Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm cov tuam ntxhab thiab cov muag khoom ntawm 3'-chloropropiophenone cas 34841-35-5 hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo 3'-chloropropiophenone cas 34841-35-5 muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
3'-Chloropropiophenone, tseem hu ua inter-chlorobenzophenone, yog ib qho tseem ceeb organic hluavtaws intermediate nrog cov mis mos molecular C9H9ClO. Nws cov tsos yog feem ntau yog dawb mus rau daj ntseg daj crystals los yog crystalline hmoov, thiab nws muaj ib tug yam ntxwv tsw tsw. Hauv kev lag luam tshuaj lom neeg, qhov sib xyaw no feem ntau yog siv los ua cov khoom siv tseem ceeb thiab tau siv dav hauv kev lag luam tshuaj thiab tshuaj zoo, ua tus thawj coj rau kev sib txuas ntawm cov tshuaj (xws li qee cov tshuaj tiv thaiv kev ntxhov siab, tshuaj tiv thaiv kab mob) thiab lwm yam siab - muaj txiaj ntsig zoo tshuaj. Cov tshuaj chlorine atom thiab benzoyl pawg nyob rau hauv nws cov qauv molecular muaj siab reactivity thiab yog nquag mus rau ntau yam tshuaj xws li nucleophilic hloov, txo, los yog cyclization. Raws li cov khoom siv tshuaj, nws cov khoom tsim, khaws cia, thiab siv yuav tsum nruj me ntsis ua raws li cov cai tswj kev nyab xeeb, vim tias nws tuaj yeem ua rau tawv nqaij, qhov muag, thiab ua pa, thiab muaj qee yam txaus ntshai rau ib puag ncig. Thaum lub sij hawm kev thauj mus los thiab pov tseg, cov kev tswj xyuas tshuaj muaj feem xyuam yuav tsum tau ua raws li kev ua haujlwm kom nyab xeeb thiab ua raws li kev tiv thaiv ib puag ncig.
| C.F |
C9H9CLO |
| E.M | 168 |
| M.W | 169 |
| E.A |
168 (100.0%), 170 (32.0%), 169 (9.7%), 171 (3.1%) |
| m/z |
C, 64,11; H 5, 38; 21.02 Nws; 9,49 ua |
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3'-Chloropropiophenone(CAS naj npawb 936-59-4) yog halogenated aromatic ketone conflate nrog cov qauv tshuaj tshwj xeeb. Nws cov molecule muaj ob pawg ketone carbonyl (- CO -) thiab chloropropyl sab saw (- CH2CH2Cl). Cov cuab yeej bifunctional no ua rau nws yog ib qho tseem ceeb hauv nruab nrab ntawm cov organic conflate. Txij li thaum nws nrhiav tau nyob rau hauv nruab nrab-20th caug xyoo, 3-chlorophenylacetone tau qhia ntau daim ntawv thov tus nqi hauv thaj chaw xws li tshuaj, tshuaj tua kab, tshuaj zawv plaub hau, thiab cov ntaub ntawv tshawb fawb, thiab nws cov kev siv tau txuas ntxiv nthuav dav nrog kev nce qib ntawm cov tshuaj sib xyaw ua ke.
1. Lub hauv paus ntawm cov synthesis ntawm antidepressant bupropion hydrochloride
Nws yog ib qho tseem ceeb precursor rau conflate ntawm Bupropion Hydrochloride. Amphetamine yog ib qho atypical antidepressant uas ua haujlwm los ntawm inhibiting reuptake ntawm norepinephrine thiab dopamine los ntawm neurons. Nws yog qhov tsim nyog rau cov neeg mob uas muaj kev ua haujlwm tsis zoo lossis kev tsis haum rau kev xaiv serotonin reuptake inhibitors (SSRIs). Nyob rau hauv nws txoj kev conflate, chloropropyl sab saw ntawm cov tshuaj yog nkag mus rau hauv cov amino pawg los ntawm nucleophilic hloov cov tshuaj tiv thaiv, thiab cov ketone carbonyl pawg raug txo thiab hloov mus rau hauv ib pab pawg hydroxyl, thaum kawg tsim cov core skeleton ntawm bupropion.
Txheej txheem txheej txheem:
Hauv cov txheej txheem patented, cov khoom no yog siv los ua cov khoom siv raw los ua ke bupropion los ntawm cov kauj ruam hauv qab no:
Kev hloov kho ntawm cov saw hlau sab: ua rau nws nrog tert butyl sulfonamide los tsim cov chiral auxiliary hloov kho intermediates, kom ntseeg tau tias cov stereoselectivity ntawm cov tshuaj tiv thaiv tom qab;
Kev txo cov tshuaj tiv thaiv: Siv sodium borohydride los yog lithium aluminium tetrahydroxide los txo cov ketone carbonyl pawg rau cov cawv thib ob;
Hydrolysis thiab purification: Lub chiral auxiliary raug tshem tawm los ntawm alkaline hydrolysis, thiab thaum kawg qhov nruab nrab ntawm bupropion nrog ib tug purity ntawm ntau tshaj los yog sib npaug rau 99.5% yog tau.
Cov txheej txheem no nce tag nrho cov txiaj ntsig mus rau ntau dua 85% thiab txo qis cov nqi tsim khoom los ntawm kev tswj cov tshuaj tiv thaiv kub (0-5 degree) thiab catalyst ntau npaum.
2. Synthesis intermediates ntawm lwm yam tshuaj psychotropic
Ntxiv nrog rau bupropion thiab malavir, nws tseem tuaj yeem siv los ua ke cov tshuaj hauv qab no:
Dapoxetine: ib qho kev xaiv serotonin reuptake inhibitor siv los kho ejaculation ntxov ntxov . 3-chlorophenylacetone tau nkag mus rau hauv lub nplhaib fluorinated benzene los ntawm kev hloov kho cov saw hlau los ua qhov tseem ceeb nruab nrab ntawm dapoxetine.
Fluoxetine Hydrochloride: Ib qho classic SSRI antidepressant . 3-chlorophenylacetone raug oxidation cov tshuaj tiv thaiv los tsim cov benzoic acid derivatives, uas ntxiv synthesize lub active ingredient ntawm fluoxetine.
Precursors ntawm anti-cov tshuaj qog nqaij hlav: Kev tshawb fawb tau pom tias 3-chlorobenzone derivatives tuaj yeem ua rau qog cell apoptosis los ntawm inhibiting topoisomerase kev ua, thiab tam sim no nyob rau hauv kev tshawb fawb theem.
Cov cheeb tsam uas tshwm sim: kev koom ua ke ntawm ntsuab chemistry thiab biotechnology
1. Enzymatic asymmetric conflate
Nrog rau kev sib sib zog nqus ntawm lub tswv yim ntawm ntsuab chemistry, enzyme catalysis thev naus laus zis tau pom muaj peev xwm loj hauv kev sib txuas ntawm 3-chlorophenylacetone derivatives vim nws qhov zoo ntawm kev xaiv siab thiab tsis muaj kuab paug. Piv txwv li:
Cov pa roj carbon raws li reductase catalysis: Siv EbSDR8 carbon raws reductase, 3-chloroacetone yog asymmetrically txo rau (R) -3-chloro-1-phenyl-1-propanol, nrog tus nqi ee (enantiomeric tshaj) Ntau dua lossis sib npaug li 99%, muab txoj hauv kev zoo rau chiral tshuaj conflate;
Lipase catalyzed esterification: Los ntawm kev siv Candida Antarctica lipase B (CALB) los catalyze esterification ntawm 3-chlorophenylacetone nrog cawv, cov tshuaj lom neeg ester derivatives tuaj yeem ua ke rau kev siv tshuaj tua kab lossis tshuaj tsw qab.
2. Kev hloov kho ntawm nanomaterials
Cov chlorinated sab chains tuaj yeem qhia cov pab pawg ua haujlwm xws li amino thiab thiol pawg los ntawm kev hloov pauv kev hloov pauv ntawm cov khoom siv nano. Piv txwv li:
Kub nanoparticle hloov kho: 3-chlorophenylacetone yog thiolated los tsim 3-mercaptobenzene, thiab nws nto yog hloov nrog Au-S daim ntawv cog lus los txhim kho nws biocompatibility rau kev kho mob qog nqaij hlav;
Quantum dot functionalization: Cov tshuaj tau hloov mus rau hauv 3-aminophenylacetone los ntawm cov tshuaj tiv thaiv amination, uas covalently khi rau pawg carboxyl nyob rau saum npoo ntawm CdSe quantum dots los npaj fluorescent biological probes.
3'-Chloropropiophenone, raws li ib qho tseem ceeb organic conflate intermediate, muaj ntau yam kev siv nyob rau hauv cov tshuaj, tshuaj tua kab, thiab cov ntaub ntawv science. Nrog rau qhov tob ntawm lub tswv yim ntawm ntsuab chemistry, cov txheej txheem hluavtaws maj mam txhim kho mus rau kev ua haujlwm siab, kev tiv thaiv ib puag ncig, thiab tus nqi qis. Cov hauv qab no yog kev tshuaj xyuas zoo ntawm nws txoj hauv kev sib koom ua ke:
Phenylacetone chlorination method: optimization thiab innovation ntawm cov txheej txheem ib txwm muaj
Txoj kev phenylacetone chlorination yog txoj kev lag luam loj tshaj plaws rau kev sib txuas 3-chlorophenylacetone, thiab nws cov ntsiab lus tseem ceeb yog qhia cov tshuaj chlorine atoms los ntawm alpha chlorination ntawm phenylacetone.
Cov txheej txheem nquag ntws yog raws li nram no:
Chlorination tshuaj tiv thaiv:
Aluminium trichloride (catalyst) thiab 1,2-dichloroethane (cov kuab tshuaj) yog ntxiv rau cov tshuaj tiv thaiv hlab ntsha, thiab cov tshuaj phenylacetone ntxiv dropwise thaum nplawm. Kev xaiv chlorination yog ua los ntawm kev qhia cov roj chlorine. Cov tshuaj tiv thaiv kub yog tswj ntawm 15-70 degree, thiab cov txheej txheem tshuaj tiv thaiv yog taug qab los ntawm chromatography. Tom qab 6-10 teev, chlorination raug tso tseg.
Tom qab kev kho mob:
Qhov qis -kub hydrolysis cov tshuaj tiv thaiv sib tov yog ntxuav nrog dej kom tshem tawm cov ntsev inorganic, thiab cov khoom nyoos yog tau los ntawm lub tshuab nqus tsev distillation. Thaum kawg, cov khoom yog purified los ntawm distillation ntawm 170 degree, nrog ib tug purity ntawm 99.7% -99.9% thiab tawm los ntawm 88% -90%.
Technological breakthrough:
Kev txhim kho catalyst: Cov txheej txheem ib txwm siv aluminium trichloride, tab sis muaj cov khoom siv corrosion. patented thev naus laus zis ntawm Shandong Polar Medicine tau txhim kho cov tshuaj tiv thaiv kev ua haujlwm rau ntau dua 95% los ntawm kev ua kom zoo rau cov catalyst system, thaum txo cov tiam los ntawm - khoom.
Cov kuab tshuaj rov qab: Cov dej kua qaub uas ua los ntawm hydrolysis tuaj yeem siv rov ua dua thiab rov siv dua, ua ke nrog cov roj av kho, kom ua tiav kaw- siv cov kuab tshuaj thiab txo cov pa phem ib puag ncig.
Chlorobenzoic acid condensation txoj kev: ib tug breakthrough nyob rau hauv atomic economy
Txoj kev condensation ntawm m-chlorobenzoic acid tsim lub hom phiaj molecule los ntawm ib tug condensation decarboxylation cov tshuaj tiv thaiv, nrog ib tug atomic siv tus nqi ze rau 100%, uas ua raws li cov qauv ntawm ntsuab chemistry. Cov kauj ruam tshwj xeeb yog raws li nram no:
Raw khoom npaj:
M-chlorobenzoic acid yog tau los ntawm alkaline hydrolysis thiab acidification ntawm m-chlorobenzonitrile.
Cov tshuaj tiv thaiv condensation:
Nyob rau hauv qhov kev txiav txim ntawm ib qho catalyst, m-chlorobenzoic acid condenses nrog propionic acid los ua ib qho nruab nrab, uas yog ces rhuab mus rau 180℃rau decarboxylation, tso carbon dioxide thiab tsim lub hom phiaj molecule.
Cov khoom sib cais:
3-chlorophenylacetone yog tau los ntawm hnyav nqus ntawm distillate, txias thiab crystallization. Cov txiaj ntsig ntawm txoj kev no nce mus txog 82% thiab tsis tas yuav siv cov khoom hnyav hlau catalysts.
Technical zoo:
Txo cov pov tseg: Cov tshuaj tiv thaiv decarboxylation tsuas yog tsim cov pa roj carbon dioxide thiab dej, uas yog raws li lub tswv yim ntawm "zero emissions".
Kev ua kom zoo tshaj tus nqi: Cov khoom siv raw m-chlorobenzoic acid tuaj yeem npaj los ntawm kev lag luam los ntawm -cov khoom ntawm m-chlorobenzonitrile, txo cov nqi raw khoom los ntawm 30%.
Biocatalysis: Sawv ntawm Enzyme Engineering
Nrog rau txoj kev loj hlob ntawm hluavtaws biology, biocatalysis tau maj mam tshwm sim vim nws cov kev xaiv siab thiab qis zog noj zoo.
Cov xwm txheej zoo li no:
Kev tshuaj ntsuam enzyme
Cov pa roj carbon raws li reductase (EbSDR8) raug cais tawm ntawm cov av, uas tuaj yeem txo cov ketone carbonyl ntawm 3-chloroacetone los tsim (R) -3-chloro-1-phenyl-1-propanol.
Tag nrho cell catalysis
Qhia cov enzyme genes rau hauv Escherichia coli los tsim lub cell catalyst tag nrho. Hauv 5L fermentation tank, thaum cov kab mob concentration nce mus txog OD 600=20, 3-chlorophenylacetone ntxiv rau kev hloov pauv. Tom qab 12 teev, tus nqi ee (enantiomer tshaj tus nqi) ntawm cov khoom yog Ntau tshaj lossis sib npaug rau 99%, thiab cov txiaj ntsig yog 85%.
Daim ntawv thov kev cia siab:
Chiral tshuaj conflate: Biocatalytic txoj kev tau siv rau asymmetric conflate ntawm cov intermediates tseem ceeb ntawm bupropion, txo cov tshuaj sib cais cov kauj ruam thiab txo nqi ntau lawm.
Sustainable ntau lawm: Enzyme catalyzed cov tshuaj tiv thaiv yog nqa tawm nyob rau hauv chav tsev kub thiab siab, txo lub zog noj los ntawm 60% piv rau tshuaj txoj kev thiab ua tau raws li carbon neutrality lub hom phiaj.
Lwm txoj hauv kev tshiab: kev sib koom ua ke
Photocatalytic chlorination: Siv phenylacetone ua cov khoom siv raw, nyob rau hauv qhov pom lub teeb irradiation, photocatalysts (xws li Ru (bpy) ∝² ⁺) qhib cov roj chlorine kom ua tiav alpha xaiv chlorination. Cov tshuaj tiv thaiv kab mob ntawm txoj kev no yog me me, thiab kev siv cov tshuaj chlorine atom yog ze li ntawm 100%, tab sis3'-Chloropropiophenoneyog tam sim no nyob rau hauv lub laboratory theem.
Electrochemical conflate: Los ntawm electrolyzing ib tov tov ntawm phenylacetone thiab sodium chloride, chlorine radicals yog generated ntawm electrode nto mus ncaj qha mus tua alpha site ntawm phenylacetone. Txoj kev no tsis tas yuav ntxiv cov oxidants thiab muaj kev lag luam atomic ntawm 95%, tab sis lub neej ntawm cov khoom siv electrode yuav tsum tau ua kom zoo ntxiv.
3'-Chloropropiophenoneyog chlorinated aromatic ketone compound. Nws cov khoom siv tshuaj lom neeg tuaj yeem ua tiav raws li hauv qab no:
Lub cev lub cev thiab qhov tsos:Nyob rau hauv chav tsev kub, nws zoo nkaus li ib tug dawb mus rau lub teeb daj los yog lub teeb txiv kab ntxwv crystalline khoom, nrog ib tug tshwj xeeb crystalline daim ntawv.
Melting point thiab boiling point:Lub melting point yog li ntawm 43 mus rau 47 degrees Celsius, thiab nyob rau hauv tsis tshua muaj siab tej yam kev mob (xws li 14 mmHg), lub boiling point yog 124 degrees Celsius, qhia tau hais tias nws volatility yog cuam tshuam los ntawm lub siab.
Solubility:Nws yog soluble hauv cov kuab tshuaj organic xws li methanol, tab sis insoluble hauv dej. Cov cuab yeej no txwv nws daim ntawv thov nyob rau hauv aqueous - theem cov tshuaj tiv thaiv, tab sis cov tshuaj tiv thaiv tuaj yeem nqa tawm hauv cov organic hnyav.
Chemical stability:Nws tseem nyob ruaj khov nyob rau hauv ib txwm cia tej yam kev mob (ceev, qhuav, nyob rau hauv chav tsev kub), tab sis nws yuav tsum tau kev tiv thaiv los ntawm muaj zog oxidants, muaj zog bases, thiab ntub ib puag ncig los tiv thaiv decomposition los yog phiv tshuaj.
Reactivity:
Cov tshuaj tiv thaiv hydrolysis: Nyob rau hauv acidic lossis alkaline tej yam kev mob, lub nplhaib lactone yuav raug hydrolysis, tsim cov hydroxy acids los yog ntsev derivatives.
Nucleophilic hloov cov tshuaj tiv thaiv: Cov tshuaj chlorine atom ua raws li cov pab pawg tawm thiab tuaj yeem koom nrog kev hloov pauv nucleophilic, raug hloov los ntawm cov amino pawg, pawg hydroxyl, thiab lwm yam, los tsim ntau yam derivatives.
Kev txo qis cov tshuaj tiv thaiv: Nrog kev pab los ntawm ib qho catalyst, pawg carbonyl tuaj yeem txo qis rau ib pawg cawv hydroxyl, tsim cov tshuaj xws li 3-chlorobenzyl cawv.
Cov tshuaj tiv thaiv oxidation: Nyob rau hauv qhov kev txiav txim ntawm ib tug muaj zog oxidizing tus neeg sawv cev, lub nplhaib benzene los yog sab saw yuav raug oxidation, tsim carboxylic acids los yog quinone tebchaw.
Kev ceeb toom kev nyab xeeb:Qhov no compound yog irritating. Kev sib cuag nrog lub qhov muag, ua pa, lossis tawv nqaij yuav ua rau tsis xis nyob. Thaum lub sijhawm ua haujlwm, cov hnab looj tes tiv thaiv thiab looj tsom iav yuav tsum hnav, thiab nws yuav tsum tau nqa tawm hauv qhov dej zoo - qhov chaw muaj cua.
FAQ
1. 3 Chloropropiophenone siv rau dab tsi?
3'-Chloropropiophenone yog ib qho tshuaj tsw qab ketone nruab nrab siv los ua ib lub tsev thaiv hauv CNS- nquag siv tshuaj synthesis, heterocyclic compound tsim, thiab txhim kho tshuaj zoo.
2. Dab tsi yog 3 chloro propiophenone synthesis?
3'-Chloropropiophenone synthesis
3'-Chloropropiophenone yog ib qho tseem ceeb nruab nrab ntawm kev sib txuas ntawm cov tshuaj xws li bupropion hydrochloride, dapoxetine thiab maraviroc, thiab tuaj yeem siv rau hauv kev kuaj cov organic synthesis thiab cov txheej txheem tsim tshuaj.
3. Cov khoom siv tshuaj lom neeg ntawm 3'-Chloropropiophenone yog dab tsi?
3'-Chloropropiophenone (CAS naj npawb: 34841-35-5) yog chlorinated aromatic ketone nrog cov mis molecular C₉H₉ClO thiab molecular hnyav 168.62. Nws cov qauv muaj xws li chlorinated benzene nplhaib thiab ib pawg propionyl. Nws yog qhov muaj zog heev thiab tuaj yeem koom tau yooj yim hauv kev hloov pauv nucleophilic, txo cov tshuaj tiv thaiv, thiab lwm yam. Nws yog ib qho tseem ceeb nruab nrab rau kev sib txuas cov organic molecules complex (xws li tshuaj, tshuaj tsw qab, tshuaj tua kab).
Cim npe nrov: 3'-Chloropropiophenone CAS 34841-35-5, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom