Benzotriazole -1- yl-oxytripyrrolidinophosphosphat heXAFLUOROPOSOSPHATCHATE CAS {2}}

Benzotriazole -1- yl-oxytripyrrolidinophosphosphate hexafluorophosphate hexafluorophosphate(Pybop) yog cov organic condensing tus neeg saib xyuas feem ntau siv nyob rau hauv peptide synthesis, nrog cov tshuaj lom neeg 1h-benzhotriazol {} yloxytripyrinyl hexafluorophylphphate. Nws molecular tus qauv yog c18h28f6n6op ₂, qhov hnyav molecular yog 520.4 G / Mol, thiab CASE}. Nws yog hmoov dawb dawb uas tsis muaj ntxhiab tsw. Nyob rau hauv chav tsev kub thiab siab, nws muaj nyob rau hauv daim ntawv ntim khoom. Soluble hauv ntau cov kuab tshuaj organic, suav nrog methanol (schhoylformamide), dmofprodrolidone), thf (tetrahydrile, thiab acetone. Qhov kev ua yeeb yam zoo no ua rau nws yooj yim siv hauv cov khoom siv organic hluavtaws. Raws li cov txheej txheem peptide peptide coupling, nws tau siv dav hauv cov tshuaj lom neeg synthesis ntawm Peptide Beptide.

1H-Benzotriazol -1- Yloxyprolidinyl Hexafluorctional organic compound tau siv dav hauv ntau yam li organic, biochemistry, thiab cov ntaub ntawv tshawb fawb. Nws lub ntsiab siv suav nrog:

Peptide synthesis:
Pybop yog ib tug classic peptide Coupling reagent dav siv nyob rau hauv cov tshuaj synthesis ntawm Peptide Beptide.
Nws muaj qhov zoo ntawm tus nqi nrawm, tsis muaj kev ntxub ntxaug lossis kev ntxub ntxaug ntawm cov khoom lag luam, thiab tuaj yeem siv hauv ob qho khoom noj thiab khoom theem.
Pybop txuag tau cov kev sib txuas lus zoo los ntawm kev txhawb nqa kev sib txuas ntawm carboxylic acids thiab amines, ua nws indispensable reagent hauv peptide synthesis.
Lwm yam hluav taws xob organic squthesis cov tshuaj tiv thaiv:
Pybop tseem tuaj yeem ua tus catalyst rau cov xwm txheej ntawm kev saib xyuas thiab lwm yam tshuaj ntxiv.
Nws cov catalytic ua tau ua rau nws yog ib qho tseem ceeb ntsuas qhov yooj yim hauv cov synthes synthesis.

Cov Ntawv Thov Cov Ntaub Ntawv Tshwj Xeeb

 

Hauv tshav pob ntawm biochemistry thiab tshuaj:
Protein synthesis: Pybop ua si lub luag haujlwm tseem ceeb hauv protein synthesis los ntawm kev txhawb kev sib txuas ntawm cov amino acids los tsim cov pob nyiaj peptide ruaj khov.
Kev txhim kho yeeb tshuaj: Pybop feem ntau siv nyob rau hauv cov txheej txheem kev tsim tshuaj kom synthesize cov kev sib txuas ua ke peptide nrog kev txhawb nqa cov khoom siv muaj zog rau kev txhim kho cov tshuaj tshiab.

Hauv thaj teb ntawm cov ntaub ntawv tshawb fawb:
Cov ntaub ntawv muaj nuj nqis: Pybop tuaj yeem siv tau los synthesize cov ntaub ntawv nrog cov haujlwm tshwj xeeb, xws li cov ntaub ntawv ua haujlwm, cov ntaub ntawv kho qhov muag, thiab lwm yam.

 

Cov electrolytes tshwj xeeb: hauv cov teb ntawm electrolytes, pybop pab ua synthesize ruaj khov electrolytes thiab txhim kho kev ua haujlwm ntawm cov khoom siv xws li roj teeb.
Lwm Teb:
Catalyst: Pybop nws tus kheej tuaj yeem siv los ua catalyst los txhawb ntau yam cov organic.
Synthesis ntawm KAUV OLIGOMERS THIAB Biomimetic Sodium Ion Raws: Pybop tseem pom nws cov txiaj ntsig tshwj xeeb hauv kev sib tw nrog cov txheej txheem nyuaj. Piv txwv li, nyob rau hauv cov synthesis ntawm heligomers heligomers, biomimetic sodium ion raws, tau siv los txuas ntxiv cov kauj ruam tseem ceeb, ua tiav cov txiaj ntsig tseem ceeb.

Lub npe ntawmBenzotriazole -1- yl-oxytripyrrolidinophosphosphate hexafluorophosphate hexafluorophosphate(Pybop) Ua raws cov cai ntawm cov kev cai ntawm International Union ntawm cov neeg siv tshuaj dawb huv thiab thov kom muaj cov qauv tshuaj lom neeg thiab cov yam ntxwv ntawm cov compound. Ntawm no yog cov ncauj lus kom ntxaws tshuaj xyuas ntawm Pybop Naming:

Cov hluavtaws ntawmBenzotriazole -1- yl-oxytripyrrolidinophosphosphate hexafluorophosphate hexafluorophosphatefeem ntau suav nrog cov kauj ruam hauv qab no:

1. Rov qab Benzotriazole -1-} ol nrog benzotylamine ntawm chav kub kom tau benzotriazole ntawm chav kub kom tau benzottriozole {2}} yl-oxytriethylammonphate hexyfluorophosphate hexyfluorophhot. Cov tshuaj tiv thaiv cov tshuaj tiv thaiv muaj raws li nram no:

Benzotriazole -1-} ol + Triethylamine + Hop (O) (O) F₆→ Benzotriazole -1- yl-oxytriethylammonium hexahafluorophosphate + h₂O

2. Cov tshuaj tiv thaiv cov tshuaj tiv thaiv muaj raws li nram no:

Benzotriazole -1- yl-oxytriethylammonium hexyfluorophphophat + litraethyl uthoposphate + li₃N → Benzotriazole -1- yl-oxytriphenyfphosphais hexyfluorophphophaphat {{} etoh + net₃

3. Reacting benzotriazole -1- yl-oxytriphenyriphphphot hexules Cov tshuaj tiv thaiv cov tshuaj tiv thaiv muaj raws li nram no:

Benzotriazole -1- yl-oxytriphenyriphyphphhaphphphphphphphphphphphphphphephprolidine {} {{} {8}} C₆H₅Ppph₂F

Hauv txoj kev sighthetic saum toj no, nws yuav tsum tau sau tseg tias qhov tshuaj tiv thaiv kub thiab cov tshuaj tiv thaiv yuav tsum tau siv los xyuas kom muaj kev vam meej ntawm cov tshuaj tiv thaiv thiab kev coj dawb huv ntawm cov khoom.

Nws tuaj yeem tau txais los ntawm cov hauv qab no synthesis txoj kev, cov kauj ruam yog raws li hauv qab no:

Nws yuav tsum raug sau tseg tias nws yog cov muaj zog oxidant thiab phosphorylation reagent, uas muaj qee yam kev phom sij, thiab kev ceev faj kev nyab xeeb thiab kev siv nws.

Pybop yog ib qho kev ua yeeb yam siv reagent hauv cov khoom siv hauv cov keeb kwm, tseem hu ua Pybop. Nws yog thawj sab seev thiab tau piav qhia thaum xyoo 1992 los ntawm Richard B. Silverman thiab Sriram Iyengar.

Thaum lub sijhawm, Silverman thiab Iyengar tab tom nrhiav kom muaj kev ntsuas dua tshiab dua li lwm cov kev ua kom haum siv nyob rau lub sijhawm. Lawv cia siab tias yuav txhim kho lub reagent uas muaj peev xwm nrawm nrawm amines thiab carboxylic acids, thiab ua li ntawd nrog kev ua haujlwm siab thiab tus nqi qis. Tom qab ib lub sijhawm sim, lawv thaum kawg pomBenzotriazole -1- yl-oxytripyrrolidinophosphosphate hexafluorophosphate hexafluorophosphate, ib qho reagent uas muaj peev xwm maj nrawm amines thiab carboxylic acids nyob rau hauv chav tsev kub.

Txij thaum ntawd los, Pybop tau dhau los ua cov khoom siv ua kom dav dav, thiab nws daim ntawv thov hauv cov synthic synthesis tau muaj dav txhawb.

Cim npe nrov: Benzotriazole -1- yl-oxytripyrrolidinophau Cas {2}}, Chaw Tsim Tshuaj, Chaw Tsim Tshuaj, Chaw Tsim Tshuaj, Yuav, Nqe, loj, rau muag