Shaanxi Bloom Tech Co., Ltd. yog ib qho ntawm cov neeg tsim khoom thiab cov khoom lag luam ntawm 4-fluoroziline CAS 371-40-4 hauv Suav. Txais tos rau kev lag luam wholesale ntau yam zoo 4-fluorooaniline CAS 371-4 rau muag ntawm no los ntawm peb lub hoobkas. Cov kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Los ntawm cov kev pom ntawm cov kev ntsuas kev ua haujlwm thiab cov voj voog ib puag ncig, 4 {{{{{}} fluoroziline nthuav qhia txog cov orguection orguectant. Tsis zoo li tus niam txiv sib txuas benzoic acid, cov carbon {4} Lub nplhaib fluorine ntawm nws lub nplhaib Benchene muaj lub zog Benchene muaj lub zog ua haujlwm Benchule nrog kev ua haujlwm ruaj khov thiab tsis kam mus rau biodegradation. Thaum nws nkag mus rau ib puag ncig, nws tuaj yeem yauv mus ntev- sij hawm} lub sij hawm tsiv teb tsaws nruab nrab ntawm av Pore dej thiab nplaim dej. Nws cov xeeb dipole lub sijhawm thiab nruab nrab octanol {{9} dej muab faib rau hauv cov huab cua lossis tsis muaj tseeb adsombed rau cov peev xwm. Hloov chaw, nws yuav ua paug paug paug paug hauv cov aquifer. Dab tsi yog ntau dua alarming yog tias thaum lub sij hawm tsis yog {}} oxidic oxidation lossis txuas ntxiv cov quinolation me me, nws tuaj yeem ua cov quinolines me me, nws tuaj yeem ua cov quinolation me me, nws tuaj yeem ua rau cov roj ntsha uas tsis paub meej, ua rau muaj cov roj ntsha uas tsis paub meej, nws tuaj yeem ua rau cov roj ntsha uas tsis paub meej, nws tuaj yeem ua cov roj ntsha me me, nws tuaj yeem ua cov roj ntsha me me, nws tuaj yeem ua rau cov quinolines me me, nws tuaj yeem ua kom cov quinolation me me, nws tuaj yeem ua cov quinolation me me, nws tuaj yeem ua cov roj ntsha me me, nws tuaj yeem ua cov roj ntsha me me, nws tuaj yeem ua kom cov quinolic almidation, nws tuaj yeem ua fluorinated quinolines lossis fluorinated azobenzene. Qhov no "zais" ib puag ncig ib puag ncig ua rau nws muaj kev cuam tshuam rau cov tshuaj lom neeg hauv av, yog li kev ua kom muaj kev phom sij rau hauv cov roj ntsha
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Tshuaj Cov Qauv |
C6h6Fn |
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Muaj pes tsawg leej |
111.05 |
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Molecular hnyav |
111.12 |
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m/z |
111.05 (100.0%), 112.05 (6.5%) |
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Kev Ntsuam Xyuas |
C, 64.85; H, 5.44; F, 17.10; N, 12.61 |
4-fluorozilineYog lub teeb pom xim pleev xim rau kua qaub, sib xyaw ntawm peb qho ua ke, insoluble hauv dej thiab denser dua li dej. Raws li kev ua yeeb yam ntawm Aniline, cov hydrogen ntawm txoj hauj lwm 4 tau hloov los ntawm Fluorine Amine thiab Fluoroaniline nrog cov ntaub ntawv dav hauv ntau thaj teb.
Kho tsev kho mob
Daim ntawv thov nyob rau hauv cov chaw tshuaj ntawm cov chaw muag tshuaj yog feem ntau xav tau raws li tus yuam sij nruab nrab rau cov hluavtaws ntawm ntau yam tshuaj.
(1) Cov tshuaj tua kab mob thiab tshuaj tiv thaiv kab mob
Muaj peev xwm koom tau hauv synthesis ntawm ntau cov tshuaj tua kab mob thiab tshuaj tiv thaiv kab mob. Kev txhim kho cov tshuaj no yog qhov tseem ceeb rau kev kho kab mob kis tau. Piv txwv li, los ntawm cov tshuaj tiv thaiv tshwj xeeb, nws tuaj yeem hloov pauv mus rau cov kab ke nrog cov kab mob antibacterial thiab luam tawm ntawm cov kab mob, yog li ua lub luag haujlwm ntawm kev kho mob. Nyob rau tib lub sijhawm, nws kuj tseem siv tau los xyuas cov tshuaj tiv thaiv kab mob antiviral, uas pab cov neeg mob rov qab lawv txoj kev noj qab haus huv los ntawm kev ua haujlwm replication thiab kev xa mus.
(2) Cov tshuaj antitumor
Nws tseem yog ib qho tseem ceeb raw rau synthesizing anti -} cov siv qog siv cov tshuaj. Cov tshuaj antitumor feem ntau muaj cov qauv nyuaj thiab muaj peev xwm muab cov pab pawg ua haujlwm thiab cov tshuaj tiv thaiv, ua cov tshuaj molecules ntau lub hom phiaj thiab biologically nquag. Cov illi {- Cov tshuaj siv qog tuaj yeem tsim kev loj hlob thiab kis cov qog nqaij hlav, ua kom cov neeg mob lub neej.
(3) lwm yam tshuaj
Ntxiv rau cov lus saum toj saud -}} Hais cov tshuaj, nws kuj tseem tuaj yeem siv los ua ke lwm cov tshuaj, xws li Cephhalporins thiab lwm yam tshuaj tua kab mob. Cov tshuaj tua kab mob no ua lub luag haujlwm tseem ceeb hauv kev kho kab mob, ua rau cov tsos mob ntawm cov tsos mob thiab kev txhawb nqa rov qab.
TSHUAJ RAU
Nws tseem dav siv hauv kev ua liaj ua teb. Nws tsis yog tsuas yog ib qho tseem ceeb hauv nruab nrab rau synthesizing kev ua tshuaj tua kab mob tsawg thiab cov tshuaj lom tsawg, tab sis kuj tseem yuav tsim kho ntau dua cov khoom lag luam thiab ib puag ncig cov khoom siv tshuaj tua kab.
(1) Tshuaj tua kab
Nws yog ib qho tseem ceeb raw rau synthesizing tshuaj ntsuab. Cov nroj ua lub luag haujlwm tseem ceeb tshaj plaws hauv kev tsim qoob loo, cov nroj tsuag tau zoo thiab txhim kho cov qoob loo tawm los thiab ua tau zoo. Los ntawm cov tshuaj tiv thaiv tshwj xeeb, nws tuaj yeem hloov mus rau hauv cov tebchaw nrog cov kev ua luam thiab luam tawm ntawm cov qoob loo ntawm cov nroj tsuag thiab raug mob los ntawm cov nroj.
(2) Tshuaj tua kab
Ntxiv nrog rau cov tshuaj tua tshuaj, nws kuj tseem siv tau rau synthesizing tshuaj tua kab. Cov tshuaj tua kab tuaj yeem tua tau lossis tsav cov kab tsuag, tiv thaiv cov qoob loo ntawm cov tshuaj tua kab. Cov pawg tau muab cov pab pawg ua haujlwm thiab cuam tshuam tua kab kom cov tshuaj tua kab kom muaj cov tshuaj tua hluav taws muaj zog thiab cov khoom siv dav dav.
(3) Cov Cawv Kev Loj Hlob Cov Neeg Sawv Cev
Nws kuj tseem siv tau los ua ke cog qoob loo kev cai lij choj. Cog qoob loo kev cai lij choj tuaj yeem tswj cov txheej txheem loj hlob thiab kev txhim kho ntawm cov nroj tsuag, txhim kho cov qoob loo tawm los thiab ua tau zoo. Los ntawm kev tswj hwm kev loj hlob tus nqi, morphology, thiab lub cev kev loj hlob kev cai lij choj tuaj yeem pab cov neeg ua liaj ua teb tau zoo dua cov qoob loo thiab ua tiav kev cog qoob loo zoo.
Ziab
Hauv thaj teb ntawm dyes, nws kuj muaj ntau yam ntawm daim ntawv thov tus nqi. Nws tuaj yeem tsim nyog tuag nrog cov xim tshwj xeeb thiab cov khoom, txhim kho qhov zoo thiab cov ntawv thov ntau yam ntawm dyes.
(1) xim txhim kho
Cov kev qhia ntawm cov khoom tuaj yeem txhim kho cov xim hais tawm muaj peev xwm ntawm cov xim lwg me me. Los ntawm kho nws cov nqi thiab cov tshuaj tiv thaiv kab mob, cov khoom zas xim nrog cov xim sib txawv thiab xim nrawm tuaj yeem npaj tau. Cov khoom zas xim no tuaj yeem ua kom tau xim rau cov xim uas yuav tsum muaj kev lag luam sib txawv, xws li cov ntawv nyeem, tawv, thiab lwm yam.
(2) Kev ua tau zoo ua kom zoo
Ntxiv rau kev txhim kho cov xim, nws kuj tseem tuaj yeem ua kom zoo tshaj plaws ntawm dyes. Piv txwv li, los ntawm kev qhia, lub teeb tiv tshuaj, thiab tshuaj lom neeg tiv thaiv kev tuag tuaj yeem txhim kho. Cov khoom siv txhim kho no ua kom zas cov khoom siv khov thiab ruaj khov, muaj peev xwm ua tau zoo ntawm cov ntawv thov ib puag ncig.
Kev tiv thaiv ib puag ncig thiab kev nyab xeeb
Txawm hais tias nws muaj cov ntawv thov thoob plaws hauv ntau thaj teb, nws kuj yog qhov tsim nyog kom them sai sai rau kev tiv thaiv ib puag ncig thiab kev nyab xeeb thaum siv.
(1) Kev tiv thaiv ib puag ncig
Kev tsim khoom thiab kev siv4-fluorozilineTej zaum yuav tsim qee cov kev ua qias tuaj xws li dej khib nyiab, tso pa tawm, thiab cov khib nyiab. Txhawm rau txo qhov kev cuam tshuam rau ib puag ncig, kev tiv thaiv ib puag ncig ib puag ncig yuav tsum tau ua. Piv txwv li, kom tau cov txheej txheem siab dua thiab cov cuab yeej siv hauv cov txheej txheem ntau lawm los txo cov neeg muaj kuab paug; Hais txog kev kho dej kom huv, kev kho mob siv tshuaj lom neeg thiab lwm cov hau kev los tshem tawm lossis hloov cov khoom siv tsis zoo hauv cov tshuaj tsis muaj teeb meem; Hais txog kev coj pov tseg khib nyiab, cov hau kev xws li kev ua kom muaj zog, av av, lossis cov peev txheej siv tau siv kom muaj pov tseg kom zoo.
(2) kev ntsuas ruaj ntseg
Nws yog cov tshuaj lom neeg uas muaj kev cuam tshuam thiab lom. Saib xyuas yuav tsum tau them rau cov teeb meem kev nyab xeeb thaum siv. Piv txwv, cov khoom tiv thaiv tus kheej xws li cov hnab looj tes tiv thaiv kev tiv thaiv, lub ntsej muag, thiab goggles yuav tsum tau hnav thaum lub sijhawm ua haujlwm; Thaum lub sijhawm cia, nws yog qhov tsim nyog los xaiv qhov chaw txias, cua, thiab qhuav kom tsis txhob sib cuag nrog oxidants, thiab lwm yam khoom; Hais txog cov khib nyiab pov tseg, nws yog ib qho tsim nyog los tuav nws kom zoo raws li cov kev cai uas tsis muaj kev phom sij kom tsis txhob ua rau ib puag ncig.
Preapment ua haujlwm carbon nrog ntau Hno3 ntau (1-14m) ntawm 366K rau 5 teev. Lim kev daws teeb meem. Yaug cov tshuaj hauv cov dej distilled kom txog thaum tus nqi p p tus nqi dhau los ua nruab nrab. Qhuav cov tshuaj ntawm 383 K rau 10 teev. Preapment ua haujlwm carbon nrog cov kev sib txawv KI concelerrations (2.5m) ntawm 333k rau 6 teev. Lim qhov sib xyaw. Yaug cov filltrate nrog dej distilled kom txog thaum tsis muaj nag los nyob hauv cov tshuaj lim. Ntxiv Agno3 daws teeb meem rau cov carbon. Qhuav qhov sib tov ntawm 383 K rau 10 teev. Ntxiv ib qho ntim ntawm H2PDCLC AQUOAGE OQUEES rau cov aqueous raug tshem tawm ntawm precinged carbon ntawm 353 k. Do cov sib xyaw rau 6 teev. Ntxiv 10% Naoh dropwise rau kev ncua thiab ceev cov p hauv qhov ntau ntawm 9-10 rau 30 feeb. Ntxuav cov catalyst tsim. Siv hydraze hydrate los txo cov nag lossis daus. Lim pd / c catalyst. Yaug cov dej nrog cov dej distilled kom txog thaum tus nqi p p kom txog 7. Khiav tawm ntawm qhov sib tov hauv lub tshuab nqus ntawm 383k rau 10 teev. Cov npe cov khoom lag luam tau raug ntxuav los ntawm Silica Gel kem. Txoj kev synthesis yog qhia hauv daim duab 1.
Sib tov cov tshuaj a a a a a a a a a a a a a a a a a a a a a a ahc · 335 ml, 0.05 ml, 0.05 ml, 0.05 ml, 0.05 ml, 0.05 mL) thiab nickel acetylacetonate (9.6 mg) nrog kev daws teeb meem uas muaj 2 g ntawm Oda. Ua kom sov cov tau sib xyaw rau 120℃c tsim cov tshuaj muaj kev daws teeb meem. Txhaj 8 g ntawm Oda ntawm 250℃c, do siv zog, thiab lub hnub nyoog rau 1.5 feeb ntawm 230℃C. Ntxuav cov nag lossis qhuav. Qhov tawg uas tau rh3ni1 bnp nyob rau hauv n {{18 18}} hexane rau yav tom ntej siv. Los ntawm kev kho tus nqi ntawm cov hlau ua ntej los ntawm cov kev pab cuam zoo sib xws, lwm tus RxniyBNP thiab RH NPS tau npaj. Ntxiv cov catalyst (muaj 0.3 mol% cov hlau sib piv rau lub substrate) rau kev daws teeb meem ntawm substrate (0.5 mmol) hauv 3ml round round. Degase cov tshuaj tiv thaiv sib tov ob zaug, siv hydrogen hloov cov nqus tsev txhua zaus. Do ntawm chav tsev kub hauv qab H2. Tom qab cov tshuaj tiv thaiv tiav lawm, cov catalyst yog rov qab los ntawm centrifugation. Soj ntsuam cov supernatant tau txais los ntawm GC. Lub npe txuas ntxiv4-fluorozilinetau huv si los ntawm Silica Gel chromatography siv cov eluent eluent rau 1h nmr kuaj. Txoj kev synthesis yog qhia hauv daim duab 1.
Ntsuab Synthesis: Rau Kev Tsim Kho Vaj Tse
Cov txheej txheem ib txwm ua rau synthesizing 4 -} {{-}} Ruam cov txheej txheem, ua rau tsawg om kev lag luam thiab nkim keve. Kev tshawb fawb yav tom ntej yuav tsum tau ua kom pom qhov tseeb eco-phooj ywg xaiv:
► Biocatalytic Fluorination
Enzymatic Fluorination: Tshawb Florinases (piv txwv li,StriTomyces CattleyaFluorinase) lossis haloperoxidases mus rau catoperoxidases mus rau catouchenation c- f b b sib txuas ua ke nyob rau hauv cov mob me (aqueous media, chav sov).
Cov Khoom Siv Hluav Taws Xob Microbial: Coli lossis Sacchanomyces Cerevisiae Cartorinating Fluorinating tag nrho- cell biotransformation ntawm Aniline derivalives mus rau 4-Fa.
Cov txiaj ntsig: Kev xaiv siab, txo kev noj hluav taws xob, thiab cov khib nyiab tsawg.
► Electrofofy Synthesis
Kev Kho Mob Electrochemical: Siv cov hluav taws xob txuas ntxiv kom tsav cov tshuaj fluorination ntawm anodic oxidation (piv txwv li, fluoride ions li fluorine.
Paired Electrolysis: sib txuas fluorination nrog hydrogen evolution lossis kev txo qis los txhim kho kev ua haujlwm ntau tshaj plaws.
Case Study: Recent studies demonstrate electrochemical C-H fluorination of anilines with >80% vim nyob rau hauv cov mob me.
Lo Synthesis photocatalytic
Pom {- Lub teeb {{1} {} {ove {ove {orgeni lossis ent orgedi orge orgedi orge
Kev xav mechanistic: Tshawb xyuas Radical radical pathways lossis ion- Khub intermediates los ua kom muaj cov kev mob tshwm sim zoo.
Tej zaum: Scalable, qis {{- tus nqi, thiab tau tshaj nrog cov txheej txheem Flow Chemistry.
Cim npe nrov: 4-fluoroziline CAS 471-400-4, Tus neeg muab khoom, chaw tsim khoom, Hoobkas, lag luam wholesale, yuav, nqe, loj, loj, rau muag