4-Hydroxyindoleyog cov organic sib txuas nrog cov molecular mis c8h7no. Cov hmoov tawv nrog cov xim greyish rau lub teeb daj, insoluble hauv dej tab sis soluble hauv cov kuab tshuaj ethere, thiab methanol. Nyob rau hauv cov qauv molecular, ib pab pawg phenroxyl hloov cov hydrogen atom ntawm lub nplhaib indole lub nplhaib, muab cov molecule qee cov khoom tshwj xeeb. Nws muaj solubility tsawg hauv dej thiab yog yuav luag Insoluble hauv dej, tab sis nws muaj lub solubility siab hauv cov kuab tshuaj muaj kuab. Nws yog ib qho yooj yim rau oxidize nyob rau saum huab cua, tshwj xeeb tshaj yog nyob rau hauv Alkaline cov xwm txheej, thiab yog ntau dua nquag mus rau oxidation oxidation, tsim cov tshuaj pleev xim oxidation. Yog li ntawd, nws yog ib qho tsim nyog kom tsis txhob sib cuag nrog huab cua kom ntau li ntau tau thaum lub sijhawm cia thiab siv. Muaj ob qho kev teeb tsa, trans thiab CIS, nrog trans kev teeb tsa tau ruaj khov. Nyob rau hauv qee qhov xwm txheej, CIIS configuration tuaj yeem hloov pauv mus rau hauv qhov kev teeb tsa trans. Nyob rau hauv ultraviolet teeb, nws tuaj yeem tawm muaj zog fluorescence vim nws conjugated ob chav sib khi thiab hydroxyl pawg. Tsis tas li ntawd, kev txheeb xyuas cov qauv thiab cov tshuaj ntsuam xyuas kom muaj peev xwm nqa tau los ntawm cov hau kev xws li infrared spectroscopy thiab nuclear sib nqus resonance spectroscopy.
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Tshuaj Cov Qauv |
C8H7NO |
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Muaj pes tsawg leej |
133 |
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Molecular hnyav |
133 |
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m/z |
133 (100.0%), 134 (8.7%) |
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Kev Ntsuam Xyuas |
C, 72.17; H, 5.30; N, 10.52; O, 12.02 |
4-Hydroxyindole(CAS naj npawb 2380-94-1) yog cov organic sib xyaw ua ke muaj lub nplhaib indole nplhaib, nrog cov molecular tus qauv c ₈ tsis muaj thiab txoj kev molecular hnyav ntawm 133.15. Nws cov xeev ruaj khov yog dawb rau lub teeb xim av xim av, nrog lub suab nrov ntawm 97-99 degree. Nws yog me ntsis soluble hauv dej thiab yooj yim soluble hauv cov kuab tshuaj organic xws li acetone. Vim yog cov siab reactivity ntawm lub nplhaib indole thiab polarity ntawm cov cuab yeej siv hydroxyl, nws tau qhia cov ntawv sau ntau ntxiv hauv cov ntawv qhia, cov ntaub ntawv tshuaj txuj, thiab biochemistry.
1. Khoom cua ntawm - adrenergic receptor anteptor
Nws yog qhov tseem ceeb hauv nruab nrab nyob rau hauv synthesis ntawm beta blockers. Piv txwv li, tshawb nrhiav hauv German phau ntawv tshaj tawm ntawm cov tshuaj chemical tau lees tias nws tuaj yeem hloov pauv mus rau isopropylas nrog rau lub nplhaib indole nplhaib sab saw. Hom tshuaj no tau siv dav los kho cov ntshav siab, angina, thiab armina, thiab arrhythmia los ntawm thaiv betrergic recenter, txo lub plawv dhia thiab ntshav siab.
2. Kev loj hlob ntawm cov khoom muaj feem xyuam nrog kev kho mob hlwb
Ua ib qho nrab nruab nrab ntawm serotonin cov tshuaj xws li PSilocybin thiab psilocin, nws yog lub tub ntxhais tseem ceeb rau synthesizes hallucinogens. Txawm hais tias nws ncaj qha daim ntawv thov raug tswj hwm nruj me ntsis, nws cov nyiaj tseem ceeb hauv kev tshawb nrhiav cov kev mob hlwb xws li kev nyuaj siab thiab ntxhov siab hauv neuroscience. Piv txwv li, kev tshawb fawb tshiab tshaj plaws hauv 2025 qhia tau tias nws tau siv rau kev txhim kho lub tshuab hluav taws xob ntawm Fiprones ntawm kev kawm cov tshuaj tshiab ntawm psychotropic tshuaj.
3. Kev tshawb nrhiav thiab kev txhim kho antioxidant thiab anti -} kev siv yeeb tshuaj
Nws pab pawg hydroxyl tuaj yeem koom nrog hauv hydrogen atom hloov cov kev hloov pauv, pib nws nrog antioxidant kev ua si. Kev tshawb fawb tau pom tias nws tuaj yeem tshem tawm dawb radicals, inhibit lipid peroxidation, thiab thaiv cov tso tawm ntawm cov khoom seem xws li tnf {}}- 6. Raws li qhov no, cov kws tshawb nrhiav tau tshawb txog nws lub peev xwm los ua ib qho kab mob uas ua rau alzheimer amyloomos tsho thiab tiv thaiv cov neurons los ntawm kev puas tsuaj toxic.
4. Muaj peev xwm rau kev kho mob ntawm cov kab mob metabolic
Cov kev sim tsiaj tau pom tias nws tuaj yeem ua rau cov kev hloov pauv ntawm cov nas, qhia tias nws yuav cuam tshuam rau kev sib tw metabolic los ntawm kev tswj hwm cov tshuaj secertion. Txawm hais tias nws toxicity (ld {=620 mg / kg, cov tswv yim intracranial) yuav tsum tau ua tib zoo saib xyuas cov tswv yim tshiab rau kev tsim cov metabolic cov tshuaj.
1. Organic teeb - emitting diode (OLED) cov ntaub ntawv
Nws lub conjugated system tuaj yeem txhim kho cov khoom siv lub teeb nqus thiab emission lub peev xwm. Indole based polyether sulfone (PESI) can be prepared by condensation reaction using 4-Hydroxxyindole and 4,4 '- difluorodiphenyl sulfone as raw materials. Cov Pesi Ultra - Cov zaj duab xis nyias muaj kev npaj siab thiab yog tsim nyog li cov khoom siv substrate rau cov khoom siv tau yooj yim OLED. Cov lus qhia ntxiv txog MG ⁺ ⁺ ⁺ los tsim cov ntawv sib txuas ua ke ntawm lub zog ntawm 45.9% nce hauv tensile, muab ib qho piv txwv rau kev txhim kho cov ntaub ntawv kho qhov muag.
2. Cov ntaub ntawv rau photoelectric sensors
The π -} electron System of Storole nplhaib yog rhiab rau lub teeb thiab cov cim hluav taws xob, thiab4-HydroxyindoleCov txiv ntseej tuaj yeem siv los tsim cov yees duab photoelectric. Piv txwv li, lub conjugated system tsim los ntawm nws cov kev sib txuas nrog porphyrin cov lus teb tuaj yeem tshawb xyuas cov kev txwv hnyav li ppb, ua kom haum rau kev soj ntsuam ib puag ncig thiab kev ntsuas roj ntsha.
3. Kev ua haujlwm siab polymer additives
Ntxiv polyimide, epoxy cob thiab lwm yam kev siv tshuab plastics tuaj yeem txhim kho cov cua sov ua kom tau thiab cov khoom siv tshuab ua haujlwm ntawm cov ntaub ntawv. Nws cov pab pawg hydroxyl filling nrog cov saw polymer, txhim kho cov qauv sib txuam thiab tswj cov qauv ruaj khov ntawm qhov kub. Nws yog dav siv nyob rau hauv cov teb ntawm Aerospace thiab ntim ntim hluav taws xob.
1. Enzyme kev ua inhibitors
Tuaj yeem tshwj xeeb inhibit cov haujlwm ntawm qee yam oxidoreditedases. Piv txwv li, nws kev sib tw khi rau lub chaw ua haujlwm ntawm monoamine oxidase xws li serotonin thiab dopamine, yog tsis muaj kev tswj hwm neural. Cov xeeb ceem no ua rau nws yog ib qho cuab yeej tseem ceeb rau kev kawm enzyme muaj nuj nqi thiab cov hom tshuaj.
2. Cov Qauv Tshawb Fawb Kev Tshawb Fawb
Hauv cov tshuaj yeeb yaj kiab metabolism, raws li cov metabolic intermediate ntawm cannabinoid JWH-018, nws pab qhia nws hauv Vivo Transformation mechanism.
Tshawb nrhiav hauv cov ntaub ntawv xov xwm ntawm cov kws tshuaj ntawm cov kws tshuaj ntawm cov kws tshuaj thiab kev ntsuas Biomedical qhia tau tias JW-artalyzed by Cytochrome P450 hauv daim ntawv mus ua 4-hydroxxyindole derivatives, uas yog tom qab ntawd excreted. Qhov kev tshawb nrhiav no muab cov ntsiab lus tseem ceeb rau kev ntsuas cov tshuaj lom ntawm cov tshuaj lom ntawm cannabinoids.
3. Kev tsim kho ntawm cov cell tiv thaiv
Nyob rau neural cell tus qauv, koob -}} {{{{{2) - Inducation Toxicity tuaj yeem tiv thaiv PC12 lub hlwb los ntawm apoptosis. Nws cov kev siv tshuab yuav cuam tshuam txog cov roj oxygen tawm cov pa roj ntsha (Ros) thiab cov neeg sib tw molecules rau kev txhim kho cov tshuaj neurrotrotective.
1. Tsim kho tshiab hauv kev zas xim
4 {- hydroxxyindole thiab nws cov derivatives tuaj yeem siv los tsim cov tshiab cationic dyes los ntawm kev qhia txog kev sib tw nemetized. Hom zas no muaj kev sib txawv rau Keratin cov plaub hau (xws li cov plaub hau thiab cov plaub hau), nrog ntev-ntev zas cov txiaj ntsig thiab xim qaim. Piv txwv li, oxidative dyes muaj lawv cov qauv tuaj yeem ua tiav cov kev cai xim dub los ntawm cov xim av xim rau hauv cov plaub hau.
2. Kuaj kev nyab xeeb thiab kev tiv thaiv
Txawm hais tias 4 {{{- hydroxxyindole yog dav siv nyob rau hauv kev tshawb fawb, nws cov phom sij tsis tuaj yeem tsis quav ntsej. Raws li cov qauv kev pheej hmoo GHS, nws yuav ua rau tawv nqaij tawv nqaij (H315), qhov muag raug mob (H319), thiab ua pa iritation (H335). Kev sim ua haujlwm yuav tsum tau nqa tawm hauv cov hnab looj tes fum, hnav cov hnab looj tes tiv thaiv kab ke thiab cov hnab looj tes, thiab khaws cia kom deb ntawm cov hluav taws thiab oxidants. Nws raug nquahu kom siv cov khoom siv tawm tsam rau kev cia.
Cov qauv Resorcinol yog ib txoj kev siv ib txwm siv rau synthesizing 4-hydroxzyindole. Hauv qab no yog cov ncauj lus kom ntxaws thiab tshuaj lom neeg sib npaug ntawm hom no:
Thaum tshav kub kub resorcinol mus rau lub xeev molten, ces maj mam ntxiv concophyloric acid thaum stirring thiab cua sov. Rov qab los ntawm qhov ntsuas kub ntawm kwv yees li 70℃rau ib lub sijhawm kom txog thaum resorcinol yog yaj tag nrho. Tom qab ntawd, ncuav cov tshuaj tiv thaiv ua ke rau hauv dej khov, kho nws rau cov kua qaub me ntsis nrog cov roj ntsha me me ntawm cov kua roj dolochloric me me, thiab tom qab ntawd rho tawm nrog ether. Qhuav cov kev daws teeb meem nrog anhydous sodium sulfium, lim thiab rov qab ether kom tau 4-hydroxybenzoic acid.
Tshuaj Muaj Tshuaj:
C6H4(Oh)2Hooc - c6H4- cooh
Dissolve 4-hydroxybenzoic acid nyob rau ethanol, ntxiv ib qho kev ntsuas ntawm cov tshuaj tua kab (xws li palladium carbon), thiab nqa tawm hydrogenation cov tshuaj tiv thaiv ntawm qhov kub thiab siab. Tom qab ib lub sijhawm ntawm cov tshuaj tiv thaiv, lim cov sib tov, rho tawm cov filtrate nrog ether ether sulfate, lim thiab rov qab ether kom tau 4-aminobenzoic acid.
Tshuaj Muaj Tshuaj:
Hooc - c6H4- cooh+ 2 h2Hooc - c6H4- ch2Naj2
Mix 4-aminobenzoic acid nrog Ethyl Bromopyruvate thiab yaig ua kev tiv thaiv kev loj hlob ntawm ib qho kub. Tom qab lub sijhawm ntawm cov tshuaj tiv thaiv, lim cov sib tov, rho tawm cov filtrate nrog ether, ua kom qhuav sodium, lim thiab rov qab ether kom tau txais cov khoom.
Tshuaj Muaj Tshuaj:
Hooc - c6H4- ch2Naj2 + Bch2Cooet → h2N-C6H4- chbrcooet → c8H7Tsis muaj + c4H8O2 + HBR
Cov saum toj no yog cov ncauj lus kom ntxaws thiab tshuaj lom neeg sib npaug rau cov synthesis ntawm4-Hydroxyindolesiv resorcinol txoj kev. Nws yuav tsum tau sau tseg tias cov khoom siv lom lossis cov teeb meem phom sij thiab cov kuab tshuaj yuav tsum zam ntau li ntau tau thaum ib puag ncig kev noj qab haus huv thiab kev noj qab haus huv. Lub caij no, cov qauv hluavtaws sib txawv thiab cov xwm txheej tuaj yeem raug xaiv thiab ua kom zoo raws li qhov xav tau tiag tiag kom tau siab- cov khoom zoo.
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