1-Bromohexadecane CAS 112-82-3

Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm cov tuam ntxhab thiab cov muag khoom ntawm 1-bromohexadecane cas 112-82-3 hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo 1-bromohexadecane cas 112-82-3 muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.

1-Bromohexadecane, tseem hu ua bromohexadecane nyob rau hauv Suav, yog ib qho tseem ceeb organic compound nrog nws kim heev kev siv nyob rau hauv cov tshuaj kev lag luam. Tshaj tawm raws li cov xim tsis muaj xim rau lub teeb daj pob tshab kua. Qhov pom tseeb no qhia tau hais tias nws qhov kev npaj molecular yog qhov kev txiav txim siab thiab cov ntsiab lus impurity tsawg. Nyob rau hauv chav tsev kub, fluidity zoo qhia tau hais tias muaj kev sib cuam tshuam ntawm intermolecular, tso cai rau cov kua dej ntws zoo. Lub melting point yog tsawg, feem ntau ntawm 16 thiab 18 ° C.

Melting point 16-18℃C (lit.), Boiling point 190℃C11 mm Hg (lit.), Ceev 0.999 g / ml ntawm 25℃C (lit.), Vapor ceev 10.6 (vs air), Vapor siab < 1 mm Hg (20℃C), Refractive index 10.4 N2. 230℃f, Cia tej yam kev mob: ntxig cua, chav tsev kub, Solubility: nyuaj rau sib tov, Daim ntawv: kua tom qab melting, tshwj xeeb gravity 1.000 (20/4 degree), xim: ntshiab amber rau xim av dub, dej solubility (insoluble), BRN 773989, Stability Incompatible nrog muaj zog oxidizing agents.

Qhov no txhais tau hais tias ntawm me ntsis hauv qab chav tsev kub, bromochexane yuav hloov los ntawm cov khoom mus rau cov kua. Cov cuab yeej no tso cai rau brominated hexadecane kom tswj tau qhov dej zoo hauv qhov chaw qis - qhov kub thiab txias, muab kev yooj yim rau nws daim ntawv thov hauv cov cheeb tsam txias. Insoluble hauv dej, tab sis yooj yim soluble hauv cov kuab tshuaj organic xws li cawv thiab ethers. Qhov ntom ntom zoo ib yam li cov dej, tab sis me ntsis hnyav dua li dej. Yog li ntawd, thaum sib tov nrog dej, nws nyhav mus rau hauv qab dej. Nws tuaj yeem ua rau cov kab mob Gram zoo kab mob puas tsuaj thiab inhibit qhov tsim cov kab mob virulence xws li metalloproteinases, uas koom nrog hauv cov kab mob ntawm qee yam kab mob. Yog li, nws tuaj yeem siv los kho cov kab mob microbial los ntawm Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, thiab Candida albicans. Qhov kev tshawb pom no qhib txoj hauv kev tshiab rau kev siv hauv kev kho cov kab mob tua kab mob.

Cov hauv qab no yog cov kauj ruam ntxaws ntxaws thiab sib npaug ntawm cov tshuaj sib npaug:

Kauj Ruam 1: Kev npaj thiab cua sov

Npaj cov khoom siv tshuaj tiv thaiv:

-Ntxiv hexadecanol (molecular mis: C16H34O, melting point kwv yees li 48 degree) rau hauv lub reactor.
-Ntxiv qhov tsim nyog ntawm cov phosphorus liab (P4) ua ib qho catalyst thiab txo tus neeg sawv cev rau cov tshuaj tiv thaiv bromination. Liab phosphorus reacts nrog hexadecanol los tsim ib co khoom nruab nrab, nteg lub hauv paus rau cov tshuaj tiv thaiv bromination.
P4+6C16H34OH → Cov khoom nruab nrab

Cua sov thiab melting:

- Pib cua sov cov tshuaj tiv thaiv sib tov kom yaj hexadecanol thiab sib tov kom huv si nrog liab phosphorus.

Kauj Ruam 2: Cov tshuaj tiv thaiv bromination

Dropwise ntxiv ntawm bromine:

-Thaum cov tshuaj tiv thaiv sib tov nce mus txog 100 degree, maj mam ntxiv bromine (Br ₂) dropwise. Qhov sib ntxiv ntawm bromine yog ib kauj ruam tseem ceeb hauv cov tshuaj tiv thaiv bromination, uas dhau los ntawm kev hloov pauv cov tshuaj tiv thaiv nrog hexadecanol, qhia bromine atoms los tsim haloalkanes.
C16H34OH + Br2 → C16H33Br + HBr
Ntawm no, Br2 yuav maj mam teb nrog hexadecanol, hloov cov hydrogen atom los tsim 1-bromochexane (C16H33Br) thiab hydrogen bromide (HBr).

Kev tswj qhov kub thiab txias:

-Control cov tshuaj tiv thaiv kub nyob rau hauv thaj tsam ntawm 120-130 degree, tswj cov xwm txheej tsim nyog los txhawb kev nce qib ntawm cov tshuaj tiv thaiv, thiab xyuas kom meej cov tshuaj tiv thaiv zoo yam tsis muaj kev tswj xyuas.

Lub sij hawm teb:

-Tom qab ntxiv bromine dropwise, txuas ntxiv cov tshuaj tiv thaiv ntawm qhov ntsuas kub li 6 teev kom tiav cov tshuaj tiv thaiv bromination.

Kauj Ruam 3: Tshem tawm hydrogen bromide thiab ntxuav

Ntxuav thiab txheej:

-Cov cov tshuaj tiv thaiv sib tov kom qis dua 50 degree, tom qab ntawd ntxiv cov dej saturated aqueous ntawm sodium chloride (NaCl). Cov kauj ruam no pab cais cov theem ntawm cov organic thiab cov theem aqueous, thaum tseem pab tshem tawm cov seem hydrogen bromide thiab lwm yam impurities.
C16H33Br + NaCl → C16H33Br + NaCl
Ntawm no, C16H33Br sawv cev rau theem organic ntawm 1-bromochexane, thiab NaCl_ {aq} sawv cev rau cov tshuaj sodium chloride nyob rau hauv lub aqueous theem.

Tsis suav nrog hydrogen bromide:

-Tom qab cov tshuaj tiv thaiv tiav, txuas ntxiv cua sov kom tshem tawm cov seem hydrogen bromide (HBr). Cov kauj ruam no yog los xyuas kom meej qhov purity thiab stability ntawm cov khoom kawg.
HBr → HBr

Ntxuav nrog dej kom nruab nrab- Ntxuav cov organic theem ntau zaus nrog dej kom txog thaum pH ntawm cov tshuaj ntxuav kom ze rau qhov nruab nrab. Cov kauj ruam no yuav pab kom tshem tawm cov ntsev seem thiab lwm yam dej huv huv -soluble impurities.

Los ntawm cov kauj ruam saum toj no, koj tuaj yeem tau txais siab -purity 1-bromohexane, uas yog cov saw hlau ntev halogenated alkane haum rau ntau yam kev cuam tshuam cov organic synthesis. Tag nrho cov txheej txheem synthesis suav nrog cov xwm txheej tseem ceeb ntawm cov tshuaj tiv thaiv thiab cov kauj ruam ua haujlwm hauv cov organic chemistry, ua kom cov purity thiab stability ntawm cov khoom kawg.

1-Bromohexadecane, tseem hu ua bromohexadecane, tau nyiam cov neeg siv thoob plaws hauv kev tshawb fawb thiab kev lag luam hauv xyoo tas los no raws li cov organic compound nrog cov qauv tshuaj thiab cov khoom tshwj xeeb. Tshwj xeeb tshaj yog nyob rau hauv nws daim ntawv thov raws li ib tug zoo inhibitor ntawm fatty acid synthase (FAS), nws muab cov tswv yim tshiab thiab tswv yim rau kev kho mob ntawm cov kab mob uas muaj feem xyuam rau fatty acid synthesis.

1. Inhibiting fatty acid synthesis

 

Nws synthase yog ib qho tseem ceeb enzyme lub luag hauj lwm rau catalyzing de novo synthesis ntawm fatty acids nyob rau hauv cov kab mob. Nws hloov cov pa roj carbon monoxide yooj yooj yim (xws li acetyl CoA) mus rau ntev - cov saw fatty los ntawm ntau cov tshuaj lom neeg tsis zoo. Ntev saw fatty tsis yog tsuas yog ib qho tseem ceeb ntawm cov cell membranes, tab sis kuj koom nrog ntau yam kev lom neeg xws li lub zog cia thiab teeb liab transduction. Yog li ntawd, inhibiting cov haujlwm ntawm fatty acid synthase tuaj yeem txo cov synthesis ntawm fatty acids, uas yog qhov tseem ceeb rau kev kho mob rog rog, ntshav qab zib mellitus, kab mob plawv thiab lwm yam kab mob uas cuam tshuam nrog kev sib txawv ntawm fatty synthesis.

2. Kho kev rog rog

 

Kev rog rog yog ib yam kab mob tshwm sim los ntawm kev sib sau ntau ntawm cov rog hauv lub cev vim kev siv hluav taws xob ntau dhau ntawm kev siv hluav taws xob. Kev tshawb fawb pom tau hais tias cov kev ua ntawm fatt synthase nyob rau hauv cov neeg mob rog rog feem ntau nce txawv txav, ua rau ntau fatty synthesis. Raws li ib qho zoo inhibitor ntawm fatty synthase, nws tuaj yeem txo cov synthesis ntawm fatty thiab ua kom poob phaus los ntawm inhibiting cov haujlwm ntawm cov enzymes. Tsis tas li ntawd, vim nws qhov tshwj xeeb inhibitory cuam tshuam rau kev sib txuas ntawm cov rog, nws cov kev mob tshwm sim yuav me dua thiab nws txoj kev nyab xeeb yuav siab dua piv rau lwm cov tshuaj poob phaus.

3. Txhim kho cov tsos mob ntshav qab zib

 

Mob ntshav qab zib yog ib hom kab mob metabolic uas tshwm sim los ntawm hyperglycemia. Cov kev tshawb fawb pom tau hais tias cov kev ua ntawm fatty synthase nyob rau hauv cov neeg mob ntshav qab zib yog feem ntau abnormality siab, ua rau ntau fatty synthesis. Cov fatty acids ntau dhau yuav tsis tsuas yog ua rau cov tshuaj insulin tsis txaus, tab sis kuj ua rau cov hlwb ua rau pancreatic los ntawm oxidative kev nyuaj siab thiab lwm txoj hauv kev, ua rau mob ntshav qab zib ntau ntxiv. Raws li ib qho zoo inhibitor ntawm fatty synthase, nws tuaj yeem txhim kho insulin tsis kam thiab pancreatic beta cell ua haujlwm los ntawm inhibiting synthesis ntawm fatty, yog li txhim kho cov tsos mob ntawm cov neeg mob ntshav qab zib.

4. Txo qhov kev pheej hmoo ntawm kab mob plawv

 

Cov kab mob plawv yog ib qho kev hem thawj rau tib neeg kev noj qab haus huv, nrog rau cov kab mob plawv, myocardial infarction, mob stroke, thiab lwm yam. Kev tshawb fawb pom tau tias cov kev ua ntawm fatty synthase nyob rau hauv cov neeg mob plawv feem ntau nce abnormality, uas ua rau fatty synthesis ntau. Kev rog dhau yuav ua rau cov ntshav lipids txawv txav, atherosclerosis thiab lwm yam kab mob, yog li ua rau muaj kev pheej hmoo ntawm cov kab mob plawv. Raws li ib qho zoo inhibitor ntawm fatty synthase, nws tuaj yeem txo cov ntshav lipids thiab atherosclerosis los ntawm inhibiting cov synthesis ntawm fatty, yog li txo qhov kev pheej hmoo ntawm cov kab mob plawv.

5. Lwm yam kev siv muaj peev xwm

 

Ntxiv nrog rau cov ntawv thov saum toj no, raws li ib qho zoo inhibitor ntawm fatty acid synthase,1-Bromohexadecanekuj tseem yuav muaj peev xwm siv tau rau hauv lwm qhov chaw. Piv txwv li, nyob rau hauv kev kho mob qog nqaij hlav, qee cov qog hlwb muaj qhov txawv txav ntawm fatty synthesis txoj hauv kev, thiab inhibiting cov kev ua ntawm fatty synthase tuaj yeem inhibit qhov kev loj hlob thiab kev loj hlob ntawm cov qog hlwb; Hauv thaj chaw ntawm cov kab mob neurological, qee cov kab mob neurological kuj muaj feem xyuam rau cov metabolism hauv cov rog tsis zoo. Los ntawm kev tswj hwm cov kev ua ntawm fatty synthase, cov tsos mob ntsig txog tuaj yeem txhim kho.

Cov tshuaj tiv thaiv tsis zoo

Cov tshuaj no (tshuaj formula: C ₁₆ H ∝③ Br, CAS naj npawb: 112-82-}3) yog ib tug ntev-chain brominated alkane feem ntau siv nyob rau hauv organic synthesis, surfactant npaj, thiab cov ntaub ntawv science. Raws li kev kuaj tshuaj thiab kev lag luam nruab nrab, nws txoj kev nyab xeeb muaj kev txhawj xeeb heev. Txawm hais tias muaj cov ntaub ntawv toxicological txwv tsis pub muaj, ib qho kev tshuaj ntsuam xyuas ntawm nws cov kev cuam tshuam tsis zoo tuaj yeem ua raws li nws cov khoom siv tshuaj (xws li cov saw ntev alkane qauv, muaj cov bromine atoms) thiab cov yam ntxwv ntawm cov khoom sib xws.

Qhov ncauj raug

Rat oral LD ₅₀>2000 mg/kg qhia tias qhov mob toxicity ntawm nws yog tsawg nyob rau hauv ib zaug siab - koob tshuaj qhov ncauj. Txawm li cas los xij, nws yuav tsum raug sau tseg tias tus nqi LD ₅₀ tsuas yog cuam tshuam txog ib nrab ntawm cov koob tshuaj tuag, thiab qhov tshwm sim tiag tiag tseem tuaj yeem ua rau cov tsos mob tsis zoo.
Muaj peev xwm txaus ntshai: Cov kab txuas ntev alkane tuaj yeem ua rau cov kab mob hauv lub plab zom mov vim lawv cov solubility tsawg, ua rau cov tsos mob ntawm plab zom mov xws li xeev siab, ntuav, thiab mob plab. Lub xub ntiag ntawm bromine atoms tuaj yeem txhim kho lipid solubility thiab txhawb kev nkag mus los ntawm cov khoom siv roj ntsha, tab sis tam sim no tsis muaj pov thawj ncaj qha los txhawb nws qhov exacerbation ntawm mob toxicity.

Tiv tauj daim tawv nqaij

SDS feem ntau qhia tias "daim tawv nqaij corrosion / khaus: tsis muaj ntaub ntawv" (xws li cov ntaub ntawv qhia los ntawm Fisher Scientific, Thermo Fisher Scientific, thiab lwm yam), tab sis GHS kev faib tawm (Angene, 2021) faib nws raws li daim tawv nqaij khaus qeb 2 (H315), qhia tias nws yuav ua rau tawv nqaij khaus.
Muaj peev xwm txaus ntshai: Cov saw ntev alkanes tuaj yeem ua rau qhuav, erythema, lossis mob me me los ntawm kev ua lub cev xws li tshem tawm cov roj ntawm daim tawv nqaij. Lub lipophilicity ntawm bromoalkanes tuaj yeem txhim kho daim tawv nqaij permeability, tab sis cov txheej txheem tshwj xeeb xav tau kev tshawb nrhiav ntxiv.

Kev nqus pa

Hauv SDS, nws feem ntau sau npe tias "Kev nqus pa: Tsis muaj ntaub ntawv", tab sis GHS kev faib tawm (Angene, 2021) cais nws raws li kev ua pa ua pa qeb 3 (H335), qhia tias kev nqus pa siab tuaj yeem ua rau ua pa ua pa.
Muaj peev xwm txaus ntshai: Nws yog kua hauv chav tsev kub (kwv yees 17.3 ° C, kub taw tes 336 ° C), tab sis cov cua sov lossis cov tshuaj tsuag ua haujlwm yuav ua rau cov organic sib txuas (VOCs). Cov saw ntev alkanes tuaj yeem tso rau hauv txoj hlab pa, ua rau hnoos, caj pas tsis xis nyob, lossis ua tsis taus pa; Bromine atoms yuav exacerbate inflammatory kev tshwm sim los ntawm oxidative kev nyuaj siab.

Tau txais los ntawm bromination ntawm hexadecanol. Muab hexadecanol (lub ntsiab lus melting ntawm 48 degree) rau hauv lub lauj kaub, do, cua sov, yaj, thiab ntxiv phosphorus liab. Ntawm 100 degree, do kom huv si thaum ntxiv bromine dropwise. Tswj qhov kub ntawm 120-130℃thiab ua kom tiav qhov sib ntxiv tom qab li 6 teev. Txuas ntxiv cov tshuaj tiv thaiv thiab tshem tawm tag nrho cov hydrogen bromide. Txias kom qis dua 50 degree, yog tias saturated nrog sodium chloride aqueous tov, do thiab ntxuav, cia sawv ntsug rau txheej, cais cov khib nyiab qis, ntxuav nrog dej kom txog thaum nruab nrab, distilled, sau cov feem ntawm 200-230℃(2kPa) kom tau txais nws.

Solubility

Cov kuab tshuaj organic: Yooj yim soluble hauv ether, me ntsis soluble hauv methanol, qhia tias nws tsis yog -polar carbon saw (C₁₆H₃₃) dominates solubility, thaum lub polarity ntawm bromine atom (Br) kuj tsis muaj zog.

Dej solubility: Yuav luag insoluble nyob rau hauv dej, raws li zoo raws li cov yam ntxwv ntawm ntev - saw alkyl bromides, vim lub ntev carbon saw hlau ua rau dej molecules nyuaj kov yeej nws hydrophobic nyhuv.

Kev nyab xeeb thiab toxicity

Stinginess: Muaj khaus khaus rau ntawm daim tawv nqaij (H315), qhov muag (H319), thiab kab mob ua pa (H335), thiab yuav tsum tau ua haujlwm hauv qhov dej - qhov cua thiab hnav cov khoom tiv thaiv.

Cia tej yam kev mob: yuav tsum tau muab kaw thiab khaws cia rau hauv qhov chaw txias, qhuav, deb ntawm qhov hluav taws kub thiab muaj zog oxidants kom tiv thaiv decomposition los yog combustion.

Cov qauv tshuaj thiab reactivity

Cov mis mos molecular: C₁₆H₃₃Br, tsim los ntawm ncaj- saw alkyl pawg ntawm 16 carbon atoms thiab lub davhlau ya nyob twg bromine atom.

Cov tshuaj tiv thaiv qhov chaw: Lub bromine atom ua raws li cov pab pawg tawm thiab tuaj yeem koom nrog kev hloov pauv nucleophilic (xws li hnov ​​​​mob nrog sodium cawv, amines los tsim ethers lossis amine derivatives); cov -carbon (cov pa roj carbon uas nyob ib sab ntawm cov bromine) tuaj yeem qhib tau vim yog cov nyhuv induction, tab sis qhov ruaj khov ntawm qhov ntev -chain alkyl pawg yog siab dua, thiab cov reactivity qis dua qhov luv luv - saw brominated alkanes.

Kev ruaj ntseg: ruaj khov ntawm chav sov, tab sis tsis txhob muaj cov oxidants muaj zog (xws li poov tshuaj permanganate, concentrated nitric acid) los tiv thaiv cov bromine atom los ntawm oxidized mus rau bromate los yog ua rau carbon saw breakage.

Refractive index thiab optical zog

Lub refractive index (n²⁰ / D) yog 1.461. Qhov txiaj ntsig no qhia txog kev teeb tsa ntawm cov saw hlau carbon thiab cov teebmeem hluav taws xob ntawm bromine atoms hauv cov molecule, thiab muaj txiaj ntsig zoo rau kev txheeb xyuas cov purity thiab kev txheeb xyuas cov qauv.

Thermodynamic zog

Melting enthalpy (ΔvapH): Cov ntaub ntawv ib feem yog 71.90 kJ / mol (Joback xam tus nqi), xav txog lub zog xav tau los rhuav tshem cov rog intermolecular (van der Waals rog) thaum melting.

Cov khoom tseem ceeb: Qhov ntsuas kub thiab qhov siab tseem ceeb tsis tau txiav txim siab, tab sis qhov ntsuas kub tseem ceeb ntawm qhov ntev -chain alkanes feem ntau yog siab, thiab nws yuav tsum muaj siab - cov kev mob siab rau liquefy.

Zuag qhia tag nrho,1-Bromohexadecanecombines ruaj khov zog thiab nruab nrab reactivity, ua rau nws yog ib tug heev practical intermediate nyob rau hauv cov organic synthesis. Nws tsis tshua muaj melting point thiab zoo liquidity nyob rau hauv chav tsev kub tso cai rau kom yooj yim kev khiav hauj lwm nyob rau hauv industrial ntau lawm thiab kev npaj kuaj. Raws li ib txwm ntev - saw alkyl halide, nws yog ib qho tseem ceeb raw khoom rau kev npaj ntawm surfactants, theem hloov catalysts, thiab ntau yam organic derivatives. Nrog txhim khu kev qha tshuaj lom neeg ruaj khov thiab cov yam ntxwv ua tau yooj yim, nws tseem ua lub luag haujlwm tseem ceeb hauv kev tsim tshuaj lom neeg zoo, hloov khoom siv, thiab kev tsim tshuaj txhua hnub.

Cim npe nrov: 1-bromohexadecane cas 112-82-3, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom