5-amino-2,4,6-triodoisophthalic acidyog cov tshwj xeeb heev organic iodine compound nrog cov qauv molecular ntau. Tus tub ntxhais ntawm nws cov molecule yog lub nplhaib benzene, thiab ntawm 1,3,5 txoj haujlwm, nws muaj ob pawg carboxylic acid thiab pab pawg amino. Qhov seem 2,4,6 txoj haujlwm yog hloov tag nrho peb iodine atoms. Qhov no ntom iodine hloov mus rau molecule nrog kev kub siab heev thiab hnyav. Qhov tshwj xeeb tshaj plaws feature ntawm no compound stems los ntawm nws iodine atom nrog lub siab atomic tus naj npawb, ua nws zoo heev x- duab tshav. Nws yog tsuas yog siv nyob rau hauv kev kho mob teb uas yog cov khoom siv hluavtaws tseem ceeb lossis cov qauv txheej txheem rau tsis- ionic cov neeg sawv cev. Los ntawm kev ua haujlwm ntxiv thiab kho nws cov roj carboxyl thiab amino {14} Tsis tas li ntawd, nws muaj zog Electron- tshem tawm cov khoom ntiag tug thiab cov khoom lag luam loj hauv cov khoom siv hauv nruab nrog cev rau kev tsim kho cov ntaub ntawv ua haujlwm. Cov tshuaj no feem ntau zoo nkaus li daj ntseg daj kom zoo nkauj thiab yuav tsum khaws cia rau hauv qhov chaw tsaus ntuj nti. Vim yog nws cov qauv nyuaj thiab qhov siab- Txoj kev pheej hmoo Halogenation Responsed koom nrog los ntawm cov khoom siv tshuaj rau kev tshawb fawb thiab kev tsim kho.
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Tshuaj Cov Qauv |
C8H4I3NO4 |
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Muaj pes tsawg leej |
559 |
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Molecular hnyav |
559 |
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m/z |
559 (100.0%), 560 (8.7%) |
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Kev Ntsuam Xyuas |
C, 17.19; H, 0.72; I, 68.13; N, 2.51; O, 11.45 |
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5-amino-2,4,6-triodoisophthalic acid(Atipa) yog cov organic sib xyaw nrog cov qauv tshuaj tshwj xeeb. Cov amino pab pawg thiab peb iodine atoms nyob rau hauv nws cov qauv xaus nws nrog kev ua haujlwm tshwj xeeb thiab cov ntawv thov kev kho mob tshwj xeeb. Hauv kev biomedical teb, Atipa tsuas yog lub luag haujlwm tseem ceeb yog cov khoom siv hluav taws xob organic, tshwj xeeb hauv cov txheej txheem npaj ntawm cov neeg ua kom sib txawv.
ATIPA raws li tus yuam sij pib cov khoom siv rau cov neeg sawv cev sib txuas
Cov khoom siv sib txawv yog qhov tseem ceeb siv cov tshuaj hauv kev kho mob ua kom pom cov kws kho mob thiab cov kws hloov pauv ntawm tib neeg lub cev kom meej meej. Atipa, raws li ib qho tseem ceeb organic hluavtaws intermediate, plays ib lub luag haujlwm tseem ceeb hauv kev npaj cov neeg sawv cev sib txawv.
(1) Txhim Kho Cov Duab Zoo Tshaj:
Cov neeg sawv cev sib txawv txhim kho cov duab sib txawv los ntawm kev hloov cov teeb liab kev siv ntawm cov ntaub so ntswg lossis plab hnyuv siab raum thaum lub sijhawm kuaj. Iodine atoms hauv Atipa muaj cov yam ntxwv ntawm qhov siab thiab muaj zog nqus cov neeg ua kom muaj cov duab hauv x - ray kev xeem.
(2) Txhim kho qhov tseeb ntawm kev kuaj mob:
Raws li cov khoom tseem ceeb rau cov khoom siv tsis sib xws, Atipa cov amino thiab iodine atoms hauv cov pab pawg ua kom sib luag thiab cov haujlwm tshwj xeeb. Cov neeg sawv cev sib txawv no tuaj yeem muab cov ncauj lus kom ntxaws thiab cov ntaub ntawv muaj tseeb ntawm kev kuaj mob kuaj mob, pab cov kws kho mob ua cov kws kho mob kom tau ntau dua.
(3) Txo kev phiv:
Cov neeg sawv cev sib xws yuav muaj cov kev mob tshwm sim xws li kev ua xua. Raws li cov khoom pib rau lub cim tshiab ntawm cov neeg sawv cev tshiab, Atipa tuaj yeem txo qhov muaj kev fab tshuaj lom neeg thiab kev txhim kho cov qauv tshuaj thiab txhim kho nws cov txheej txheem ntau lawm.
Daim ntawv thov ntawm Atipa hauv cov tshuaj synthesis
Atipa tsis tsuas yog ua si lub luag haujlwm tseem ceeb hauv kev npaj ntawm cov neeg sawv cev sib txawv, tab sis kuj muaj cov ntawv thov tseem ceeb hauv kev sib xyaw ntawm lwm cov tshuaj.
(1) Cov tshuaj antitumor: Iodine atoms thiab amino pawg nyob rau hauv tus qauv ntawm ATIPA tuaj yeem khi nrog lwm pab pawg ua tebchaw nrog anti- cov qog nqaij hlav. Cov tebchaw no tuaj yeem cuam tshuam txoj kev loj hlob thiab kis cov qog ntawm cov qog, yog li ua kom muaj sia nyob ntawm cov neeg mob.
(2) Antibacterial drugs: The amino and iodine atoms of ATIPA can bind with other antibacterial groups to form compounds with broad-spectrum antibacterial activity. Cov tebchaw no tuaj yeem cuam tshuam qhov kev loj hlob thiab luam ntawm cov kab mob, yog li kho ntau yam kab mob sib kis.
(3) Cov tshuaj tiv thaiv kab mob: Atipa tseem tuaj yeem ua cov yeeb tshuaj ua ntej rau cov tshuaj tiv thaiv kab mob. Los ntawm kev hloov kho tshuaj lom neeg thiab kev hloov kho, nws tuaj yeem hloov mus rau hauv cov chaw sib txuas nrog kev kho mob kis tau tus kab mob ntau yam.
Daim Ntawv Thov ntawm Atipa hauv Kev Tshawb Fawb Biomedical
Atipa tseem muaj cov ntawv thov tseem ceeb hauv Biomedical kev tshawb fawb, tshwj xeeb tshaj yog nyob rau hauv molecular kev ntsuam xyuas, tshuaj ntsuam xyuas kev siv tshuaj, thiab kab mob qauv tsim.
(1) cov duab molecular:
Iodine atoms thiab cov pab pawg amino hauv Atipa tuaj yeem ua cov kev sim molecular rau kev siv cov tswv yim molecular. Los ntawm kev khi cov kev ua ntu zus rau cov proteincules xws li cov protein, nucleic acids, thiab lwm yam ntawm biomolecules hauv cov hlwb thiab cov ntaub so ntswg tuaj yeem ua tiav.
(2) Tshuaj Ntsuam Xyuas Yeeb Tshuaj:
Atipa tuaj yeem ua tus qauv ua qauv rau tshuaj ntsuam tshuaj. Los ntawm kev kho thiab kho nws cov qauv, cov lus sib txuas nrog cov kev sib txuas nrog cov roj ntsha sib txawv tuaj yeem ua ke. Cov tebchaw no tuaj yeem siv rau kev tshawb tshuaj ntsuam xyuas thiab chaw muag tshuaj, muab kev txhawb nqa muaj zog rau kev loj hlob tshuaj.
(3) Tus Qauv Kho Mob Siv:
Atipa kuj tseem siv tau los tsim cov qauv kab mob. Los ntawm kev sib txuas nrog nws nrog lwm biomolecules, cov pathogenesis thiab pathologes txheej txheem ntawm cov kab mob tuaj yeem simulated. Cov qauv no tuaj yeem siv rau kev tshawb fawb txog kab mob thiab tshawb nrhiav cov qauv kev kho mob, muab cov ntaub ntawv tseem ceeb rau kev tshawb nrhiav kev kho mob thiab kev tshawb nrhiav kev kho mob.
Txoj kev txhim kho cov kev cia siab ntawm ATIPA hauv Biomedical teb
Nrog kev txhim kho kev txuas ntxiv thiab kev nce qib ntawm biomedical tshuab, daim ntawv thov cov kev cia siab ntawm Atipa hauv Biomedical teb tau dhau los kom dav.
(1) Kev tshawb fawb thiab kev txhim kho cov neeg sawv cev tshiab:
Nrog kev tsim kho cov thev naus laus zis siv tshuab kho mob, cov kev xav tau ua tau zoo rau cov neeg sawv cev sib txawv kuj nce ntxiv. Raws li cov khoom tseem ceeb rau cov khoom siv tsis sib xws, Atipa cov amino thiab iodine atoms hauv nws cov qauv muab ntau ntawm cov tshiab sib txawv. Los ntawm kev ua kom zoo rau cov qauv tshuaj thiab txhim kho cov txheej txheem tsim khoom, cov neeg sawv cev tshiab dua nrog kev daws teeb meem siab dua, thiab ntev dua tuaj yeem tsim kho.
(2) Kev loj hlob ntawm cov tshuaj uas tau tsom:
Cov tshuaj yuav tau muaj ib qho ntawm cov hotspots hauv kev txhim kho cov tshuaj ntawm xyoo tsis ntev los no. Raws li qhov tseem ceeb hauv cov tshuaj sthtisiate, Atipa cov amino thiab iodine atoms hauv nws cov qauv tuaj yeem siv los tsim cov tshuaj molecular ntawm cov tshuaj uas tsom. Los ntawm kev khi nrog lwm pab pawg ua kom nquag plias, yeeb tshuaj yeeb yaj kiab nrog cov peev xwm tshwj xeeb cov peev xwm tuaj yeem tsim cov kab mob zoo.
(3) Kev tsim kho tshiab hauv Biomedical im technology:
Biomedicalical impression yog ib qho tseem ceeb txhais tau tias hauv kev tshawb fawb kho mob thiab kev tshawb fawb. Raws li ib qho kev sojntsuam hauv cov tshuab molecular thaj, Atipa lub iodine atoms thiab cov pab pawg muab cov kev tsim kho tshiab hauv kev tsim kho hauv biomedical. Los ntawm kev sib txuas cov kev ua haujlwm no nrog cov kev faib tawm ntawm biomolecules tshwj xeeb, muab kev txhawb nqa muaj zog rau kev tshawb nrhiav kev kho mob thiab kev tshawb fawb.
Kev tshawb fawb ntawm ATIPA cov ntawv thov biomedical
Txhawm rau kom nkag siab zoo dua cov ntawv thov tshwj xeeb ntawm5-amino-2,4,6-triodoisophthalic acidNyob rau hauv biomedical teb, cov xwm txheej hauv qab no yog teev rau kev tsom xam.
Rooj plaub 1: Kev loj hlob ntawm hom tshiab ntawm tus neeg saib xyuas kev sib txawv
Tom qab: Tsoos X - Ray Shares cov neeg sawv cev muaj kev phiv ntau xws li kev ua xua xws li ua xua, thiab qee qhov duab ntshiab tsis txaus. Yog li ntawd, kev txhim kho ntawm cov neeg sawv cev tshiab tau dhau los ua kev xav tau ceev hauv thaj teb kev ua haujlwm.
Method: Researchers used ATIPA as the starting material and synthesized a novel non-ionic X-ray contrast agent through chemical modification and modification. Tus neeg sawv cev sib txawv no muaj qhov qis dua ntawm kev fab tshuaj tsis haum thiab cov duab siab dua.
Qhov tshwm sim: Tus neeg sawv cev sib piv tshiab tau ua kom pom kev nyab xeeb zoo thiab ua tau zoo hauv chaw kuaj mob. Piv nrog cov tsoos ib txwm muaj cov neeg sawv cev, tus neeg sawv cev pom tseeb thiab muaj tseeb dua cov lus qhia, pab cov kws kho mob ua cov kws kho mob kom raug ntau ntxiv.
Xaus: Atipa, raws li pib cov khoom siv rau cov tswv cuab tshiab, muab cov tswv yim thiab cov hau kev tshiab rau kev txhim kho kev kho mob. Los ntawm kev ua kom zoo rau cov qauv tshuaj thiab txhim kho cov txheej txheem ntau lawm, cov khoom tsis sib xws tshiab nrog cov kev ua tau zoo dua tuaj yeem tsim tau.
Rooj plaub 2: kev txhim kho cov tshuaj tiv thaiv
Tom qab: cov qog yog ib qho ntawm cov kab mob tseem ceeb uas hem tib neeg kev noj qab haus huv. Kev siv tshuaj kho ib txwm muaj tshuaj muaj teeb meem xws li muaj kev lom zem thiab cov txiaj ntsig tsis zoo. Yog li, kev txhim kho cov tshuaj uas tau ua ib qho ntawm hotspots hauv tshav pob kev kho mob.
Txoj Kev: Cov kws tshawb nrhiav siv Atipa yog qhov tseem ceeb hauv cov tshuaj synthesis thiab synthesized}}} pawg siv tshuaj rau lwm tus. Cov tshuaj no tuaj yeem paub tseeb thiab cuam tshuam txoj kev loj hlob thiab kis cov qog ntawm cov qog.
Qhov tshwm sim: Cov tshuaj yuav pom tau pom zoo anti {{0} Cov qog ua si hauv chaw kuaj mob. Piv nrog siv tshuaj kho mob tsoos, cov tshuaj no tuaj yeem txo qis kev loj hlob ntawm cov qog ntawm cov qog thiab ua kom cov neeg mob muaj sia nyob.
Xaus: ATIPA, raws li ib qho tseem ceeb hauv nruab nrab rau cov tshuaj uas muaj hom phiaj, muab cov tswv yim thiab cov qauv rau kev txhim kho kev kho mob qog. Los ntawm kev sib txuas nrog lwm pawg nquag, anti {{{1} Dub cov tshuaj siv qog ua ke nrog cov qog nqaij hlav tuaj yeem tsim kho.
Rooj plaub 3: Innovation nyob rau hauv biomedical im technology
Tom qab: Biomedical ntsuas thev naus laus zis yog ib qho tseem ceeb hauv kev tshawb fawb txog kev kho mob thiab kev tshawb fawb. Cov kev ntsuas ib txwm muaj kev txom nyem los ntawm cov teeb meem xws li kev daws teeb meem tsawg thiab kev rhiab heev. Yog li, kev siv tshuab thev naus laus zis tshiab tau dhau los ua qhov tseem ceeb rau kev tshawb nrhiav kev kho mob thiab chaw kuaj mob.
Txoj Kev: Cov kws tshawb nrhiav siv ATIPA raws li kev sojntsuam hauv molecular compound tshuab, thiab ua tsim cov txheej txheem tshiab biomedical los ntawm binding nws rau kev qhia biomolecules. Cov thev naus laus zis no tuaj yeem ua tiav tiag {1} Kev tshuaj xyuas cov kev faib tawm thiab cov haujlwm ntawm biomolecules hauv cov hlwb thiab cov ntaub so ntswg.
Qhov tshwm sim: Qhov tshiab biomedical ntsuas thev naus laus zis pom kev daws teeb meem zoo thiab rhiab rau hauv chaw kuaj mob sim. Cov thev naus laus zis no tuaj yeem pom qhov chaw thiab xa tawm ntawm biomolecules hauv cov hlwb thiab cov ntaub so ntswg, muab kev txhawb zog rau kev kho mob thiab kev tshawb fawb.
Xaus: Atipa, raws li kev sojntsuam, muab cov tswv yim thiab cov qauv tshiab thiab cov kev tsim kho tshiab ntawm biomedical ntsuas thev naus laus zis. Los ntawm kev sib txuas nrog cov biomolecules tshwj xeeb nrog kev daws teeb meem ntau dua thiab kev txhawb nqa muaj zog rau kev tshawb nrhiav kev kho mob thiab kev tshawb fawb.
Tus qauv ntawm synthesizing5-amino-2,4,6-triodoisophthalic acidHauv chav sim feem ntau feem ntau yuav cuam tshuam ntau cov kauj ruam. Cov hauv qab no yog ib txoj kev muaj peev xwm ua tau zoo nkauj thiab nws cov tshuaj sib txig sib luag:
Pib Khoom:
Npaj cov ntaub ntawv pib, xws li 2,4,6-diaiodoiodoiodoidic acid, ammonia, sulfuric acid, thiab lwm yam.
Esterification tiv thaiv:
Sib tov 2,4,6-triaiodoiodoiodoophthalic acid nrog tus nqi ntawm ammonia, cua sov kom muaj qhov tsim nyog kub, thiab nqa tawm cov kev tiv thaiv esterification. Thaum lub sij hawm cov txheej txheem cov tshuaj tiv thaiv, dej ammonia ua ke ua lub hauv paus thiab cov pa roj acidic 2,4,6-diaiodoiodoiodoid los tsim cov ntawv esters.
C8H3I3O4 + 2 nh3 → C8H3I3O4Naj2 + 2H2O
Hydrolysis tiv thaiv:
Dissolve cov khoom lag luam esterificated tau nyob rau hauv cov kauj ruam dhau los hauv dilute sulfuric acid, ua kom sov rau qhov tsim nyog kub, thiab nqa tawm hydrolysis kev tawm tsam. Kev hloov siab Hydrolysis hloov dua siab dua cov pab pawg Eserter rau hauv cov pawg tsheb thauj khoom.
C8H3I3O4Naj2 + H2Yog li4 → C8H3I3O4Naj4Yog li4
Nitricification tiv thaiv:
Nyob rau hauv acidic sulfuric acid mob, cov khoom tau nyob rau hauv kauj ruam dhau los yog nitric acid kom hloov cov pab pawg carboxyl rau hauv pawg carboxyl.
C8H3I3O4Naj4Yog li4 + Hno3 → C8H3I3O5Naj4Yog li4
Txo cov tshuaj tiv thaiv:
Siv cov tshuaj tiv thaiv kom tsim nyog (xws li cov hmoov hlau, hydrogen roj, thiab lwm yam) kom txo cov pab pawg nitro rau cov pab pawg amino.
C8H3I3O5Naj4Yog li4 + Fe → c8H3I3O5Naj2Yog li4
Desulfation |
Nyob rau hauv cov kev mob alkaline, cua sov kom tshem tawm cov sulfonic kua qaub thiab tau txais cov khoom lag luam.
C8H3I3O5Naj2+ Naoh → c8H2I3O2Naj2
Kev Ua Haujlwm:
Tau txais cov khoom kawg los ntawm kev tsim nyog tshaj tawm - processing processing} processing} processing processing processing processingမ်းက မing,,, such such suchດ, kom qhuav, thiab lwm yam.
Cim npe nrov: 5-amino-2,4,6-triodoisophthalic acid CAS 35453-19-1, chaw tsim khoom, chaw tsim khoom, chaw lag luam, yuav, nqe, loj, rau muag