Propylthiouracil Hmoov(PTU), cov npe khoom siv {{}}}}} {} 51-52-5 Nws yog feem ntau yog dawb crystalline khoom. Nws tuaj yeem muaj nyob hauv daim ntawv ntawm cov muaju lossis hmoov. Qes solubility hauv dej. Nws yog qhov yooj yim rau yaj hauv cov kuab tshuaj organic xws li ethanol, ether, thiab acetic acid. Nws yog ib tug thiouracil sib xyaw nrog cov khoom siv tshuaj uas tawm tsam hyperthyroidism. Nws ua haujlwm los ntawm inhibiting synthesis ntawm cov thyroid hormones. Los ntawm inhibiting peroxidase systems nyob rau hauv lub ntsws caj pas, lub iodization ntawm tyrosine hauv cov thyroid gorroses hauv cov phau thyroid hormones thormoid.
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Tshuaj Cov Qauv |
C7h10N2os |
|
Muaj pes tsawg leej |
170 |
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Molecular hnyav |
170 |
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m/z |
170 (100.0%), 171 (7.6%), 172 (4.5%) |
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Kev Ntsuam Xyuas |
C, 49.39; H, 5.92; N, 16.46; O, 9.40; S, 18.83 |
Propylthiouracil siv
(1) Kev kho mob ntawm hyperthyroidism: Hyperthyroidism yog qhov tshaj ntawm cov thyroid cov tshuaj hormones, qhia kev ua yeeb yam, endocrine thiab lwm yam tsos mob.Propylthiouracil Hmoovyog ib hom tshuaj uas muaj los kho hyperthyroidism. Nws txo cov thyroid hormones los ntawm kev ua cov yeeb yam saum toj no, yog li tswj cov txiaj ntsig ntawm cov txiaj ntsig zoo thiab txo cov tsos mob ntawm hyperthyroidism.
(2) Kev kho cua daj cua dub yog ib qho tsawg kawg nkaus, mob hnyav, uas yog ib txwm muaj rau cov neeg mob hyperthyroidism. Thaum ptu induces ib qib tsawg, nws kuj tuaj yeem txo cov kev tso tawm ntau dhau ntawm thyroxine.
(3) Kev kho mob ntawm hypothyroidism: Hypothyroidism yog cov tsis muaj cov qog ua synthesized los ntawm cov tsos mob ntawm lub zog xws li txo lub zog ntawm lub cev thiab qeeb metabolism. PTU yog tsawg dua hauv kev kho hypothyroidism vim nws tsis nce thyroxine synthesis.
(4) Kev Kho Mob ntawm Graves Tus Kab Mob Thiab Autoimmune thyroiditis: PTU tuaj yeem siv tau los kho cov ntxa 'thiab auternatitis ua rau lub cev tiv thaiv cov qog ua lub qog ua cov thyroid caj pas.
Propylthiouracil Hmoov(PTU) yog cov tshuaj siv dav hauv cov thyroid kho lossis kho cov hyperthyroidism, thiab cov qauv hluavtaws ntau yam tau tsim. Kab lus no yuav qhia qee cov qauv tseem ceeb dua.
Ua ntej, ib qho yooj yim propylthiouracil ptu synthesis txoj kev tau qhia. Txoj kev no tau txais Ethanolyllthiouracil los ntawm cov tshuaj tiv thaiv ntawm ThanaminoAmINL Chloride thiab Isopropanol, thiab tom qab ntawd tau PTU los ntawm kev ua kom viurcanization.
1. Khoom cua ntawm eethanolylliourthioourcil los ntawm cov tshuaj tiv thaiv ntawm thioamino acid chloride thiab isopropanol
Siv cov chloride thiab isopropanol yog cov ntaub ntawv raw, ethanolyllthiouracil tuaj yeem tau los ntawm cov tshuaj tiv thaiv hauv qab no:
Scl2 + 2C3H7Oh + nh3 → C3H7NHCS2Cl + 3 h2O
C3H7Nhcs2Cl + naoh → c3H7Nhcs2Na + hcl
C3H7Nhcs2Na + i2 → C3H7Nhc (s) sch2Ch2oh + nai
Hauv qhov kev tawm tsam no, thanoaminoInineryl chloride reacts nrog isoPropanol los tsim cov alkalics2NS2na, thiab dhau los ntawm cov kev hloov pauv hydrogen ntau, ethanolylliourcil tau txais.
2. Volcanization cov tshuaj tiv thaiv los ua ke PTU:
Tom qab tau txais ethanolyllthioouracil, ptu propylthiouracil tuaj yeem tau los ntawm sulfidation kev tawm tsam. Vulcanization kev phiv tshuaj siv Mercaptans lossis Sulfites ua vulcanizing cov neeg sawv cev los tsim ib tus neeg Sulphur-Sulpur Bond nyob rau hauv lub lwg me me.
Ntawm no yog ib qho ntawm cov qauv hluavtaws:
C3H7Nhc (s) sch2Ch2Oh + h2S → C3H7Nhc (s) sch3 + H2O
C3H7Nhc (s) sch3 + I2 → C7H8N2OS + Hi
Nyob rau hauv cov tshuaj tiv thaiv no, ethanolylliourcil reacts nrog H2s los ua kom muaj sulfurized ethanolyl, uas yog reacted nrog I2 kom tau txais PTU.
Ntxiv rau cov hau kev tau piav qhia saum toj no, muaj ntau txoj hauv kev los ua kePropylthiouracil Hmoov, xws li:
3. Ob chav tshuaj tiv thaiv hluav taws xob:
Cov txheej txheem yog cov synthesis muaj txiaj ntsig zoo uas kho cov nitrobenzene thiab acetone nrog tetrahydrofuran thiab txog li 3% cesium chloride lossis zirconium chloride. Lub intermediates tsim los ntawm cov tshuaj tiv thaiv tau dhau los txo mus rau lub amino rings rau synthesis ntawm PTU.
4. Ntau qib synthesis:
Lub synthesis pib nrog 5-}} sulfonyluracil. Ob pab pawg sulfruryL yog txo qis rau cov pab pawg txo los ntawm kev txo qis cov tshuaj lom neeg thiab txo nrog tus neeg sawv cev unitionary. Brunswick Acid Chloride (BZCl) tau siv los ua kom tau ib pawg thib peb methylthio, thiab thaum kawg acetone (AC2O) rau kev ua kom muaj txiaj ntsig.
Hauv kev xaus, ptu yog cov tshuaj yooj yim los ua ke. Txawm hais tias muaj ntau hom hluavtaws, lub hom phiaj kawg yog muab cov pab pawg thioettic thiab cov amino thiab cov tshuaj uas xav tau ib qho kev siv tshwj xeeb.
Pharmacological cuam tshuam
PTU belongs rau lub thiol metionsine chav kawm, uas yog ib qho tshuaj uas tuaj yeem cuam tshuam cov khoom siv cov thyroid hormones los ntawm cov thyroid caj pas. Nws txo cov thyroid muaj nuj nqi los ntawm:
(1) Inhibition ntawm cov thyroid peroxidase (tpo): PTU tuaj yeem tiv thaiv cov thyroid hormones thyroid los ntawm kev ua haujlwm ntawm TPO.
(2) Txo cov thyroid hormone prinite: PTU tseem tuaj yeem txo cov synthestery precursors, uas yog li inhibiting synthesis ntawm cov thyroid hormones.
Nrog rau kev tshawb nrhiav kev tshawb nrhiav kev kho mob thiab kev txhim kho thev naus laus zis, cov cuab yeej siv kev lag luam tau yooj yim, thiab kev lag luam lag luam tau hloov pauv tseem ceeb. Propylthiouracil, raws li ib qho ntawm nws cov ntaub ntawv tseem ceeb, muaj cov ntawv thov nthuav dav hauv kev kho mob, chaw muag tshuaj thiab lwm thaj teb. Cov hauv qab no yog cov ncauj lus kom ntxaws tshuaj xyuas ntawm kev txhim kho cov kev pab cuam tom ntej ntawm nws cov tshuaj yauv:
1. Cov xwm txheej thiab cov qauv
Kev ua lag luam loj
Raws li lub teb chaws neeg nyob tsam, Tuam Tshoj txoj kev thov kev kho mob tau nce ntau. Nyob rau tib lub sijhawm, nrog kev txhim kho ntawm kev paub txog kev noj qab haus huv thiab qib kev pab kho mob, qhov kev thov rau propylthiouracil kuj tseem loj hlob. Kev loj hlob ntawm kev ua lag luam loj yog feem ntau vim yog cov lus qhia hauv qab no: ua ntej, nce kev nce hauv tus neeg mob xav tau. Nrog cov neeg mob loj ntawm cov pejxeem kev laus thiab nce zuj zus ntawm cov kab mob ntev,
Kev ua lag luam loj
Tus naj npawb ntawm cov neeg mob uas xav tau kev siv propylthiouracil raws li kev kho mob rau cov thyroid tsis sib xws nce; Qhov thib ob yog kev nce qib thiab kev tsim kho ntawm kev kho mob thev naus laus zis. Niaj hnub nimno cov tuam txhab kev tshawb nrhiav tsis tu ncua kev tshawb fawb thiab ua kom muaj txiaj ntsig proficonazole los txhim kho kev ua tau tshuaj siv tshuaj thiab txo cov kev mob tshwm sim, yog li txhim kho kev lag luam kev lag luam.
Kev loj hlob lub zog
Nrog rau kev siv zog ntawm kev laus hauv Suav teb, kev sib faib ntawm cov neeg laus tau nce ntxiv, thiab cov pab pawg laus yog cov tshuaj thyroid. Nyob rau tib lub sijhawm, lub caij nyoog ntawm cov kab mob uas ntev ntev xws li hyperthyroidism tseem muaj nce xyoo dhau los, uas muaj qhov cuam tshuam zoo ntawm kev lag luam xav tau cov propylthiouracil. Cov tuam txhab ua lag luam txuas ntxiv mus nqis peev thiab txhim kho cov qauv tsim qauv thiab cov mis ntawm cov propylliouracil, thiab txhim kho cov khoom lag luam zoo thiab kev nyab xeeb. Tsis tas li ntawd, qhov tshwm sim ntawm cov yeeb yaj kiab ntawm qhov ncauj tshiab lossis raug tso tawm tau txhim kho cov tshuaj Bioavailability thiab kho cov tshuaj, ntxiv kev txhawb nqa kev ua lag luam.
Kev loj hlob lub zog
Tsoomfwv kuj tau nce peev hauv kev pabcuam kev noj qab haus huv, txhim kho kev noj qab haus huv cov kev pab cuam kom txo tus nqi kho mob rau cov neeg mob. Nyob rau tib lub sijhawm, Txoj Cai Kev Lag Luam Hauv Tshuaj kuj tseem qhia txog qhov tseem ceeb ntawm kev tshawb fawb, muab cov tshuaj uas muaj txiaj ntsig zoo, muab cov tshuaj uas muaj txiaj ntsig zoo xws li proteliouracil.
2. Daim ntawv txheeb xyuas
Daim Ntawv Thov Kev Pab Cuam
Propylthiouracil yog siv los kho cov mob xws li hyperthyroidism thiab autoimmunitis thyroid. Tsis tas li ntawd, nws kuj tseem tuaj yeem siv los ua kev sib ntsib rau kev kho iodine kev kho rau kev npaj kho mob rau kev npaj kho mob rau kev npaj cov thyroid.
Cov yam ntxwv yuav tsum tau ua
Nrog rau cov neeg loj hlob ntawm cov pej xeem kev laus thiab nce zuj zus ntawm cov qog cov thyroid, qhov kev thov rau propylthiouracil yuav loj hlob ntxiv. Nrog kev tawm tsam cov tshuaj kho mob, daim ntawv thov ntawm cov kev kho mob kho tshuaj rau tus kheej yuav dhau los ua kev loj hlob tshiab hauv kev ua lag luam. Qhov kev thov rau ntau lub hom phiaj thiab cov phiaj xwm kev kho mob tsis zoo los ntawm cov neeg mob yuav txuas ntxiv ntxiv.
Tus Neeg Siv Khoom Noj thiab Kev Yuav Khoom Siv Zog
Qhov kev thov nce zuj zus los ntawm cov neeg siv khoom rau cov tshuaj zoo, muaj kev nyab xeeb thiab siv tau cov tshuaj tau tsav ncaj qha rau kev txhim kho kev ua lag luam propylikouracil ncaj qha. Nyob rau tib lub sijhawm, tsoomfwv tau nce peev hauv cov kev khomob, txhim kho kev pab kho mob, thiab txuas ntxiv txhim kho kev lag luam lub zog. Nrog rau kev loj hlob txuas ntxiv ntawm kev lag luam hauv tebchaws thiab kev nce ntawm cov nyiaj tau los ntawm cov neeg tau txais txiaj ntsig ntawm cov neeg tau txais txiaj ntsig ntawm tus kheej, cov neeg siv khoom muaj peev xwm them rau cov tshuaj kuj yog hloov kho tas li.
3.Technological Kev Loj Hlob Loj
Kev Tsim Kho Khoom Tiam
Cov tuam txhab cov tuam txhab txuas ntxiv txhawm rau tshawb xyuas cov kev tshawb fawb thiab kev tsim tawm tshiab ntawm cov khoom siv propiconazole npaj xws li kev ua tiav cov tshuaj thiab cov tshuaj zoo. Los ntawm kev siv cov khoom siab ua kom siab tshaj plaws Nanotechnology thiab txhim kho Dosage foos tsim los txhim kho cov tshuaj sib haum tshuaj thiab bioavailability tuaj yeem muab tau.
Qhov cuam tshuam ntawm kev siv thev naus laus zis ntawm kev ua lag luam
Kev siv thev naus laus zis tsis tsuas yog txhim kho kev kho mob thiab kev nyab xeeb ntawm propylthiouracil, tab sis kuj tau txo cov nqi tsim thiab txhim kho kev lag luam kev sib tw. Nrog rau kev nce qib nruam ntawm kev siv thev naus laus zis, ntau dua thiab qis cov txiaj ntsig proffylthioouracil cov khoom yuav tawm hauv lub neej tom ntej kom tau raws li kev ua lag luam xav tau.
4.Txoj kev thiab cov nyom
Kev pheej hmoo ua lag luam
Kev siv zog ntawm kev sib tw ua lag luam yuav ua rau kev sib tw ua lag luam ntau dua rau cov lag luam. Lub caij no, qhov ntau dua rhiab ntawm cov neeg mob mus rau cov nqi tshuaj kuj tseem yuav cuam tshuam rau kev ua lag luam tus nqi kev ua lag luam.
Thev naus laus zis kev pheej hmoo
Kev siv thev naus laus zis yog ib qho tseem ceeb ntawm kev txhim kho kev txhim kho ntawm cov khoom lag luam proplinouracil, tab sis kuj muaj qee qhov kev pheej hmoo cuam tshuam nrog. Piv txwv li, cov ntsiab lus xws li kev nqis peev kev nyab xeeb kev txhim kho, kev nqis peev tseem ceeb, thiab tsis paub meej txoj kev ua tiav kev ua tiav txoj cai thiab kev ua lag luam kev sib tw ua lag luam.
Muab Kev Nyuaj Siab
Yam khoom xws li tsis ruaj khov khoom siv khoom siv thiab nce cov nqi tsim khoom yuav cuam tshuam rau kev tsim khoom thiab muab cov khoom ruaj khov ntawm propylthiouracil. Kev lag luam yuav tsum muaj zog txhawb kev muab cov khoom siv raw siv tau thiab txhim kho ntau lawm.
Cim npe nrov: Propylthioouracil Hmoov Li No ...}}, cov neeg muag khoom, chaw tsim khoom, chaw tsim khoom, yuav khoom, rau muag