Diethylhexyl Phthalate CAS:

Diethylhexyl phthalatefeem ntau yog hais txog (DEMP), tseem hu ua di ({0}}ethylhexyl) phthalate, uas yog cov organic compound nrog CAS 117-81-7 thiab tshuaj formula C24H38O4. Tsis muaj xim los yog lub teeb daj kua nplaum nrog cov ntxhiab tsw tshwj xeeb. Nws tuaj yeem ua rau miscible nrog cov kuab tshuaj organic xws li ntxhia roj thiab hexane, tab sis yuav luag insoluble hauv dej. Nws muaj zoo compatibility nrog rau feem ntau industrial resins. Nws yog ib nrab soluble hauv cellulose acetate thiab polyvinyl acetate. Nws feem ntau yog siv los ua plasticizer rau cov khoom yas xws li polyvinyl chloride (PVC). Nws tuaj yeem nce elasticity thiab toughness ntawm plastics thiab yog siv dav hauv kev lag luam yas. Tab sis nws qhov cuam tshuam rau tib neeg lub cev thiab ib puag ncig muaj teeb meem. Qee qhov kev tshawb fawb qhia tias nws yuav muaj kev cuam tshuam tsis zoo rau tib neeg kev noj qab haus huv, suav nrog kev cuam tshuam rau endocrine thiab cov kab mob kev ua me nyuam. Tej zaum yuav muaj feem cuam tshuam rau tib neeg kev noj qab haus huv, yog li ntawd muaj peev xwm ua haujlwm carcinogenic txaus ntshai. Lub Chaw Haujlwm Saib Xyuas Kev Nyab Xeeb thiab Kev Noj Qab Haus Huv (OSHA) thiab National Institute of Occupational Safety and Health (NIOSH) tau tsim cov kev txwv tsis pub dhau.

Melting point {{0}} degree C, Boiling point 386 degree C (lit.), Ceev 0.985 g / ml ntawm 20 degree C (lit.), Vapor ntom> 16 (vs huab cua), Vapor siab 1.2 mm Hg (93 degree C), Refractive index N20 / D 1.488, Flashpoint 405 degree f, Cia txias 2-8 degree C, Solubility nrog ntxhia roj thiab hexane (US EPA, 1985), Daim ntawv kua, Xim APHA: Tsawg tshaj los yog sib npaug rau 10, ntxhiab tsw heev lub teeb, yam ntxwv, Dej-soluble negligible, Freezing point < - 60 degree , BRN 1890696, Henry's Law Constant(x 10-5} atm?m3/mol): 1.1 ntawm 25 degree (xam, Howard, 1989), Muaj peev xwm ua haujlwm carcinogen NIOSH REL: TWA 5, STEL 10, IDLH 5,000; OSHA PEL: TWA 5; ACGIH TLV: TWA 5 (adapted).

1. Cov khoom no yog cov khoom siv dav siv ntau tshaj plaws. Ntxiv rau cellulose acetate thiab polyvinyl acetate, nws muaj kev sib raug zoo nrog feem ntau cov khoom siv hluavtaws thiab roj hmab siv hauv kev lag luam.

2. Cov khoom lag luam muaj kev ua tau zoo, kev sib xyaw ua haujlwm zoo, kev ua haujlwm siab plasticizing, tsis tshua muaj hluav taws xob, qhov kub thiab txias hloov tau yooj yim, dej extraction kuj, hluav taws xob ua haujlwm siab, kub tsis kam thiab huab cua tsis kam.

3. Diethylhexyl Phthalatetuaj yeem siv los ua cov kua dej ruaj khov rau cov roj chromatography los xaiv khaws cia thiab cais cov tshuaj tsw qab, cov tshuaj tsis txaus ntseeg thiab ntau yam oxygenated compounds (cawv, aldehydes, ketones, esters, thiab lwm yam), cov kuab tshuaj thiab plasticizers.

4. DEHP tej zaum yuav muaj nyob rau hauv ntau yam khoom siv kho mob PVC (xws li cov hlab ntsha hauv cov hlab ntsha, cov hlab ntsha hauv cov hlab ntsha, cov hlab ntsha hauv lub ntsws, cov hnab lim ntshav thiab cov hlab ntsha, cov hnab ntshav thiab cov thawv ntim ntshav, cov hlab pas, thiab lwm yam). Yog li ntawd, peb tau pib ua tib zoo saib seb DEHP hauv cov cuab yeej siv kho mob puas nkag mus rau cov neeg mob, tshwj xeeb tshaj yog cov neeg uas xav tau kev sib cuag nrog cov cuab yeej kho mob no, suav nrog cov menyuam mos hauv cov tsev kho mob me me, hemophiliacs lossis cov neeg mob uas xav tau lub raum lim ntshav mus ntev. Lub European Health thiab Environmental Science Commission tau taw qhia tias DEHP raug rau cov neeg mob uas lub raum lim ntshav mus ntev yuav dhau qhov kev tso cai txhua hnub (TDI).

US Food and Drug Administration tau tshaj tawm tsab ntawv ceeb toom txog kev noj qab haus huv rau pej xeem ntawm DEHP thaum Lub Xya Hli 2002, uas tau hais cov lus hauv qab no: "Peb pom zoo tias yuav tsum muaj lwm txoj hauv kev los txiav txim siab thaum siv cov txheej txheem kev pheej hmoo siab saum toj no rau cov txiv neej yug tshiab, poj niam cev xeeb tub nrog txiv neej fetuses, thiab cov txiv neej nkag mus rau kev laus. " Lwm txoj hauv kev yog siv cov khoom siv lossis khoom siv yam tsis muaj DEHP, thiab cov ntawv xov xwm kev noj qab haus huv rau pej xeem kuj hais txog lwm cov ntaub ntawv.

Peb yog cov chaw tsim khoomDiethylhexyl phthalate.

Lus Cim: BLOOM TECH (Txij li xyoo 2008), ACHIEVE CHEM-TECH yog lub chaw pabcuam ntawm peb.

Cov synthesis ntawm di (2-}ethylhexyl) phthalate tsuas yog siv txoj hauv kev ntawm esterification, feem ntau yog los ntawm reacting phthalic anhydride nrog 2-ethylhexyl cawv nyob rau hauv kub thiab catalyst tej yam kev mob. Cov nram qab no yog cov ncauj lus kom ntxaws cov kauj ruam ntawm txoj kev no thiab nws cov chemical sib npaug:

1. Kev npaj cov ntaub ntawv raw: Ua ntej, npaj cov khoom siv raw: phthalic anhydride, 2-ethylhexanol, thiab catalysts (xws li sulfuric acid, phosphoric acid, lossis acidic ion exchange resin). Purify thiab qhuav phthalic anhydride thiab 2-ethylhexanol cais los xyuas kom meej cov khoom raw zoo.

2. Cov ntaub ntawv sib xyaw ua ke: Sib tov cov purified phthalic anhydride thiab 2-ethylhexanol hauv ib qho kev faib ua feem thiab ntxiv cov catalyst. Lub luag haujlwm ntawm cov catalyst yog los txhawb cov tshuaj tiv thaiv esterification thiab nce cov tshuaj tiv thaiv.

3. Cov tshuaj tiv thaiv cua sov: Ua kom sov qhov sib xyaw kom sov, feem ntau ntawm 150 ° C thiab 250 ° C. Thaum lub sij hawm cua sov, phthalic anhydride undergoes esterification cov tshuaj tiv thaiv nrog 2-ethylhexanol los tsim di (2-ethylhexyl. ) phthalate. Meanwhile, dej yuav raug tsim raws li ib tug byproduct.

4. Tshem tawm los ntawm cov khoom siv: Thaum lub sij hawm cov txheej txheem tshuaj tiv thaiv, nws yog ib qho tsim nyog yuav tsum tau tshem tawm cov dej los ntawm cov khoom los txhawb cov tshuaj tiv thaiv. Cov dej tuaj yeem raug tshem tawm los ntawm kev ntxiv cov dej nqus dej lossis ua haujlwm sib cais dej.

5. Kev ua kom txias thiab crystallization: Thaum cov tshuaj tiv thaiv mus txog qhov ua tiav, txias qhov sib tov kom qis qis kom cia cov crystallization ntawm di (2-}} ethylhexyl) phthalate rau precipitate.

6. Pom thiab ziab: cais cov crystals ntawm di (2-ethylhexyl) phthalate los ntawm cov tshuaj tiv thaiv sib tov los ntawm kev pom thiab ua kom qhuav kev kho mob.

7. Purification: Yuav kom tau txais high-purity di (2-}ethylhexyl) phthalate, kev ua kom huv huv xws li recrystallization lossis distillation tuaj yeem ua tau. Cov khoom purified yuav tsum tau kuaj xyuas kom zoo kom ua tau raws li cov qauv tsim nyog.

Chemical Equation:

(C₆H₄)₂CO + 2C₈H₁₈O → (C₆H₄COOB₂CH₃)₂ + 2H₂O

Qhov kev sib npaug tshuaj no sawv cev rau cov tshuaj tiv thaiv esterification ntawm phthalic anhydride thiab 2-ethylhexanol nyob rau hauv qhov kev txiav txim ntawm ib qho catalyst, uas ua rau tsim cov di (2- ethylhexyl) phthalate thiab dej. Cov tshuaj tiv thaiv yog thim rov qab, yog li nws yog qhov yuav tsum tau tshem tawm cov dej los txhawb cov tshuaj tiv thaiv nyob rau hauv cov kev taw qhia ntawm generating lub hom phiaj cov khoom.

Di (2-ethylhexyl) phthalate (DEHP) yog cov yas yas uas siv dav hauv kev tsim cov khoom yas thiab cov khoom siv roj hmab. Txawm li cas los xij, DEHP muaj qhov ruaj khov qis hauv dej thiab tuaj yeem ua rau cov tshuaj tiv thaiv hydrolysis.

Cov kauj ruam tshwj xeeb yog raws li nram no:

1. Npaj reagents thiab khoom siv: Npaj cov reagents thiab cov khoom siv xws li DEHP, dej, pH meter, qhov kub thiab txias dej da dej, sib cais funnel, thiab lwm yam.

Kev npaj ntawm DEHP tov: Dissolve ib tug tsim nyog tus nqi ntawm DEHP nyob rau hauv dej los npaj ib tug tej yam concentration ntawm DEHP tov.

2. Kev tswj qhov kub thiab txias: Teem lub da dej kub tas li ntawm qhov kub thiab txias, xws li 40 ° C, kom simulate kub hauv ib puag ncig ntuj.

3. Kev soj ntsuam pH: Thaum lub sij hawm cov txheej txheem tshuaj tiv thaiv, siv lub ntsuas pH los saib xyuas cov kev hloov hauv pH ntawm cov tshuaj.

4. Kev soj ntsuam ntawm qhov tshwm sim hydrolysis: Lub sijhawm dhau los, DEHP tau txais cov tshuaj tiv thaiv hydrolysis, ua rau DEMP. Nws tuaj yeem pom tias cov tshuaj maj mam ua turbid, raws li cov DEMP generated yaj hauv dej.

5. Kev sib cais ntawm cov khoom: Cov tshuaj tiv thaiv hydrolysis yog sib cais los ntawm kev sib cais funnel, nrog cov dej ntshiab ntawm txheej txheej sab saud thiab DEMP roj txheej ntawm txheej qis.

6. Cov khoom ntim khoom: Sau cov roj qis qis, uas yog cov khoom tsim tawm DEMP.

7. Purification khoom: Yuav kom tau txais high-purity Bis ({2}}ethylhexyl) phthalate, purification kev ua hauj lwm xws li recrystallization los yog distillation yuav ua tau rau ntawm cov khoom.

Chemical Equation:

DEHP + H₂O → C₂₄H₃₈O₄+ lwm yam khoom siv

Qhov kev sib npaug tshuaj no sawv cev rau cov tshuaj tiv thaiv hydrolysis ntawm DEHP hauv dej, tsim DEMP thiab lwm yam khoom siv. Nws yuav tsum tau muab sau tseg hais tias cov tshuaj tiv thaiv yog reversible, yog li nyob rau hauv lub tswv yim ua hauj lwm, nws yog tsim nyog los tswj cov tshuaj tiv thaiv tej yam kev mob, xws li kub, pH tus nqi, thiab lwm yam. Lub caij no, raws li cov tshuaj tiv thaiv hydrolysis yog qhov sib npaug ntawm cov tshuaj tiv thaiv, nws yog ib qho tsim nyog yuav tsum tau cais cov tsim DEMPE raws sij hawm kom tawg qhov sib npaug thiab txhawb cov tshuaj tiv thaiv mus ntxiv.

Lub invention muab ob yam ntawm cov khoom siv dag zog immunogens ntawmDiethylhexyl Phthalatethiab lawv txoj kev npaj. Cov qauv qauv ntawm DEHP BSA yog: txoj kev npaj ntawm DEHP BSA yog los ntawm kev sib txuas ntawm DEHP hapten nrog cov protein molecule BSA.

Txoj kev npaj ntawm immunogen muaj qhov zoo ntawm txoj kev npaj yooj yim, kev ruaj ntseg zoo, tus nqi qis thiab kev lag luam yooj yim. Cov khoom siv tshuaj tiv thaiv kab mob DEHP-BSA ntawm di (2-}ethyl) hexyl phthalate tau siv los tiv thaiv tsiaj los npaj cov tshuaj tiv thaiv tshwj xeeb, uas tau tsim lub hauv paus rau kev tsim avidin biotinylated enzyme-txuas immunosorbent assay.

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