Shaanxi BLOOM Tech Co., Ltd. yog ib tug ntawm cov uas paub txog manufacturers thiab lwm tus neeg ntawm 2-amino-4-chloropyrimidine cas 3993-78-0 nyob Suav teb. Txais tos rau cov lag luam wholesale bulk zoo 2-amino-4-chloropyrimidine cas 3993-78-0 muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
2-Amino-4-chloropyrimidineyog ib qho organic compound nrog cov mis mos Molecular ntawm C4H4ClN3 thiab CAS 3993-78-0. Nws yog cov khoom siv dawb dawb uas tsis muaj ntxhiab tsw. Lub melting point feem ntau yog nyob rau hauv thaj tsam ntawm 165-170 ° C. Cov ntaub ntawv hais txog nws cov boiling point tej zaum yuav raug txwv, tab sis vim hais tias cov compound yog ib tug khoom, nws boiling point yuav siab dua. Nws yog soluble nyob rau hauv ntau cov organic solvents ntawm chav tsev kub, xws li ethanol, di N-Methylformamide (DMF) thiab dichloromethane. Nws muaj tsawg solubility hauv dej. Kev ruaj khov nyob rau hauv cov qauv kev sim, tab sis kev sib cuag nrog cov oxidants los yog cov kua qaub muaj zog yuav tsum raug zam kom tsis txhob muaj kev cuam tshuam tsis tsim nyog. Nws tuaj yeem nkag siab rau lub teeb ultraviolet lossis lwm yam hluav taws xob, yog li yuav tsum tau saib xyuas kom tsis txhob muaj teeb pom kev zoo thaum khaws cia thiab ua haujlwm. Nws yog ib qho tseem ceeb nruab nrab ntawm cov tshuaj synthesis thiab tuaj yeem siv los ua ke ntau yam organic tebchaw. Nws tuaj yeem siv los ua tus neeg sawv cev aminating kom hnov mob nrog lwm cov tshuaj hauv cov organic synthesis los tsim cov tshuaj tshiab. Nws kuj tseem tuaj yeem siv los ua tus qauv hauv kev tshuaj xyuas tshuaj, rau kev ntsuas ntsuas, ntsuas tshuaj, thiab lwm yam kev tshuaj xyuas tshuaj. Nws kuj tseem siv tau rau kev siv tshuaj tua kab thiab tswj ntau yam kab tsuag hauv kev ua liaj ua teb.
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Tshuaj Formula |
C4H4ClN3 |
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Exact Mass |
129 |
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Molecular Luj |
130 |
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m/z |
129 (100.0%), 131 (32.0%), 130 (4.3%), 132 (1.4%), 130 (1.1%) |
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Elemental Analysis |
C, 37,09; H, 3.11; Kuv, 27.36; Ib., 32.44 |
Kev tshuaj xyuas Molecular ntawm cov qauv ntawm 2-Amino-4 chloropyrimidine:
1. Cov mis mos molecular: C4H4ClN3
Molecular formula ntawm2-Amino-4-chloropyrimidineQhia txog hom thiab qhov ntau ntawm nws cov ntsiab lus, suav nrog plaub lub atoms (C), plaub lub atoms hydrogen (H), ib qho chlorine atom (Cl) thiab peb nitrogen atoms (N).
2. Molecular Luj: 127.55 g/mol
Los ntawm kev suav cov lej ntawm cov txheeb ze atomic masses ntawm txhua lub caij, qhov hnyav molecular ntawm 2-Amino-4 chloropyrimidine tuaj yeem tau. Nyob rau hauv cov ntaub ntawv no, tus txheeb ze atomic mass ntawm carbon yog 12.01 g / mol, hydrogen yog 1.008 g / mol, chlorine yog 35.45 g / mol, thiab nitrogen yog 14.01 g / mol.
3. Cov yam ntxwv zoo:
2-Amino-4 chloropyrimidine yog ib qho chaw uas muaj lub nplhaib pyrimidine, nrog ob pawg amino (NH2) thiab ib qho chlorine atom (Cl) hloov ntawm lub nplhaib pyrimidine. Cov tshuaj chlorine atom hloov cov pa roj carbon atom 4 ntawm lub nplhaib pyrimidine, thaum cov amino pawg nyob ntawm txoj haujlwm 2 thiab 6.
Qhov sib xyaw no muaj cov qauv tsim, qhov twg lub nplhaib pyrimidine yog tiaj tus, thiab cov amino thiab chlorine atoms nyob saum toj lossis hauv qab ntawm lub dav hlau. Cov qauv ntawm 2-Amino-4 chloropyrimidine ua rau nws siv dav hauv cov organic synthesis thiab tuaj yeem siv los ua ib qho nruab nrab rau kev sib txuas ntawm lwm cov tebchaw.
2-amino-4 chloropyrimidine, ua ib qho tseem ceeb ntawm cov organic synthesis nruab nrab, muaj ntau yam kev siv hauv tshuaj synthesis. Nov yog qee qhov piv txwv ntawm daim ntawv thov:
Cov tshuaj tua kab mob
2-Amino-4 chloropyrimidine thiab nws cov derivatives tuaj yeem siv los ua cov khoom xyaw hauv cov tshuaj tua kab mob rau kev sib txuas ntawm ntau yam tshuaj tua kab mob. Cov tshuaj tua kab mob no muaj qhov cuam tshuam loj heev rau ntau yam kab mob thiab tuaj yeem siv los kho ntau yam kab mob sib kis. Piv txwv li, los ntawm kev qhia cov khoom siv sib txawv, cov tshuaj molecules nrog broad-spectrum antibacterial kev ua haujlwm tuaj yeem ua ke rau kev kho mob ntawm ntau yam kab mob xws li ua pa, plab, thiab kab mob urinary.
Tshuaj tua kab
2-Amino-4 chloropyrimidine kuj tseem siv tau los ua cov tshuaj tua kab. Cov tshuaj tua kab no muaj peev xwm tua tau ntau yam kab tsuag thiab tuaj yeem siv rau kev tswj kab tsuag hauv kev ua liaj ua teb thiab hav zoov. Los ntawm kev qhia cov khoom siv tshwj xeeb, cov tshuaj tua kab thiab kev ua haujlwm ntawm cov tshuaj tua kab tuaj yeem hloov kho kom tau raws li qhov xav tau ntawm ntau qhov chaw thiab cov qoob loo.
Enzyme inhibitor
2-amino-4-chloropyrimidinethiab nws cov derivatives kuj ua lub luag haujlwm tseem ceeb hauv kev tsim cov enzyme inhibitors. Enzyme inhibitors yog ib chav kawm ntawm cov tebchaw uas tuaj yeem cuam tshuam kev ua haujlwm enzyme thiab tuaj yeem siv los kho ntau yam kab mob ntsig txog enzyme. Piv txwv li, los ntawm synthesizing enzyme inhibitors uas muaj cov khoom tsim, cov haujlwm ntawm cov enzymes tshwj xeeb tuaj yeem cuam tshuam, yog li tswj cov txheej txheem metabolic hauv lub cev thiab ua tiav lub hom phiaj ntawm kev kho cov kab mob.
Antitumor tshuaj
Nyob rau hauv xyoo tas los no, kev tshawb fawb tau pom tias 2-amino 4-chloropyrimidine thiab nws cov derivatives muaj peev xwm siv tau rau hauv kev sib txuas ntawm cov tshuaj tiv thaiv kab mob. Cov tebchaw no tuaj yeem cuam tshuam qhov kev loj hlob thiab kev sib kis ntawm cov qog hlwb thiab muaj cov haujlwm tseem ceeb los tiv thaiv qog. Los ntawm kev tshawb fawb ntxiv thiab kev ua kom zoo, nws xav tias yuav tsim cov tshuaj tiv thaiv qog noj ntshav tshiab thiab ua tau zoo, muab cov kev xaiv tshiab rau kev kho mob qog noj ntshav.
Kev siv dav ntawm 2-amino-4 chloropyrimidine thiab nws cov derivatives hauv cov tshuaj synthesis yog ze ze rau lawv cov qauv tshuaj lom neeg thiab kev ua haujlwm lom neeg. Cov hauv qab no yog cov txheej txheem tseem ceeb ntawm kev ua ntawm 2-amino-4 chloropyrimidine hauv tshuaj synthesis:
inhibits kev ua haujlwm enzyme
2-Amino-4 chloropyrimidine thiab nws cov derivatives tuaj yeem cuam tshuam kev ua haujlwm enzyme los ntawm kev khi rau enzymes. Enzymes yog cov proteins tseem ceeb uas ua rau cov tshuaj lom neeg muaj sia nyob, thiab lawv txoj haujlwm yog cuam tshuam los ntawm ntau yam . 2-Amino-4 chloropyrimidine tuaj yeem khi rau qhov chaw nquag ntawm cov enzyme, hloov pauv nws txoj kev sib haum xeeb, thiab yog li inhibit nws txoj haujlwm catalytic. Cov nyhuv inhibitory no tuaj yeem siv los kho ntau yam enzyme ntsig txog kab mob, xws li mob, qog, thiab lwm yam.
Inhibit cell proliferation
2-Amino-4 chloropyrimidine thiab nws cov derivatives muaj inhibitory cuam tshuam ntawm cell proliferation. Kev loj hlob ntawm tes yog lub hauv paus ntawm kev loj hlob thiab kev loj hlob, tab sis nws kuj yog ib qho tseem ceeb hauv kev tshwm sim thiab kev loj hlob ntawm cov qog nqaij hlav . 2-Amino-4 chloropyrimidine tuaj yeem cuam tshuam rau txoj kev qhia txog kev loj hlob ntawm tes thiab inhibit qhov kev loj hlob thiab kev sib kis ntawm cov qog hlwb. Cov nyhuv inhibitory no tuaj yeem siv los kho ntau yam kab mob qog, xws li mob ntsws cancer, mob qog noj ntshav mis, thiab lwm yam.
Tswj kev tiv thaiv kab mob
2-amino 4-chloropyrimidine thiab nws cov derivatives kuj tuaj yeem siv cov tshuaj kho mob los ntawm kev tswj lub cev tiv thaiv kab mob. Lub cev tiv thaiv kab mob yog ib qho tseem ceeb tiv thaiv mechanism ntawm kab mob tawm tsam cov kab mob thiab cov khoom txawv teb chaws. Txawm li cas los xij, qee zaum, cov tshuaj tiv thaiv kab mob tuaj yeem ua rau overactivated lossis dysregulated, ua rau cov kab mob autoimmune lossis inflammatory reactions . 2-amino-4 chloropyrimidine tuaj yeem tswj kev ua haujlwm thiab kev ua haujlwm ntawm lub cev tiv thaiv kab mob, tiv thaiv kev tiv thaiv kab mob tiv thaiv kab mob, thiab txo cov tsos mob ntawm o thiab kab mob autoimmune.
Tswj kev tiv thaiv kab mob
2-amino 4-chloropyrimidine thiab nws cov derivatives kuj tuaj yeem siv cov tshuaj kho mob los ntawm kev tswj lub cev tiv thaiv kab mob. Lub cev tiv thaiv kab mob yog ib qho tseem ceeb tiv thaiv mechanism ntawm kab mob tawm tsam cov kab mob thiab cov khoom txawv teb chaws. Txawm li cas los xij, qee zaum, cov tshuaj tiv thaiv kab mob tuaj yeem ua rau overactivated lossis dysregulated, ua rau cov kab mob autoimmune lossis inflammatory reactions . 2-amino-4 chloropyrimidine tuaj yeem tswj kev ua haujlwm thiab kev ua haujlwm ntawm lub cev tiv thaiv kab mob, tiv thaiv kev tiv thaiv kab mob tiv thaiv kab mob, thiab txo cov tsos mob ntawm o thiab kab mob autoimmune.
inhibit DNA replication
2-amino-4 chloropyrimidine thiab nws cov derivatives kuj tuaj yeem cuam tshuam cov txheej txheem ntawm DNA replication. DNA replication yog lub hauv paus ntawm genetic ntaub ntawv kis tau tus mob nyob rau hauv cov kab mob, tab sis nws kuj yog ib tug tseem ceeb txheej txheem rau tus kab mob replication thiab qog cell proliferation . 2-Amino 4-chloropyrimidine tuaj yeem khi rau DNA polymerase, inhibit nws txoj haujlwm, thiab yog li thaiv cov txheej txheem DNA replication. Cov nyhuv inhibitory no tuaj yeem siv los kho ntau yam kab mob viral thiab qog.
Muaj ntau txoj hauv kev rau kev sib txuas2-amino-4-chloropyrimidine, suav nrog cov hauv qab no:
Txoj Kev 1: Pib los ntawm Isocytosine
Reacting isocytosine nrog phosphorus oxychloride, lub hom phiaj compound 2-amino-4 chloropyrimidine yog npaj los ntawm cov tshuaj tiv thaiv chlorination. Cov txheej txheem kev sim tshwj xeeb yog raws li hauv qab no:
Ntxiv phosphorus oxychloride thiab isocytosine rau cov tshuaj tiv thaiv hlab ntsha, do thiab nce qhov kub ntawm 80 degrees, thiab khaws cia ntawm qhov kub li 1 teev; Tom qab lub rwb thaiv tsev tiav lawm, txuas ntxiv kom sov txog 120℃thiab tswj reflux rau 3 teev. Absorb tus Tsov tus tw roj los ntawm cov txheej txheem tshuaj tiv thaiv nrog dej kom tau hydrochloric acid byproduct. Tom qab cov tshuaj tiv thaiv tiav, cov tshuaj tiv thaiv yog distilled kom rov qab tau cov pa thiab phosphorus hauv cov tshuaj tiv thaiv. Tso cov tshuaj tiv thaiv kom tshem tawm cov pa oxygen thiab phosphorus rau hauv dej khov, thiab tswj qhov poob qis dua 40 degree. Tom qab ua tiav dropwise ntxiv, dichloromethane tau ntxiv rau ntau-theem rho tawm kom tau cov theem ua kua thiab qis dua theem ntawm dichloromethane. Ntxiv cov pa roj carbon activated mus rau qis dichloromethane kua theem rau decolorization thiab impurity tshem tawm, lim thiab cua sov rau 40 mus rau 60℃kom tshem tawm dichloromethane, ces ntxiv 80 grams ethanol thiab do rau 1 teev, txias kom qis dua 0℃thiab crystallize rau 2 teev. Tom qab pom, tau txais cov khoom dawb 2-amino-4 chloropyrimidine nrog cov txiaj ntsig ntawm 76.4%.
Txoj Kev 2: Pib los ntawm 2,4-dichloropyrimidine
Npaj 2-amino-4 chloropyrimidine los ntawm ammonolysis cov tshuaj tiv thaiv ntawm 2,4-dichloropyrimidine thiab ammonia dej. Cov txheej txheem kev sim tshwj xeeb yog raws li hauv qab no:
Ntxiv 2,4-dichloropyrimidine thiab ammonia dej rau peb lub caj dab, do thiab reflux cov tshuaj tiv thaiv rau 3 mus rau 5 teev, thiab taug qab qhov ua tiav ntawm cov tshuaj tiv thaiv los ntawm TLC. Txias cov tshuaj tiv thaiv rau chav sov thiab lim nws. Cov khoom nyoos raug ntxuav ua ntu zus nrog ethanol (200mL) thiab dej (500mL), qhuav, thiab tom qab ntawd recrystallized siv cov kuab tshuaj sib xyaw ntawm V (chloroform): V (petroleum ether)=1: 1. Tom qab ziab, cov khoom dawb 2-amino-4 chloropyrimidine tau txais nrog cov txiaj ntsig ntawm 84.4%.
Lwm cov txheej txheem synthesis
Ntxiv rau cov txheej txheem saum toj no, 2 amino-4-chloropyrimidine kuj tuaj yeem ua ke los ntawm lwm txoj hauv kev. Piv txwv li, 2-Amino 4-chloropyrimidine yog synthesized los ntawm 2-nitro-3H-4-hydroxypyrimidine los ntawm cov kauj ruam xws li chlorination thiab txo. Xwb, 2-amino-4-hydroxypyrimidine tuaj yeem siv los ua cov khoom siv raw thiab ua kom sov thaum muaj phosphorus oxychloride thiab nitrogen dimethylaniline los tsim 2-amino 4-chloropyrimidine.
2-Amino-4-chloropyrimidineyog ib qho tshwj xeeb thiab tseem ceeb organic compound nyob rau hauv lub teb ntawm chemistry, nrog rau cov pab pawg neeg ua hauj lwm nyob rau hauv nws cov qauv endowing nws nrog ib tug series ntawm tshwj xeeb tshuaj zog.
Acid thiab alkaline yam ntxwv:
Cov amino (NH2) feem ntawm 2-amino 4-chloropyrimidine molecule nthuav tawm alkalinity vim yog ib leeg khub electrons ntawm nws cov nitrogen atom. Qhov alkalinity no tso cai rau nws mus rau kev tsis sib haum xeeb nrog cov kua qaub (xws li hydrochloric acid, sulfuric acid, thiab lwm yam) hauv cov tshuaj aqueous, tsim cov ntsev sib xws. Cov txheej txheem no tsis tsuas yog hloov cov khoom ntawm lub cev ntawm cov khoom qub (xws li solubility, melting point, thiab lwm yam), tab sis kuj tseem tuaj yeem cuam tshuam rau nws cov kev ua haujlwm lom neeg lossis kev ua haujlwm. Nws yog ib qho tsim nyog sau cia tias cov tshuaj tiv thaiv nrog cov acids muaj zog feem ntau yog ua tiav, thiab cov ntsev tsim tau ruaj khov thiab yooj yim rau kev cais thiab ntxuav.
Redox khoom:
Ntxiv nrog rau cov khoom saum toj no, cov amino thiab chlorine atoms hauv 2-amino 4-chloropyrimidine kuj muaj qee yam redox zog. Nyob rau hauv qhov kev txiav txim ntawm cov oxidants tsim nyog los yog txo cov neeg sawv cev, lawv muaj peev xwm undergo electron nce thiab poob, ua rau kev hloov nyob rau hauv molecular qauv. Cov cuab yeej redox no tsis tsuas yog txhawb nqa cov cwj pwm ntawm cov tshuaj lom neeg, tab sis kuj tseem muaj peev xwm kho nws lub cev thiab kev ua haujlwm lom neeg los ntawm kev hloov kho tshuaj. Piv txwv li, cov amino pawg tuaj yeem hloov mus rau nitro pawg los ntawm cov tshuaj tiv thaiv oxidation, yog li hloov cov polarity thiab solubility ntawm cov tebchaw; Thiab los ntawm kev txo cov tshuaj tiv thaiv, halogens ntawm chlorine atoms tuaj yeem raug tshem tawm, tsim cov cawv los yog hydrocarbons.
Cov kev mob tshwm sim ntawm cov tshuaj no yog dab tsi?
Yog hais tias lub compound yog siv los ua ib qho tshuaj muaj tshuaj los yog cov tshuaj nquag, nws cov kev mob tshwm sim tuaj yeem suav nrog:
Neurological teebmeem:
Cov tshuaj uas muaj cov qauv zoo sib xws tej zaum yuav muaj qee yam cuam tshuam rau lub paj hlwb, xws li mob taub hau, kiv taub hau, insomnia, tes tshee, thiab lwm yam.
Daim tawv nqaij thiab mucosal irritation:
Qee cov tshuaj yuav ua rau khaus ntawm daim tawv nqaij thiab cov mucous daim nyias nyias, ua rau liab, o, mob, lossis ua xua.
Cov teebmeem ntawm digestive system:
Cov tsos mob ntawm kev zom zaub mov tsis zoo xws li xeev siab, ntuav, thiab raws plab kuj tuaj yeem tshwm sim.
Lwm yam teebmeem tshwm sim:
Lub sij hawm ntev lossis kev siv ntau dhau kuj tseem tuaj yeem muaj kev cuam tshuam rau lub siab thiab lub raum kev ua haujlwm, cov hlab ntsha, thiab lwm yam.
Cim npe nrov: 2-amino-4-chloropyrimidine cas 3993-78-0, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom