2-chloro-4-pyridinecarboxylic acid CAS 6313-54-8

Shaanxi Bloom Tech Co., Ltd. yog ib qho ntawm cov neeg tsim khoom thiab cov chaw muag khoom ntawm 2-cyridine-4-pyridine-4-pyrico-4-pyrico-4-pyrico-4-pyrico-4-pyrico-4-pyrico-4-pyrico-4-pyrico-4-pyrico-4-pyrico-4-pyrico-4-pyrico-4-pyrico-4-pyrico-4-pyrico-4-pyrico-4-pyrico-4-pyrico-4-pyrico-4-pyrico-4-pyrico-4-pyricoCarboxylic Accial Phot 6313-54-8 nyob rau hauv Suav teb. Txais tos rau kev lag luam wholesale loj zoo 2-chloro-4-pyridinecarboxylic acid CAS 6313-54-8 Kev muag khoom ntawm no los ntawm peb lub hoobkas. Cov kev pabcuam zoo thiab tus nqi tsim nyog muaj.

2-chloro-4-pyridinecarboxylic acidyog cov organic sib xyaw nrog CAS 6313-54-8 thiab chemical mish4Clno2. Feem ntau dawb lossis lub teeb daj hmoov nrog tus ntxhiab tsw me me. Soluble me ntsis hauv dej, me ntsis soluble hauv ethanol, insoluble hauv ether. Ruaj khov nyob rau hauv chav tsev kub, tab sis yuav decompose nyob rau hauv nyob rau hauv kub lossis raug rau lub teeb. Tus qauv muaj cov carboxyl chav tsev thiab cov chlorine atom. Vim yog cov hluav taws xob tsis txaus ntawm lub nplhaib pyridine, cov tshuaj no tuaj yeem yucleophilic hloov cov kev tawm tsam hauv qab no, ua rau muaj cov khoom siv ntawm kev ua haujlwm zoo. Nws yog pyridine derivative uas tuaj yeem sib txuas nrog cov tshuaj acidic los tsim cov ntsev. Nws tuaj yeem raug siv los ua qhov nruab nrab hauv cov khoom siv hluav taws xob cov organic thiab siv rau kev hloov kho qauv thiab hluavtaws ntawm cov tshuaj molecules thiab cov lwg me me. Piv txwv li, cov ntaub ntawv tseem ceeb tau tshaj tawm tias cov khoom siv no tuaj yeem siv rau hauv cov khoom siv camptisterthecin derivatives nrog anticancer kev ua haujlwm.

2,6-dichlorooisoniacin yog tau los ntawm chlorination tiv thaiv kom tau 2-chlorination tiv thaiv kom tau 2-chlorooisoniacin, uas yog ces synthesized los ntawm kev coj ua kev lom zem.

Kauj ruam 1: Cov tshuaj tiv thaiv chlorination kom tau 2,6-dichlorooisononic acid:

(1) raws li cov tshuaj tiv thaiv uas tsim nyog, hnov ​​cov tshuaj tiv thaiv yog.roniacin nrog chlorinating tus sawv cev (xws li sulfoxide chloride). Txoj haujlwm ntawm chlorinating tus neeg sawv cev yog los hloov cov hydrogen atom hauv iMoniacin nrog cov chlorine atom.

(2) Tom qab cov tshuaj tiv thaiv tau ua tiav, 2,6-dichlorooisonotInIstinic acid tau txais los ntawm kev sib cais thiab cov kev ua kom huv (xws li distillation, crystallization, thiab lwm yam). Cov khoom lag luam ntawm cov kauj ruam no yog 2,6-dichloroisonotInicInicIr.

C₆H₃Kwj Cl₂Tsis muaj₂+ HCL → 2,6-dichlorooisonicoticicic Acid Hydrochloride

Kauj ruam 2: Tshuaj tiv thaiv Chlorination kom tau 2-chlorooisoniatIniStisic Acid:

(1) REQUE 2,6-DICHHLOROONEISNIVER tau nyob rau hauv cov kauj ruam dhau los nrog cov tshuaj chlorinating ib zaug ntxiv. Lub sijhawm no, kev ua ntawm chlorinating tus neeg sawv cev yog txhawm rau hloov ib chlorine atom nrog lwm chlorine atom, yog li kev sib sau 2-chlorooisonicicissicissinic acid.

(2) Tom qab cov tshuaj tiv thaiv tiav, 2-chlorooisonicicoicInicSinic Acid tseem muaj kev sib cais kom tsim nyog thiab txoj kev ua kom huv. Cov khoom lag luam ntawm cov kauj ruam no yog 2-chlorooisonicicicicissicissicissississississississississississississyinic Acid.

2,6-dichloroisoniazid hydrochloride + hc → c₆H₄Pob tsuas₂

Kauj ruam 3: Npaj ntawm 2-chlorooisonicicicissicInicSulotinic acid los ntawm kev hais txog kev lom zem:

(1) ReslorooisonicicoIsinic acid tau nyob rau hauv kauj ruam dhau los nrog tus neeg sawv cev qhia. Txoj haujlwm ntawm kev coj ua dechlalination tshem cov chlorine atoms ntawm 2-chlorooisoniacin, yog li tau txais cov khoom lag luam 2-chlorooisoniacin.

(2) Tom qab cov tshuaj tiv thaiv tau ua tiav, ntshiab 2-chlorooisonicicoInicInicInicInicInicInicInicInicInicInicInicInicInicSinic Acid tau txais los ntawm kev sib cais thiab txoj kev ua kom huv. Cov khoom ntawm cov kauj ruam no yog lub hom phiaj2-chloro-4-pyridinecarboxylic acid.

C₆H₄Pob tsuas₂ + Directional dechlorination Tus Neeg Sawv Cev → C₆H₄Pob tsuas₂

Peb yog lub Hoobkas ntawm 2-chloro 4-pyridinecarboxylic acid. Cov lus hais: Bloom Tech (Txij xyoo 2008), ua tiav chem-tech yog tus muab kev pabcuam ntawm peb. Peb hom kev thauj mus los suav nrog kev thauj mus los hiav txwv, cov tsheb thauj mus los thiab tsheb thauj mus los hauv av. Peb npaj ntau txoj hauv kev kom tau raws li cov kev xav tau sib txawv ntawm cov neeg siv khoom, yog li ua tau cov neeg siv khoom zoo dua thiab ua tiav qhov xwm txheej yeej.

Kev thauj mus los ntawm cov tshuaj chemical feem ntau yuav tsum tau ua raws li cov kev nyab xeeb ntawm cov kev cai tswjfwm thiab cov txheej txheem kom paub meej tias kev nyab xeeb thiab kev ua tau zoo thaum lub sijhawm thauj mus los. Nov yog qee cov kauj ruam yooj yim thiab cov kev ceev faj rau kev thauj mus los:
1. Kev them nqi thauj mus los: Ua ntej pib thauj mus los, nws yog qhov tsim nyog kom nkag siab thiab ua raws li cov kev cai kev thauj mus los. Cov kev cai no yuav suav nrog cov kev cai ntawm cov khoom thauj khoom txaus ntshai, nrog rau kev thauj mus los kom muaj tshwj xeeb rau cov tshuaj lom neeg.
2. Xaiv txoj kev thauj mus los uas haum: Xaiv cov kev thauj mus los uas haum raws li cov xwm, kom muaj nuj nqis nyob deb ntawm cov khoom siv tshuaj lom neeg. Cov hom kev sib koom ua ke suav nrog thaj av, hiav txwv, thiab huab cua.
3. Npaj cov ntaub ntawv thauj mus los: Cov ntaub ntawv thauj kom ntxaws yuav tsum tau npaj, suav nrog cov ncauj lus kom ntxaws ntawm cov khoom, kom muaj nuj nqis, kev thauj mus los, cov ntaub ntawv thauj mus los, thiab cov ntaub ntawv thauj mus los. Ib qho ntxiv, nws yog ib qho tsim nyog los muab cov ntaub ntawv ua pov thawj ntawm kev nyab xeeb thiab ruaj khov ntawm cov khoom.
4. Ntim cov tshuaj: cov tshuaj uas feem ntau yuav tsum ntim khoom tshwj xeeb kom muaj kev nyab xeeb thaum kev thauj mus los. Cov ntim yuav tsum ua raws li cov khoom ntim khoom uas muaj kev phom sij ntim khoom thiab cov ntawv sau npe hauv cov huab cua thoob ntiaj teb (Iiata).
5. Ua raws li txoj cai kev thauj mus los: thaum lub sijhawm kev thauj mus los, nws yog qhov tsim nyog los ua raws li cov cai thauj mus los, suav nrog kev thauj khoom, kev nyab xeeb, thiab tiv thaiv kom tsis txhob to taub. Ib qho ntxiv, cov cai tsav tsheb tshwj xeeb thiab cov kev txwv kev nrawm yuav tsum tau ua raws.
6. Kev sib txuas lus: thoob plaws cov txheej txheem thauj mus los, nws yog qhov tsim nyog los tswj kev sib txuas lus nrog cov cab kuj thiab lo lus uas peb yuav ua kom cov teeb meem tseem ceeb rau cov teeb meem sai.
7. Teev thiab ceeb toom: thaum lawv caij tsheb thauj mus los, txhua yam haujlwm thiab cov xwm txheej yuav tsum tau sau cia thiab qhia rau chav haujlwm uas xav tau.
Thov nco ntsoov tias cov kauj ruam no tsuas yog cov kev coj ua thiab tsis tuaj yeem hloov cov kev cai tshwj xeeb thiab cov cai. Ua ntej pib kev thauj mus los, nws yog qhov zoo tshaj plaws los txhawb nqa lub tuam txhab kev lag luam lossis lub koom haum kom ua raws li txhua txoj cai thiab cov cai.

2-chloro-4-pyridinecarboxylic acidmuaj ntau cov ntawv thov hauv Chemistry. Cov hauv qab no yog cov ncauj lus kom ntxaws ntawm tag nrho nws cov kev siv hauv Chemistry:
1. Organic synthesis
Nws yog qhov nruab nrab tseem ceeb hauv synthic synthesis. Nws tuaj yeem koom nrog ntau cov organic, xws li Esterification, Kev Amimation, AroL tsim ntau yam ua ke olecules. Los ntawm kev hloov pauv thiab kho nws cov pab pawg ua haujlwm, sib xyaw nrog cov qauv sib txawv, muab cov tswv yim nplua nuj rau cov tswv yim zoo nkauj thiab cov tswv yim rau cov organic synthesis.
2. Kev Tshawb Fawb Kev Ntsuas
Nws tseem muaj cov ntawv thov hauv kev ntsuas tshuaj chemisterical. Nws tuaj yeem siv los ua kev sojntsuam fluorescent, chratatographic Separator, thiab lwm yam rau tshuaj tsom duab tshuaj. Piv txwv li, los ntawm kev siv fluorescence cov khoom ntawm 2-cyroro 4-pyridine 4-pyricoCal probing tuaj yeem tsim cov kuab paug nyob rau hauv ib puag ncig, thiab ntau dua. Ib qho ntxiv, nws tseem tuaj yeem ua ib tus neeg sawv cev Chromatographic sib cais rau kev sib cais thiab tsom xam ntawm cov qauv nyuaj.
3. Electrofonemistry
Nws tseem muaj qee cov kev siv hauv kev sib txuas ntawm electrochemistry. Nws tuaj yeem siv los ua lub roj teeb khoom, capacitor cov khoom siv, thiab lwm yam. Rau Electrochemical Zog Cia thiab hloov dua siab tshiab. Piv txwv li, los ntawm kev siv Redox cov yam ntxwv ntawm 2-chloro 4 pyridine 4 pyridine 4 pyridine 4 pyridoCarboxylic cov khoom siv tau los txhim kho lub zog khaws cia thiab caij tsheb kauj vab ntawm lub roj teeb. Tsis tas li ntawd, nws kuj tseem tuaj yeem siv los ua cov ntaub ntawv capacitor cov ntaub ntawv, txhim kho kev ua haujlwm thiab kev pabcuam lub neej ntawm lub peev xwm.

2-chloro-4-pyridinecarboxylic acid nyob deb dua li chav kuaj mob tsis xav - nws yog alinchpin ntawm niaj hnub chemistry, ua kom tawg rau hauv cov tshuaj, kev ua liaj ua teb, thiab cov ntaub ntawv. Nws cov qauv tshwj xeeb, txuas nrog nws cov kev cuam tshuam thiab versatility, kom nws qhov chaw nyob rau hauv lub pantheon ntawm cov organic sib xyaw.

Raws li cov kws tshawb fawb thawb cov ciam ntawm cov khoom siv thiab cov ntawv thov, 2-cl-4-PCA tseem tuaj yeem tsav tau yooj yim science thiab kev lag luam nce qib. Txawm li cas los xij hauv kev sib ntaus ntawm tus kab mob, kev tiv thaiv ntawm cov qoob loo, lossis kev tsim cov ntaub ntawv ntawm ntug, no pyridine derivive lub zog ntawm kev hloov kho lub zog los hloov peb lub ntiaj teb.

Intermaceuticals

2-cl-4-pca yog lub tsev tseem ceeb hauv kev tiv thaiv kev tiv thaiv, tshuaj tua kab mob, thiab tshuaj tiv thaiv tshuaj tiv thaiv.

Kev Kawm Kev Kawm: COX-2 Inhibitors

CyclooxyGarase-2 (Cox-2) Inhibitors, siv los kho mob caj dab, feem ntau koom tes ua pa rau kev txhim kho lub potency {-pca ua haujlwm ua tus ua ntej rau:

CelecloceB(CelebEx®): Ib qho kev xaiv cox-2 inhibitor.

Tus rofecoxib(Vioxx®, rho tawm): Lwm Cox-2 inhibitor.

Hluavtaw txoj hauv kev:

2-cl-4-pca hloov dua siab tshiab rau nws cov kua txiv duaj acidide (2-cl-4-pca-cl) siv socl₂.

Cov tshuaj yaj duab acidide nrog cov ntoo hauv tsev arylamine (piv txwv li, 4-methylsulfonylphyllamine) los tsim ib qho chaw nyob.

Cov sawv daws sawv daws kev ntseeg siab cyclization kom cov txiaj ntsig rau cov cox-2 inhibitor).

► agnemical kev loj hlob

Pyridine derivatives tau siv dav hauv cov tshuaj tua kab, tshuaj tua kab, thiab fungicides {{} cl-4-pca pab txhawb rau:

Tshuaj ntsuab synthesis

Fluroxypyr: Ib tug lawb quav tshuaj siv hauv cov qoob loo cereal.

2-cl-4-pca yog esterified nrog 3,4,5-trifluorophenol los ua fluroxypyr.

Cov tshuaj tua kab tsis zoo

Imidacloprid: Ib qho kev tawm tsam hluav taws xob.

2-cl-4-pca tau hloov mus rau nitroobine derivative, ib qho tseem ceeb hauv nruab nrab hauv Imidaclobroprid synthesis.

► Cov Khoom Tshawb Fawb: Kev Koom Tes Polymeration thiab Cataly

Cov carboxylic acid pawg ntawm 2-cl-4-pca ua rau nws siv hauv hlau-organic qauv (mofs) thiab catalysts.

Mof synthesis

2-cl-4-pca tuaj yeem koom tes nrog kev hloov pauv hlau (piv txwv li, zn²⁺, cu²⁺) los ua cov ntxiab mofs rau cov roj av lossis sib cais.

Heterogeneous catalysis

Palladium complexes ntawm 2-close-4-pca yog siv nyob rau hauv kev sib txuas lus sib txuas (piv txwv li, suzuki-miyaura sib txuas).

► Cov tshuaj tshwj xeeb heev

Dyes thiab pigments: Lub nplhaib pyridine tuaj yeem ua haujlwm los tsim cov chromophores.

Corrosion Inhibitors: 2-cl-4-pca derivatives tsim cov yeeb yaj kiab tiv thaiv ntawm cov hlau chaw.

Cim npe nrov: 2-chloro-4-pyridinecarboxylic acid CAS 6313-54-8, cov neeg lag luam, Hoobkas, yuav, nqe, loj, rau muag