1-Bromodibenzothiophene, molecular mis C12H7BrS, CAS 65642-94-6, nws cov tsos yog dawb rau txiv kab ntxwv mus rau ntsuab hmoov los yog siv lead ua. Nws muaj solubility zoo dua hauv cov kuab tshuaj organic, tab sis cov solubility tsis zoo hauv dej. Cov cuab yeej no muaj qhov cuam tshuam loj rau nws cov ntawv thov hauv cov organic synthesis, kev npaj cov khoom siv, thiab kev tshuaj ntsuam xyuas.Piv txwv li, hauv kev siv tshuaj tua kab, nws tuaj yeem ua haujlwm nruab nrab rau kev siv tshuaj tua kab molecules nrog cov tshuaj tua kab tshwj xeeb lossis tshuaj tua kab;
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Tshuaj Formula |
C12H7BrS |
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Exact Mass |
262 |
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Molecular Luj |
263 |
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m/z |
262 (100.0%), 264 (97.3%), 263 (13.0%), 265 (12.6%), 264 (4.5%), 266 (4.4%) |
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Elemental Analysis |
C, 54,77; H, 2,68; Saib, 30.36; S, 12.18 Nws |
Optoelectronic cov ntaub ntawv
Cov khoom no thiab nws cov derivatives muaj peev xwm siv tau rau hauv cov khoom siv optoelectronic. Vim lub conjugated xwm ntawm thiophene rings, cov tebchaw muaj peev xwm nqus thiab emit lub teeb ntawm tej wavelengths, ua rau lawv haum raws li cov khoom siv rau optoelectronic li xws li organic solar cells thiab organic light-emitting diodes (OLEDs). Tsis tas li ntawd, los ntawm kev tswj cov qauv molecular thiab muaj pes tsawg leeg ntawm cov tebchaw.
Cov khoom siv semiconductor
Qee cov derivatives ntawm cov khoom no muaj cov khoom siv semiconductor thiab tuaj yeem siv los ua cov khoom siv semiconductor. Cov ntaub ntawv no muaj kev pom dav dav hauv kev lag luam xws li cov khoom siv hluav taws xob thiab cov sensors. Piv txwv li, lawv tuaj yeem siv los ua cov ntaub ntawv channel rau thaj chaw - cuam tshuam cov transistors lossis rau kev tsim cov sensors nrog cov haujlwm tshwj xeeb.
Catalyst cab kuj
Hauv cov tshuaj tiv thaiv catalytic, cov tshuaj no thiab nws cov derivatives kuj tuaj yeem ua cov cab rau catalysts. Los ntawm kev kho cov catalyst ntawm tus neeg nqa khoom, kev ruaj ntseg thiab rov ua dua ntawm cov catalyst tuaj yeem txhim kho, yog li txo cov nqi tsim khoom thiab txo qis ib puag ncig. Tsis tas li ntawd, cov pab pawg ua haujlwm ntawm cov cab kuj tseem tuaj yeem muaj kev sib koom ua ke nrog cov catalyst, ntxiv kev txhim kho cov catalytic efficiency.
Lub synthesis ntawm 1-Bromodibenzothiophene yog ib qho tseem ceeb ntawm cov organic synthesis ua hauj lwm, thiab cov compound no muaj ntau yam kev siv nyob rau hauv cov tshuaj thiab cov ntaub ntawv science. Cov hauv qab no yog ib txoj hauv kev sim ua kom sib xyaw ua ke, suav nrog cov kauj ruam ntxaws thiab sib npaug ntawm cov tshuaj lom neeg:
Cov ntaub ntawv thiab cov cuab yeej
1. Cov khoom siv raw:
2,3-Dibromothiophene
-Diphenyl sulfide
-Kua: xws li acetonitrile, dimethyl sulfoxide (DMSO), thiab lwm yam
2. Reagents:
-Sodium hydroxide (NaOH)
-Bromine (Br2)
- tooj liab iodide (CuI)
-Dimethyl sulfoxide (DMSO)
3. Cov cuab yeej:
-Reflux ntaus ntawv
-Cov tshuaj tiv thaiv kab mob hauv qab huab cua tsis zoo (xws li nitrogen) tiv thaiv
-Magnetic stirrer
Synthesis cov kauj ruam
Kev npaj ntawm 2,3-dibromothiophene:
2,3-dibromothiophene yog ib qho precursor ntawm 1-bromo-2,3-dibenzothiophene, uas tuaj yeem ua ke los ntawm cov tshuaj tiv thaiv hauv qab no:
Reaction sib npaug:
2,3-dibromothiophene + bromine → CuI, DMSO 1-bromo-2,3-dibromothiophene
Hauv cov kuab tshuaj DMSO, 2,3-dibromothiophene reacts nrog bromine los tsim 1-bromo-2,3-dibromothiophene.
Kev npaj ntawm 1-bromo-2,3-dibenzothiophene:
Tam sim no, peb yuav hloov 1-bromo-2,3-dibromothiophene rau hauv cov khoom lag luam 1-bromo-2,3-dibenzothiophene. Cov tshuaj tiv thaiv yog raws li nram no:
Reaction sib npaug:
1-bromo-2,3-dibromothiophene + C12H10S + NaOH → 1-bromo-2,3-dibenzothiophene + NaBr + C8H6
Nyob rau hauv cov xwm txheej alkaline (siv NaOH), 1-bromo-2,3-dibromothiophene reacts nrog diphenyl sulfide los tsim 1-bromo-2,3-dibenzothiophene thiab benzothiophene raws li cov khoom lag luam. Cov tshuaj tiv thaiv no feem ntau yog ua nyob rau hauv ib qho chaw inert los tiv thaiv oxidation los yog lwm yam kev cuam tshuam los ntawm qhov tshwm sim.
Cov tshuaj tiv thaiv mechanism
Cov tshuaj tiv thaiv mechanism rau kev npaj 2,3-dibromothiophene:
Hauv DMSO cov kuab tshuaj, CuI ua haujlwm los txhawb cov tshuaj tiv thaiv ntawm bromine thiab 2,3-dibromothiophene. Thawj kauj ruam ntawm cov tshuaj tiv thaiv yuav koom nrog cov tiam ntawm bromide ions los ntawm CuI, uas nyob rau hauv lem ua rau ib tug bromine hloov cov tshuaj tiv thaiv nyob rau hauv lub 2,3-dibromothiophene molecule. Cov nyhuv catalytic no pab ua kom cov tshuaj tiv thaiv bromination.
Cov tshuaj tiv thaiv mechanism rau kev npaj 1-bromo-2,3-dibenzothiophene:
Cov txheej txheem ntawm cov tshuaj tiv thaiv ntawm 1-bromo-2,3-dibromothiophene thiab diphenyl sulfide nyob rau hauv lub xub ntiag ntawm NaOH koom nrog nucleophilic hloov cov tshuaj tiv thaiv nyob rau hauv alkaline tej yam kev mob. NaOH muab cov alkaline ib puag ncig, uas txhawb kev tawm ntawm bromide ions hauv 1-bromo-2,3-dibromothiophene, tsim cov carbocation nruab nrab. Cov carbocation no reacts nrog diphenyl sulfide ntawm SNAR cov tshuaj tiv thaiv (nucleophilic aromatic hloov).
Fine Chemical Synthesis
1-bromodibenzothiophene kuj tseem siv rau hauv kev sib txuas ntawm ntau yam tshuaj zoo, xws li dyes, pigments, thiab fragrances. Cov khoom siv hluav taws xob tshwj xeeb ntawm cov khoom sib xyaw tuaj yeem cuam tshuam cov xim thiab kho qhov muag ntawm dyes thiab pigments, ua rau lawv tsim nyog rau kev siv hauv textile, luam ntawv, thiab txheej kev lag luam. Piv txwv li, 1-bromodibenzothiophene-raws li dyes tau ua ke nrog cov xim zoo nkauj thiab muaj zog xim, ua tau raws li qhov xav tau ntawm cov txheej txheem dyeing niaj hnub.
1-bromodibenzothiophene tuaj yeem siv los ua lub tsev thaiv hauv kev sib xyaw ntawm cov tshuaj tsw qab. Los ntawm kev qhia cov pab pawg sib txawv los ntawm cov tshuaj tiv thaiv, cov kws tshawb fawb tuaj yeem tsim ntau hom tshuaj tsw qab molecules nrog cov ntxhiab tsw tshwj xeeb. Cov tshuaj tsw qab no pom cov ntawv thov hauv cov tshuaj tsw qab, tshuaj pleev ib ce, thiab kev lag luam tu tus kheej, txhim kho cov kev paub ntawm cov neeg siv khoom.
1-Bromodibenzothiophene muaj tus nqi tshwj xeeb raws li kev sojntsuam molecule hauv kev tshawb fawb bioscience. Nws tuaj yeem cuam tshuam nrog qee cov qauv lossis cov molecules hauv cov kab mob uas muaj sia nyob los ntawm cov khoom siv tshuaj lom neeg, yog li nthuav tawm cov txheej txheem lom neeg tshwj xeeb lossis qhia txoj hauv kev hauv cov kab mob muaj sia.
Tsim thiab xaiv cov kev sojntsuam molecules
Structure Properties:
Cov qauv molecular ntawm nws muaj bromine atoms thiab thiophene rings, thiab cov khoom siv no ua rau nws tshwj xeeb khi rau qee yam receptors lossis enzymes hauv cov kab mob.
Hom phiaj xaiv:
ib qho txheej txheem lom neeg tshwj xeeb lossis txoj kev taw qhia raug xaiv los ua cov khoom ntawm kev kawm raws li lub hom phiaj ntawm kev tshawb fawb. Piv txwv li, cov txheej txheem tuaj yeem tsom mus rau.
Synthesis thiab labeling:
Npaj 1-bromodibenzothiophene los ntawm chemical synthesis method thiab sau nws los ntawm cov txheej txheem sau npe tsim nyog rau kev taug qab thiab kuaj pom hauv kab mob.
Kev siv tshuaj ntsuam xyuas molecules
Intra-biological binding:
Qhia cov ntawv sau rau hauv lub cev, thiab qhia txog kev faib tawm thiab kev ua haujlwm ntawm cov molecules los ntawm nws qhov tshwj xeeb khi rau lub hom phiaj molecules (xws li receptors, enzymes, thiab lwm yam).
Tiag tiag - xyuas lub sijhawm:
Siv cov thev naus laus zis zoo tshaj plaws (piv txwv li, fluorescence imaging, magnetic resonance imaging, thiab lwm yam), cov kev hloov pauv ntawm 1-bromodibenzothiophene hauv cov kab mob raug saib xyuas hauv lub sijhawm, kom nkag siab txog lub sijhawm tiag tiag ntawm lub hom phiaj ntawm cov txheej txheem lom neeg lossis cov kev taw qhia.
Kev txheeb xyuas cov ntaub ntawv:
Los ntawm kev sib sau ua ke thiab kev txheeb xyuas cov txheej txheem tag nrho ntawm cov ntaub ntawv txheeb xyuas txog roj ntsha muaj tseeb, cov kws tshawb fawb muaj peev xwm tau txais cov ntaub ntawv qhia ntxaws thiab ntxaws ntxaws txog cov txheej txheem tshwj xeeb hauv cov txheej txheem lom neeg thiab cov txheej txheem hauv lub cev. Qhov no suav nrog lub sijhawm tshwm sim tiag tiag, spatial faib txoj haujlwm, dynamic tshuaj tiv thaiv tus nqi raws li qhov tseeb kev sib raug zoo ntawm cov ntaub ntawv kawm thiab lwm yam biomolecules, tso cov ntaub ntawv txhawb nqa rau kev tshawb fawb ntxiv.
Piv txwv Daim Ntawv Thov & Raws li cov tshuaj antipsychotic
Siv cov kev tshawb fawb neuroscience ua piv txwv, nws tuaj yeem siv los ua kev sojntsuam molecule los kawm txog cov txheej txheem ntawm cov neurotransmitter tso tawm thiab kev sib kis. Los ntawm kev qhia nws mus rau hauv lub paj hlwb, nws txoj kev khi rau cov neurotransmitter receptors tshwj xeeb tuaj yeem pom, yog li nthuav tawm cov neurotransmitter txoj kev sib kis ntawm cov neurons thiab cov txheej txheem tswj. Lawv tuaj yeem txhim kho tus neeg mob cov tsos mob ntawm kev puas siab puas ntsws los ntawm kev hloov kho cov theem ntawm cov neurotransmitters.
Modulation ntawm neurotransmitters:
dibenzothiophene tuaj yeem nce qib ntawm 5-hydroxytryptamine transporter, norepinephrine transporter, thiab dopamine transporter los ntawm thaiv tag nrho peb cov neurotransmitters. Cov neurotransmitters no ua lub luag haujlwm tseem ceeb hauv kev tswj kev xav, kev ntxhov siab, thiab lwm yam. Yog li ntawd, dibenzothiophene yuav tsum yog cov tshuaj zoo rau kev kho mob hlwb.
Antipsychotic teebmeem:
Cov kev tshawb fawb soj ntsuam tau pom tias dibenzothiophene derivatives, xws li quetiapine, tau pom zoo rau kev kho mob ntawm tus mob schizophrenia. Quetiapine muaj kev sib raug zoo rau 5-hydroxytryptamine receptor thiab dopamine D2 receptor, thiab lwm yam. Nws tuaj yeem tswj cov kev nyuaj siab biphasic thiab mania, uas qhia cov txiaj ntsig zoo.
Cov kev siv tau zoo ntawm dibenzothiophene hauv kev tshawb fawb txog neuroscience feem ntau yog nyob rau hauv nws lub peev xwm los cuam tshuam rau kev ua haujlwm thiab cov txheej txheem ntawm lub paj hlwb raws li kev siv tshuaj lossis tshuaj ua ntej, uas tuaj yeem siv rau kev kho mob ntawm ntau yam kab mob neurological.
Kev kho mob ntawm kev puas siab puas ntsws
Dibenzothiophene tuaj yeem siv los ua API rau kev npaj lwm yam tshuaj uas tuaj yeem siv rau kev kho mob ntawm kev puas siab puas ntsws xws li kev nyuaj siab thiab kev ntxhov siab. Dibenzothiophene tuaj yeem txhim kho cov neeg mob kev nyuaj siab thiab cov tsos mob ntxhov siab los ntawm kev tswj cov theem ntawm cov neurotransmitters, xws li nce qib ntawm cov neurotransmitters xws li 5-hydroxytryptamine, norepinephrine thiab dopamine, txhawm rau txhim kho kev ruaj ntseg ntawm cov neeg mob lub siab thiab kev ntxhov siab. Piv txwv li, quetiapine, ib tug dibenzothiophene derivative, tau pom zoo raws li ib tug atypical antipsychotic rau kev kho mob ntawm tus mob schizophrenia, thiab tseem muaj cov kev tshawb fawb qhia tias nws yuav muaj peev xwm los kho kev puas siab puas ntsws bipolar thiab mania.
Lwm yam kev siv muaj peev xwm
Ntxiv nrog rau cov ntawv thov saum toj no, dibenzothiophene tuaj yeem muaj lwm yam kev siv hauv neuroscience. Piv txwv li, nws tuaj yeem siv los ua cov cuab yeej tshawb fawb rau kev tshawb nrhiav cov haujlwm thiab cov txheej txheem ntawm lub paj hlwb, muab cov tswv yim tshiab thiab cov txheej txheem rau kev tshawb fawb neuroscience.
Kev kho cov kab mob plawv
Dibenzothiophene kuj tuaj yeem ua raws li kev tiv thaiv - mob vwm thiab txo cov tsos mob ntawm Parkinson tus kab mob los ntawm kev tswj cov qib ntawm cov neurotransmitters. Txawm hais tias nws daim ntawv thov nyob rau hauv kev kho mob ntawm cov kab mob neurological xav tau kev tshawb fawb ntxiv, nws tau pom zoo rau daim ntawv thov kev cia siab.
Anti- mob qog noj ntshav
Tsis tas li ntawd, dibenzothiophene muaj tshuaj tiv thaiv - mob qog noj ntshav. Nws tuaj yeem muaj peev xwm siv tau zoo hauv kev kho mob qog noj ntshav los ntawm kev ua kom lub autophagy ntawm cov qog hlwb, txhawb cov apoptosis ntawm cov qog hlwb thiab inhibiting kev loj hlob ntawm cov qog hlwb.
Txawm hais tias daim ntawv thov ntawm cov tshuaj no hauv kev kho mob qog noj ntshav tseem nyob rau theem pib, nws cov txiaj ntsig thiab kev nyab xeeb tau raug lees paub ua ntej.
Kev kho cov kab mob neurological
Dibenzothiophene kuj tuaj yeem ua raws li kev tiv thaiv - mob vwm thiab txo cov tsos mob ntawm Parkinson tus kab mob los ntawm kev tswj cov qib ntawm cov neurotransmitters.
Txawm hais tias nws daim ntawv thov nyob rau hauv kev kho mob ntawm cov kab mob neurological xav tau kev tshawb fawb ntxiv, nws tau pom zoo rau daim ntawv thov kev cia siab.
Hauv cov ntsiab lus, dibenzothiophene muaj ntau yam kev siv peev xwm hauv kev tshawb fawb neuroscience. Nws tuaj yeem siv rau hauv ntau yam xws li kev kho mob hlwb, kev puas siab puas ntsws, kab mob plawv thiab mob qog noj ntshav, muab cov kev xaiv tshiab thiab muaj peev xwm rau kev tshawb fawb neuroscience thiab kev kho mob. Txawm li cas los xij, cov ntawv thov no xav tau kev tshawb fawb ntxiv thiab kev lees paub kom ntseeg tau tias lawv muaj kev nyab xeeb thiab ua tau zoo.
Cov lus nug nquag
Cov mis rau dibenzothiophene yog dab tsi?
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C12H8S
Dibenzothiophene (DBT, diphenylene sulfide) yog organosulfur compound uas muaj ob lub nplhaib benzene fused rau lub nplhaib thiophene hauv nruab nrab. Nws muaj cov tshuaj formula C12H8S.
Lub ntsej muag zoo li cas?
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Dawb rau txiv kab ntxwv mus rau ntsuab hmoov los yog muaju.
Melting point?
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Kwv yees li 84 degree.
Yuav khaws cia li cas?
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Khaws ntawm chav tsev kub. Tsis txhob sib cuag nrog cov neeg muaj zog oxidizing, muaj zog acids, los yog muaj zog alkalis los tiv thaiv kev phom sij.
1-bromodibenzothiophene puas tuaj yeem siv rau kev sib txuas ntawm lwm cov organic molecules?
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Yog lawm, 1-bromodibenzothiophene, raws li ib tug brominated aromatic compound, exhibits siab reactivity. Nws tuaj yeem koom nrog kev hloov pauv, kev sib txuas lus sib txuas, thiab lwm yam txheej txheem ntawm nws cov atom bromine, ua kom cov synthesis ntawm ntau cov organic molecules.
Cim npe nrov: 1-bromodibenzothiophene cas 65642-94-6, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom