Methylumbelliferone CASE 90-33-5

Shaanxi Bloom Tech Co., Ltd. yog ib qho ntawm cov neeg tsim khoom thiab cov khoom siv ntawm methylumbelliferone CASE 90-33-5 nyob rau Suav teb. Txais tos rau kev lag luam wholesale? Cov kev pabcuam zoo thiab tus nqi tsim nyog muaj.

Methylumbelliferone(4 {{{{}} MetylcoMarin) yog cov organic compound nrog cov organic colound nrog mish8o3, Cas 90 {-} 337g / mol. Nws muaj 8 lub zog ruaj khov atoms thiab ib cov phenyl, uas txuas nrog glycosides los ntawm cov pa atoms. Glycoside yog tsib tus tswv cuab ntawm furus flucose, qhov twg C-3 txoj hauj lwm yog hloov los ntawm ib pab pawg methyl. Nws yog tus dawb rau lub teeb daj crystalline khoom. Feem ntau tam sim no tsis muaj ntxhiab tsw lossis muaju me me. Nws muaj cov solubility zoo nyob hauv qee cov kuab organic. Nws tuaj yeem ua tau nyob rau hauv polar solvents xws li ethanol, dimethyl sulfoxide (DMOPS), ethyl acetate, thiab chloroform. Txawm li cas los xij, cov solubility yog tsis zoo nyob rau hauv tsis-polar cov kuab tshuaj xws li n-hephane thiab ete. Nws ua yeeb yam photoluminescence cov khoom nyob rau hauv cov teeb ci ci. Nws muaj ntau qhov siab tshaj plaws wavelengthen rau hauv thaj tsam ntawm 300-400 nm thiab lub siab tshaj plaws emissen wavelength nyob rau hauv ntau yam ntawm 400-500 nm. Nws yog ib qho tseem ceeb organic nruab nrab thiab fluorescent raw khoom, nrog cov ntawv thov dav dav hauv kev lag luam hauv tsev thiab thoob ntiaj teb. Nws yog tsuas yog siv rau kev tsim cov khoom hauv cov dej ntws xws li fluorescent brainters, zas cov intermediates, tshuaj thiab tshuaj tua kab.

Hymecromone, Npe NpeMethylumbelliferone, yog dawb kom tawm dawb crystalline hmoov yog mus rau Coumarin derivatives. Nws cov ntawv thov cov tseem ceeb muaj cov kev kho mob ntawm cov kab mob biliary, thiab nws muaj cov ntawv thov dav, thiab khoom siv muaj.

Kev teb kho mob: Cov tshuaj tseem ceeb rau kev kho mob ntawm cov kab mob biliary

 

Hauv cov tshuaj, nws yog tsuas yog siv los kho cov kab mob ntsig txog cov kev nqis tes ua kom pom plaub yam: anti {{otecotionective, thiab hepatoprotrotive
1. Choleretic nyhuv
Los ntawm kev txhawb nqa lub siab hlwb rau cov lus zais cia thiab nce bile flow (25% -30%), nws txhawb nqa cov pob zeb duct pob zeb, cov tshuaj pleev plab, thiab cov khib nyiab thiab metabolic. Cov txiaj ntsig no tuaj yeem daws cov tsos mob xws li Jaundice thiab mob plab thiab haum rau cov neeg mob uas muaj mob ntsws, thiab cov kab mob sib kis tau. Cov ntaub ntawv kuaj mob qhia tau tias tom qab 2-4 lub lim tiam ntawm kev noj tshuaj tas li, cov neeg mob 'bile zais cia nce thiab bilriae siab dua.

 

2. Spasmodic thiab analgesic cuam tshuam
Muaj peev xwm so cov leeg du (sphincter) ntawm biliary qua ntxiag thiab txo qis biliary colic tshwm sim los ntawm biliary spasm. Nws cov nyhuv analgesic muaj zog dua li atropine, thiab nws siv cov nyhuv sai (hauv 30 feeb) nrog lub sijhawm ntev txog 6-8 teev. Rau cov neeg mob uas muaj lub gallbarder syndrome, tshuaj antispasmodic cov teebmeem tuaj yeem txo qhov tshwm sim ntawm kev ncua ntawm kev coj noj mov.

3. Anti o thiab daim siab tiv thaiv
Los ntawm inhibiting kev tsim cov tshuaj kho mob (xws li ★-}}}}}}}

 

Nyob rau tib lub sijhawm, nws cov hepatoproprotective cov nyhuv tau pom nyob rau hauv kev txo cov oxidative (inhibiting)}} κ {{κ b everwhy. Rau cov neeg mob uas muaj lub siab tsis sib haum (alt / ast nce siab), tom qab noj tshuaj, tsheb ciav hlau tuaj yeem rov qab mus ua si li o.

4. Pab cov pob zeb tshem tawm thiab cov tshuaj tua kabmob
Nws tuaj yeem txhim kho cov gallhabbadder (nce kev sib xyaw ua ke los ntawm kev siv tshuaj tua kab mob (xws li siv tshuaj tua kab mob thiab amoxicillin), nws tuaj yeem txhawb nqa lub pob zeb me me (taub<0.5cm) in the common bile duct. Its antibacterial effect is achieved by destroying bacterial cell membranes, and it has a certain inhibitory effect on common biliary pathogens such as Escherichia coli and Klebsiella pneumoniae.

 

Cov Ntawv Thov Kev Noj Qab Haus Huv scenarios:
Cholecystitis: Txo qhov mob, kub taub hau, thiab zoo murphy lub cim nyob rau sab xis sab sauv.
Gallstones: Txhawb txoj kev sib cais lossis tshem tawm ntawm pob zeb, txo qhov xav tau kev phais mob.
Postperative biliary synistic: kev tiv thaiv ntawm kev txwv tsis pub mob rau kev mob sab txig thiab kis tus kab mob.
Kev Kho Mob Txom Nyem rau cov kab mob siab: Txhim kho lub siab ua haujlwm thiab txo txoj kev pheej hmoo ntawm cov kev pheej hmoo ntawm tus mob cirrhosis.

Industrial Femi: Cov ntaub ntawv muaj kev cuam tshuam thiab cov ntaub ntawv ua haujlwm

 

Raws li ib qho tseem ceeb organic nruab nrab ntawm synthemes,Methylumbelliferonemuaj ntau cov kev siv hauv tshuaj, tshuaj tua kab, thiab cov khoom siv tshuaj ntsuam
1. Tshuaj Nruab Nrab Nruab Nrab
Hydroxycarin yog cov khoom siv raw rau cov synthesis ntawm antiagulant tshuaj (xws li hydroxoolycarin derivatives), thiab tshuaj tiv thaiv tshuaj. Nws cov derivatives, xws li 7-muttercy-4-muttercy-4-acetic acid, pom kev ua haujlwm siab hauv cov tshuaj synthesis.
2. Tshuaj tua kab thiab tshuaj tua kab
Hydroxymethyl coumarin derivatives (xws li Tribromide hloov) tau muaj txiaj ntsig zoo tua ntawm Aignapti Larvae, thiab lwm yam (LC50=10}} {. Ya venom phosphorus tshuaj synthesized los ntawm hydroxymethylcowmalylcarin ua ib qho kev tswj hwm tau dav rau kev tswj cov tshuaj tua kab thiab tsiaj cov txiv.

 

3. Cov ntaub ntawv ua haujlwm
Cov khoom siv fluorescent: nws ua rau cov fluorescence xiav hauv cov tshuaj ntxuav thiab tuaj yeem siv ua laser down.
Nonline cov khoom siv kho qhov muag: nrog cov nyhuv muaj zog thib ob (seb) cov nyhuv, lawv yog cov khoom zoo tshaj plaws uas siv nyob rau hauv kev sib txuas lus kho qhov muag thiab cov tshuab laser.
Hlau cov hlau nplaum: cov tebchaw tsim cov hlau xws li hlau thiab cerium muaj anticoagulant (icoling trotting sijhawm) thiab ⁻⁵ mmol) teebmeem, thiab tuaj yeem siv los tsim cov tshuaj tshiab.

Kev Lag Luam Khoom Noj: Ntuj Kev Lag Luam Zoo thiab Kev Ua Ntxiv

 

Daim ntawv thov hauv kev lag luam khoom noj yog tsuas yog ua raws li nws cov tshuaj tiv thaiv kab mob, thiab anti {{{{}}}}}}}}}}}}}}}}}}}}}}}}}} kev laus zog:
1. Antioxidant thiab anti - corrosion
By clearing free radicals (DPPH clearance rate>80%) thiab inhibiting enzyme kev ua (xws li LipoxyGenase), lub txee lub neej ntawm cov nqaij khoom, cov khoom noj siv mis, thiab dej haus tuaj yeem txuas ntxiv. Cov kev sim tau qhia tias ntxiv 0.1 hydroxymethylcowmalylcoin rau mis tuaj yeem txuas nws lub txee tsim los ntawm 3-5 hnub.

 

2. Tiv Thaiv Kev Laus thiab Kev Kho Mob
Nws tuaj yeem tswj cov metricular metabolism (ua kom lub sirt1 txoj kev) thiab ncua cov tawv nqaij thiab cov tawv nqaij laus. Hauv cov zaub mov kev noj qab haus huv, thaum siv nrog cov vitamins nrog 20%) thiab tswj cov ntshav qab zib (txo cov ntshav qab zib los ntawm 15%).
3. Daim ntawv thov zaub mov ntsuab
Raws li ib tug ntoo txig, hydroxymethyl Coumarin ntsib kev nyab xeeb thiab ib puag ncig kev tiv thaiv, thiab tau siv nyob rau hauv cov zaub mov organic thiab dej haus.

Kev Tshawb Fawb: Cov Qauv Ua Teb thiab Kev Tshawb Fawb Kev Tshawb Fawb

 

Hauv kev tshawb fawb, nws feem ntau siv los ua tus qauv sib txuas los kawm cov kev ua haujlwm roj ntsha thiab kev ua haujlwm ntawm kev ua ntawm Coumarin tebchaw:
1. Anti cov qog tshawb fawb
Nws tuaj yeem ua rau DNA / RNA synthesis hauv cov lus hais tawm (hL-60) thiab ua rau cov mob cell Lub inhibition tus nqi ntawm nws cov derivatives ntawm cov qog nqaij hlav cancer mis (MCF-7) tau txog 60%.

 

2. Inhibition ntawm Hyaluronic Acid Synthesis

Los ntawm inhibiting qhov kev hais tawm ntawm hyaluronic acid synthease 2 (HY2), yog li inhaluronic acid cov ntsiab lus hauv lung metastatic nolules los ntawm 40%).
3. Enzyme substrate Nrhiav tau
Hydroxsylcoumlcoin tuaj yeem ua tau zoo li cov txheej txheem (xws li methyl u6 galactosy)}

MethylumbelliferoneMuaj peev xwm muab tau los ntawm ntau txoj kev, cov hauv qab no yog qee cov txheej txheem ntau:

1. Cov Qauv Coumarin

(1) Coumarin thiab Acetone yauv tsis txaus ntseeg hauv kev siv hluav taws xob hauv lub xub ntiag ntawm cov iodine kom tau txais 7-hydroxycoumarin.

(2) Nyob rau hauv Alkaline tej yam kev mob, 7-hydroxycoumarin reacts nrog methyl bromide kom tau 4-metylcoumarin.

2. Pechmann txoj kev

(1) Kev tsim txiaj ntawm Coumarin thiab formic acid nyob rau hauv acidic tej yam kev mob kom tau txais 2-metoxycarbonyl Coumarin.

(2) Nyob rau hauv Alkaline tej yam kev mob, 2-methoxycarbonyl Coumarin Undergarin undergoes ib txoj kev tiv thaiv lactonization kom tau 4-methyl coumarin.

3. Heptanone txoj kev

(1) Cov yeeb tshuaj yeeb yam ntawm Coumarin thiab Heptanone nyob rau hauv lub xub ntiag ntawm sodium acetylacetonate catalylacetonate catalylacetonate catalylacetonate catalysst muab 7-Heptanyl Coumarin.

(2) Nyob rau hauv lub catalyly hydroxide, 7-heptany bevolarin reacts nrog methyl bromide kom tau 4-methyl coumarin.

Cov hau kev no txhua qhov kev siv Coumarin lossis nws cov derivatives li pib cov ntaub ntawv thiab yov} Cov khoom txhiv ntau ntxiv thaum kawg tau 4 {{}} methylcarin. Cov hau kev no muaj qhov zoo ntawm cov tshuaj tiv thaiv me me thiab cov qoob loo siab, thiab haum rau kev sim tshuaj-teev synthesis.

4-Methylcarin yog ib qho kev sojntsuam fluorescent sib txuas nrog ntau cov khoom sib xyaw. Cov hauv qab no yog qee cov kev tawm tsam ntawm 4-methylcarin:

1. HydroSxylationgeion: 4thylcoMarin tuaj yeem npaj los ntawm hydroxylation cov tshuaj tiv thaiv ntawm Phenol. Hydroxylation feem ntau yog ib txwm ua tiav los ntawm kev rov ua kom zoo 4-metylcarin nrog sodium hydroxide (NAOH) thiab hydrogen peroxide (h2o2).

2. Esterification Repe: 4-MethylcoMarin tuaj yeem hnov ​​cov kua qaub los ua tus estrate lossis 4-metylcoTuav lossis 4-metylcoin benzyl tuaj yeem npaj nrog acetic acid los yog benzoic acid esters.

3. Carboxylationge: 4 methylcoMarin tuaj yeem tsim cov roj carboxylic acid derivatives los ntawm carboxylation cov tshuaj tiv thaiv. Piv txwv li, cov tshuaj tiv thaiv nrog tshaj iodic acid los yog ferrous chloride (FERCL2) tuaj yeem tsim cov 4-metylcoummarin-7-carboxylic acid.

4. Bromination Refore: 4-MethylcoMarin tuaj yeem hnov ​​mob nrog bromine nyob rau hauv alkaline tej yam kev mob los tsim brominated derivatives.

5. Fluorescent yam ntxwv: Fluorescent cov yam ntxwv ntawm 4-methylcoMarin tau muaj dav tau kawm thiab thov. Nws tuaj yeem siv ua qhov ntsuas kev tsom xam los ntawm kev ua kom fluorescent complexes nrog qee cov kab hlau, magnesium, zinc thiab hlau ntshav.

MethylumbelliferonePuas yog ib qho tshuaj sib xyaw siv tshuaj lom neeg organic, cov hauv qab no yog qee qhov ntawm nws cov tshuaj lom neeg:

1. Acidity thiab Alkalinity: 4-MethylcoMarin yog cov phenolic compound nrog acidity thiab alkalinity. Nws tuaj yeem cuam tshuam nrog cov hauv paus muaj zog (xws li sodium hydroxide) los ua cov ntsev ua haujlwm.

2. Oxidation -} Kev txo cov khoom: 4-MethylcoMarin yog qhov yooj yim oxidized cov neeg sawv cev (xws li hydrogen peroxide) rau hauv cov phenoling phenoltive phenolic derivatives. Tsis tas li ntawd, nws tuaj yeem raug txo mus rau cov phenoling phenolic derivatives los ntawm kev txo cov kev cuam tshuam xws li sodium bisulfite.

3. Electrophilicity: 4-Methylcarin yog hluav taws xob compound uas tuaj yeem ua rau nucleophilic reagents (xws li Alkylal Halides) los ua cov khoom hloov chaw.

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5. Hydrebroylationge: 4 methylcoMarin tuaj yeem npaj los ntawm hydroxylation cov tshuaj tiv thaiv ntawm Phenol. Hydroxylation feem ntau yog ib txwm ua tiav los ntawm kev rov ua kom zoo 4-metylcarin nrog sodium hydroxide (NAOH) thiab hydrogen peroxide (h2o2).

Hauv kev xaus, 4-Methylcarin yog qhov sib txuas nrog ntau cov tshuaj tiv thaiv tshuaj lom neeg, uas tuaj yeem siv rau hauv cov synthic synthesis thiab tshuaj ntsuam xyuas tshuaj lom neeg.

Cim npe nrov: Methylumbelliferone CASE 90-33-5, Tuam Tshoj chaw tsim khoom, chaw tsim khoom, Hoobkas, lag luam Wholesale, yuav, nqe, loj, rau muag