Diethyl 2, 5- dibromohexanedioate, Cas {869-10-3, molecular cov mis c10h16br2o4, insolubs {}}}} Koj tuaj yeem dhau mus rau Esterification Cov tshuaj tiv thaiv nrog dej cawv thiab hloov cov khoom siv hauv cov neeg ua haujlwm hauv cov neeg ua haujlwm uas tau raug rau Benzene kom ntev lub sijhawm, yog li cov kab sib txuas no muaj qee qhov kev thov muaj nuj nqis hauv toxicology thiab biomedical kev tshawb fawb .
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Tshuaj Cov Qauv |
C10H16br2o4 |
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Muaj pes tsawg leej |
357.94 |
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Molecular hnyav |
360.04 |
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m/z |
359.94 (100.0%), 357.94 (51.4%), 361.94 (48.6%), 360.94 (9.7%), 362.94 (5.3%), 358.94 (4.4%), 358.94 (1.1%), 360.94 (1.1%) |
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Kev Ntsuam Xyuas |
C, 33.36; H, 4.48; Br, 44.39; O, 17.77 |
Diethyl 2, 5- dibromohexanedioate(CAS naj npawb: {{{869-10-3) yog ib qho tseem ceeb organic uas tau pom dav ntawm ntau lub cev vim nws lub cev muaj tshuaj lom thiab tshuaj lom neeg.
Hauv thaj chaw ntawm cov tshuaj, nws yog qhov tseem ceeb tshaj plaws hauv cov hauv qab no:
1.} Kev Txhim Kho Tshuaj:
Raws li pib cov khoom siv lossis qhov tseem ceeb rau kev txhim kho tshuaj tshiab, nws muab cov khoom siv tseem ceeb rau kev txhim kho cov tshuaj tshiab .
Los ntawm kev tshawb nrhiav hauv kev ua haujlwm ntawm nws cov kev ua haujlwm thiab kev siv tshuab ntawm kev tsim kho tshiab thiab kev mob siab dua tuaj yeem tsim kho .
{{0 {}}} metab metabolism tshawb fawb:
Nws tseem tuaj yeem ua cov cuab yeej ua yeeb yam rau cov txheej txheem tshuaj yeeb yaj kiab. los ntawm kev kawm txog kev hloov pauv yeeb yam thiab kev hloov pauv yeeb tshuaj thiab kev hloov pauv hauv lub cev .
Qhov no pab ntsuas cov xyoob ntoo thiab ntev ntawm kev ua yeeb tshuaj yeeb tshuaj, muab kev tshawb fawb rau cov tshuaj kho mob ntawm cov tshuaj .
Cov ntaub ntawv kawm txuj ci
Nyob rau hauv cov ntaub ntawv ntawm cov ntaub ntawv kev tshawb fawb, kev siv cov ntawv thov tau tshwm sim hauv cov hauv qab no:
Composite Khoom Hloov Kho:
Sib txuas ua ke nrog cov khoom siv inorganic lossis cov organic tuaj yeem txhim kho cov neeg kho tshuab thiab cov cua sov tsis kam ua ntawm cov khoom sib xyaw ntawm cov khoom sib xyaw .
Piv txwv li, los ntawm kev sib txuas nrog nws nrog nanomaterials xws li cov nanotubes xws li cov ntaub ntawv carbon thiab carbon thiab conduction, thiab kev coj ua tau npaj tau npaj}
Hauv kev tshawb fawb ib puag ncig, kev siv cov ntawv thov tau tshwm sim hauv cov hauv qab no:
1.} Ib puag ncig cov pa egutant kom pom:
Diethyl 2, 5- dibromohexanedioatetuaj yeem siv los ua kev siv cov ntaub ntawv lossis kev sojntsuam cov pa rau ib puag ncig patencant .
Los ntawm kev kawm txog nws tsiv teb tsaws, kev hloov pauv, thiab cov qauv kuaj pom thiab cov qauv kuab paug thiab cov qauv paug ib puag ncig tuaj yeem tsim {}}
Qhov no pab saib xyuas thiab ntsuas cov pa paug thiab muab kev tiv thaiv ib puag ncig, muab kev tiv thaiv ib puag ncig thiab kev tswj hwm .
2. Kev Ntsuam Xyuas Kev Ntsuam Xyuas Kev Lag Luam Ib Puag Ncig:
Los ntawm kev kawm nws cov kev ruaj ntseg thiab kev pheej hmoo, cov peev xwm muaj peev xwm rau cov ecosystems thiab tib neeg kev noj qab haus huv tuaj yeem raug ntsuas .
Qhov no yuav pab ua kom tsim kev tshawb fawb txog kev muaj kev tiv thaiv ib puag ncig thiab kev tsim txom ntawm ib puag ncig pa paug rau tib neeg thiab cov ecosystems {}}
Lwm daim teb
Ntxiv nrog rau cov chaw thov cov chaw thov, nws tseem pom tau cov ntawv thov muaj nuj nqis rau lwm cov teb:
{1.} zas xim cov hlwb solar:
Tuaj yeem siv tau li zas molecules lossis sensitizers nyob rau hauv zas-sensitives solig hlwb {}}
Los ntawm kev ua kom zoo dua nws cov qauv thiab kev ua tau zoo, kev ua yeeb yam zoo dua qub kev ua tau zoo thiab muaj kev ruaj ntseg ntawm cov hlwb hnub ci tuaj yeem hloov kho .
{{02. organic Optoelectronic khoom:
Los ntawm kev siv nws cov khoom lag luam optoelectronic khoom, etoric ettoelronic cuab yeej nrog kev ua tau zoo Optoelectronic ua tau tuaj yeem tsim .
Cov cuab yeej siv no muaj cov kev cia siab ua tiav cov kev cia siab, cov teeb pom kev zoo, teeb tsa, thiab lwm cov liaj teb.
3.}} essalytical chemistry:
Nws kuj tseem siv tau los ua cov tshuaj txheem lossis siv cov khoom siv hauv cov tshuaj aneverical .
Los ntawm kev kawm nws cov tshuaj lom neeg thiab cov tshuaj tiv thaiv nyob rau hauv cov kev mob sib txawv, cov ntaub ntawv kev sim tseem ceeb tuaj yeem muab rau cov tshuaj aneverical {}}
Hauv cov ntsiab lus, 2, 5- dibromohexanedioic acids accompators, tshuaj tua kab thiab cov nroj tsuag thiab cov nroj tsuag ua ke thiab ntseeg tias nws cov ntawv thov thiab muaj peev xwm tus nqi yuav txuas ntxiv thiab tshawb nrhiav . Cov txheej txheem kev nyab xeeb, thiab coj kev ntsuas kev nyab xeeb, thiab ua kom muaj kev txaus ntshai thiab muaj kev phom sij {4}
Cov roj-dej coefficient, tseem hu ua logp tus nqi, ntawm 2, {{} Txawm li cas los xij, raws li cov ntaub ntawv muaj nyob hauv NODE muab . Tus nqi logp feem ntau yuav cuam tshuam nrog cov qauv orgarine, yog li cuam tshuam rau kev faib tawm, yog li cuam tshuam nws cov kev faib tawm hauv N-Octanol thiab Dej .
Nws yuav tsum raug sau tseg tias yog qhov ntsuas muaj nuj nqis yog tau los ntawm ntau qhov kev ntsuas, nws raug pom zoo kom tau txais qhov kev ntsuas sib txawv los ntawm kev sim ntsuas kev sim ntsuas kev .
Diethyl 2, 5- dibromohexanedioate, raws li ib tug organic synthesis Qib, muaj peev xwm kev ua yeeb yam hauv kev sib raug zoo ntawm kev sib raug zoo ntawm nws cov kev ua yeeb yam ntawm cov tshuaj yeeb tshuaj thiab yeeb tshuaj metabolism hauv qab no los ntawm ntau qhov:
Nyob rau hauv cov txheej txheem ntawm cov tshuaj metabolism, yeeb tshuaj los ntawm cov metabolites los ntawm cov tshuaj metabolites los yog cov tshuaj lom neeg tuaj yeem koom nrog cov biotransformation no cov txheej txheem . Piv txwv, ntawm cov metabolites acid) yog qhov tseem ceeb rau cov acidming acid (diethylsatural acid)
Cov tshuaj yeeb dej haus yeeb tshuaj yog cov qauv siv tshuaj, suav nrog cov kev ua yeeb yam, thiab lwm yam ntawm cov metaboles, thiab lwm yam ntawm cov metabolites, thiab lwm yam} ua a metabolite ntawm tej yam tshuaj, nws yuav cuam tshuam rau enzyme kev ua los ntawm kev khi lossis sib tw nrog cov kev sib tw, nws tuaj yeem hloov cov metabolic tus nqi thiab txoj hauv kev ntawm cov tshuaj {}}
Kev sib cuam tshuam yeeb tshuaj yog ib qho tseem ceeb hauv tshuaj yeeb tshawb fawb, thiab kev sib tw rau lwm cov tshuaj hauv lub cev, thiab cuam tshuam nrog lwm cov tshuaj hauv lub cev, thiab cuam tshuam nrog lwm cov tshuaj hauv lub cev, thiab cuam tshuam nrog lwm cov tshuaj hauv lub cev, thiab cuam tshuam nrog lwm cov yeeb tshuaj {2 thiab cov txheej txheem excretion ntawm lwm cov tshuaj los ntawm kev sib tw rau tib qho kev sib tw metabolic los yog kev sib cuam tshuam zoo li no, nce cov tshuaj lom neeg .
Hauv cov txheej txheem kev txhim kho kev siv tshuaj, kev tshuaj xyuas kev nyab xeeb thiab kev ntsuas kev nyab xeeb yog qhov tseem ceeb ntawm cov tshuaj lom neeg muaj peev xwm ua tau kev nyab xeeb, muab qhov tseem ceeb ntawm kev nyab xeeb rau kev nyab xeeb Kev ntsuam xyuas cov tshuaj . tib lub sijhawm, los ntawm kev ntsuas cov tshuaj lom neeg, muab cov kev taw qhia rau kev nyab xeeb tshuaj {}}
Kev Tshawb Fawb Txog Kev Ruaj Ntseg
Cov qauv tshuaj thiab cov kev ruaj khov yooj yim
2, {5- dibromoadipic acid (c / molecular.}}}}}} Skeleton, ntsig txog, nrog cov pab pawg hauv kev (-och₂₃) ntawm ob qho kawg. Tus qauv no tso nws nrog cov yam ntxwv ruaj khov:
Thermal ruaj khov
Lub ntsiab lus melting yog 65-67 degree, lub boiling point yog 134}}}}}}}} {{} 6 degree. Debromination lossis Ester Kev Sib Tw Breakage yuav tshwm sim thaum kub siab, tab sis nws muaj qhov zoo thermal ruaj khov nyob rau hauv cov kev sim kom sov (xws li chav nyob mus rau 100 degree).
Kev yees duab
Rhiab rau ultraviolet lub teeb . Lub teeb sib txig ua rau lub teeb dawb paug (xws li hloov cov pab pawg atoms) lossis cov pab pawg Es ester nyob hauv lub teeb xim av .
Redox ruaj khov
Lub bromine atom yog cov pab pawg hluav taws xob-rho tawm cov pa roj ntsha (xws li soc.culture
Qhov cuam tshuam ntawm cov txheej txheem ib puag ncig ntawm kev ruaj khov
Qho so
Kev ntsuas luv luv: ruaj khov ntawm chav tsev kub (25℃yuav tsum tau tswj qhov kub (40), cov ntsiab lus nrawm nrawm (xws li adipic acid bromide) nce los ntawm 2% .
Kev tiv thaiv kub tsawg: nws raug pom zoo kom khaws cia hauv lub tub yees ntawm {}}}}}} degree, cov ntsiab lus poob qis dua 1% .
Vaum thiab cov kuab tshuaj
Hydrolysis risk: Ester bonds are prone to hydrolysis under strong acid or strong base conditions, generating adipic acid and ethanol. The hydrolysis rate is extremely low in a neutral environment, but high humidity (such as RH>80%) yuav ua kom nrawm hygroscopic depradation .
Solvent selection: Readily soluble in organic solvents such as alcohol, ether and acetone, but poorly soluble in water. After dissolving in dichloromethane (DCM), if the solvent contains trace amounts of moisture (such as >0 {{. 1%), nws yuav ua rau muaj cov kuab roj qeeb qeeb, thiab cov kuab tshuaj uas muaj kuab heev yuav tsum tau siv.
Cov pa thiab ntim
Oxidative kev qias: oxygen yuav ua rau oxidative sab kev tawm tsam tuaj yeem txo qhov kev pheej hmoo ntawm oxidation thiab txuas lub txee lub neej.
Ntim khoom Ntim: Cov Hnab Ntim Khoom Loj Ntim (xws li lub hnab ntim aluminium) yog qhov tseem ceeb rau cov pa tawm hauv lub ntsej muag (98%)
Kev Tshawb Fawb Txog Kev Ruaj Ntseg
Kev Ntsuam Xyuas Kev Ntsuas Ruaj Ntseg
Cov Zwj: 40℃/ 75% Rh, kav ntev li 6 lub hlis .
Cov Lus Qhia Nrhiav Tau: Cov Ntsiab Lus (HPLC), P muaj nuj nqis, noo noo, tsos (xim / sediment) {}}
Qhov tshwm sim: Cov ntsiab lus txo qis dua los ntawm tsawg dua lossis sib npaug ntawm 5%, thiab tag nrho cov nyiaj tsis tau muaj dua lossis sib npaug ntawm 2%, uas yoog raws li ntawm ich)) {4 4}}
Kev ntsuas ntev ntev
Cov xwm txheej: 25℃/ 60% rh, kav ntev rau 24 lub hlis .
Kuaj zaus: kuaj thiab tshuaj ntsuam xyuas txhua rau lub hlis .
Qhov tshwm sim: cov ntsiab lus txo qis dua los ntawm tsawg dua lossis sib npaug ntawm cov impurities yog tsawg dua lossis sib npaug nws tau ruaj khov nyob rau hauv cov neeg muaj kev pom zoo.
Kuaj kev ruaj khov hauv kev siv
Simulation Kev Ua Haujlwm: Simulate qhib cov xwm txheej, ntu, thiab dilution kom pom cov kev hloov pauv hauv cov ntsiab lus ntawm cov khoom xyaw nquag.
Qhov txiaj ntsig: Cov ntsiab lus khaws cia yog ntau dua lossis sib npaug ntawm 25 hnub lossis ntawm {}} .
Cov tswv yim rau kev txhim kho kev ruaj khov
Qhov Ntsuas Optimization
Ntxiv tshuaj antioxidants (xws li BHT) lossis hlau ion chelating cov neeg sawv cev (xws li Edta) kom tiv thaiv .
Kho cov ph thiaj li nruab nrab (ph {=6-8) kom txo qis kev pheej hmoo ntawm hydrolysis.
Txheej Txheem Tswj
Kom tsis muaj menyuam txheej xaiv: Tsis txhob muaj qhov kub siab thiab kub siab ua ntej} 2}}}}}}}}}
Txhaws ib puag ncig: sau rau hauv nitrogen tiv thaiv kom txo cov pa oxygen nyob rau .
Cia thiab Tsheb Thauj Mus Los
Lub sij hawm luv luv: Hauv 2-8 degree, zam kom khov .
Ntev sij hawm: khov ntawm -20℃c.} {2} {2} {{0.
Kev Thauj Mus Los: Thauj hauv qhov chaw tsaus dua 25℃thiab tsis txhob muaj kev co kom loj .
Cim npe nrov: diethyl 2, {5- dibromohexanedioate Cas869-10-3, chaw tsim khoom, chaw tsim khoom, yuav khoom, rau muag