khaus khaus ntawm daim tawv nqaij tuaj yeem tshwm sim los ntawm 4-n-butylresorcinol, uas yog ib qho resorcinol derivative, thiab tshwj xeeb tshaj yog thaum nws siv rau hauv high concentrations11. Ntawm ntau txoj hauv kev, qhov qis dua ntawm 4-n-butylresorcinol tuaj yeem siv los txo qis ntawm cov tawv nqaij khaus.
4 butyl resorcinol siv rau dab tsi?
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Feem ntau pom muaj nyob rau hauv cov tshuaj pleev ib ce xws li cov tshuaj pleev ib ce, tshuaj pleev, thiab tshuaj pleev ib ce, 4-Butylresorcinol yog qhov tsim nyog rau kev hais txog ntau yam kev txhawj xeeb ntawm pigmentation, nrog rau cov melasma thiab lub hnub ci ntsa iab. Zuag qhia tag nrho, cov khoom xyaw no pab kom ua tiav lub ntsej muag ci dua thiab ci dua.
Cim npe nrov: 4-butylresorcinol hmoov CAS 18979-61-8, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom