4-bromobenesulforonyl chlorideyog cov organic sib xyaw, CAS 98- 58-8, nrog tshuaj chemical c6h4brlo2s. Nws yog tus dawb rau lub teeb daj. Nws muaj qee qhov solubility nyob rau hauv cov kuab tshuaj uas muaj ntau xws li chlorinated hydrocarbons, dej cawv, thiab lwm yam neeg. Nws tuaj yeem siv rau kev tawm tsam cov kev tawm tsam ntawm cov sib xyaw uas muaj ntxhiab los npaj cov organic muaj cov muaj cov neeg sulfonic pawg. Feem ntau, cov compound no tuaj yeem ua tus neeg tawm suab paj nruag sulfation rau ntau pawg neeg ntxhiab tsw qab, xws li p-cluor fluorescent fluorescent fluored fluoricity macromolecules lossis organic me me molecules. Nws kuj tseem tuaj yeem siv los npaj Heterocyclic tebchaw, xws li organic sib sau uas muaj piperidine rings. Nws kuj tseem siv tau ua nucleophilic reagent los qhia qee pab pawg neeg siv tshuaj, xws li pawg neeg lossis cov pab pawg hydroxene.
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Tshuaj Cov Qauv |
C6h4brCllo2S |
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Muaj pes tsawg leej |
254 |
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Molecular hnyav |
256 |
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m/z |
254 (100.0%), 256 (97.3%), 256 (32.0%), 258 (31.1%), 255 (6.5%), 257 (6.3%), 256 (4.5%), 258 (4.4%), 257 (2.1%), 259 (2.0%), 258 (1.4%), 260 (1.4%) |
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Kev Ntsuam Xyuas |
C, 28.20; H, 1.58; Br, 31.27; Cl, 13.87; O, 12.52; S, 12.55 |
Lub cev thiab tshuaj
► Molecular qauv thiab cov qauv
Nws muaj cov mis molecular c₆h₄brlooss. Nws cov qauv muaj cov nplhaib benzene nrog cov kab nrig benzene nrog ib qho chaw para nyob rau hauv para txoj hauj lwm (4} txoj hauj lwm) thiab ib pab pawg sulgoride (-Shcl) txuas rau lub nplhaib. Sulfonyl Chloride cov neeg ua haujlwm tau pab pawg yog reactive, ua rau no compound muaj txiaj ntsig zoo hauv cov organic synthesis.
Inity Lub xeev thiab cov tsos
Nyob rau hauv cov qauv ntawm cov qauv, 4-bromobenesulforoningulforony zoo li pom raws li lub teeb dawb rau lub teeb daj crystalline khoom. Qhov sib xyaw ua ke lub ntsej muag yuav txawv me ntsis nyob ntawm nws cov kev coj ua tub rog thiab kev cia khoom. Nws yog tsis muaj ntxhiab, uas yog qhov zoo rau kev kuaj kom zoo raws li nws txo qhov kev pheej hmoo ntawm kev nqus tau pa.
► Melting thiab Boiling Cov Ntsiab Lus
Lub ntsiab lus melting ntawm 4-bromobenesulforonyl chloride ranges los ntawm 73 Qib mus rau 77 degree, muaj qee qhov chaw tshaj tawm cov txiaj ntsig raws li 75.00-76.00 degree. Nws lub point boiling yog kwv yees li 152℃rau 154℃ntawm lub siab ntawm 26 mmHg, qhia tias nws subimposes los yog decomposes ntawm ntau dua cov cua txias nyob rau hauv cov atmospheric siab. Qhov no thermal intility tsis tau ceev faj tuav thaum ua cua sov.
► solubility
Nws yog soluble nyob rau hauv ntau yam ntawm cov kuab tshuaj organic, suav nrog TetranhyDrofuran (Thf), Pethroleum Ether, 1,4-DICHOROMETHANE, thiab chloroform. Txawm li cas los xij, nws yog insoluble hauv dej, uas yog ib qho kev tshwm sim ntau ntawm sulfonyl chloride compounds. Qhov Insolubility hauv dej yog qhov tseem ceeb rau nws siv hauv kev ua kom mob siab, qhov twg cov dej yuav cuam tshuam nrog cov tshuaj tiv thaiv txheej txheem.
► Sensitive thiab ruaj khov
Qhov sib xyaw yog noo noo -} rhiab, lub ntsiab lus nws tuaj yeem hnov nrog dej los ua cov tshuaj hydrogen hydrogen thiab lwm yam ntawm cov khoom lag luam. Qhov kev cuam tshuam no tau txwv tsis pub muaj qhov tseem ceeb ntawm khaws cia 4-bromobenesulforoningulforoningulforonyl chloride nyob rau hauv ib lub taub ntim qhuav, airtight thawv deb ntawm cov dej noo. Nyob rau hauv ib txwm kub thiab kev ntsuas, qhov sib txuas yog ruaj khov tab sis yuav tsum tau tiv thaiv los ntawm plua plav tiam, thiab muaj zog oxidants los tiv thaiv kev txiav txim siab.
Daim ntawv thov
► organic synthesis
Nws yog ib qho reagent ntau hauv cov articic synthesis, tshwj xeeb hauv kev npaj sulfonamides thiab lwm yam sulfonyl derivatives. Nws cov kev cuam tshuam yog ib tus neeg sib tw hluav taws xob rau kev hloov kho Nucleophilic uas yuav ua rau cov neeg siv nyiaj txiag, qhov twg nws tuaj yeem ua rau sulfonamides, sulfonively esters, lossis sulfonall thioetely, feem.
► Synthesis ntawm sulfonamides
Sulfonamides yog chav kawm ntawm cov tebchaw muaj ntau yam kev ua si, suav nrog cov tshuaj tua kabmob, tshuaj tiv thaiv kab mob rau cov tshuaj tua kab mob, thiab anti {{pob khoom. Nws tuaj yeem siv tau los sulthesize sulfonamides los ntawm reacting nrog thawj cov amines. Cov tshuaj tiv thaiv dhau los ntawm Nucleophilic tawm ntawm Amine ntawm cov pab pawg sulfonyl, ua raws li kev tshem tawm cov tshuaj sulgonamide.
Kev tiv thaiv ntawm cov khib nyiab
Ntxiv nrog rau nws lub luag haujlwm hauv Sulfonamide synthesis, nws kuj tseem tuaj yeem siv los tiv thaiv amines {{} {qib xwm txheej cov txheej txheem. Los ntawm kev hloov pauv amine rau hauv Sulfonamide derivative, cov pab pawg amino me me yog ib ntus cov khoom noj. Tom qab cov kev hloov pauv tau ua tiav, cov pab pawg Sulfonamide tuaj yeem raug tshem tawm raws cov cai kom rov qab kho dua tshiab.
► Nucleotide synthesis
Nws tau ua haujlwm raws li kev ua kom tus neeg sawv cev hauv synthesis ntawm oligodexyribo - thiab oligoribonucleides hauv kev daws teeb meem. Cov pab pawg sulfonyl tuaj yeem hnov mob nrog cov pawg hydroxyl ntawm cov suab thaj nucleotide uas txhim kho cov kev siv hluav taws xob uas txhim kho ntawm lub sijhawm ua ke thaum sib txuas. Cov hau kev no tau siv los ua ke los ua ke oligonucleotides nrog kev txhim kho qoob loo thiab kev nyab xeeb piv rau cov qauv ib txwm muaj.
► Lwm yam kev siv
Tshaj dhau qhov kev siv hauv cov organic synthesis thiab nucleotide chemistry, nws muaj cov ntawv thov hauv cov khoom kev tshawb fawb, polymer chemistry, thiab agnemical kev tshawb fawb. Nws muaj peev xwm los ua kev sib haum cua nrog ntau pab pawg ua rau nws muaj txiaj ntsig zoo rau kev hloov kho cov zog ntawm cov polymuls, lossis cov qauv me me.
Ib txoj kev sib xws rau synthesizing4-bromobenesulforonyl chlorideyog tau los ntawm reacting p -} bromobenzene nrog sulfonyl chloride. Cov hauv qab no yog cov kauj ruam tshwj xeeb:
Tshuaj Muaj Tshuaj:
Cov tshuaj tiv thaiv 1: Hloov kev xav txog ntawm P - bromobenzene thiab sulfonyl chloride
C6h5br + So2Cl2 → C6h5So2Cl + HBR
Cov tshuaj tiv thaiv 2: kev tawm nruab nrab ntawm kev tiv thaiv sulfonyl chloride thiab sodium sulfide
C6h5So2Cl - na2s → C6H5Sssssss + NACL + S
Kev Npaj Kev sim:
-4-Bromobenzene: Raws li lub substrate ntawm cov tshuaj tiv thaiv, nws muab cov bromine atoms.
-}} sulfonyl chloride: siv rau kev hloov pauv nrog p - bromobenzene sulfonyl chloride.
{-}}} aphydrous dihloromomethane: Ua haujlwm raws li cov kuab tshuaj thiab muab cov tshuaj tiv thaiv nruab nrab.
-}} sodium sulfide: siv rau neutralize tsis kam lees cov tshuaj sulfonall chloride.
{{0-}} sulfuric acid: siv los tswj cov kev mob tshwm sim.
{{0-} ice thiab dej qab zib ua kom sib xyaw: siv los tswj qhov tsawg ntawm cov tshuaj tiv thaiv.
► Koos Xis:
a. Nyob rau hauv ib lub pas dej qhuav, ntxiv 4-bromobenzene thiab anhydrous dihloromoobethane thaum tswj hwm qhov kub tsawg.
b. Maj mam ntxiv sulfonyl chloride thaum txhib cov tshuaj tiv thaiv.
c. Tswj qhov kub kom tswj tau qhov kub tsawg thiab tswj hwm lub sijhawm cov txheej txheem kev tshuaj tiv thaiv. Qhov tshuaj tiv thaiv no yuav tsum tau nqa tawm ntawm qhov ntsuas kub qis los tswj cov khoom ntawm cov kev phiv.
d. Tom qab cov tshuaj tiv thaiv tiav, hloov cov tshuaj tiv thaiv sib tov sib xyaw rau cov tshuaj sodium noo sodium
e. Cais cov theem organic thiab ntxuav nrog dej ntsev.
f. Nqus cov kuab tshuaj kom tau 4-bromobenesulforonyl chloride.
Kev ceev faj kev nyab xeeb
▪ Cov kev cim teeb meem
Nws yog txoj kev xeb thiab khaus khaus uas tuaj yeem ua rau tawv nqaij hnyav, qhov muag, thiab ua pa nyuaj rau kev tiv thaiv lossis nqus tau. Qhov sib xyaw ua ke reactivity nrog dej thiab noo noo ntxiv yuav ntxiv qhov kev pheej hmoo ntawm cov roj av roj av, uas tuaj yeem tsim kev puas tsuaj yog tias nqus tau.
► Muaj phom sij rau kev noj qab haus huv
1) Kev Tiv Thaiv Daim tawv: Tej zaum yuav ua rau kub hnyiab, liab, thiab cem. Kev ntev lossis rov kis tau dua tuaj yeem ua rau muaj mob dermatitis lossis lwm yam tawv nqaij tsis zoo.
2) Hu rau qhov muag: tuaj yeem ua rau qhov muag puas hnyav, suav nrog ceneal opacity, mob pob txha, thiab dig muag yog tias tsis dig muag.
3) Inhalation: nqus tau cov vapors lossis hmoov av puas tuaj yeem ua pa ua pa, ua pa ua pa, ua pa, mob hauv siab. Kev nthuav tawm ntev yuav ua rau mob ntsws lossis lwm yam kev ua pa tsis zoo.
4) Kev noj haus: txawm hais tias kev siv tsis zoo li vim muaj kev sib xyaw ua rau lub xeev cov plab thiab kev nqos ceev xwm txheej, xeev siab, thiab mob plab, thiab mob plab.
Hormauference Kev Nyab Xeeb Kev Nyab Xeeb
Txhawm rau txo cov kev pheej hmoo cuam tshuam nrog kov 4-bromobenesulforingulforonyl chloride, cov nram qab no yuav tsum tau ceev faj:
1) Cov Khoom Siv Tiv Thaiv Tus Kheej (PPE): Hnav hnab looj tes- cov hnab looj tes tiv thaiv, thiab lub tsho tiv no kev tiv thaiv lossis tiv thaiv cov tawv nqaij thiab qhov muag. Lub tshuab nqus nrog lim tsim nyog yuav tsim nyog thaum ua haujlwm nrog cov chaw loj lossis hauv cov chaw tsis zoo.
2) Qhov cua: Ua tag nrho cov haujlwm nyob rau hauv lub zoo - ventilated thaj chaw lossis fume hood los tiv thaiv cov vapors lossis hmoov av.
3) Cia: Muab cov khoom ntim rau hauv qhov chaw txias, qhuav kom deb ntawm ya raws, cov khoom siv kub ua ke xws li oxidizing cov neeg sawv cev thiab cov hauv paus muaj zog.
4) Kev tuav: Zam kev zam cov hmoov av thiab txeej. Siv cov cuab yeej spatula lossis lwm cov cuab yeej uas tsim nyog los hloov cov khoom sib txuas, thiab ntxuav cov khoom nchuav tam sim ntawd siv cov ntaub ntawv tsim nyog thiab cov txheej txheem pov tseg.
5) Cov txheej txheem txheej xwm ceev: tsam muaj kev sib cuag nrog tawv nqaij lossis qhov muag, yaug tam sim ntawd nrog ntau li 15 feeb thiab nrhiav kev kho mob. Yog tias nqus tau, txav tus neeg cuam tshuam rau huab cua ntshiab thiab muab cov pa ua si yog tias tsim nyog.
OP Octional Ceev Kev Nyab Xeeb
Nws yuav tsum tsis txhob tso tawm mus rau hauv ib puag ncig, raws li nws yuav ua rau muaj kev phom sij rau cov neeg muaj lub neej thiab cov kab muaj sia. Muab cov khoom sib xyaw thiab nws cov khoom tsis huv pov tseg raws li hauv zos, xeev, thiab tsoomfwv cov cai rau kev phom sij.
Nws yog cov organic muaj txiaj ntsig nrog ntau cov ntawv thov hauv cov khoom siv hluav taws xob hauv nruab nrog cev, nibleotide chemistry, thiab lwm thaj teb. Nws tshwj xeeb cov tshuaj xws li thiab lub cev ua kom nws ua nws lub tswv yim zoo tshaj plaws rau ntau cov txheej txheem hluavtaws. Txawm li cas los xij, cov compound lub corrosive thiab ua rau kev ua kom ceev faj kom ceev faj thiab kev ua kom muaj kev tiv thaiv kev mob rau tib neeg kev noj qab haus huv thiab ib puag ncig. Los ntawm kev nkag siab cov khoom siv, cov qauv siv hluav taws xob, cov ntawv thov, thiab cov tshuaj tiv thaiv kev nyab xeeb thiab cov peev xwm tuaj yeem ua rau nws muaj peev xwm thaum txo cov kev pheej hmoo.
Cim npe nrov: 4-Bromobenesulforonyl Chloride CAS 98-58-8-8, Cov chaw tsim khoom, chaw tsim khoom, chaw tsim khoom, yuav khoom, nqe, loj, rau muag