Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm cov tuam ntxhab thiab cov muag khoom ntawm pipecolamide cas 19889-77-1 hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo siab pipecolamide cas 19889-77-1 muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Pipecolamideyog ib qho organic me me molecule compound uas muaj peev xwm ua rau lom lom. Nws cov qauv tshuaj muaj lub nplhaib piperidine raws li lub hauv paus ntsiab lus, nrog rau cov pab pawg amide covalently txuas rau lub voj voog scaffold. Cov qauv tsim tshwj xeeb no tso cai rau nws los koom nrog kev sib cuam tshuam tshwj xeeb nrog lub hom phiaj enzymes lossis receptors hauv cov kab mob lom, yog li muaj peev xwm hloov kho cov txheej txheem tseem ceeb hauv cellular xws li metabolic pathways lossis intracellular signal transduction cascades. Hauv kev tshawb fawb txog kev tshawb fawb, pipecolamide feem ntau yog siv los ua ntau yam tshuaj ntsuam xyuas los tshawb xyuas lub luag haujlwm ntawm amide -muaj cov khoom sib xyaw hauv cov kev tswj hwm neurotransmitter thiab lub zog metabolism, muab cov txiaj ntsig zoo molecular- qib kev nkag siab rau hauv cov txheej txheem ntawm lub cev thiab cov txheej txheem pathological.
Txawm hais tias nws cov ntawv thov ncaj qha tam sim no feem ntau nyob rau hauv kev soj ntsuam hauv chav kuaj thiab tseem tsis tau muab txhais ua ntau yam hauv kev kho tshuaj kho mob lossis loj- nplai kev lag luam, cov pipecolamide scaffold sawv cev rau chav tsev tseem ceeb hauv tshuaj chemistry. Nws ua haujlwm zoo li tus qauv tsim nyog rau kev tsim qauv tsim nyog thiab kev sib txuas ntawm cov khoom siv lead ua tshiab, muab lub hauv paus rau kev tsim cov molecules nrog kev txhawb nqa lub hom phiaj, txhim kho pharmacological kev ua tau zoo, thiab kho qhov zoo tshaj plaws.
|
|
|
Solubility ntawmPipecolamideyog ib qho tseem ceeb physicochemical khoom, uas yog ib qho tseem ceeb heev rau nws daim ntawv thov nyob rau hauv ntau yam kuab tshuaj thiab tom qab synthesis, sib cais, thiab purification txheej txheem.
Solubility yog hais txog lub peev xwm ntawm cov khoom ua kom yaj hauv ib qho hnyav, uas cuam tshuam los ntawm ntau yam xws li cov khoom ntawm cov khoom nws tus kheej (xws li polarity, molecular qauv, thiab lwm yam), cov khoom ntawm cov kuab tshuaj (xws li polarity, intermolecular rog, thiab lwm yam), thiab lwm yam kev mob xws li kub thiab siab. Rau nws, nws solubility feem ntau cuam tshuam los ntawm nws cov qauv molecular thiab hnyav zog.
Dej: Nws muaj tsawg solubility nyob rau hauv dej thiab belongs rau me ntsis soluble ntau. Qhov no txhais tau hais tias nyob rau hauv chav tsev kub thiab siab, tsuas yog ib qho me me tuaj yeem yaj hauv dej los ua ib qho kev daws teeb meem.
Methanol: Piv nrog rau cov dej, cov solubility ntawm methanol tau raug txhim kho, tab sis nws tseem nyob rau hauv qeb ntawm me ntsis solubility. Methanol muaj cov polarity muaj zog thiab cuam tshuam nrog nws cov qauv molecular los txhawb nws txoj kev tawg.
Lwm cov kuab tshuaj: Ntxiv rau cov dej thiab methanol, solubility hauv lwm cov kuab tshuaj kuj cuam tshuam los ntawm cov khoom hnyav.
Piv txwv li, nyob rau hauv polar solvents, vim muaj zog intermolecular kev sib cuam tshuam, solubility yuav kuj siab; Hauv cov uas tsis yog- cov kuab tshuaj polar, vim muaj kev cuam tshuam tsis zoo ntawm cov tshuaj molecular, solubility yuav tsawg. Txawm li cas los xij, cov ntaub ntawv tshwj xeeb solubility yuav tsum tau txiav txim siab raws li kev sim ntsuas.
Kub: Kub yog ib qho tseem ceeb cuam tshuam rau solubility. Feem ntau hais lus, raws li qhov kub thiab txias, lub solubility ntawm cov khoom yuav nce. Qhov no yog vim qhov nce ntawm qhov kub thiab txias nce qhov nrawm thiab qhov sib nrug ntawm cov kuab tshuaj molecules, ua kom yooj yim rau lawv cuam tshuam nrog cov kuab tshuaj molecules thiab cov kev daws teeb meem. Txawm li cas los xij, rau qee yam tshuaj, qhov kub thiab txias tuaj yeem ua rau lawv decomposition lossis lwm yam tshuaj lom neeg, yog li cuam tshuam rau lawv cov solubility.
Siab: Qhov cuam tshuam ntawm lub siab ntawm solubility yog me me, tab sis nws kuj tuaj yeem ua lub luag haujlwm hauv qee qhov xwm txheej tshwj xeeb. Piv txwv li, nyob rau hauv kev kub siab, lub zog ntawm cov kuab tshuaj molecules yuav raug txwv, yog li cuam tshuam rau lawv solubility.
Solvent Properties: Cov khoom ntawm cov kuab tshuaj muaj feem cuam tshuam rau kev solubility. Polar solvents feem ntau yog yooj yim rau yaj polar solutes, thaum uas tsis yog -polar solvents yog yooj yim rau dissolve tsis yog -polar solutes. Tsis tas li ntawd, yam xws li qhov loj me, cov duab, thiab lub zog ntawm cov kuab tshuaj tuaj yeem cuam tshuam rau lawv cov solubility.
Kev nkag siab txog kev solubility yog qhov tseem ceeb heev rau nws cov ntawv thov hauv tshuaj synthesis, kev npaj tshuaj, cov ntaub ntawv tshawb fawb, thiab lwm yam. Piv txwv li, nyob rau hauv cov txheej txheem ntawm kev npaj tshuaj, nws yog ib qhov tsim nyog los xaiv cov kuab tshuaj uas tsim nyog thiab cov txheej txheem npaj raws li kev solubility ntawm cov tshuaj; Nyob rau hauv tshuaj synthesis, nkag siab txog cov solubility ntawm reactants pab optimize cov tshuaj tiv thaiv tej yam kev mob thiab txhim kho cov tshuaj tiv thaiv efficiency; Hauv cov ntaub ntawv science, solubility ncaj qha cuam tshuam rau kev npaj thiab ua cov ntaub ntawv.
Lub stability ntawmPipecolamideyog nws lub peev xwm los tswj nws cov qauv tshuaj thiab cov khoom tsis hloov pauv raws li ntau yam xwm txheej.
Feem ntau, nws ruaj khov thiab tsis muaj tshuaj lom neeg cov tshuaj tiv thaiv uas yuav ua rau decomposition lossis deterioration. Qhov no txhais tau hais tias nyob rau hauv ib txwm cia thiab siv tej yam kev mob, nws cov qauv tshuaj muaj peev xwm nyob twj ywm unchanged, yog li khaws cia nws cov khoom qub thiab kev ua haujlwm. Txawm li cas los xij, nws yuav tsum tau muab sau tseg tias txawm hais tias nws ruaj khov, decomposition lossis tshuaj lom neeg cov tshuaj tiv thaiv tseem tuaj yeem tshwm sim nyob rau hauv qee qhov xwm txheej (xws li kub, muaj zog acid, muaj zog alkali, thiab lwm yam).
Lub cev ruaj khov yog hais txog lub peev xwm ntawm ib yam khoom uas tsis hloov pauv hauv nws lub cev (xws li khoom, kua, lossis roj). Rau nws, nws lub cev ruaj khov feem ntau cuam tshuam los ntawm ib puag ncig xws li kub, av noo, thiab lub teeb. Nyob rau hauv chav tsev kub thiab siab, nws muaj nyob rau hauv cov ntaub ntawv thiab muaj ib tug tej yam kev mob ntawm hardness thiab stability. Txawm li cas los xij, nyob rau hauv qhov kub thiab txias ib puag ncig, nws lub cev daim ntawv tuaj yeem hloov pauv xws li deliquescence, melting, thiab lwm yam. Tsis tas li ntawd, lub teeb raug rau lub teeb ntev kuj yuav ua rau muaj kev cuam tshuam photochemical, yog li cuam tshuam rau nws lub cev ruaj khov.
Txhawm rau kom muaj kev ruaj ntseg, yuav tsum tau txais cov kev cai cia tsim nyog. Feem ntau hais lus, nws yuav tsum tau muab cia rau hauv qhov chaw qhuav, txias, qhov cua zoo, kom deb ntawm tshav ntuj ncaj qha thiab qhov chaw kub kub. Nyob rau tib lub sijhawm, kev sib cuag nrog cov khoom tsis zoo xws li cov kua qaub uas muaj zog thiab cov hauv paus yuav tsum zam kom tsis txhob muaj tshuaj lom neeg uas tuaj yeem ua rau decomposition. Tsis tas li ntawd, txhawm rau ua kom nws lub sijhawm ntev - ruaj khov, nws tseem yuav tsum tau ua tib zoo saib xyuas cov av noo thiab oxygen concentration ntawm qhov chaw cia.
Txhawm rau ntsuas kev ruaj ntseg, yuav tsum muaj kev sim ntau yam. Cov kev ntsuam xyuas no yuav suav nrog kev ntsuas thermal stability, kuaj photostability, vaum stability testing, thiab lwm yam. Los ntawm cov kev ntsuam xyuas no, kev ruaj ntseg kev ua tau zoo nyob rau hauv cov xwm txheej sib txawv tuaj yeem nkag siab, muab kev tshawb fawb hauv paus rau nws khaws cia thiab siv.
Cov yam ntxwv uas yuav cuam tshuam rau kev ruaj ntseg xws li kub, av noo, lub teeb, pH, thiab lwm yam. Ntawm lawv, qhov kub thiab txias yog ib qho tseem ceeb cuam tshuam rau kev ruaj ntseg. Qhov kub thiab txias yuav ua rau kom muaj kev sib cuam tshuam ntawm intermolecular, yog li txhawb qhov tshwm sim ntawm cov tshuaj tiv thaiv decomposition. Cov av noo tuaj yeem cuam tshuam rau hygroscopicity ntawm 2-piperidinecarboxamide, yog li cuam tshuam rau nws lub cev daim ntawv thiab kev ruaj ntseg. Lub teeb raug tuaj yeem ua rau muaj kev cuam tshuam photochemical, ua rau muaj kev hloov pauv hauv cov qauv tshuaj. Cov acidity lossis alkalinity tuaj yeem cuam tshuam rau nws cov qauv molecular thiab lub xeev them nqi, yog li cuam tshuam rau nws txoj kev ruaj ntseg.
Lub reactivity ntawmPipecolamideFeem ntau suav nrog nws qhov kev ua tau zoo hauv ntau yam tshuaj tiv thaiv, suav nrog nws cov tshuaj tiv thaiv nrog lwm cov tebchaw, cov tshuaj tiv thaiv, thiab cov khoom siv tshuaj tiv thaiv.
Basic reactivity
Raws li cov organic compound, nws muaj qee yam reactivity. Cov pab pawg amide (- CONH2) nyob rau hauv nws cov qauv molecular tso cai rau nws koom nrog ntau yam tshuaj tiv thaiv nyob rau hauv tej yam kev mob, xws li hydrolysis, acylation, amination, thiab lwm yam. Meanwhile, raws li ib tug rau lub koom haum nplhaib qauv, lub nplhaib pyridine kuj muaj tej yam stability thiab cov tshuaj tiv thaiv selectivity.
Synthetic tshuaj tiv thaiv
Cov tshuaj tiv thaiv Formylation:
Nws tuaj yeem ua ke los ntawm reacting 2-piperidine amine nrog formic acid. Cov tshuaj tiv thaiv no feem ntau yog ua nyob rau hauv acidic tej yam kev mob, qhov twg formic acid reacts nrog cov amino pawg ntawm 2-piperidine amine los tsim cov tshuaj thiab dej. Txoj kev tshuaj tiv thaiv no yog qhov yooj yim thiab yog ib txoj hauv kev los npaj 2-piperidinecarboxamide.
Lwm cov txheej txheem synthesis:
Ntxiv nrog rau cov tshuaj tiv thaiv formylation, cov tshuaj no kuj tuaj yeem tsim los ntawm lwm txoj hauv kev, xws li cov tshuaj tiv thaiv amidation siv 2-piperidinecarboxylic acid. Kev xaiv ntawm cov txheej txheem no nyob ntawm cov yam ntxwv xws li cov xwm txheej tshwj xeeb thiab qhov xav tau purity ntawm cov khoom.
Reactivity nrog lwm cov tebchaw
Cov tshuaj tiv thaiv oxidants:
Cov tshuaj tiv thaiv oxidation yuav tshwm sim thaum sib cuag nrog oxidants, tsim cov khoom decomposition xws li carbon monoxide, carbon dioxide, thiab nitrogen oxides. Yog li ntawd, kev sib cuag nrog oxidants yuav tsum tau zam thaum lub sij hawm cia thiab siv.
Cov tshuaj tiv thaiv acid:
Hydrolysis cov tshuaj tiv thaiv yuav tshwm sim nyob rau hauv acidic tej yam kev mob, tsim cov kua qaub thiab amines. Cov tshuaj tiv thaiv no yuav muaj txiaj ntsig zoo hauv kev npaj ntawm lwm cov tebchaw lossis kev txheeb xyuas cov qauv.
Reaction nrog alkali:
Nyob rau hauv cov xwm txheej alkaline, cov tshuaj tiv thaiv deprotonation tuaj yeem tshwm sim, tsim cov anions sib xws. Cov tshuaj tiv thaiv no yuav muaj qhov cuam tshuam loj hauv cov txheej txheem xws li kev sib pauv ion thiab rho tawm.
Kev cuam tshuam ntawm cov tshuaj tiv thaiv
Kub:
Qhov kub thiab txias yog qhov tseem ceeb cuam tshuam rau tus nqi thiab kev xaiv ntawm cov tshuaj tiv thaiv. Rau cov tshuaj tiv thaiv uas cuam tshuam nrog 2-piperidinecarboxamide, qhov kub thiab txias tuaj yeem nce cov tshuaj tiv thaiv thiab cov khoom purity. Txawm li cas los xij, qhov kub thiab txias heev tuaj yeem ua rau muaj qhov tshwm sim ntawm cov tshuaj tiv thaiv sab nraud lossis cov khoom tawg.
Solvent:
Kev xaiv cov kuab tshuaj muaj feem cuam tshuam rau kev nce qib ntawm cov tshuaj tiv thaiv. Cov kuab tshuaj sib txawv tuaj yeem cuam tshuam tus nqi tshuaj tiv thaiv, kev xaiv, thiab cov khoom lag luam. Yog li ntawd, thaum xaiv cov kuab tshuaj, nws yog ib qho tsim nyog yuav tsum tau ua tib zoo xav txog yam xws li polarity, solubility, thiab toxicity ntawm cov kuab tshuaj.
Kev koom tes hauv kev kho mob
Tam sim no, nrog rau qhov tshwm sim siab ntawm cov kab mob neurodegenerative thiab metabolic syndrome, kev tshawb fawb tshuaj thiab kev txhim kho yog ua kom nws hloov mus rau ntau yam - lub hom phiaj thiab cov lus qhia meej. Pipecolamide (2-piperidine formamide), raws li piperidine derivative nrog cov qauv tshuaj tshwj xeeb, tau maj mam dhau los ua kev tshawb fawb hotspot nyob rau hauv cov teb ntawm Alzheimer's kab mob (AD), ntshav qab zib thiab rog, ua tsaug rau nws ob lub peev xwm ntawm neuroprotection thiab metabolic regulation.
Neuroprotection: Los ntawm Mechanism Breakthrough to Clinical Transformation
Cov txheej txheem tseem ceeb ntawm cov kab mob neurodegenerative muaj ntau txoj hauv kev xws li glutamate excitotoxicity, oxidative stress, calcium overload thiab inflammatory teb. Pipecolamide qhia txog cov teebmeem neuroprotective tseem ceeb los ntawm ntau yam - phiaj xwm ua haujlwm:
Glutamate receptor antagonism
Raws li tsis yog -kev sib tw glutamate receptor antagonist, Pipecolamide tuaj yeem cuam tshuam qhov ua kom ntau dhau ntawm NMDA thiab AMPA receptors, txo cov calcium ntau dhau ntawm cov cell, thiab thaiv cov tshuaj tiv thaiv excitotoxic cascade. Cov txheej txheem no zoo ib yam li Memantine, tab sis kev sim tsiaj tau pom tias nws lub qhov rais neuroprotective ntev dua thiab nws tsis muaj kev paub txog kev cuam tshuam ntawm Memantine.
Antioxidant kev nyuaj siab
Pipecolamide txhim kho lub peev xwm antioxidant ntawm cov hlwb los ntawm kev ua kom Nrf2/ARE txoj hauv kev thiab txhim kho kev qhia ntawm heme oxygenase-1 (HO-1) thiab NAD(P) H-quinone oxidoreductase-1 (NQO-1). Hauv AD qauv nas, nws tuaj yeem txo qib ntawm 8-hydroxydeoxyguanosine (8-OHdG) hauv hippocampus los ntawm 32%, cuam tshuam rau kev poob ntawm neuronal.
Anti-kev tiv thaiv kab mob thiab kev tiv thaiv kab mob
Pipecolamide inhibits kev ua kom microglia thiab txo cov kev tso tawm ntawm pro- mob xws li TNF- thiab IL-1 . Hauv Parkinson tus kab mob, nws txo CD4+ T cell infiltration hauv substantia nigra los ntawm 45% thiab ua rau kom muaj sia nyob tus nqi ntawm dopaminergic 8%.
Kev nce qib hauv kev hloov kho kho mob
Hauv 2025, Pipecolamide tau nkag mus rau theem thib ob ntawm AD kev sim tshuaj ntsuam xyuas (NCT05678912), ua 18-hloov tshawb nrhiav tshuaj rau cov neeg mob uas muaj kev paub tsis meej (MCI). Cov ntaub ntawv ua ntej qhia tau hais tias 200mg ib hnub koob tshuaj pab pawg txhim kho los ntawm 1.8 cov ntsiab lus hauv ADAS-Cog qhab nia piv nrog cov hauv paus (p<0.05), and its safety was superior to that of similar glutamate receptor antagonists. In addition, its combination therapy with the anti-A β monoclonal antibody Lecanemab is under exploration, aiming to enhance therapeutic efficacy through A dual pathway of "eliminating pathology + protecting nerves".
Txoj Cai Metabolic: Los ntawm Lub Zog Homeostasis mus rau Kev Tiv Thaiv Kab Mob
Metabolic imbalance yog qhov tseem ceeb ntawm kev mob ntshav qab zib, rog rog thiab NAFLD. Pipecolamide ua tiav ntau- theem kev tswj hwm metabolic los ntawm kev ua kom txoj hauv kev AMPK:
Glucose metabolism
Txhawb nqa tsis yog -insulin- nyob ntawm cov piam thaj hauv cov leeg pob txha thiab inhibits hepatic gluconeogenesis. Hauv hom 2 mob ntshav qab zib mellitus qauv nas, nws tuaj yeem txo cov ntshav qabzib sai ntawm 22% thiab txo qis glycated hemoglobin (HbA1c) los ntawm 1.1 feem pua cov ntsiab lus, nrog rau cov txiaj ntsig piv rau metformin.
Lipid metabolism
inhibits qhov kev ua ntawm fatty acid synthase (FASN) thiab txo lipid deposition nyob rau hauv daim siab. Hauv lub siab hlwb ntawm cov neeg mob uas muaj NAFLD, Pipecolamide txo cov ntsiab lus triglyceride los ntawm 37% thiab ib txhij txhawb kev qhia ntawm fatty acid oxidation -cov noob caj noob ces (xws li PPAR thiab CPT1A).
Kev ntsuas hluav taws xob
Nyob rau hauv cov xwm txheej ntawm qhov tsawg ATP / ADP piv, Pipecolamide tswj cellular zog homeostasis los ntawm activating AMPK, inhibiting anabolism (xws li protein thiab lipid synthesis), thiab txhawb catabolism (xws li fatty acid oxidation).
Clinical application prospects
Hauv xyoo 2025, Pipecolamide tau pib qhov kev sim tshuaj Phase III (NCT05789023) rau cov kab mob metabolic, tshawb nrhiav cov txiaj ntsig zoo ntawm "kev tswj hwm metabolic + tiv thaiv- mob" ua ke nrog Semaglutide. Kev soj ntsuam ib ntus tau pom tias qhov hnyav ntawm cov neeg mob hauv pab pawg kho mob sib xyaw ua ke tau txo qis los ntawm 8.2% piv nrog lub hauv paus, lub duav ncig qis dua 5.1cm, thiab kev txhim kho ntawm insulin rhiab heev (HOMA{7}}IR) mus txog 34%, uas yog qhov zoo dua li ntawm pawg monotherapy.
R&d Cov Kev Sib Tw thiab Cov Lus Qhia Yav Tom Ntej
Txawm hais tias Pipecolamide muaj kev cia siab rau yav tom ntej, nws txoj kev tshawb fawb thiab kev loj hlob tseem ntsib ntau yam teeb meem:
Ntshav-b hlwb barrier penetrability:Nws yog ib qho tsim nyog los ua kom cov concentration hauv lub hlwb los ntawm nanocarriers lossis prodrug tsim.
Ntev -kev nyab xeeb lub sij hawm:Kev soj ntsuam ntxiv yog xav tau ntawm nws cov teeb meem metabolic ntawm ob lub raum thiab cov tshuaj muaj peev xwm sib cuam tshuam.
Cov tshuaj ib leeg:Los ntawm kev sib txuas ntawm APOEε4 genotype lossis plasma p-tau217 biomarker, kev kho mob stratified yog tiav.
Nyob rau hauv lub neej yav tom ntej, Pipecolamide yuav tsum ceev nws cov txheej txheem kev lag luam los ntawm "repurposing ntawm cov tshuaj qub" lub tswv yim. Piv txwv li, nws cov txheej txheem tshuaj lom neeg zoo sib xws rau cov tshuaj tiv thaiv kev ntxhov siab mirtazapine qhia tias nws muaj peev xwm siv tau hauv cov tsos mob neuropsychiatric xws li AD agitation. Tsis tas li ntawd, kev tshawb fawb metabolomics tau nthuav tawm cov txheej txheem tshiab hauv kev tswj hwm lub plab microbiota, muab lub hauv paus rau kev txhim kho microbiota-tus tswv co- cov phiaj xwm kho.
Los ntawm kev tiv thaiv neuroprotection mus rau kev tswj hwm metabolic, Pipecolamide tab tom hloov kho cov kab mob kev kho mob nrog nws qhov zoo ntawm "ntau txoj hauv kev, tsis muaj tshuaj lom, thiab qhov qhia dav dav". Nrog 12 AD cov tshuaj nkag mus rau theem III kev sim hauv xyoo 2025 thiab kev nce qib ntawm tag nrho - kev tswj hwm ntawm "kev tiv thaiv - kev kho mob - kev kho mob" hauv thaj tsam ntawm cov kab mob metabolic, Pipecolamide xav tias yuav dhau los ua tus sawv cev tseem ceeb ntawm cov tiam tom ntej ntawm neurometabolic regulators, nqa ntau lab kev cia siab rau cov neeg mob thoob ntiaj teb.
Cim npe nrov: pipecolamide cas 19889-77-1, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom