Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm cov tuam ntxhab thiab cov muag khoom ntawm methyl isothiocyanate cas 556-61-6 hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo methyl isothiocyanate cas 556-61-6 muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Methyl isothiocyanate, CAS 556-61-6, molecular mis C2H3NS, tsis muaj kob crystal ntawm chav tsev kub thiab siab, me ntsis soluble nyob rau hauv dej, tab sis yooj yim soluble nyob rau hauv cov organic solvents. Nws tuaj yeem siv los ua ib qho nruab nrab hauv cov organic synthesis thiab tshuaj tua kab chemistry, feem ntau yog rau kev hloov kho thiab kev sib txuas ntawm cov organic molecules thiab tshuaj tua kab molecules. Tsis tas li ntawd, cov tshuaj tseem tuaj yeem siv los ua cov av fumigant los tua fungi, nematodes, kab tsuag hauv av, thiab cov noob nroj tsuag hauv av ua ntej cog qoob loo. Nws yog ib qho khoom siv los ntawm cov av fumigant, uas yog tshuaj lom thiab corrosive, thiab muaj teebmeem rau ntawm daim tawv nqaij thiab ua pa. Nws tuaj yeem decomposed thiab tshem tawm ntawm cov dej qias neeg los ntawm kev tawm tsam dawb radical. Nws yog ib qho tsis ruaj tsis khov uas yog qhov yooj yim rau decomposition. Nws maj mam decomposes thaum raug huab cua lossis cua sov, tsim cov khoom xws li isothiocyanate thiab formaldehyde. Cov tshuaj no yog cov khoom siv hluav taws xob nrog cov nucleophilicity, feem ntau siv los ua cov tshuaj reagent hauv cov tshuaj lom neeg cov tshuaj tiv thaiv. Nws tuaj yeem cuam tshuam nrog nucleophilic reagents xws li amines thiab cawv.
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Tshuaj Formula |
C2H3NS |
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Exact Mass |
73 |
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Molecular Luj |
73 |
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m/z |
73 (100.0%), 75 (4.5%), 74 (2.2%) |
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Elemental Analysis |
C, 32.86; H, 4.14; N, 19.16; S, 43.85 |
Methyl isothiocyanatetuaj yeem siv los ua ib qho nruab nrab hauv cov organic synthesis thiab tshuaj tua kab chemistry, feem ntau yog rau kev hloov kho thiab kev sib txuas ntawm cov organic molecules thiab tshuaj tua kab molecules. Piv txwv li, cov khoom siv yog cov khoom siv hluavtaws rau kev sib xyaw ua ke 1,3,4-thiadiazole, uas yog cov tshuaj heterocyclic uas tuaj yeem siv los ua tshuaj ntsuab. Cov tshuaj nto moo npaj siv MITC suav nrog ranitidine, cimetidine, thiab sunitinib. Tsis tas li ntawd, cov tshuaj no kuj yog ib qho txaus ntshai thiab muaj kuab tshuaj kua muag.
Hauv cov tshuaj tiv thaiv qhuav, 1-methylpiperazine (100 μL, 0.80mmol) tau yaj hauv ether qhuav (4mL / mmol). Tom qab ntawd maj mam ntxiv cov khoom (64 mg, 0.88 mmol) rau cov tshuaj. Los ntawm kev taug qab qhov kev nce qib ntawm cov tshuaj tiv thaiv los ntawm TLC, nws feem ntau ua tiav tom qab nplawm hauv chav sov li 0.5 teev. Tom qab cov tshuaj tiv thaiv tiav, lim cov tshuaj tiv thaiv sib tov ncaj qha kom tshem tawm cov precipitate hauv cov tshuaj tiv thaiv sib tov, thiab tom qab ntawd mloog zoo rau qhov tau txais cov lim dej hauv lub tshuab nqus tsev kom tau txais cov khoom lag luam molecule.
Npaj los ntawm methylamine, carbon disulfide, thiab ethyl chloroformate los ntawm cov kauj ruam hauv qab no. Sib tov carbon disulfide thiab sodium hydroxide tov, do thiab txias rau 10-15 degree, thiab ntxiv 35% methylamine aqueous tov nyob rau hauv 0.5 teev. Ua kom sov so rau 1-2 teev kom tiav cov tshuaj tiv thaiv thiab tsim kom muaj cov kua liab liab. Txias nws mus rau 35-40 degree, ntxiv ethyl chloroformate dropwise thaum nplawm, thiab txuas ntxiv stirring rau 30 feeb kom txog thaum kub poob mus rau ib ncig ntawm 30 degree. Cais txheej sab sauv ntawm isothiocyanate, qhuav nws nrog anhydrous sodium sulfate, thiab ua fractionation. Sau cov 115-121℃feem kom tau txais cov khoom tiav. Cov qoob loo yog kwv yees li 70%.
Cov khoom siv raw muaj xws li methylamine, carbon disulfide, thiab ethyl chloroformate. Lub hom phiaj yog los tsim ib qho methyl isothiocynate los ntawm ntau cov tshuaj tiv thaiv, thiab cov ncauj lus kom ntxaws cov tshuaj tiv thaiv thiab cov kauj ruam ua haujlwm tau muab.
Sib tov carbon disulfide thiab sodium hydroxide tov, thiab ntxiv 35% methylamine aqueous tov thaum txias rau 10-15 degree. Hauv cov kauj ruam no, carbon disulfide reacts nrog methylamine nyob rau hauv alkaline tej yam kev mob. Xav txog cov carbon sulfur ob daim ntawv cog lus hauv carbon disulfide thiab cov amino pawg hauv methylamine, lawv tuaj yeem tsim cov sodium ntsev ntawm thioamide (tseem hu ua thiocarbamate) los ntawm cov tshuaj tiv thaiv nucleophilic ntxiv. Cov tshuaj tiv thaiv no yog ib txoj hauv kev los npaj cov tshuaj thioamide.
Kev xaiv ntawm cov tshuaj tiv thaiv: Cov tshuaj tiv thaiv yog ua los ntawm qhov kub thiab txias, uas pab tswj cov tshuaj tiv thaiv tus nqi thiab kev xaiv, thiab zam kev tsim los ntawm - cov khoom. Meanwhile, alkaline tej yam kev mob yog haum rau cov nucleophilic ntxiv cov tshuaj tiv thaiv.
Sov thiab do cov tshuaj tiv thaiv uas tau txais nyob rau hauv cov kauj ruam dhau los rau 1-2 teev kom tiav cov tshuaj tiv thaiv thiab tsim kom muaj ib tug kaj liab kua. Cov kauj ruam no tsuas yog los xyuas kom meej tias cov tshuaj tiv thaiv hauv thawj kauj ruam ua tiav, thiab xyuas kom meej tias cov khoom siv raw tau hloov mus rau hauv cov khoom kom ntau li ntau tau. Cov kua liab ci tuaj yeem yog xim yam ntxwv ntawm cov khoom lossis nruab nrab.
Txias cov tshuaj tiv thaiv rau 35-40℃thiab ntxiv ethyl chloroformate dropwise thaum nplawm. Cov kauj ruam no qhia txog ethyl chloroformate ua cov tshuaj reactant tshiab. Cov ester pawg hauv ethyl chloroformate tuaj yeem raug hydrolysis lossis nucleophilic hloov pauv cov tshuaj tiv thaiv nyob rau hauv cov xwm txheej alkaline. Tab sis ntawm no, nws muaj feem ntau dua tias nws tau dhau qee yam tshuaj tiv thaiv nrog thioamide sodium ntsev tsim hauv thawj kauj ruam, xws li nucleophilic hloov pauv lossis ntxiv tshem tawm cov tshuaj tiv thaiv, los tsim isothiocyanates.
Tom qab ntxiv ethyl chloroformate, txuas ntxiv stirring rau 30 feeb thiab txo qhov kub kom txog 30 degrees. Cov kauj ruam no yog los xyuas kom meej tias cov tshuaj tiv thaiv tshwm sim txaus. Tom qab ntawd cais cov txheej sab sauv ntawm isothiocyanate, qhuav nws nrog anhydrous sodium sulfate, thiab ua fractionation. Sau cov 115-121℃feem kom tau txais cov khoom tiav. Kev sib cais thiab kev ua kom huv hauv cov kauj ruam no yog kom tau txais cov khoom ntshiab isothiocyanate.
Raws li ib tug tub rog toxic agent
Methyl isothiocyanatemuaj zog irritant thiab toxicity, thiab yog li ntawd kuj siv los ua tub rog tshuaj lom. Hauv kev ua tsov ua rog lossis kev tsis sib haum xeeb, methyl isothiocynate tuaj yeem siv los ua riam phom tshuaj, ua rau muaj kev phom sij loj lossis tuag taus rau cov neeg ua yeeb ncuab. Txawm li cas los xij, vim nws muaj toxicity siab thiab txaus ntshai, kev siv methyl isothiocynate tau raug txwv nruj thiab txwv tsis pub los ntawm cov zej zog thoob ntiaj teb.
Txawm hais tias methyl isothiocynate muaj peev xwm siv tau hauv kev ua tub rog, nws qhov kev phom sij thiab kev ua tsis ncaj ncees ua rau qhov kev siv no muaj kev tsis sib haum xeeb. Yog li ntawd, tsoomfwv thiab cov koom haum thoob ntiaj teb tau ua haujlwm ntxiv dag zog rau kev tswj hwm thiab kev puas tsuaj ntawm riam phom tshuaj lom neeg los tiv thaiv cov tshuaj lom xws li methyl isothiocynate los ntawm kev siv rau lub hom phiaj ua neeg tsis zoo.
Lwm yam kev siv
Ntxiv rau cov kev siv tseem ceeb uas tau hais los saum no, methyl isothiocynate kuj muaj qee qhov kev siv tau. Piv txwv li, nyob rau hauv lub chaw kuaj mob, methyl isothiocynate tuaj yeem siv los ua cov tshuaj reagent lossis catalyst rau kev kawm txog cov tshuaj lom neeg cov tshuaj lom neeg. Tsis tas li ntawd, methyl isothiocynate tuaj yeem siv los npaj qee cov khoom siv organic lossis cov khoom siv molecules nrog cov khoom tshwj xeeb.
Txawm li cas los xij, nws yuav tsum tau muab sau tseg tias vim muaj tshuaj lom thiab khaus heev ntawm methyl isothiocynate, nws yuav tsum tau ua raws li cov txheej txheem kev nyab xeeb thiab kev tiv thaiv thaum siv nws. Ib qho kev siv tsis raug lossis tuav yuav ua rau tus kheej raug mob hnyav lossis ib puag ncig muaj kuab lom.
Tsis ntev los no, pab pawg tshiab rau kev tswj cov kab tsuag hauv av ntawm Lub Tsev Haujlwm Saib Xyuas Kev Tiv Thaiv, Suav Academy ntawm Kev Tshawb Fawb Txog Kev Ua Liaj Ua Teb, tau luam tawm cov ntaub ntawv tshawb fawb online hauv cov ntawv xov xwm thoob ntiaj teb Environmental pollution hu ua "Systematic kev soj ntsuam ntawm cov tshuaj tiv thaiv kab mob ntawm cov av fume.methyl isothiocyanateTawm tsam Fusarium oxysporum "Daim ntawv no txheeb xyuas cov txheej txheem inhibitory ntawm MITC, cov khoom siv degradation zoo ntawm cov av fumigant paj rwb, ntawm cov av uas muaj kab mob fungus Fusarium oxysporum, muab cov ntaub ntawv muaj txiaj ntsig rau cov tshuaj lom neeg ntawm cov av fumigants hauv inhibiting pathogenic fungi.
Cov kab mob hauv av tau dhau los ua ib qho tseem ceeb hauv kev txwv tsis pub cov khoom muaj txiaj ntsig siab - ntxiv cov qoob loo, thiab cov av fumigation technology tam sim no yog cov cuab yeej tseem ceeb tshaj plaws thiab ruaj khov rau kev tiv thaiv thiab tswj cov kab mob hauv av. Txawm li cas los xij, cov txheej txheem uas cov av fumigants inhibit av borne pathogens tseem tsis meej. Yog li ntawd, txoj kev tshawb no siv MITC ua tus neeg sawv cev kuaj thiab F. oxysporum ua cov khoom tshawb fawb, ua ke nrog kev siv tshuab transcriptome sequencing los tshawb txog cov txheej txheem ntawm kev ua ntawm MITC ntawm cov av borne pathogenic fungi.
Kev tshawb fawb tau pom tias tom qab kev kho mob nrog MITC, lub cell phab ntsa thiab daim nyias nyias ntawm Fusarium oxysporum shrinkage thiab quav, vacuoles nce, mitochondria o thiab deform, lawv cov duab yuav tsis zoo, thiab lawv yog unevenly faib nyob rau hauv lub cytoplasm. Tom qab kev kho mob nrog MITC, cov tshuaj antioxidant enzyme (SOD, CAT, POD) thiab cov enzymes tseem ceeb koom nrog hauv lub voj voog tricarboxylic acid (SDH thiab MDH) hauv mycelium ntawm Fusarium oxysporum tau txo qis, thaum cov ntsiab lus ntawm malondialdehyde (MDA), uas ua rau cov membrane lipid peroxidation tau nce ntau.
Cov txiaj ntsig transcriptome sequencing tau pom cov kev hloov pauv tseem ceeb hauv cov noob caj noob ces (DEGs) koom nrog hauv cov khoom siv thiab lub zog metabolism, teeb liab hloov, thauj, thiab catalysis hauv Fusarium oxysporum cells. DEGs (membrane Cheebtsam, binding thiab catalytic kev ua si) muaj feem xyuam rau lub siab thiab DEGs (lub teeb liab transduction thiab daim nyias nyias) muaj feem xyuam rau ib puag ncig cov ntaub ntawv txheej txheem nyob rau hauv lub mycelium yog heev downregulated, thaum DEGs hais txog cov metabolism (amino acid metabolism, lwm yam amino acid metabolism, carbohydrate metabolism, thiab lipid metabolism) yog ho upregulated.
Tsis tas li ntawd, MITC cuam tshuam cov cell homeostasis thiab inhibits qhov kev loj hlob ib txwm ntawm Fusarium oxysporum los ntawm kev cuam tshuam cov kev qhia ntawm cov noob tseem ceeb xws li chitin synthase (CHS1, chitinase, thiab nagZ), ascorbate synthase (MIOX, AKR1A1, RGN, thiab ASO), glutathione metabolism (GPD), lwm yam antioxidants. (CYP450, CAT), thiab cov khoom siv thauj mus los (AMT2, ABCB1, CAX) hauv mycelium. Ntawm qhov tod tes, Fusarium oxysporum kuj tiv thaiv kev cuam tshuam ntawm MITC los ntawm kev tswj cov noob koom nrog hauv kev sib txuas ntawm lub zog (xws li upregulating cov lus qhia ntawm acnA, CS, thiab LSC2 cov noob hauv TCA) thiab cov noob uas tshem tawm cov pa oxygen (POD), tab sis thaum kawg tsis tuaj yeem hloov qhov tshwm sim ntawm cell apoptosis. Txoj kev tshawb no enriches theoretical kev nkag siab ntawm mechanism ntawm kev txiav txim ntawm av fumigants ntawm av borne pathogenic fungi.
Lub koom haum ntawm Kev Tiv Thaiv Kev Tiv Thaiv, Suav Academy ntawm Kev Tshawb Fawb Txog Kev Ua Liaj Ua Teb yog qhov ua tiav ntawm daim ntawv no, nrog tus kws kho mob tub ntxhais kawm Zhang Daqi ua thawj tus sau, tus kws tshawb fawb Cao Aocheng ua tus sau sau, thiab cov kws tshawb fawb Yan Dongdong, Wang Qiuxia, Li Yuan, thiab Fang Wensheng ua tus taw qhia rau qhov kev tshawb fawb no. Qhov kev tshawb fawb no tau txais kev txhawb nqa los ntawm cov haujlwm xws li National Natural Science Foundation ntawm Tuam Tshoj, Pab Pawg Kev Tsim Kho Tshiab ntawm Beijing Kev Lag Luam Kev Lag Luam Niaj Hnub No, thiab Hebei Xeev Green Prevention and Control Technology Innovation Center for Av borne Diseases.
Cov lus nug nquag
Vim li cas nws thiaj ntsib ib qho kev hloov ntawm "txhaum" lossis "txhim txwv" hauv kev ua liaj ua teb raws li qhov ua tau zoo fumigant?
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Feem ntau vim nws cov volatility siab, siab toxicity, thiab muaj peev xwm tsiv teb tsaws hauv av. Cov yam ntxwv no tsis yog tsuas yog ua rau muaj kev pheej hmoo siab rau cov neeg siv tshuaj tua kab, tab sis kuj tseem tuaj yeem ua paug hauv av thiab ua rau ntau thiab ntev -kev puas tsuaj rau cov zej zog tsis yog hom kab mob microbial, yog li maj mam hloov los ntawm cov khoom muaj kev nyab xeeb thiab xaiv ntau dua.
Yuav ua li cas nws "infiltrate" thiab tua kab mob nyob rau hauv cov av thaum lub sij hawm fumigation?
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Qhov tseem ceeb nyob rau hauv nws qhov kub tsis tshua muaj kub (txog 119 ° C) thiab cov yam ntxwv siab vapor siab. Tom qab siv rau hauv av, nws tuaj yeem vaporize sai thiab tsim cov pa roj carbon monoxide siab, uas nthuav tawm thiab nkag mus rau hauv av pores nyob rau hauv tag nrho cov lus qhia, yog li nkag mus rau hauv kev sib cuag nrog thiab tua ntau yam av uas muaj teeb meem kab mob xws li nematodes, fungi, nroj tsuag noob, thiab kab.
Sib nrug los ntawm kev ua liaj ua teb, dab tsi yog qhov txaus ntshai ntawm "los ntawm- khoom" hauv kev lag luam?
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Nws yog ib qho tshuaj lom neeg los ntawm kev siab -kub pyrolysis ntawm cov organic tebchaw uas muaj nitrogen thiab sulfur, xws li qee cov amines thiab cov proteins. Piv txwv li, kev tsim kev raug tsim txom yuav tshwm sim hauv kev tsim tshuaj lom neeg, kev tsim khoom pov tseg, lossis hluav taws kub uas muaj qee yam khoom siv, uas yog lub hom phiaj tseem ceeb ntawm kev saib xyuas kev nyab xeeb ntawm kev lag luam.
Dab tsi yog qhov zoo sib xws thiab qhov sib txawv ntawm pawg "isothiocyanate" hauv nws cov molecule thiab cov khoom ntsim hauv mustard thiab horseradish?
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Cov pab pawg tseem ceeb yog tib yam (- N=C=S) thiab txhua tus muaj qhov ntsim thiab khaus. Tab sis cov allyl isothiocyanate nyob rau hauv mustard yog ib yam khoom ntuj uas tsis tshua muaj volatility thiab toxicity. Methyl isothiocyanate yog ib qho me me molecule compound synthesized, nrog ntau zog volatility, tshuaj lom neeg kev ua si, thiab systemic toxicity, thiab yuav tsum tsis txhob totaub.
Vim li cas nws thiaj siv los ua ib qho tshwj xeeb "protein modifier" hauv kev tshawb fawb hauv chav kuaj?
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Vim nws cov electrophilicity siab, cov pab pawg isothiocyanate tuaj yeem hloov tsis tau covalently khi nrog nucleophilic pawg xws li thiol thiab amino pawg hauv cov protein, yog li hloov cov qauv thiab kev ua haujlwm ntawm cov protein. Qhov no ua rau nws yog ib qho cuab yeej siv tshuaj rau kev kawm cov khoom siv protein ntau los yog immobilizing proteins.
Cim npe nrov: methyl isothiocyanate cas 556-61-6, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom