N - boc-4-piperidinemethanol CAS 1238555-51-6

Shaanxi Bloom Tech Co., Ltd. yog ib qho ntawm cov neeg tsim khoom lag luam thiab cov muag khoom ntawm n {}} n} 4-piperidinemethanol CAS 123855 nyob rau hauv Suav teb. Txais tos rau kev lag luam wholesale mis siab zoo n-boc-4-piperidinemethanol CAS 1238555-51-6 kev muag ntawm no los ntawm peb lub hoobkas. Cov kev pabcuam zoo thiab tus nqi tsim nyog muaj.

N - boc-4-piperidinemethangethanolYog cov tshuaj sib txuas nrog cov mis c11h23no3. Nws zwm rau chav kawm ntawm cov organic sib txuas hu ua piperidines, uas yog cyclic amines nrog rau tus tswv cuab hauv lawv cov qauv nplhaib. Cov kab ke tshwj xeeb no cov boc (tert {{4 4}} board ntawm lub piperidinel) pab pawg txuas rau ntawm cov pa roj hmab. Cov pab pawg BOC, feem ntau siv hauv cov synthic, ua hauj lwm yog tiv thaiv pab pawg rau amines, tiv thaiv lawv kom tsis txhob muaj kev tsis xav tau.

Kev siv methhanol qhia txog kev haus cawv rau cov miv, ua kom haum rau ntau yam kev hloov tshuaj lom neeg xws li Etrerification, lossis oxidation. Cov versatility no tso cai rau nws yog ua ntej ua ntej nyob rau hauv synthesis ntawm ntau nyuaj piperidine scaffold nrog cov pab pawg ua haujlwm tshwj xeeb.

Vim nws ruaj khov thiab crystalline qhov, nws yog feem ntau ua haujlwm hauv cov khoom {}}}}}}}}}}}}}} pa taws ntawm cov tshuaj thiab cov foob pob. Nws cov khoom siv hluavtaws tau txais txiaj ntsig thiab cov yooj yim ntawm kev ntxias ntawm nws cov pab pawg ua haujlwm pab nws cov kev siv thoob plaws hauv kev tshawb fawb thiab kev lag luam. Hauv cov ntsiab lus xaus,N - boc-4-piperidinemethangethanolyog lub tsev muaj txiaj ntsig zoo hauv cov organic chemistry, muab rau ntau yam platform rau kev sib txawv ntawm cov khoom siv sib txawv.

N - boc-4-piperidinemethangethanolTau txheeb xyuas ua tus inhibitor ntawm acetylchoterase (mob), ib qho enzyme koom nrog kev rhuav tshem ntawm acetylcholine. Cov cuab yeej no ua rau nws tus neeg sib tw uas muaj peev xwm tshawb nrhiav rau hauv Alzheimer tus kab mob, qhov twg inhibiting ache tuaj yeem pab txo cov txiaj ntsig pab ntau theem hauv lub hlwb.

Acetylcholineterase (mob), tseem hu ua Colinesterase I lossis Cholinesteresase, yog ib qho tseem ceeb enzyme nyob rau hauv kev siv tshuaj lom neeg. Nws plays lub luag haujlwm tseem ceeb hauv kev hydrolysis ntawm acetylcholine, ib tug neurotransmitter uas yog qhov tseem ceeb rau kev xa tawm. Cov tshuaj tiv thaiv catchalyzed los ntawm ib ce yog: acetylcholine + dej → choline + acetate.

Ache pom feem ntau hauv cov teeb meem grey ntawm cov nqaij mos, lub cev muaj zog ntawm cov leeg pob txha, thiab cov ntshav liab. Cov enzyme no yog cim los ntawm nws qhov tshwj xeeb thiab kev ua tau zoo rau cov leeg acetylcholine, yog li sim cov hlab ntsha impectse thiab ua rau lub synaptic cleft kom rov qab mus rau nws lub xeev so.

Mob plab muaj qhov hnyav molecular ntawm kwv yees li 280 kda thiab ib qho kev coj zoo rau kev ua ib ncig 5.5. Nws muaj nyob rau hauv ntau hom ntawv, suav nrog cov uas tau muab los ntawm hluav taws xob eel, uas yog feem ntau siv hauv kev tshawb fawb. Tus enzyme yog lub hom phiaj rau ntau cov neeg tsis muaj kev tiv thaiv, uas tseem ceeb hauv kev kho mob xws li kev kho mob neurological thiab tshuaj tua kab mob neurological thiab tshuaj tua kab.

Ntxiv rau nws lub zog kev ua haujlwm, mob ib ce kuj siv hauv kev tshawb fawb organophosphorus thiab txiv hmab txiv ntoo los ntawm cov txheej txheem enzyme inhibition. Nws lub luag haujlwm hauv kev tswj hwm cov kev ua haujlwm zoo nkauj thiab nws cov kev koom tes nyob rau ntau cov txheej txheem roj ntsha ua rau mob siab tseem ceeb hauv neuroscience thiab toxicology.

Acetylcholineterase (AGE) yog tus tseem ceeb enzyme nyob rau hauv cholinerergic system, lub luag hauj lwm rau cov roj av thiab acetic acid. Ach yog ib tug neurotransmitter tseem ceeb rau kev nco, kev kawm, thiab kev txawj ntse thiab kev txawj ntse thiab kev txawj ntse. Hauv Alzheimer tus kab mob, muaj qhov txo qis hauv Ach qib vim kev poob ntawm cholinergic neurons thiab nce kev ua haujlwm ntawm ib ce.

Hauv Alzheimer tus kab mob, muaj qhov txo qis hauv theem ntawm ACH vim tias qhov ploj ntawm cholinergic neurons thiab cov haujlwm ntau dua ntawm ib ce. Cov cholinergic no yog xav tias yog ib tus thawj tsav ntawm kev txawj ntse ntawm kev txawj ntse thiab lub cim xeeb poob hauv tus kab mob.

Ahe inhibitors ua haujlwm los ntawm kev khi rau lub chaw ua haujlwm ntawm enzyme thiab tiv thaiv nws los ntawm catalyzing rhuav tshem ntawm Ach. Qhov no ua rau muaj kev nce qib nyob rau hauv cov qib ntawm synaptic cleft, qhov chaw nws tuaj yeem txuas ntxiv khi rau nws cov receptors thiab xa cov paib.

Txhim kho kev txawj ntse

 

Qib siab dua ntawm kev ua haujlwm siab dua ntawm kev ua haujlwm ntawm cholinergic signaling, ua rau kev txhim kho hauv kev nco, kev kawm, thiab mloog.

Txo cov tsos mob ntawm Alzheimer tus kab mob

 

Los ntawm kev them nyiaj rau cov cholinergic tsis txaus ntseeg, Ache inhibitors tuaj yeem pab txo cov tsos mob xws li kev poob qis, thiab kev coj tus cwj pwm tsis zoo.

Ahe Inhibitors yog cov tshuaj uas ua haujlwm los ntawm kev thaiv cov haujlwm ntawm enzyme acetylchoteresase (mob). Cov enzyme no yog lub luag haujlwm rau kev rhuav tshem cov neurotransmitter acetylcholine (Ach), uas ua lub cim xeeb uas yog qhov cim xeeb, kev kawm, thiab mloog. Los ntawm inhibiting ache, cov tshuaj no tiv thaiv kom tawg ntawm Ach, ua rau muaj kev nce qib hauv nws qib hauv synaptic cleft.

Ahe inhibitors feem ntau siv nyob rau hauv kev kho mob ntawm Alzheimer tus kab mob, ib tug neurodegenerative yam ntxwv ntawm kev txo qis hauv cholinergic neurons thiab nce kev ua si ntawm ib ce. Cov cholinergic tau pom nyob rau hauv Alzheimer tus kab mob yog xav tias yog ib tus thawj tsav ntawm kev ua kom poob siab thiab nco poob. Los ntawm kev tswj cov qib siab, mob siab tuaj yeem txhim kho kev ua haujlwm zoo thiab txo cov kev mob tshwm sim xws li lub cim xeeb tsis txaus thiab tsis meej pem.

Ob peb ache inhibitors tam sim no tau pom zoo rau kev kho mob ntawm Alzheimer tus kab mob, suav nrog ua kom tiav, Rivastigmine, thiab Galantamine. Cov tshuaj no tau pom tias muaj kev txhim kho kev txhim kho kev txhim kho hauv kev txawj ntse thiab kev ua haujlwm nyob hauv qee cov neeg mob. Txawm li cas los xij, nws yog ib qho tseem ceeb kom nco ntsoov tias Ache inhibitors tsis yog kho rau Alzheimer tus kab mob thiab tsis txhob nres qhov muaj kev loj hlob ntawm tus kab mob. Lawv feem ntau tau sau tseg ua ib feem ntawm cov phiaj xwm kho mob txhua yam uas tseem yuav suav lwm cov tshuaj, kev kho mob, thiab cov kev pab cuam pab txhawb nqa.

Hauv ib rooj plaub sim,N - boc-4-piperidinemethangethanolTau synthesized los ntawm 4 {- piperidinemethangethangethantanol thiab di- butyldicarbonate. Tshwj xeeb, 4 {- piperidinem (70ml), thiab tom qab ntawd Di-Tert-Butyllicarbonate (8.91g, 40.8mm) tau ntxiv. Cov tshuaj tiv thaiv tau muab do ntawm chav tsev kub txog 3 teev. Tom qab hais tias, cov tshuaj tiv thaiv kab mob tau nchuav rau hauv ethyl etheth (25ml a enseous daws (3 × purine Cov kua qhuav tau lim kom tshem tawm cov kom qhuav tus neeg sawv cev thiab cov khoom siv hauv qab los muab cov khoom lag luam phiaj (9.78G, Quanitative Conversion).

Kev Tshawb Fawb TxogN - boc-4-piperidinemethangethanolFeem ntau qeeb ntawm nws cov kev siv cov ntaub ntawv muaj peev xwm kho hauv neurological discorders, tshwj xeeb alzheimer tus kab mob. Los ntawm inhibiting ache, cov compound no tuaj yeem pab tswj cov qib siab hauv synaptic cleft, muaj peev xwm them rau cov cholinergic pom hauv Alzheimer cov neeg mob. Qhov no, nyob rau hauv lem, yuav ua rau kev txhim kho hauv kev txawj ntse thiab txo qis hauv cov tsos mob poob thiab kev nco qab poob.

Ntxiv mus, nws pabcuam ua kev kawm theem tseem ceeb hauv cov khoom siv hauv cov organic thiab tshuaj chemical. Nws cov qauv tshuaj muaj txiaj ntsig rau kev hloov kho ntxiv, ua rau nws muaj txiaj ntsig zoo hauv kev txhim kho cov tshuaj tshiab thiab kho cov neeg sawv cev. Cov kws tshawb nrhiav tau nquag tshawb txog nws lub peev xwm hauv synthesizing cov neeg sawv cev thiab cov moleculeative molecules nrog lub peev xwm kho.

Cim npe nrov: n - boc-4-Piperidinemethanol CAS 123855}}} boc-4-{555-51-6, chaw tsim khoom, chaw muag khoom, yuav khoom, loj, rau muag