Myristyl sulfobetaine, ib qho txiaj ntsig ntau yam ntau yam thiab muaj txiaj ntsig zoo, zwm rau cov chav ua kom huv si, muaj koob meej rau lawv cov kev sib npaug ntawm kev ntxuav kom huv thiab kev ntxuav tsis huv. Nws yog muab tau los ntawm ntuj los yog cog- atoms, uas muab nws zoo nkauj {{4 4} Cov khoom lag luam.
Qhov no tshwj xeeb surfactant sib txuas ua ke ntawm pawg ammonium uas muaj kev them nyiaj tsis zoo nyob rau hauv tib lub ntsej muag, tsim kom muaj ntsev nyob rau hauv nruab nrab. No zwitterionic qhov tso cai rau nws los cuam tshuam zoo nrog ob qho hydrophobic (roj- hlub), ua rau nws zoo tagnrho rau ntau cov ntawv thov.
Ib qho ntawm nws cov ntsiab lus tseem ceeb nyob rau hauv nws cov peev xwm tsawg, ua rau kev siv tshuaj zawv plaub hau xws li cov tshuaj zawv plaub hau xws li cov tshuaj zawv plaub hau xws li cov tshuaj zawv plaub hau xws li cov tshuaj zawv plaub hau xws li cov tshuaj zawv plaub hau xws li cov tshuaj zawv plaub hau xws li cov tshuaj zawv plaub hau xws li cov tshuaj zawv plaub hau, cov khoom noj kom huv, lub ntsej muag ntxuav lub cev. Nws maj mam ntxuav daim tawv nqaij thiab plaub hau, tawm hauv lawv lub siab, thiab hydrated yam tsis muaj kev tshem tawm cov roj ntuj uas tsis muaj dej lossis ua rau muaj kev qhuav. Ib qho ntxiv, nws yog biodegradable, ib puag ncig phooj ywg, thiab tau sib haum nrog ntau ntau ntawm lwm yam khoom xyaw, txhim kho mis nyuj ruaj thiab ua haujlwm.
Tsis tas li ntawd, nws muaj peev xwm ua npuas ncauj zoo thiab yooj yim ua rau muaj kev paub zoo. Hauv chaw muaj kev muaj, nws pom cov ntawv thov nyob rau hauv cov tshuaj ntxuav tes nyuaj, thiab ua ib qho kev kho mob rau kom zoo rau cov av thiab txoj kev tswj hwm maj mam kov ntawm thaj chaw.
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Tshuaj Cov Qauv |
C19h41no3s |
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Muaj pes tsawg leej |
363.28 |
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Molecular hnyav |
363.60 |
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m/z |
363.28 (100.0%), 364.28 (20.5%), 365.28 (4.5%), 365.29 (2.0%) |
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Kev Ntsuam Xyuas |
C, 62.76; H, 11.37; N, 3.85; O, 13.20; S, 8.82 |
Biochemical thiab Kev Tshawb Nrhiav Kev Tshawb Fawb
Membrane protein solubilization thiab purification:
- Feem ntau siv nyob rau hauv sububilization thiab purification ntawm membrane - khi cov protein thiab lwm yam dab tsi hydrophobic biomolecules. Nws Amphiphilic Xwm nrog kev cuam tshuam ntawm Lipid Whip, tso cai cov protein kom raug tso tawm rau hauv kev daws teeb meem thaum tswj lawv cov qauv haiv neeg thiab ua haujlwm.
Electrophoresis thiab chromatography:
- Hauv Electrophorises thiab chromataphy sim, nws ua raws li kev ua tau zoo ntxiv, txhim kho kev sib cais thiab daws teeb meem ntawm biomolecules.
Tshuaj pleev ib ce thiab cov khoom siv saib xyuas tus kheej
Vim yog nws cov khoom siv me me thiab ua npuas dej zoo heev, nws pom cov ntawv thov hauv cov tshuaj pleev ib ce ntau yam xws li cov tshuaj pleev ib ce thiab cov khoom siv saib xyuas tus kheej xws li ntxuav lub cev, thiab ntxuav lub ntsej muag kom huv. Nws pab tsim cov txiv neej nplua nuj thiab qab zib ua ob txhais cov txiv ntoo thaum ua qhov maj mam rau ntawm daim tawv nqaij thiab plaub hau.
Kws Tshuaj Kho Mob
Nyob rau hauv lub tshuaj ntsuam kws tshuaj, nws tau siv nyob rau hauv kev tsim cov tshuaj thiab cov tshuaj siv tshuaj yeeb. Nws lub peev xwm los cuam tshuam nrog cov ntaub qhwv cell ua rau nws muaj peev xwm sib tw rau kev txhim kho cov xyoob ntoo thiab phiaj ua haujlwm ntawm qee yam tshuaj.
Muaj kev tu thiab tshuaj ntxuav
Nws zoo tshaj surfactant cov khoom ua rau nws haum rau siv hauv kev lag luam tu, uas nws pab tshem tawm cov stains nyuaj thiab roj. Nws tuaj yeem muab tso rau hauv cov tshuaj ntxuav tes rau cov chaw nyuaj, textiles, thiab kev siv hlau ntxuav cov ntawv thov.
Emulsifiers thiab stabilizers
Hauv cov khoom noj khoom haus thiab dej haus hauv dej, nws tuaj yeem siv ua emulsifier thiab stabilizer kom pab ua kom muaj kev sib xws thiab kev ntxhib los mos ntawm ntau yam khoom. Nws tseem tuaj yeem txhim kho cov dispersion ntawm flavorings thiab xim.
Lwm Cov Ntawv Thov
- Roj thiab Roj Kev Lag Luam: Siv los ua cov av nkos ntxiv los txhim kho cov kua dej drilling.
- Textile Kev Lag Luam Textile: Nws tuaj yeem ua haujlwm ua tus neeg sawv cev fiber ntau los txhim kho lub wettability thiab tuag ntawm textiles.
Hais Txog Cov Tshuaj Tiv Thaiv
Cov tshuaj tiv thaiv yeeb tshuaj, tseem hu ua cov tshuaj kho mob uas tau tawm tsam, sawv cev rau cov chav kawm uas muaj cov qauv kev sib txuam lossis cov kab mob cancer txuam nrog kev mob qog noj ntshav lossis lwm yam kab mob. Cov tshuaj no tau tsim los cuam tshuam nrog lossis thaiv cov haujlwm ntawm cov lwg me me lossis cov hlwb koom nrog kev kis kab mob, yog ua tiav cov hom phiaj kho.
Cov tshuaj uas tsom tau yog cov tshuaj lom neeg nrog cov hom phiaj tshwj xeeb. Lawv txoj ntsiab cai yog Akin rau cov kev taw qhia precision system ntawm cov cuaj luaj lossis cov hom phiaj molecular) yog xaiv tau cov hom phiaj hlwb) yog xaiv tau cov hom phiaj hlwb) yog kev tawm tsam cov hlwb, kev ua kom zoo nkauj rau cov hlwb ib txwm muaj.
Me Molecule Hom Tshuaj
Cov no feem ntau tswj hwm qhov ncauj lus. Piv txwv li imatinib, siv los kho cov qog ua pa, thiab Gefitinib, uas cov phiaj xwm EGFr hloov hauv tsis {1} Cov mob ntsws me me cancer me me.
Monoclonal Antibodies
Muab tshuaj tiv thaiv los ntawm kev txhaj tshuaj, cov tshuaj no tshwj xeeb rau cov khoom siv rau cov protein lossis receptors rau saum npoo ntawm lub hlwb. Piv txwv li, trastuzumab yog siv los kho nws-2 tus mob cancer mis.
Mechanism ntawm Kev Ua
Inhibiting Cellular Cov Phiaj Xwm Transduction Kev Hloov Pathways
Thaiv cov phiajcim tseem ceeb rau cov qog nqaij thiab muaj sia nyob.
Thaiv cov qog angiogenesis
Tiv thaiv kev tsim ntawm cov ntshav tshiab uas muab cov qog uas tau muab cov qog thiab cov pa roj oxygen.
Modulating lub cev tiv thaiv kab mob
Txhim kho lub zog tiv thaiv kab mob qog nqaij hlav cancer.
Qhov Zoo
Yam tshwj xeeb
Lawv precisely hom qog hlwb los yog kab mob -}} muaj cov lwg me me, txo kev puas tsuaj rau cov hlwb zoo.
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Txo cov kev mob tshwm sim
Vim yog lawv qhov tshwj xeeb, cov tshuaj muaj peev xwm muaj tsawg dua thiab muaj kev mob tshwm sim tsawg dua li cov tshuaj kho mob ib txwm.
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Nce kev ua tau zoo
Los ntawm kev tsom cov tshuaj tua tsiaj tshwj xeeb, cov tshuaj tsom tau ntau zaus muaj kev cuam tshuam ntau dua hauv kev cuam tshuam ntawm kev muaj sia nyob ntawm lub luag haujlwm ntawm tes thiab muaj sia nyob.
03
Kev Kho Mob Ib Leeg
Kev txhim kho cov tshuaj uas tau ua kom muaj kev kho mob, pub tus kws kho mob kom cov kws kho mob txhawm rau kho cov neeg mob cov qauv molecular.
04
Kev tswj hwm kev tiv thaiv
Qee cov tshuaj tiv thaiv tuaj yeem qeeb lossis rov qab tshuaj tiv thaiv, ntev lub sijhawm ntawm kev kho mob zoo.
05
Cov tshuaj tiv thaiv sawv cev sawv cev rau qhov kev nce qib tseem ceeb hauv kev kho mob cancer thiab lwm txoj kab mob. Los ntawm precisely tsom molecular lossis cov txheej txheem cell txuam nrog tus kab mob, lawv tau nce cov kev mob tshwm sim, thiab txhim kho kev phiv tshuaj rau cov khoom siv kho tshuaj ib txwm muaj. Txawm li cas los xij, lawv siv yuav tsum tau xaiv cov neeg mob xaiv, thiab kev saib xyuas txuas ntxiv, thiab kev ntsuam xyuas txuas ntxiv mus txuas ntxiv mus ntxiv cov lus teb.
Myristyl sulfobetaineKev tshawb nrhiav thaum ntxov ntxov rau nws cov ntawv teev kev kawm nyob rau hauv kev kawm biological, tshwj xeeb hauv membilization thiab purification ntawm cov protein thiab lwm yam khoom siv hydrophobic biomolecules. Cov kws tshawb fawb tau siv lub peev xwm hauv electrophorises thiab chromatographesis thiab chromatographis, txuas ntxiv piv txwv tias nws cov nqi hluav taws xob hauv kev kuaj sim. Sij hawm dhau los, cov kws tshawb nrhiav tau txuas ntxiv ua kom zoo dua nws siv hauv ntau txoj kev sim ua, txhim kho nws cov kev ua haujlwm thiab muaj kev ntseeg tau.
Muaj kev txaus siab rau kev nthuav dav cov ntawv thov dhau ntawm kev tshawb fawb yooj yim tshaj plaws, muaj peev xwm rau hauv kev kuaj mob thiab kho kom zoo. Tshawb nrhiav rau nws lub luag haujlwm hauv cov khoom siv tshuaj tsis huv thiab raws li lub stabilizer nyob rau hauv biological formulations yog txuas ntxiv. Kev nce qib hauv kev siv tshuaj chemtectic yuav ua rau kev txhim kho ntawmmyristyl sulfobetainederivatives nrog txawm ntau cov khoom tshwj xeeb, ua raws li cov kev tshawb fawb xav tau.
Cov tshuaj tiv thaiv tsis zoo
Myristyl sulfobetaine(CAS naj npawb 14933 {- 09 -}}}}}}} Nws cov qauv molecular muaj ntev {{Chain alkyl pawg (- yog li ⁻ (ch3), uas end (ch3), uas end (ch3), uas end (ch3), uas end (ch3), uas end⁺ end am am), thiab cov end), thiab tej zaum cov kev pheej hmoo noj qab haus huv thiab ib puag ncig.
Cov tawv nqaij Irritation mechanismism thiab chaw kho mob tshwm sim
Alkyl saw ntawm myristyl sulfobetaine tuaj yeem nkag mus rau hauv cov tawv nqaij ntawm daim tawv nqaij daim tawv nqaij daim tawv nqaij daim tawv nqaij daim tawv nqaij daim tawv nqaij daim tawv nqaij daim tawv nqaij daim tawv nqaij daim tawv nqaij daim tawv nqaij daim tawv nqaij daim tawv nqaij daim tawv nqaij daim tawv nqaij daim tawv nqaij daim tawv nqaij daim tawv nqaij daim tawv nqaij li cas thiaj nkag mus rau hauv daim tawv nqaij phospholip hauv cov membrane Nyob rau tib lub sijhawm, nws cov pab pawg neeg ammonium tuaj yeem khi cov pab pawg carboxyl hauv cov qauv nqaij tawv, thiab cov qauv protein, thiab ua rau muaj cov protein. Cov chaw kho mob tshwm sim muaj xws li:
Kev npau taws: Tsis pub dhau 1-24 teev tom qab hu, liab, thiab papules tshwm sim nrog cov chaw ntshiab xws li sab nraub qaum thiab caj npab.
Kev ua phem rau kev ua phem: ntev lub sij hawm rov qab raug (xws li kev ua hauj lwm ua hauj lwm) yuav ua rau qhuav, tawg tawv nqaij, nrog cov khaus khaus khaus.
Mucosal khaus thiab kev pheej hmoo pheej hmoo
Txawm hais tias myristyl sulfobetaine tau txo qis kev txhua yam zoo li cov pab pawg ntawm cov nqaij nyuj Cov chaw kho mob tshwm sim muaj xws li:
Qhov muag khaus: thaum kev hais plaub yog ntau dua lossis sib npaug ntawm 1%, nws tuaj yeem ua rau kev sib tw, thiab muaj mob heev, pob txhaselelial peeling yuav tshwm sim.
Ua pa nyuaj: nqus tau Aerosols tuaj yeem ua rau cov neeg mob ua kom mob siab, thiab ntshav ntswg, thiab hawb pob cov tsos mob cov tsos mob tuaj yeem ua phem.
Kev sim cov ntaub ntawv: daim tawv nqaij luav puas tau pom tias ntawm 0.5%, cov qhab nia ntawm 24-teev (0-4 Tab sis ntawm lub concentration ntawm 10%, Erherhema cov qhab nia tau nce rau 2.5, ntsib cov qauv rau kev txob taus nruab nrab.
Mechanism ntawm kev raug mob qhov muag
Qhov muag puas nyhuv ntawm myristyl sulfobetaine yog feem ntau muaj feem xyuam rau nws cov kev ua si. Thaum cov kua tau nkag mus rau hauv kev sib cuag nrog qhov chaw hauv nroog, nws Alkyls tuaj yeem nkag rau hauv qhov chaw sib txuas lus (xws li cov kev sib tw sib txuas lus (xws li dovmosomes), ua rau cell detachment. Lub caij no, cov pab pawg Qiv ammonium tau khi rau cov mucins hauv lub kua muag, txo cov kua muag ua yeeb yaj kiab ruaj khov thiab exacerbating casteal qhuav.
Tsiaj Xyaum: New Zealand Dawb luav Qhov Muag Ntsuas Qhov Muag tau qhia tias tom qab 0.1 ml undiluted kua tau poob mus rau hauv lub ntsej muag sej:
1 teev: Cornal opacity mus txog qib 2 (0-4), thiab IRIS kev ntxhib los mos yog qhov muag plooj.
24 teev: tus nqi zoo ntawm pob kws flueal fluoresCein staining yog 100%, thiab opacity tseem nyob rau theem 2.
7 hnub: Tus pob ntaub caws pliav yog kho, tab sis kev caws pliav me me pom tau pom hauv txheej stromal.
Kev thab plaub ua pa thiab kev tiv thaiv kev noj qab haus huv
Lub aerosol hais ntawm myristyl sulfobetaine (particle loj<5 μ m) can deposit in the lower respiratory tract, and their surface activity can destroy the pulmonary surfactant, leading to alveolar collapse and ventilation/blood flow imbalance. At the same time, quaternary ammonium groups can activate alveolar macrophages, release inflammatory factors such as tumor necrosis factor alpha (TNF - α) and interleukin (IL-6), and trigger airway hyperresponsiveness.
Cov neeg nyob hauv cov pej xeem: Tus ntoo khaub lig - cov neeg ua haujlwm tau pom tias muaj ntau pawg neeg tswj hwm (10%), thiab siv cov tsos mob ntev dua, tus mob hnyav dua (r}}, p<0.01).
Cim npe nrov: MyRistyl sulfobetaine CAS 14933-09-6, Cov chaw muag khoom, chaw tsim khoom, Hoobkas, lag luam Wholesale, yuav, nqe, loj, loj, rau muag