2-amino-4-methylprodimidaudineyog cov organic sib xyaw. Nws yog ib qho tsis muaj kob rau lub teeb crystalline khoom nrog tsis muaj ntxhiab tshwj xeeb. Nws yog yooj yim soluble nyob rau hauv ntau cov emvents ethanic, xws li ethanol, di} Metylorformamide (DICHhloromeMethanes (etc. Nws muaj solubility tsis muaj dej hauv dej. Tus nqi ua haujlwm kom dej siab yuav txawv ntawm cov wavelengths. Noj 20 degrees Celsius ua piv txwv, nws tus nqi ND (sodium daj lub teeb, nthwv dej 589.3 nm) yog kwv yees li 1.578. Nws yog combustible. Thaum rhuab lossis taws teeb, nws tuaj yeem hlawv thiab tso cov khoom xws li cov pa roj carbon dioxide, nitrogen oxides, thiab dej. Cov tebchaw ruaj khov yog qhov ruaj khov nyob rau hauv chav tsev kub. Tab sis nws yog ib qho tsim nyog kom tsis txhob muaj kev sib cuag nrog cov neeg sawv cev oxidizing muaj zog.
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Tshuaj Cov Qauv |
C5H7N3 |
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Muaj pes tsawg leej |
109.06 |
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Molecular hnyav |
109.13 |
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m/z |
109.06 (100.0%), 110.07 (5.4%), 110.06 (1.1%) |
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Kev Ntsuam Xyuas |
C, 55.03; H, 6.47; N, 38.50 |
Khoom siv hluav taws xob:
2 {{{4} Amino--4 Methylpyrimidididididididididididididididididididididididididididation yog ib qho tseem ceeb hauv nruab nrab rau ntau cov tshuaj tseem ceeb. Nws tuaj yeem raug siv ua qhov pib cov khoom rau cov khoom siv tshuaj tiv thaiv tshuaj xws li fluorouracil thiab sunitinib. In addition, it can also be used to synthesize Antiviral drug and antibacterial drugs, such as HIV Reverse-transcriptase inhibitor.
Tshuaj Tshuaj Zoo Synthesis:
Nws tuaj yeem siv los ua qhov nruab nrab rau kev npaj ntawm ntau yam tshuaj tua kab, xws li pyrimidine tshuaj tua kab (xws li pyrimidin thiab pyrimidin). Cov tshuaj tua kab no yog siv dav rau cov tshuaj tiv thaiv qoob loo thiab muaj cov tshuaj tua kab zoo thiab cov tshuaj lom neeg tiv thaiv ntau yam kab tsuag thiab pathogens.
Sunscreen:
Cov amino pab pawg hauv 2-amino-4 methylyridine muaj peev xwm nqus cov ultraviolet rays, ua rau lawv dav siv nyob rau hauv Sunscreens. Nws tuaj yeem nqus cov ultraviolet b (UVB) thiab qee ultraviolet A (UVA), ua lub luag haujlwm ntawm kev tiv thaiv cov tawv nqaij los ntawm UV puas.
Zas synthesis:
Vim yog cov txheej txheem tshwj xeeb ntawm 2-amino-4 methylyridine, nws tuaj yeem siv los npaj cov fluorescence lossis cov xim ua kom zoo nkauj. Cov dyes no tau siv dav hauv cov liaj teb xws li textiles, number case, thiab number cas.
Polymer cov khoom siv hluavtaws:
2-amino-4 methylyridine tuaj yeem siv los ua tus neeg sawv cev hla lossis cov haujlwm monomer rau cov khoom siv polymers thiab polymer. Los ntawm reacting nrog lwm cov tebchaw, polymer cov ntaub ntawv tuaj yeem tsim, xws li polyamide, polyimide thiab polyurethane. Cov ntaub ntawv Polymer no muaj cov ntawv thov tseem ceeb hauv liaj teb xws li plastics, txheej, cov nplaum, thiab lwm yam.
Cov Khoom Siv Kho Dua Tshiab thiab Ua Kua Crystal Khoom:
2-amino-4 methylyridine tuaj yeem siv ua ntej ua ntej rau synthesizing kho qhov muag thiab cov ntaub ua kua crystal cov ntaub ntawv. Nws cov derivatives yog feem ntau siv nyob rau hauv kev npaj kho kho kho qhov muag, thiab lwm yam, thiab muaj cov khoom zoo tshaj plaws thiab cov khoom siv hluav taws xob zoo.
Tshuaj Ntsuam Xyuas Tshuaj:
2-amino-4 methylyridine tuaj yeem siv los ua qhov reagent hauv kev tsom xam tshuaj los soj ntsuam thiab txiav txim siab cov ntsiab lus, thiab cov khoom ntawm cov tshuaj sib txawv. Nws yog dav siv nyob rau hauv fields xws li kev soj ntsuam tshuaj yeeb, ib puag ncig saib xyuas, thiab kev nyab xeeb khoom noj.
Lwm Yam Kev Siv:
2-amino-4 methylyridine kuj tseem siv tau los npaj cov khoom siv hluav taws xob hloov tau, thiab cov khoom siv. Ntxiv rau, vim nws cov qauv tshuaj tshwj xeeb, nws tseem muaj qee cov ntawv thov yuav muaj, xws li cov ntaub ntawv roj teeb, Photocatalysalys, thiab lwm yam.
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Cov ntawv thov hauv cov tshuaj synthesis
2-amino-4-methylprodimidaudinetuaj yeem ua qhov tseem ceeb nyob rau hauv cov synthesis ntawm heterocyclic tebchaw, uas feem ntau pom nyob rau hauv ntau cov neeg sawv cev pharmorological.
Nws amino thiab pyrimididine rings muab cov tshuaj kho kom zoo dua, ua rau kev tsim cov kev ua haujlwm sib txawv nrog cov haujlwm muaj peev xwm kho tau.
Qee cov derivatives tau qhia cov kev ua antiiviral, tshwj xeeb yog tiv thaiv qee cov kab mob los ntawm kev txwv lawv cov txheej txheem rephibing.
Cov tebchaw no tuaj yeem ua tau zoo dua los txhim kho lawv cov antiviral kev ua tau zoo thiab txo cov kev mob tshwm sim, ua rau lawv cog lus sib tw.
Qee qhov kev tshawb fawb tau qhia tias kev hloov tshwj xeeb tuaj yeem ua rau muaj kev sib txuas nrog anticancer thaj chaw.
Cov tebchaw no yuav ua rau cov kab ntsig molecular koom nrog Cancer Canceration thiab ciaj sia taus, uas tsis muaj kev vam meej txog kev ua cancer.
Vim nws lub peev xwm los cuam tshuam nrog neurotransmitter thiab ion raws, nws thiab nws cov nyiaj muaj peev xwm siv cov ntawv thov kev txhim kho lub cav hauv nruab nrab cuam tshuam.
Cov tebchaw no tuaj yeem tswj cov kev ua si neuronal thiab txhim kho cov tsos mob xws li ntxhov siab, kev nyuaj siab, thiab mob.
Dhau li ntawm cov ntawv thov hais ua ke, nws tseem yuav pom muaj kev siv tshuaj rau lwm qhov chaw kho, xws li cov kab mob plawv, thiab kis kab mob.
Nws cov khoom siv tshuaj lom neeg tso cai rau kev tsim ntau ntawm cov derivatives nrog cov chaw muag tshuaj sib txawv, ua rau nws muaj txiaj ntsig zoo hauv kev tshuaj thiab kev loj hlob.
Kev Tshawb Fawb Txog Kev Tshawb Fawb
Kev Tshawb Fawb Txog2-amino-4-methylprodimidaudinetau dav dav, nrog ntau cov hluavtaws thiab cov qauv kev tshawb fawb tau ua. Ib rooj plaub uas tseem ceeb yog synthesis thiab cov qauv ntawm cov hlau ntawm cov hlau ua ke nrog cov compound no. Hauv txoj kev tshawb no, cov neeg tshawb xyuas tau npaj ntau yam nyiaj (i) thiab tooj (II) cov nyom los ntawm kev rov ua cov roj av hauv methanol. Lub resulting complexes tau ces tus cwj pwm siv x {{}} Way crystallography, ft {ipa}}} nmr spectra. Cov complex no nthuav tawm cov qauv qauv tshwj xeeb, nrog cov lwg me ntsis sib txuas los ntawm tus kheej {} Cov makechlenary ob zaug - qhov seem molecular chains.
Lwm rooj tshawb fawb tsom rau cov xwm txheej ntawm zinc sib txuas nrog nws. Nyob rau hauv txoj kev tshawb no, ib qho ntawm zinc tebchaw tau npaj thiab qauv cwj pwm los ntawm x {{1} Way Crystallogrography. Lub tebchaw qhia tetrawshedral geometries, nrog lub central zinc atom kev sib koom ua ke los ntawm ob tus organic ligands thiab ob lub anions. Cov lwg me me tau txuas los ntawm ntau qhov kev sib txuas lus, xws li c-h {{{{{{{.
2-amino-4-methylprodimidaudineyog ib qho organic sib sau ua ke nrog lub pyrimidine tsev neeg ntawm heterocyclic molecules. Nws muaj cov pyrimidine nplhaib qauv qhov twg cov nitrogen atoms otoms offs widts 1 thiab 3, thaum cov pa roj atoms ua tus so ntawm lub nplhaib. Qhov tshwj xeeb hloov cov qauv hauv nws suav nrog cov amino pab pawg ({}} {{} txoj hauj lwm thiab pawg metyl pab (-ch3) ntawm 4-txoj haujlwm.
Qhov no compound cov tshuaj muaj cov tshuaj sib txawv, suav nrog nws lub peev xwm los tsim cov pab pawg hydrogen los ntawm cov amino pab pawg, uas txhim kho nws cov solubility hauv cov kuab tshuaj polar. Lub xub ntiag ntawm methyl pab pawg cuam tshuam nws lub zog lub zog thiab reactivity, feem ntau muab cov khoom ruaj khov thiab hloov kho hluav taws xob hluav taws xob.
Nyob rau hauv lub realm ntawm synthetic cov tshuaj chemistry, nws pabcuam yog qhov muaj txiaj ntsig zoo nyob rau hauv kev npaj ntawm ntau yam tshuaj, agrochemicals, thiab lwm yam tshuaj tshwj xeeb. Nws cov qauv ntau yam tso cai rau kev derivatization ntxiv, xws li alkylation, los yog ua kom muaj qhov loj tshaj plaws ntawm cov pyrimidine vyrimidine derivatives.
Ntxiv mus, vim nws pyrimidine scaffold, nws pom cov ntawv thov hauv kev txhim kho nucleotide analogs thiab bioconjugates analogs thiab bioconjugates analogs thiab bioconjugates analogs thiab bioconjugates analogs thiab bioconjugates analogs thiab bioconjugates analogs thiab bioconjugates analogs thiab bioconjugates analogs thiab bioconjugates analogs thiab bioconjugates analogs thiab bioconjugates analogs thiab bioconjugates analogs thiab bioconjugates analogs thiab bioconjugates analogs thiab bioconjugates analogs thiab bioconjugates analogs thiab bioconjugates analogs thiab bioconjugates analogs thiab bioconjugates rau kev tshawb fawb lub hom phiaj hauv biology thiab tshuaj. Nws lub peev xwm los ua lub tsev nrhiav tau hauv kev tshuaj tau kawm tau yooj yim, tshwj xeeb hauv cov cheeb tsam zoo li antivirer thiab kev kho mob tawm tsam.
Yuav ua li cas kom txo cov kev phiv ntawm qhov no?
Kev ntsuas thiab cov lus qhia kom txo cov kev mob tshwm sim
Txhawm rau txo nws cov kev mob tshwm sim thiab cov kev pheej hmoo txaus ntshai, hauv qab no yog qee yam kev ntsuas thiab cov lus qhia:
- Kev dag zog thiab ntsuas: Txhawb kev tshawb fawb thiab kev tsim kho kom tob thiab kev nkag siab tob ntawm cov tshuaj lom neeg, kev ua haujlwm roj ntsha, thiab cov yam ntxwv lom neeg. Nyob rau tib lub sijhawm, kev soj ntsuam kev nyab xeeb kom muaj kev ruaj ntseg rau nws txoj kev nyab xeeb hauv ntau thaj teb.
- Kev siv nruj thiab kev tswj hwm: thaum siv, nws yog qhov tsim nyog kom ua raws li cov lus qhia hauv phau ntawv kom tsis txhob siv ntau dhau los yog kev tsim txom ntau dhau los yog kev tsim txom ntau dhau los yog kev tsim txom ntau dhau los yog kev tsim txom ntau dhau los yog kev tsim txom ntau dhau los yog kev tsim txom ntau dhau los. Nyob rau tib lub sijhawm, ntxiv dag zog rau kev tswj hwm kev nyab xeeb thaum lub sijhawm khaws cia, kev thauj mus los, thiab siv kom paub tseeb tias tsis muaj kev nyab xeeb uas tsis muaj kev nyab xeeb.
- Noj kev tiv thaiv ib puag ncig: kev tiv thaiv ib puag ncig tsim nyog ib puag ncig yuav tsum tau ua thaum siv thiab pov tseg kom tsis txhob muaj kuab paug rau cov kuab paug rau cov khoom ua paug, ib puag ncig hauv av, thiab thaj chaw thaj chaw. Piv txwv li, kev ntsuas xws li kev kho dej kom huv thiab kev zam cov av tuaj yeem coj nws cov kev cuam tshuam rau ib puag ncig.
- Ntxiv dag zog rau kev soj ntsuam thiab ceeb toom ntxov: tsim kev saib xyuas thiab kev ceeb toom thaum ntxov rau nws, kom pom kev phom sij txaus ntshai thiab ua rau muaj kev phom sij kev nyab xeeb. Piv txwv li, kev tshuaj xyuas thiab kev soj ntsuam ib txwm muaj ntawm cov kev siv kev siv tau tuaj yeem ua kom ntsuas cov kev txaus ntshai thiab siv cov kev ntsuas uas tsim nyog.
- Nqa cov kev tshawb fawb tawm tswv yim pom zoo: ntxiv dag zog rau cov kev tshawb fawb nrov tshuaj ntsuam xyuas ntawm cov tshuaj no, thiab txhim kho kev paub txog pej xeem thiab nkag siab txog nws. Los ntawm kev paub kev kawm tshwj xeeb, pej xeem kev nyab xeeb ntawm kev tiv thaiv kev nyab xeeb thiab ib puag ncig tuaj yeem txhim kho qhov txaus ntshai uas yuav tshwm sim thaum siv sijhawm.
Kev ntsuas kev kub ntxhov ceev
- Npaj cov phiaj xwm xwm txheej ceev: suav cov txheej txheem qhia xwm txheej ceev, kev kawm thaum muaj xwm ceev, kev coj ua kom muaj peev xwm kho thaum muaj xwm txheej ceev thiab ntau qib.
- Kev paub ua ntej kev paub: Nkag siab thiab txawj ua ntej kev pabcuam ntawm2-amino-4-methylprodimidaudineKev lom, xws li thawj zaug kev pab rau kev tiv thaiv tawv nqaij, qhov muag sib tiv, nqus tau, thiab noj.
Kev cob qhia thiab kev saib xyuas
- Tsheb nqaj hlau: Muab kev qhia txog kev nyab xeeb rau cov kws tshawb nrhiav thiab cov neeg siv kom nkag siab cov khoom, kev ua haujlwm ua haujlwm, thiab kev nyab xeeb kev ua haujlwm ntawm 2-amino-4-methylpeprimidididble. Txhim kho kev nyab xeeb thiab ua haujlwm ntawm cov kws tshawb nrhiav thiab cov neeg siv.
- Kev tswj kev cai tswj hwm: Tsim thiab txhim kho kev saib xyuas kev nyab xeeb los tswj cov kws tshawb fawb thiab ntsuas cov kev ntsuas kev nyab xeeb ntau.
Kev kuaj xyuas kev nyab xeeb
Cov Ntaub Ntawv Toxicity
Lub LD50 rau kev txhaj tshuaj ntawm cov nas yog 730 mg / kg, qhia tias kev mob siab tawv yog nyob rau theem theem nrab. Thaum lub sijhawm ua haujlwm, kev sib chwv cov tawv nqaij ncaj qha lossis nqus tau cov plua plav yuav tsum tau zam. Nws raug nquahu kom hnav lub ntsej muag roj, qhwv hnab looj tes thiab cov hnab looj tes tiv hnab looj tes, thiab ua cov kev sim hauv cov ntawv sau fum.
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Tawv thiab Qhov Muag
Cov kab ke no tau cais ua cov tawv nqaij tsis sib cais (qeb 2) thiab lub qhov muag tsis muaj tseeb (qeb 2a). Yog tias kev tiv thaiv tawv nqaij tshwm sim, nws yog qhov tsim nyog los ntxuav kom huv si nrog cov dej xau ntau; Yog tias qhov muag tiv thaiv pom tshwm sim, nws yog qhov tsim nyog los yaug nrog dej ntws tsawg kawg yog 15 feeb thiab nrhiav kev pab kho mob.
02
Kev tiv thaiv pa
Nqus tau cov hmoov av los yog vapor yuav ua rau muaj kev cuam tshuam ua pa. Yuav tsum tau ua haujlwm rau cov chaw ua haujlwm hauv zos
03
Kev Nyab Xeeb Ib puag ncig
Nws muaj cov tshuaj lom me me rau dej yug tsiaj thiab xau dej yuav tsum zam cov chaw. Khib nyiab pov tseg thiab ua raws li cov tsev haujlwm ua haujlwm los ntawm kev ua kom sov (qhov ntsuas kub yuav tsum muaj ntau dua los yog sib npaug rau 1200℃los xyuas kom meej cov decomposition).
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Kev Tshawb Xyuas Kev Ruaj Ntseg
Lub cev ruaj khov
Nyob rau hauv chav tsev kub (25 degree) thiab nyob rau hauv ib puag ncig qhuav, 2-amino-4-Methylpaurdine tuaj yeem khaws cia tsawg kawg 2 xyoos. Nws lub taw tes melting yog 158-160℃thiab nws lub ntsiab lus npau npau yog 283.4 ± 33.0 Degree, qhia tias nws tsis yog qhov kev txiav txim siab hauv kev sim ua ntu zus. Txawm li cas los xij, Nco tseg:
Lub teeb rhiab heev:Ntev -}} Tod raug rau lub teeb ulaviolet yuav ua rau muaj txiaj ntsig, thiab nws raug nquahu kom khaws nws hauv qhov chaw tsaus.
Thermal Stability:Cov tshuaj tiv thaiv kev ua tau zoo tshaj 150 degree, ua kom muaj 4-methylpypernidide, thiab cua sov yuav tsum nruj me ntsis tswj tau.
Tshuaj Muaj Peev Xwm
Oxidrant cov tshuaj tiv thaiv:Sib cuag nrog cov oxidants muaj zog (xws li potassium permanganate, hydrogen peroxide (hydrogen peroxide) yuav ua rau muaj kev kub ntxhov, thiab cov compound yuav tsum muab cia cais tawm thiab muaj kev sib cais ntawm cov tshuaj yeeb zoo.
Kua qaub thiab paus ruaj khov:Nws yog ruaj khov nyob rau hauv lub hom ntawm 4-9, tab sis nws yuav hydrolyze nyob rau hauv muaj zog acids (pH> lossis muaj zog 2-amino pyrimidine thiab formic acid.
Hlau ion cuam tshuam:Hu rau cov kev hloov pauv hlau xws li tooj liab thiab hlau yuav tsim cov ntau, txo cov compound ua haujlwm. Nws raug nquahu kom khaws nws hauv khob lossis polyethylene ntim.
Optimized tej yam kev mob
Kub:Cov kev cia siab pom kub yog 2-8 degree, uas tuaj yeem ua kom ntev dua lub txee lub neej mus rau ntau tshaj 3 xyoos.
Vaum noo:Tus txheeb ze cov av noo yuav tsum tau ceev cia hauv qab 60% los tiv thaiv kev nqus dej noo thiab noj.
Ntim:Siv ob npaug- txheej txheej ntim khoom (sab hauv txheej ci yog lub siab alyethylene chims thiab oxygen.
Kev pheej hmoo tswj kev ntsuas
Cov Kev Ua Haujlwm Tshwj Xeeb
Siv lub siab tsis zoo nyhav thaum lub siab kom tsis txhob muaj plua plav tawg.
Thaum hloov kua dej, siv cov roj tiv thaiv roj (xws li nitrogen) kom txo qis kev pheej hmoo ntawm oxidation.
Tom qab sim, txhua cov khoom siv uas tau nkag mus rau hauv kev sib cuag nrog cov compound yuav tsum tau tsau rau 5% sodium bicarbonate daws teeb meem thiab tom qab ntawd ntxuav.
Kev kub ceev ntawm to
Tsis muaj me me- teev kav dej: Npog nrog adsomaceous ntiaj teb) thiab sau rau kev muab pov tseg.
Loj - nplai xau: Ua kom muaj kev lom zem, siv ib qho tsis muaj roj av kom hloov mus rau lub tanker, thiab tshuaj tua kab tsuag nrog cov tshuaj hypochlorous acid ntawm qhov chaw.
Cov Khoom Siv Tiv Thaiv Tus Kheej (PPE)
Kev tiv thaiv yooj yim: N95 daim npog ntsej muag, tshuaj lom neeg geggles, nitrile hnab looj tes.
Kev tiv thaiv siab heev (loj - kev ua haujlwm ntsuas): {{{}}}} pa tshuaj tiv thaiv, muaj kev ua pa kom zoo.
Cov Neeg Muaj Zog Hauv Kev Lag Luam Kev Lag Luam
Hauv kev lag luam kws tshuaj, 2-amino-4-methylppernidine feem ntau siv nyob rau hauv cov synthesis ntawm cov tshuaj tiv thaiv tshuaj tiv thaiv cov tshuaj ua ntej. Ib qho kev lag luam qee yam tau ua kom zoo rau cov neeg muaj kev cia (qhov kub thiab txo cov ntsiab lus ntawm cov khoom siv los ntawm 0.8% mus rau 0,%, txhim kho kev txhim kho cov khoom zoo.
Cim npe nrov: 2-amino-4-metino-4-methylprimidide CAS 108-52-1, cov chaw tsim khoom, chaw tsim khoom, chaw tsim khoom, yuav khoom, nqe, loj, rau muag