Shaanxi BLOOM Tech Co., Ltd. yog ib tug ntawm cov uas paub txog manufacturers thiab lwm tus neeg ntawm 2-amino-5-chlorobenzophenone cas 719-59-5 nyob rau hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo 2-amino-5-chlorobenzophenone cas 719-59-5 muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
2-Amino-5-Chlorobenzophenone, daj crystalline hmoov, molecular mis C13H10ClNO, CAS 719-59-5, ceev 1.33g/mL, qhia 1.33 grams 2-amino-5-chlorodibenzophenone ib milliliter. Solubility nyob rau hauv methanol yog tsawg heev, tsim ib tug me ntsis turbid tov; Nyob rau hauv dimethyl sulfoxide, nws muaj ib tug siab solubility. Tsis tas li ntawd, nws muaj qhov zoo solubility hauv cov kuab tshuaj organic xws li ethanol, ether, thiab chloroform. Lub solubility hauv dej yog qhov tsawg. Pharmaceutical intermediates. Kev tsim cov tshuaj tsaug zog, diazepam thiab lwm yam tshuaj. Cov tshuaj lom, flammable; Kev kub hnyiab ua rau muaj tshuaj lom nitrogen oxides thiab chloride pa luam yeeb, warehouse cua cua, thiab cua kub kom qhuav. Cov tshuaj tua hluav taws muaj xws li cov hmoov qhuav, ua npuas ncauj, xuab zeb, carbon dioxide thiab dej pos huab.
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Tshuaj Formula |
C13H10 NPO |
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Exact Mass |
231 |
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Molecular Luj |
232 |
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m/z |
231 (100.0%), 233 (32.0%), 232 (14.1%), 234 (4.5%) |
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Elemental Analysis |
C, 67,40; H, 4,35; 15.30 Nws; N, 6,05; ua 6,91 |
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Melting point 96-98℃C (lit.), Boiling point 207℃C, Density 1.33, Refractive index 1.6000 (kwv yees), Flashpoint 211℃C, Storage condition: store below + 30℃C, Solubility in methanol provides very fault solubility KA.P. 0.06 ± 0.10 (kwv yees), Morphology siv lead ua hmoov, Xim daj, BRN 475640, Stable Incompatible nrog muaj zog oxidizing agents. InChIKeyZUWXHHBROGLWNH-UHFFFAOYSA-N
Npaj los ntawm reacting p-chloroaniline nrog2-Amino-5-Chlorobenzophenone
Ntxiv p-chlorobenzene mus rau lub iav lined cov tshuaj tiv thaiv lub nkoj, thiab tom qab ntawd ntxiv cov zinc chloride anhydrous ntawm qhov kub hauv qab 70 degree.
Nyob rau hauv cov xwm txheej stirring, benzoyl chloride yog ntxiv dropwise. Tom qab ntawd, ua kom sov thiab khaws cia ntawm 195-205 degrees rau 2 teev.
Ntxuav tsib zaug nrog dej kub ntawm 90-95 degree, thiab cov txheej txheem dej thiab cov tshuaj ntxuav yuav siv tau los rov ua dua benzoic acid thiab zinc chloride.
Maj mam ntxiv sulfuric acid nyob ib ncig ntawm 100 degree, thiab tom qab ntawd khaws cia ntawm 142℃rau 40 feeb.
Txhaj cov kua rau hauv dej ntawm 05℃thaum nws kub kom precipitate cov khoom. Nyob rau hauv cov xwm txheej nplawm, kho tus nqi pH kom tsis txhob siab tshaj 1 nrog kua alkali, thiab tom qab ntawd lim ntawm 2025 degree. Cov lim dej tuaj yeem siv rau kev rov qab los ntawm p-chloroaniline.
Lub ncuav mog qab zib lim tau raug tshem tawm hauv dej, nruab nrab rau pH 6, lim thiab qhuav, ntxuav nrog dej kom txog thaum nruab nrab, thiab thaum kawg qhuav kom tau cov khoom nyoos.
Ntxiv 6-7 zaug ethanol thiab 6% cov pa roj carbon activated rau cov khoom nyoos, reflux rau 30 feeb, lim thiab crystallize, thiab qhuav kom tau cov khoom zoo 2-amino-5-chlorobezophenone.
Raws li ib qho tseem ceeb kws tshuaj intermediate,2-amino-5-chlorobenzophenoneCov qauv tshuaj tshwj xeeb thiab cov khoom ua kom nws tuaj yeem koom nrog ntau yam tshuaj lom neeg, yog li kev sib xyaw drgs nrog ntau yam tshuaj siv tshuaj. Cov tshuaj no muaj ntau yam kev siv hauv kev lag luam tshuaj, suav nrog sedation, hypnosis, tiv thaiv kev ntxhov siab, tiv thaiv kev nyuaj siab, tiv thaiv kab mob vwm, tshuaj tua kab mob, thiab lwm yam. Yog li ntawd, nyob rau hauv - kev tshawb fawb tob txog kev siv tshuaj intermediates yog qhov tseem ceeb rau kev txhawb nqa kev txhim kho thiab kev tsim kho tshiab ntawm kev lag luam kws tshuaj.
(1) Limianning: Limianning yog ib hom tshuaj sedative uas feem ntau siv los kho cov tsos mob xws li insomnia thiab ntxhov siab vim. Nws yog ib qho tseem ceeb intermediates rau synthesis ntawm levonorgestrel. Los ntawm cov tshuaj tiv thaiv tshwj xeeb, nws tuaj yeem hloov mus rau hauv levonorgestrel kom tau raws li kev kho mob.
(2) Diazepam: Diazepam yog lwm cov tshuaj sedative uas siv ntau yam tshuaj xws li tshuaj tiv thaiv kev ntxhov siab, sedative hypnotic, anticonvulsant, thiab cov leeg so. Nws kuj tseem ua lub luag haujlwm tseem ceeb hauv cov txheej txheem kev sib txuas ruaj khov. Los ntawm cov txheej txheem tshuaj tsim nyog, nws tuaj yeem hloov mus rau hauv kev ruaj ntseg, muab txoj hauv kev zoo rau kev kho mob.
(3) Shu Le An Ding: Shu Le An Ding yog ib qho ntev - ua yeeb yam benzodiazepine nrog sedative, hypnotic, thiab los tiv thaiv kev ntxhov siab. Nws kuj yog synthesized los ntawm nws raws li ib tug intermediate. Cov nyhuv kho ntawm Shule Anding yog qhov ntev - kav ntev thiab cov kev mob tshwm sim me me, yog li nws tau siv dav hauv kev kho mob.
Nws yog ib qho tseem ceeb intermediate rau synthesizing ntau yam sedative drgs. Cov tshuaj sedatives yog ib hom tshuaj uas tuaj yeem cuam tshuam lub hauv nruab nrab lub paj hlwb kev ua haujlwm, ua rau muaj kev xav ntawm kev ntsiag to, kev nplij siab, thiab qaug zog hauv tib neeg lub cev. Hauv kev lag luam tshuaj, sedatives tau siv dav los kho cov tsos mob xws li insomnia, ntxhov siab vim, thiab nruj.
(1) Carbamazepine: Carbamazepine yog ib qho dav - spectrum antiepileptic tshuaj nrog ntau yam tshuaj xws li tshuaj tua kab mob, neuropathic, thiab tshuaj tiv thaiv manic. Ua lub luag haujlwm tseem ceeb hauv cov txheej txheem synthesis ntawm carbamazepine. Los ntawm cov tshuaj tiv thaiv tshwj xeeb, nws tuaj yeem hloov mus rau hauv cov khoom sib xyaw ua ntej ntawm carbamazepine, uas tuaj yeem rov ua dua ntxiv kom tau txais carbamazepine.
(2) Sodium valproate: Sodium valproate yog lwm cov tshuaj tiv thaiv kab mob, feem ntau yog siv los kho ntau hom mob vwm. Txawm hais tias nws tsis yog ib qho ncaj qha cuam tshuam rau kev sib txuas ntawm sodium valproate, nws tuaj yeem ua lub luag haujlwm tsis ncaj hauv nws cov txheej txheem synthesis. Piv txwv li, los ntawm cov tshuaj tiv thaiv tshwj xeeb, nws tuaj yeem hloov mus rau hauv qee cov tebchaw, uas tuaj yeem rov ua dua ntxiv kom tau txais cov khoom siv raw lossis nruab nrab ntawm sodium valproate.
Antiepileptic drgs yog ib hom tshuaj uas tuaj yeem txo qis qaug dab peg. Hauv kev lag luam tshuaj, tshuaj antiepileptic drgs tau dav siv los kho ntau hom mob vwm. Raws li ib tug kws tshuaj intermediate, nws muaj peev xwm koom nyob rau hauv synthesis ntawm ntau yam antiepileptic drgs.
(1) Fluoxetine: Fluoxetine yog ib hom tshuaj tiv thaiv kev nyuaj siab uas feem ntau siv nrog ntau yam tshuaj xws li tshuaj tiv thaiv kev ntxhov siab, tshuaj tiv thaiv kev ntxhov siab, thiab tshuaj tiv thaiv. Txawm hais tias tsis yog ib qho kev sib txuas ncaj qha ntawm fluoxetine, nws tuaj yeem ua lub luag haujlwm txhawb lossis pab rau qee yam hauv nws cov txheej txheem synthesis. Piv txwv li, los ntawm cov tshuaj tiv thaiv tshwj xeeb, nws tuaj yeem hloov mus rau hauv qee cov tebchaw, uas tuaj yeem rov ua dua ntxiv kom tau txais cov ntaub ntawv raw lossis intermediates ntawm fluoxetine.
(2) Shequlin: Shequlin yog lwm cov tshuaj tiv thaiv kev nyuaj siab, feem ntau yog siv los kho cov tsos mob xws li kev nyuaj siab thiab obsessive -compulsive disorder. Txawm hais tias tsis ncaj qha cuam tshuam raws li tus neeg nruab nrab hauv cov txheej txheem synthesis ntawm sertraline, nws yuav cuam tshuam rau kev sib xyaw ua haujlwm lossis cov txiaj ntsig ntawm sertraline hauv qee txoj kev. Piv txwv li, los ntawm optimizing nws cov txheej txheem synthesis los yog purification txoj kev, qhov zoo los yog purity ntawm Shequlin raw cov ntaub ntawv tuaj yeem txhim kho, yog li indirectly txhim kho cov synthesis efficiency thiab tawm los ntawm Shequlin.
Antidepressants yog ib hom tshuaj uas tuaj yeem txhim kho cov tsos mob ntawm kev nyuaj siab. Hauv kev kho mob, cov tshuaj tiv thaiv kev ntxhov siab tau siv dav los kho cov kev puas siab puas ntsws xws li kev nyuaj siab thiab kev ntxhov siab. Raws li ib tug kws tshuaj intermediate, nws muaj peev xwm koom nyob rau hauv synthesis ntawm ntau yam antidepressant drgs.
Synthesis ntawm cov tshuaj tua kab mob
(1) Cephalosporins: Cephalosporins yog drgs nrog dav -spectrum antibacterial kev ua haujlwm, feem ntau yog siv los kho ntau yam kab mob sib kis. Txawm hais tias nws tsis yog ib qho kev sib txuas ncaj qha ntawm cov tshuaj tua kab mob cephalosporin, nws tuaj yeem ua lub luag haujlwm txhawb lossis pab rau qee yam thaum nws cov txheej txheem synthesis. Piv txwv li, los ntawm cov tshuaj tiv thaiv tshwj xeeb, qee cov tebchaw tuaj yeem hloov pauv, thiab cov tebchaw no tuaj yeem cuam tshuam ntxiv kom tau txais cov ntaub ntawv raw lossis intermediates ntawm cephalosporin tshuaj tua kab mob.
(2) Cov tshuaj tua kab mob Quinolone: Cov tshuaj tua kab mob Quinolone yog ib chav kawm ntawm drgs nrog dav -spectrum antibacterial kev ua haujlwm, feem ntau yog siv los kho cov kab mob hauv lub ntsws, kab mob urinary, plab hnyuv, thiab lwm qhov chaw. Txawm tias 2-Amino-5-Chlorobenzophenonetsis yog ib qho ncaj qha nruab nrab ntawm cov tshuaj tua kab mob quinolone, nws tuaj yeem ua si txhawb lossis pab lub luag haujlwm rau qee qhov thaum nws cov txheej txheem synthesis. Piv txwv li, los ntawm optimizing nws cov txheej txheem synthesis los yog purification txoj kev, qhov zoo los yog purity ntawm quinolone tshuaj tua kab mob raw cov ntaub ntawv tuaj yeem txhim kho, yog li indirectly txhim kho cov synthesis efficiency thiab tawm los ntawm quinolone tshuaj tua kab mob.
Cov teebmeem tsis zoo rau ib puag ncig
2-Amino-5-Chlorobenzophenone(CAS naj npawb 719-59-5) yog ib qho tseem ceeb organic hluavtaws intermediate dav siv nyob rau hauv kev lag luam tshuaj, tshwj xeeb tshaj yog nyob rau hauv zus tau tej cov sedatives xws li levonorgestrel thiab diazepam. Nrog rau kev nthuav dav ntawm nws cov ntawv thov kev lag luam, nws tus cwj pwm ib puag ncig thiab kev pheej hmoo ecological tau maj mam nyiam.
Environmental faib thiab tsiv teb tsaws
Tso txoj kev
Kev tso tawm ib puag ncig ntawm 2-Amino-5-Chorobenzophene feem ntau yog los ntawm cov hauv qab no:
Kev tsim khoom thiab kev siv: Thaum lub sij hawm kev sib txuas ntawm cov tshuaj intermediates, cov khoom siv tsis zoo, los ntawm - cov khoom, thiab cov khib nyiab tuaj yeem nkag mus rau hauv dej los yog av los ntawm cov dej pov tseg.
Kev pov tseg pov tseg: Cov chaw kuaj lossis cov khoom pov tseg uas muaj cov khoom siv no tuaj yeem nkag mus rau ib puag ncig los ntawm kev pov tseg lossis kev ua haujlwm yog tias tsis muab pov tseg kom zoo.
Khoom degradation: Cov metabolism lossis decomposition ntawm cov tshuaj uas muaj cov tshuaj no nyob rau hauv ib puag ncig yuav tso nws cov khoom xyaw.
Kev faib tawm hauv ib puag ncig xov xwm
Lub cev dej: Vim nws cov hydrophobicity (logP=3.16), qhov sib xyaw no tau yooj yim adsorbed mus rau cov khoom uas raug tshem tawm los yog sediments, uas ua rau muaj qhov qis dua hauv cov dej theem, tab sis tuaj yeem ua rau hauv cov sediment. Kev tshawb fawb tau pom tias halogenated benzophenone tebchaw nrog cov qauv zoo sib xws tuaj yeem ncav cuag qhov siab txog li μ g / kg hauv cov dej ntws.
Av: Tus nqi Koc siab (500-2000 L / kg) qhia tau tias muaj zog adsorption rau cov av organic teeb meem, tsis tshua muaj kev txav mus los, thiab tuaj yeem nyob hauv av mus ntev.
Atmosphere: Tsawg volatility, negligible concentration nyob rau hauv cov huab cua, tab sis tej zaum yuav muaj kuab paug nyob rau hauv lub zos nyob rau hauv daim ntawv ntawm aerosols nyob ze thaj chaw muaj kev lag luam.
Ecotoxicity
Cov tshuaj no muaj peev xwm toxicity rau ob qho tib si hauv dej thiab cov kab mob hauv av, thiab nws cov tshuaj lom neeg muaj feem cuam tshuam nrog cov teebmeem hluav taws xob thiab lipid solubility ntawm amino thiab chlorine atoms.
Toxicity rau cov kab mob hauv dej
Ntses: 96 teev LC ₅₀ tus nqi rau zaj sawv trout yog 1-10 mg/L, qhia tias kev raug luv luv tuaj yeem ua rau ua pa puas lossis kab mob gill. Lub sij hawm ntev uas tsis tshua muaj concentration raug (<1 mg/L) may affect fish reproduction or behavior.
Invertebrates: 48 teev EC ₅₀ tus nqi rau Daphnia magna yog 0.5-5 mg / L, feem ntau cuam tshuam nrog paj hlwb lossis lub zog metabolism.
Algae: Kev loj hlob inhibitory concentration (IC ₅₀) yog kwv yees li 5-20 mg / L, uas tuaj yeem cuam tshuam rau cov qauv hauv zej zog algal los ntawm inhibiting photosynthesis lossis cuam tshuam cov cell membrane qauv, yog li cuam tshuam lub hauv paus ntawm cov khoom noj hauv dej.
Cov av biotoxicity
Cov kab mob kab mob: Kev sim tau pom tias raug cov av ntawm 10-50 mg / kg tuaj yeem txo cov kev ua urease los ntawm 20-40%, inhibit nitrogen cycling txheej txheem, thiab indirectly cuam tshuam rau cov nroj tsuag kev loj hlob.
Nroj tsuag: Cov ntsiab lus siab tuaj yeem cuam tshuam cov nroj tsuag physiological zog los ntawm cov av adsorption los yog hauv paus nqus, tab sis cov ntaub ntawv tshwj xeeb toxicity tseem tsis muaj.
Bioaccumulation thiab Amplification nyhuv
Txawm hais tias nws tus nqi logP (3.16) qis dua qhov muaj kuab paug hydrophobic (xws li DDT, logP ≈ 6), qhov ruaj khov ntawm nws cov pyridine nplhaib qauv tso cai rau nws maj mam nce hauv cov ntaub so ntswg adipose. Lub biocontrol factor (BCF) ntawm halogenated benzophenone tebchaw tuaj yeem ncav cuag 10-100, qhia tias muaj peev xwm hloov cov khoom noj khoom haus, tshwj xeeb tshaj yog rau cov kab mob benthic thiab ntses.
Cim npe nrov: 2-amino-5-chlorobenzophenone cas 719-59-5, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom