Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm cov tuam ntxhab thiab cov muag khoom ntawm 3,6-dibromopyridazide cas 17973-86-3 hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo 3,6-dibromopyridazide cas 17973-86-3 muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
3,6-Dibromopyridazideyog ib qho organic compound. Nws yog xim tsis muaj xim rau dawb crystalline lossis crystalline hmoov. Nws muaj ib tug siab crystallinity thiab ib tug siv lead ua daim ntawv nyob rau hauv daim ntawv ntawm nplooj los yog rods. Vim muaj cov bromine atoms nyob rau hauv nws cov qauv molecular, nws lub boiling point yog siab dua li ntawm ib co tsis halogenated tebchaw. Nws tuaj yeem hlawv hauv huab cua, tsim cov khoom xws li carbon dioxide, nitrogen oxides, thiab bromide. Thaum ua qhov kev sim ua haujlwm, yuav tsum tau saib xyuas kom tiv thaiv kev sib cuag nrog cov khoom siv hluav taws xob. Nws cov conductivity tsawg qhia tau hais tias nws yog ib tug tsis zoo electrolyte nyob rau hauv nws cov ntshiab lub xeev. Nws tuaj yeem siv los ua ib qho tseem ceeb reagent hauv organic synthesis.
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Tshuaj Formula |
C4H3Br2N2- |
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Exact Mass |
237 |
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Molecular Luj |
239 |
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m/z |
239 (100.0%), 237 (51.4%), 241 (48.6%), 240 (4.3%), 238 (2.2%), 242 (2.1%) |
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Elemental Analysis |
C, 20.11; H, 1,27; Ib., 66,90; Ib., 11.73 |
Nws raws li halogen- muaj cov organic ligand, tuaj yeem siv los tsim cov tsev nyob hauv cov hlau organic. Tshwj xeeb, 3,6-Dibromopyridazine tuaj yeem cuam tshuam nrog cov hlau tshwj xeeb los tsim cov hlau ruaj khov thiab sib sau ua ke rau hauv MOF cov qauv nrog lwm cov ligands.
Synthesis ntawm 3,6-Dibromopyridazine derivatives
Ua ntej synthesizing MOF,3,6-Dibromopyridazidetuaj yeem hloov kho kom tau txais derivatives nrog kev sib koom tes zoo dua thiab cov yam ntxwv ntawm cov qauv. Los ntawm kev qhia cov pab pawg ua haujlwm sib txawv ntawm 3,6-Dibromopyridazine molecules, lawv cov khoom siv tshuaj lom neeg ua haujlwm, solubility, spatial orientation, thiab lwm yam tuaj yeem tswj tau, yog li optimizing lawv cov kev ua tau zoo hauv MOF synthesis.
Kev sib koom tes nrog hlau ions
Thaum synthesizing MOFs, 3,6-Dibromopyridazine tuaj yeem koom tes nrog cov hlau tshwj xeeb ions lossis pawg los tsim cov hlau ruaj khov. Cov hlau complexes muaj ntau yam qauv thiab cov khoom, thiab tuaj yeem ua lub tsev thaiv rau kev tsim cov qauv MOF peb sab. Cov kev xaiv feem ntau siv rau cov hlau ions xws li npib tsib xee (Ni), zinc (Zn), tooj liab (Cu), thiab lwm yam.
Sib dhos nrog lwm cov ligands
Tom qab kev sib koom tes nrog cov hlau ions, 3,6-Dibromopyridazine tuaj yeem sib sau ua ke nrog lwm cov organic ligands los tsim ntau cov qauv MOF. Cov ligands tuaj yeem nruj, yoog raws, muaj ntxhiab lossis tsis muaj ntxhiab. Los ntawm kev sib koom tes nrog 3,6-Dibromopyridazine, kev tsim thiab kev tswj hwm ntawm MOF qauv tuaj yeem ua tiav, uas ua rau muaj kev cuam tshuam rau cov qauv pore, cov khoom nto, thiab kev ua haujlwm catalytic ntawm MOFs.
Regulating pore qauv thiab thaj chaw tshwj xeeb
Daim ntawv thov ntawm3,6-Dibromopyridazidethiab nws cov derivatives hauv MOFs tuaj yeem tswj cov qauv pore thiab thaj chaw tshwj xeeb ntawm MOFs. Lub halogen atoms nyob rau hauv nws cov qauv molecular muaj peev xwm muab ntxiv pores los yog adsorption qhov chaw, ua rau cov roj adsorption muaj peev xwm thiab xaiv ntawm MOFs. Los ntawm kev kho qhov sib piv thiab cov tshuaj tiv thaiv ntawm 3,6-Dibromopyridazine rau lwm cov ligands, kev tswj ntawm MOF pore loj, pore zoo, thiab molecular channels tuaj yeem ua tiav.
Gas cia thiab sib cais
MOFs feem ntau yog siv nyob rau hauv lub tshav pob ntawm kev cia thiab kev sib cais raws li kev tsim kho units ntawm 3,6-Dibromopyridazine. Vim nws qhov chaw tshwj xeeb ntawm qhov chaw thiab cov qauv pore tswj tau, MOFs tuaj yeem nqus tau zoo thiab khaws ntau cov roj molecules, suav nrog hydrogen, oxygen, nitrogen, thiab carbon dioxide. Tsis tas li ntawd, MOF tseem tuaj yeem ua tiav kev sib cais thiab ua kom muaj txiaj ntsig ntawm cov roj sib xyaw ua ke, uas muaj peev xwm siv tau hauv kev siv roj sib cais.
Dab tsi yog qhov kev pheej hmoo thiab cov teeb meem ntawm biobased lwm txoj hauv kev rau qhov sib xyaw no?
Tus nqi teeb meem: Tus nqi ntawm cov khoom siv bio-based feem ntau siab dua li cov khoom siv roj av ib txwm muaj. Qhov no yog vim tias cov txheej txheem ntawm cov khoom siv biobased feem ntau cuam tshuam nrog cov txheej txheem biotransformation nyuaj, xav tau ntau lub zog thiab cov cuab yeej siv peev. Tsis tas li ntawd, kev hloov pauv raws caij nyoog thiab qhov sib txawv hauv cheeb tsam hauv biomass raw cov ntaub ntawv tuaj yeem ua rau cov nqi raw khoom tsis ruaj khov.
Cov teeb meem kev ua tau zoo: tseem muaj qee qhov sib txawv ntawm cov ntaub ntawv biobased thiab cov khoom siv roj av ib txwm muaj nyob rau hauv cov ntsiab lus ntawm kev ua haujlwm kub, tshuaj tiv thaiv, thiab lwm yam khoom. Piv txwv li, qee cov bioplastics yog feem ntau deformation los yog decomposition nyob rau hauv qhov kub thiab txias los yog muaj zog acid thiab alkali ib puag ncig, uas txwv lawv daim ntawv thov ntau yam.
Qhov teeb meem kev lag luam nce qib: Cov neeg siv khoom paub txog cov ntaub ntawv biobased tsis siab txaus, thiab lawv qhov kev lees paub ntawm cov khoom tshiab kuj siv sijhawm. Tsis tas li ntawd, cov saw hlau uas twb muaj lawm thiab kev tsim kho vaj tse kuj yuav tsum tau hloov kho raws li kev hloov kho kom zoo rau kev tsim cov khoom siv bio-based.
Kev lag luam tsis txaus ntawm cov nplai: Vim tias qhov kev xav tau ntawm cov khoom siv biobased hauv kev ua lag luam, ntau lub tuam txhab muaj kev txwv ntau lawm thiab tsis tuaj yeem txo cov nqi los ntawm loj - teev ntau lawm xws li kev lag luam petrochemical.
Kev cuam tshuam ib puag ncig: Qee cov kev tshawb fawb tau pom tias bio-based fibers tuaj yeem ua rau muaj kev tuag ntau dua, txo qis kev loj hlob, thiab muaj peev xwm ua rau cov kab mob hauv av. Piv nrog rau cov yas yas, bio-based fibers tej zaum yuav muaj kev cuam tshuam ntau dua rau ib puag ncig.
Cov yam ntxwv tshuaj lom neeg thiab cov teeb meem toxicity: Feem ntau cov biobased thiab cov nroj tsuag-raws li plastics lawv tus kheej muaj cov tshuaj lom thiab yuav ua rau muaj kev phom sij zoo ib yam li cov yas yas, ua cov khoom muaj kuab paug thiab cov kab mob pathogenic.
Kev paub txog pej xeem thiab teeb meem-kev daws teeb meem: Cov pej xeem muaj kev pom zoo ntawm biodegradable plastics, tab sis tib lub sijhawm qhia tsis meej txog seb cov yas no puas yuav muaj kev cuam tshuam tsis zoo rau ib puag ncig, thiab feem ntau tsis paub yuav ua li cas siv cov yas biodegradable.
Kev tsim vaj tse tsis txaus: Ob peb lub nroog thiab cov zej zog tau nruab nrog cov txheej txheem tsim nyog rau kev tuav cov yas biodegradable, yog li ntau lub koom haum tswj xyuas cov khib nyiab yuav txuas ntxiv xa cov pov tseg mus rau qhov chaw pov tseg, ua rau lub nra ntawm qhov chaw pov tseg.
Cov kev mob tshwm sim ntawm cov tshuaj no yog dab tsi?
Muaj peev xwm cuam tshuam rau tib neeg lub cev
Txaus siab heev
Cov tshuaj no muaj kev cuam tshuam rau lub qhov muag, ua pa, thiab tawv nqaij. Yog li ntawd, thaum soj ntsuam nrog cov tshuaj no, nws yog ib qho tsim nyog yuav tsum hnav cov khaub ncaws tiv thaiv tsim nyog, hnab looj tes, thiab siv cov looj tsom iav los yog daim npog ntsej muag.
Yog tias tsis sib cuag nrog lub qhov muag, yaug tam sim nrog dej kom ntau thiab nrhiav kev kho mob sai li sai tau.
Toxicity
Txawm hais tias cov ntaub ntawv tshwj xeeb ntawm tib neeg toxicity tej zaum yuav txawv vim qhov kev sim thiab qhov sib txawv ntawm tus kheej, feem ntau hais lus, tshuaj lom neeg xws li cov tshuaj no tuaj yeem muaj kev phom sij rau tib neeg lub cev thaum raug ntau dhau lossis tsis tsim nyog. Nws yuav tsum tau muab sau tseg tias qhov ncauj mob LD50 (qhov nruab nrab ntawm cov neeg tuag) ntawm nas yog ib qho tseem ceeb qhia rau kev ntsuam xyuas cov tshuaj lom neeg, tab sis nws cov nqi LD50 tshwj xeeb yuav txawv nyob ntawm qhov kev sim thiab daim ntawv ntawm cov tshuaj (xws li ntshiab, tov, thiab lwm yam).
Muaj feem cuam tshuam rau ib puag ncig
Toxicity rau cov kab mob hauv dej
Lub toxicity ntawm no compound rau ntses yog tsawg, tab sis qhov tshwj xeeb LC50 tus nqi nyob ntawm qhov kev sim thiab hom ntses. Nws tsis yog - lom rau muv, tab sis xav tau kev tshawb fawb ntxiv ntawm nws lub sij hawm ntev - cuam tshuam rau lwm yam kab mob hauv dej los yog ecosystems.
Environmental persistence thiab bioaccumululation
Tej zaum yuav muaj tsawg cov ntaub ntawv ntawm ib puag ncig persistence thiab bioaccumululation ntawm no compound. Txawm li cas los xij, raws li bromine uas muaj cov organic compound, nws yuav muaj qee qhov kev ruaj ntseg hauv ib puag ncig thiab tuaj yeem sib sau hauv cov kab mob los ntawm cov khoom noj khoom haus.
Kev ceev faj rau kev siv
Thaum siv, cov txheej txheem kev nyab xeeb thiab kev tswj hwm ib puag ncig yuav tsum tau ua raws li nruj me ntsis.
Tsis txhob ncua sij hawm los yog nthuav dav rau cov tshuaj no los txo cov kev pheej hmoo rau tib neeg kev noj qab haus huv thiab ib puag ncig.
Yog tias tsim nyog los pov tseg cov khoom pov tseg lossis nws cov khoom pov tseg, cov koom haum pov tseg kev tshaj lij yuav tsum tau sab laj lossis kev taw qhia los ntawm cov chaw tiv thaiv ib puag ncig hauv zos yuav tsum ua raws.
Pyridazine, raws li ib tug neeg sawv cev ntawm cov diazones, yog ib tug rau lub koom haum heterocyclic system muaj li ntawm ob tug nitrogen atoms.
Kev tshawb fawb keeb kwm ntawm hom kev sib xyaw no tuaj yeem taug qab rov qab mus rau lub xyoo pua puv 19, thaum German chemist Heinrich Blau thawj zaug tsim cov pyridazine nucleus los ntawm cov tshuaj tiv thaiv condensation ntawm phenylhydrazine thiab dicarbonyl compounds hauv 1886.
Xyoo 1886, Blau thawj zaug tau tshaj tawm ib txoj hauv kev npaj pyridazine los ntawm cov tshuaj tiv thaiv condensation ntawm phenylhydrazine thiab glyoxal, uas tom qab ntawd hu ua "Blau" Synthesis method ". Txawm li cas los xij, tseem muaj kev sib cav txog kev nkag siab ntawm cov qauv khoom nyob rau lub sijhawm, thiab nws tsis yog txog 1901 tias Arthur Hantzsch tau lees paub cov qauv ntawm cov qauv ntawm cov khoom siv hauv lub sijhawm. kev tshawb fawb tau ntsib ob qhov teeb meem loj: cov khoom siv hluav taws xob tsawg (feem ntau<30%) and lack of effective structural characterization methods, which limited the in-depth study of pyridazine derivatives.
Txawm li cas los xij, vim muaj kev txwv nyob rau hauv cov organic chemistry theories thaum ntxov thiab cov txheej txheem thev naus laus zis, kev tshawb fawb ntawm pyridine derivatives tsis tau pib tiag tiag kom txog rau thaum nruab nrab xyoo pua 20th. Nyob rau hauv txoj kev loj hlob ntawm heterocyclic chemistry, halogenated pyridines tau maj mam nyiam cov xim vim lawv cov cim reactivity thiab cov yam ntxwv ntawm cov qauv. Ntawm lawv, 3,6-dibromopyridazine, raws li ib tug neeg sawv cev ntawm symmetric dihalogenated derivatives, tau dhau los ua ib qho tseem ceeb hluavtaws thaiv rau kev tsim complex heterocyclic systems vim nws siab reactivity nyob rau hauv nucleophilic hloov cov tshuaj tiv thaiv thiab kev ua tau zoo heev nyob rau hauv cov hlau catalyzed coupling tshua. Kev tshawb pom thiab kev ua kom zoo ntawm cov txheej txheem no tsis yog tsuas yog qhia txog kev nce qib ntawm cov txheej txheem kev sib xyaw ua ke ntawm cov organic, tab sis kuj tseem qhia tau tias yog ib qho tseem ceeb rau kev hloov pauv ntawm kev tshawb fawb hauv cov ntawv thov.
Lub sijhawm lig 19th thiab thaum ntxov 20th centuries yog lub sijhawm tseem ceeb ntawm cov organic heterocyclic chemistry.
Nyob rau xyoo 1930, nrog kev txhim kho ntawm cov organic halogenation cov tshuaj tiv thaiv txoj kev xav, cov kws tshawb fawb tau pib sim ncaj qha halogenation ntawm pyridazine nplhaib tshuab. Nyob rau hauv 1935, British chemist Robert Robinson pab neeg ua ntej tshaj tawm cov tshuaj tiv thaiv halogenation ntawm pyridazine nyob rau hauv dej bromine thiab ua tiav tau cov khoom monobrominated. Txawm li cas los xij, vim muaj cov yam ntxwv ntawm cov khoom siv hluav taws xob siab ntawm pyridazine nplhaib, bromination ncaj qha raug txwv. Feem ntau ua rau muaj ntau yam halogenated los ntawm - cov khoom, thiab cov regioselectivity nyuaj rau tswj.
Xyoo 1948, Hans Meerwein los ntawm Max Planck Lub Tsev Kawm Ntawv hauv Tebchaws Yelemees tau tsim cov tswv yim tshiab halogenation - siv N-bromosuccinimide (NBS) ua cov khoom siv bromine kom ua tiav cov kev taw qhia bromination ntawm pyridine raws li cov kuab tshuaj tshwj xeeb. Txoj kev no tau tso lub hauv paus tseem ceeb rau kev tshawb pom tom ntej ntawm 3,6-dibromopyridazine.
Xyoo 1953 tau cim qhov kev hloov pauv tseem ceeb hauv kev tshawb fawb ntawm3,6-Dibromopyridazide. Professor Charles D. Hurd's team from the University of Illinois has published a key paper in the Journal of the American Chemical Society, reporting the first highly selective synthesis of 3,6-dibromopyridazine through the reaction of pyridazine-N-oxide with phosphorus tribromide. This method has the following advantages: regional selectivity>95%
Cov tshuaj tiv thaiv tawm mus txog 65-70%, thiab cov khoom lag luam yooj yim crystallize thiab purify. Txoj kev tshawb no ntawm cov tshuaj tiv thaiv mechanism qhia tau hais tias N-oxide thawj zaug ua ib tug active intermediate nrog PBr ∝, ces undergoes electrophilic bromination, thiab thaum kawg tau txais lub hom phiaj cov khoom los ntawm kev tshem tawm cov tshuaj tiv thaiv. Qhov kev tshawb pom no daws qhov teeb meem ntawm kev xaiv tsis zoo hauv txoj kev ncaj qha bromination.
Nyob rau xyoo 1960, nrog rau kev txhim kho ntawm cov txheej txheem analytical niaj hnub, cov qauv ntawm cov khoom sib txuas tau raug tus yam ntxwv.
Xyoo 1962, nws cov qauv siv lead ua tau raug txiav txim thawj zaug los ntawm X-ray ib leeg siv lead ua diffraction (Cambridge Crystallographic Database nkag tus lej: PYRDAZ01)
1965: Nuclear magnetic resonance thev naus laus zis (¹ H NMR) tau siv los txheeb xyuas qhov sib xyaw, lees paub nws cov qauv sib luag
Xyoo 1968, cov kev tshawb fawb loj spectrometry tau nthuav tawm nws cov yam ntxwv fragmentation hom (molecular ion peaks nrog m/z=236/238/240)
Cov kev txhim kho thev naus laus zis no tsis tsuas yog siv tau cov qauv ntawm cov khoom sib txuas, tab sis kuj muab cov cuab yeej tseem ceeb rau kev tshawb fawb tom ntej ntawm cov tshuaj tiv thaiv mechanisms.
Cov lus nug nquag
Dab tsi yog kev siv thiab kev siv thaj chaw ntawm 3,6-dibromopyridazide
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Organic synthesis intermediates: siv rau kev npaj cov tebchaw uas muaj cov qauv bromopyridazine, xws li tshuaj thiab tshuaj tua kab intermediates.
Hla- cov tshuaj tiv thaiv sib txuas: Tsim cov pa roj carbon-carbon lossis carbon-nitrogen bonds hauv Suzuki lossis Buchwald-Hartwig coupling cov tshuaj tiv thaiv rau kev tshawb nrhiav tshuaj.
Synthesis of bioactive molecules: synthesis of antifungal agents, herbicides, thiab cov tshuaj tshwj xeeb (xws li celecoxib analogues) ua cov ntaub ntawv tseem ceeb.
Cov xwm txheej khaws cia yog dab tsi?
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Cov kev cai ib puag ncig: Khaws rau hauv lub thawv ntim rau hauv qhov txias, qhuav, zoo- qhov chaw cua, kom deb ntawm tshav ntuj ncaj qha, muaj zog alkalis, thiab txo cov neeg ua haujlwm.
Kev tswj qhov kub thiab txias: Qhov ntsuas kub tau pom zoo yog chav tsev kub (kwv yees li 20-25 degree), tsis txhob muaj qhov kub thiab txias.
Purity thiab kev tswj kom zoo?
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Tus qauv purity: Cov purity feem ntau yog 97% -98%, uas tuaj yeem kuaj tau los ntawm kev ua haujlwm siab ua kua chromatography (HPLC) lossis roj chromatography (GC).
Kev tswj hwm impurity: Nws yog ib qho tsim nyog los kuaj xyuas cov khoom siv tsis zoo, cov khoom siv hnyav, thiab cov isomers ua tau kom ua tau raws li cov ntawv thov.
Cim npe nrov: 3,6-dibromopyridazide cas 17973-86-3, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom