Ethyl oleate roj, tseem hu ua cis 9-octadecenoic acid ethyl ester lossis 9-octadecenoic acid ethyl ester, yog cov kua roj tsis muaj xim nrog cov ntxhiab tsw. Volatile, flammable, insoluble nyob rau hauv dej, soluble nyob rau hauv organic solvents. Nws yog ib qho ester compound, CAS 112-62-6, nrog rau cov tshuaj formula C18H32O. Feem ntau yog siv los npaj cov tshuaj organic xws li cov roj nplua nyeem, cov tshuaj tiv thaiv dej, cov tshuaj tiv thaiv toughening, surfactants, tshuaj excipients, plasticizers, ointment matrices, thiab fragrances. Nws yog ib tug fatty acid ester tsim los ntawm condensation ntawm oleic acid thiab ethanol. Ethyl oleate yog cov kua lipid tivthaiv hauv nanostructured lipid carriers (NLCs). NLC yog tus neeg nqa khoom ntawm qhov ncauj ntawm trans ferulic acid (TFA). Shaanxi BLOOM Tech Co., Ltd muaj ethyl oleate muag. Yog tias koj xav paub tus nqi ntawm ethyl oleate, thov xa email rau peb.
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Tshuaj Formula |
C20H38O2 |
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Exact Mass |
310 |
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Molecular Luj |
311 |
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m/z |
310 (100.0%), 311 (21.6%), 312 (2.2%) |
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Elemental Analysis |
C, 77.36; H, 12.34; O, 10.30 |
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Ethyl oleate, raws li ib qho ester compound tsim los ntawm esterification cov tshuaj tiv thaiv ntawm oleic acid thiab ethanol, tau qhia dav daim ntawv thov nqi nyob rau hauv ntau yam kev lag luam teb vim nws cov cim tshuaj qauv thiab lub cev zog. Nws cov mis molecular yog C20H38O2, uas yog xim tsis muaj xim lossis lub teeb daj oily kua ntawm chav tsev kub. Nws muaj qhov tsis tshua muaj polarity, kub kub taw tes (txog 360 degree), thiab zoo solubility, ua rau nws yog ib qho tseem ceeb raw khoom rau kev lag luam xws li tshuaj, tshuaj, zaub mov, thiab tshuaj txhua hnub.
Daim ntawv thov qhov tob thiab dav hauv kev lag luam kws tshuaj txuas ntxiv nthuav dav, thiab nws cov biocompatibility thiab tsis muaj tshuaj lom ua rau nws yog ib qho tseem ceeb rau kev tsim kho tshuaj.
1. Solvent thiab Carrier System
Raws li qhov hnyav rau cov tshuaj hormones steroid (xws li testosterone thiab progesterone) thiab cov tshuaj lipophilic (xws li cyclosporine thiab tshuaj tiv thaiv kab mob), nws tuaj yeem txhim kho qhov solubility thiab stability ntawm cov tshuaj insoluble. Piv txwv li, hauv microemulsion formulations,ethyl oleate yog 'ua haujlwm synergistically nrog surfactants los tsim cov neeg nqa khoom nanoscale nrog qhov ntau thiab tsawg dua 100nm, ua tiav lub hom phiaj xa khoom thiab kev tswj xyuas kev tso tawm cov tshuaj.
Lub oleic acid ethyl ester raws li microcapsule system tsim los ntawm ib pab pawg tshawb fawb tau ua tiav qhov bioavailability ntawm cyclosporine mus rau peb npaug ntawm cov ntawv siv tshuaj.
2. Kev txhaj tshuaj thiab cog kev loj hlob
Hauv kev txhaj tshuaj intramuscular, raws li lub tsheb muaj zog, nws tuaj yeem txo qhov kev txhaj tshuaj thiab qhov mob ntawm lub cev, thaum lub sij hawm ntev lub voj voog tso tshuaj. Piv txwv li, ib qho ntev ntev - ua yeeb yam tshuaj testosterone siv ethyl oleate raws li matrix los tswj cov ntshav cov tshuaj kom ruaj khov los ntawm kev tswj hwm ib hlis ib zaug. Tsis tas li ntawd, nws biodegradability ua rau nws yog ib qho khoom siv zoo tshaj plaws rau implantable microcapsules.
Cov oleate ethyl ester polylactic acid copolymer microcapsules tsim los ntawm ib lub tuam txhab biotechnology tau siv rau hauv zos sustained -tso tawm kev kho mob qog noj ntshav.
3. Standardized daim ntawv thov ntawm cov tshuaj excipients
Raws li Suav Pharmacopoeia thiab USP-NF cov qauv, qib tshuaj ethyl oleate yuav tsum ua tau raws li cov ntsuas xws li cov ntsiab lus monoester Ntau dua lossis sib npaug li 60% thiab tus nqi peroxide tsawg dua lossis sib npaug li 10meq / kg. Ultra ntshiab qib ethyl oleate uas tsim los ntawm ib lub tuam txhab los ntawm cov tshuab molecular distillation tau dhau FDA ntawv pov thawj thiab yog dav siv nyob rau hauv txhaj tshuaj, ophthalmic npaj, thiab transdermal thaj ua rau thaj.
Kev lag luam khoom noj khoom haus: Lub luag haujlwm Dual ntawm Natural Flavors thiab Safety Additives
Nrog nws cov GRAS (feem ntau suav hais tias muaj kev nyab xeeb) ntawv pov thawj thiab cov yam ntxwv ntawm ntuj, nws tau dhau los ua cov khoom lag luam tseem ceeb thiab cov khoom siv ntxiv hauv kev lag luam khoom noj.
1. Khoom noj khoom haus hauv paus
Raws li cov ntsiab lus tseem ceeb ntawm floral thiab fruity essence, nws muaj peev xwm simulate lub aroma ntawm ntuj roj thiab txhim khu lub tsw hierarchy ntawm zaub mov. Piv txwv li, ntxiv 0.1% -0.5% ethyl oleate rau cov khoom ci tuaj yeem txhim kho butter aroma ntawm qhob cij; Nyob rau hauv cov khoom noj siv mis, nws ua ke nrog vanillin tuaj yeem tsim lub ntsej muag ntev ntev.
2. Kev ntim khoom noj thiab khaws cia
Nws hydrophobicity ua rau nws yog ib qho khoom siv zoo tagnrho rau cov khoom ntim khoom noj. Cov oleic acid ethyl ester chitosan composite zaj duab xis tsim los ntawm pab pawg tshawb fawb muaj 92% cov kab mob tua kab mob tiv thaiv Escherichia coli thiab tuaj yeem txuas lub txee lub neej ntawm strawberries mus rau 14 hnub. Tsis tas li ntawd, nws daim ntawv thov ua lub roj nplua nyeem hauv kev tsim cov chocolate tuaj yeem txo cov pwm demolding kuj thiab txo cov khoom puas tsuaj.
Txhua hnub tshuaj teb: synergistic nyhuv ntawm softener thiab essence carrier
Hauv cov tshuaj pleev ib ce thiab cov khoom siv tu tus kheej, nws tau dhau los ua cov khoom tseem ceeb hauv cov qauv siab - kawg los ntawm nws cov tawv nqaij tshwj xeeb xav txog kev tswj hwm thiab cov txiaj ntsig zoo.
1. Cov tawv nqaij softening thiab barrier kho
Raws li tsis yog - ionic lubricant, nws tuaj yeem nkag mus rau hauv qhov sib txawv ntawm stratum corneum, tsim cov yeeb yaj kiab hydrophobic los tiv thaiv dej. Ntxiv 3% ethyl oleate rau qee hom tshuaj pleev ib ce, kev tshuaj ntsuam xyuas tau pom tias tom qab 4 lub lis piam ntawm kev siv, daim tawv nqaij noo noo cov ntsiab lus nce los ntawm 28% thiab transdermal dej poob tus nqi txo los ntawm 15%.
2. Essence stabilization thiab qeeb tso tshuab
Nws tsis tshua muaj volatility ua rau nws nyiam cov khoom siv phab ntsa rau essence microcapsules. Ib hom tshuaj tsw qab siv cov cuab yeej sib xyaw microcapsule ntawm ethyl oleate thiab cov pos hniav arabic kom ncua lub sij hawm tso tawm ntawm cov ntsiab lus mus rau 8 teev, thaum txo cov degradation ntawm aroma Cheebtsam los ntawm ultraviolet hluav taws xob.
Muaj daim ntawv thov ntawm lubrication thiab dej-cov haujlwm ua haujlwm tiv taus hauv kev lag luam chemical engineering
Lubricity thiab dej tsis kam ntawm ethyl oleate ua rau nws yog ib qho tseem ceeb additive nyob rau hauv industries xws li hlau ua, textile printing thiab dyeing.
1. Muaj roj nplua nyeem
Hauv cov hlau txiav cov kua dej, qhov sib txhuam coefficient tuaj yeem raug txo kom qis dua 0.05, thaum tsim cov yeeb yaj kiab tiv thaiv kom tsis txhob ua haujlwm oxidation. Tom qab qee qhov chaw tsim khoom siv tsheb tau txais ethyl oleate raws li cov roj nplua nyeem, lub cuab yeej lub neej tau txuas ntxiv los ntawm 40%, thiab qhov roughness ntawm lub tshuab ua haujlwm tau txo mus rau Ra0.8 μ m.
2. Textile dej -Resistant finishing agent
Los ntawm kev sib xyaw nrog fluorinated polymers, cov ntaub tuaj yeem tau txais txiaj ntsig nrog superhydrophobic zog. Lub oleic acid ethyl ester perfluorooctanoic acid copolymer txheej tsim los ntawm qee yam khaub ncaws sab nraum zoov ua tiav cov ntaub tiv toj lub kaum sab xis ntawm 152℃thiab qhov ntsuas dej tsis zoo tshaj 20000mmH ₂ O.
Cov tshuaj stability thiab selectivity uaethyl oleate yog 'Cov khoom siv tseem ceeb hauv cov pa roj chromatography (GC) thiab kua chromatography (HPLC) tsom xam.
1. Gas chromatography nyob ruaj ruaj theem
Raws li tsis yog -polar nyob ruaj khov theem, nws tsim nyog rau kev sib cais cov polarity tsawg xws li hydrocarbons thiab esters. Ib lub chaw soj nstuam tau zoo sib cais C ₅ - C ₁ ₂ tivthaiv hauv cov roj av siv cov chromatography kem coated nrog ethyl oleate, nrog rau kev sib cais ntawm ntau tshaj 1.8.
2. Kev ua haujlwm siab ua kua chromatography hnyav
Nyob rau theem rov qab chromatography, nws tuaj yeem siv los ua lub sijhawm txawb ntxiv los txhim kho tus cwj pwm tuav ntawm cov polar tebchaw. Pab pawg tshawb fawb tau ua tiav qhov kev sib cais ntawm flavonoids los ntawm kev ntxiv cov tshuaj methanol dej uas muaj 0.5% ethyl oleate.
Agricultural teb: txhim kho cov tshuaj tua kab thiab tswj cov nroj tsuag kev loj hlob
Nws permeability thiab kev ua lom lom ua rau nws nthuav tawm ob txoj haujlwm hauv kev ua liaj ua teb.
1. Cov tshuaj tua kab mob
Raws li ib tug penetrant, nws muaj peev xwm rhuav tshem cov ciab txheej ntawm kab epidermis thiab txhim khu kev nkag tau mus rau tus neeg sawv cev. Cov oleic acid ethyl ester organic silicon compound additive tsim los ntawm ib lub tuam txhab tshuaj tua kab tau nce kev sib cuag tua cov tshuaj tua kab pyrethroid los ntawm peb zaug.
2. Kev cai cog qoob loo
Tsawg concentrations ntawm ethyl oleate (0.01% -0.1%) tuaj yeem ua rau muaj kev ntxhov siab resistant noob hauv cov nroj tsuag. Ib txoj kev tshawb nrhiav pom tias cov txiv lws suav uas tau kho nrog ethyl oleate tau nce 2.3 npaug ntawm cov ntsiab lus proline thiab 45% nce ntawm kev ciaj sia nyob rau hauv drought tej yam kev mob.
Nrog rau kev nce qib ntawm cov ntaub ntawv kev tshawb fawb, cov txiaj ntsig muaj peev xwm tau pom nyob rau hauv thaj chaw ntawm nano synthesis thiab lub zog cia.
1. Nano particle synthesis template
Nws ntev -chain alkyl pawg tuaj yeem tswj cov morphology ntawm hlau nanoparticles. Ib pab pawg neeg tsim cov monodisperse kub nanorods siv ethyl oleate li ligand, nrog ib tug longitudinal plasmon resonance ncov ntawm 820nm, haum rau biological imaging thiab photothermal kho.
2. Lithium ion roj teeb electrolyte additive
Ethyl oleate, ua ib zaj duab xis- tsim cov khoom siv ntxiv, tuaj yeem tsim cov yeeb yaj kiab SEI ruaj khov ntawm qhov tsis zoo electrode. Ib lub tuam txhab roj teeb tau nce lub voj voog ntawm lithium-ion roj teeb rau ntau dua 2000 zaug thiab ua tiav lub peev xwm tuav tau ntawm 92% los ntawm kev ntxiv 1% ethyl oleate.
(1) Qhov zoo tshaj plaws tshuaj tiv thaiv tej yam kev mob rau synthesis ntawmEthyl oleate rojlos ntawm cov txheej txheem ua ke ntawm catalytic esterification ntawm p-toluene sulfonic acid txhawb rau cov pa roj carbon activated thiab deacetylation ntawm calcium oxide yog: n (ethyl acetate): n (oleic acid)=40: 1, tus nqi ntawm p-toluene sulfonic acid txhawb rau cov pa roj carbon monoxide yog 10% ntawm tag nrho cov huab hwm coj. oleic acid thiab ethyl acetate, cov tshuaj tiv thaiv kub yog 110C, thiab lub sij hawm tshuaj tiv thaiv yog 4h. Nyob rau hauv cov xwm txheej no, qhov nruab nrab hloov pauv tus nqi (transesterification tus nqi) ntawm oleic acid yog 8762%.
(2) P-Toluenesulfonic acid txhawb rau cov pa roj carbon activated yog ib qho zoo catalyst rau transesterification ntawm ethyl acetate thiab oleic acid los ua ke ethyl oleate. Lub catalyst muaj kev ua haujlwm siab, kev xaiv siab, tshem tawm yooj yim, decolorization muaj nuj nqi thiab siab quotient tus nqi.
(3) Nrog rau kev siv tshuab sab nraud, calcium oxide thiab acetic acid nqa los ntawm ethyl acetate yog siv los tsim calcium acetate, uas plays lub luag haujlwm ntawm kev sib cais cov kua qaub txias, ua kom cov tshuaj tiv thaiv ntawm oleic acid thiab ethyl acetate los tsim ethyl oleate los ntawm acidolysis thiab transesterification. Cov txheej txheem synthesis no yooj yim thiab yooj yim, nrog rau siab transesterification tus nqi, txo cov load nyob rau hauv cov txheej txheem sib cais thiab tsawg zog noj nyob rau hauv cov tshuaj tiv thaiv txheej txheem.
Piav ib txoj kev npaj ethyl oleate los ntawm esterification ntawm ethanol nrog oleic acid.
Synthesis cov kauj ruam
Sib tov oleic acid thiab ethanol hauv ib qho kev faib ua feem, ntxiv catalyst concentrated sulfuric acid los yog p-toluenesulfonic acid, thiab do sib npaug.
01
Tshav kub qhov sib tov rau qhov kub thiab txias (feem ntau yog 120-140 degree) thiab txuas ntxiv reflux rau lub sijhawm (feem ntau 2-4 teev), tso cai rau cov oleic acid thiab ethanol los ua kom tag nrho.
02
Txias lub reactant rau hauv chav tsev kub, neutralize nws nrog alkaline tov (xws li NaOH los yog KOH) rau pH 8 -9, thiab tso cai rau lub catalyst react nrog concentrated sulfuric acid los yog p-toluenesulfonic acid los tsim sodium sulfate los yog poov tshuaj sulfate, thaum tseem cia cov unreacted oleic acid los tsim oleic acid.
03
Ntxuav tawm cov dej cawv uas tsis muaj tshuaj thiab cov catalysts nrog dej kom tig cov reactants mus rau hauv cov tshuaj aqueous. Lim cov tshuaj aqueous kom tshem tawm cov khoom impurities.
04
Distilled lub filtrate thiab txiav tawm ethyl oleate feem. Thaum lub sij hawm distillation txheej txheem, ethyl oleate yog sib cais raws li lwm yam uas tsis muaj boiling tshuaj evaporate.
05
Qhuav qhov tau txais ethyl oleate feem nrog anhydrous calcium chloride kom tshem tawm cov dej noo thiab lwm yam impurities.
06
Ua lub tshuab nqus tsev distillation ntawm qhuav ethyl oleate rau kev ua kom huv ntxiv. Thaum lub sij hawm txheej txheem ntawm lub tshuab nqus tsev distillation, ethyl oleate yog sib cais nrog cov evaporation ntawm lwm yam kub boiling tshuaj.
07
Kev sib npaug tshuaj tiv thaiv
C18H34O2 + C2H5OH → C18H34O2-COOC2H5 + H2O
Hauv cov tshuaj tiv thaiv no, ib pawg carboxyl nyob rau hauv oleic acid molecule undergoes esterification nrog ib pawg hydroxyl hauv ethanol molecule, tsim.Ethyl Oleate Rojthiab dej.
C18H34O2-COOC2H5 + H2SO4(concentrated) → C18H34O2-COOC2H5 + H2O + TSO2 ↑
los yog
C18H34O2-COOC2H5 + H2SO4(p-toluenesulfonic acid) → C18H34O2-COOC2H5 + H2O + CH3C6H4SO3H
Hauv cov tshuaj tiv thaiv no, cov catalyst concentrated sulfuric acid los yog p-toluenesulfonic acid koom nrog cov tshuaj tiv thaiv esterification, tsim bisulfate los yog p-toluenesulfonate thiab dej. Cov ntsev no yog neutralized hauv cov kauj ruam tom ntej alkaline neutralization.
C18H34O2-COOC2H5 + NaOH (los yog KOH) → C18H34O2-COONa (los yog KNa) + C2H5OH
Nyob rau hauv cov tshuaj tiv thaiv no, cov unreacted oleic acid undergoes ib tug neutralization cov tshuaj tiv thaiv nrog alkaline tov, ua sodium oleate los yog potassium oleate thiab ethanol. Cov sodium los yog potassium ntsev yog ntxuav tawm hauv cov kauj ruam tom ntej ntxuav dej.
C18H34O2-COONa (los yog KNa) + H2O → C18H34O2-COOH + NaOH (los yog KOH)
Nyob rau hauv cov tshuaj tiv thaiv no, unreacted ethanol undergoes ib tug hydrolysis cov tshuaj tiv thaiv nrog dej, ua acetaldehyde thiab dej. Nyob rau tib lub sijhawm, cov tshuaj alkaline kuj yog diluted rau hauv cov kua dej alkali. Cov tshuaj tiv thaiv hydrolysis no tau ua nyob rau hauv acidic tej yam kev mob, yog li txhawb cov hydrolysis ntawm sodium los yog potassium oleate.
Cov lus nug nquag
ethyl oleate roj yog dab tsi?
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Ethyl oleate yogester tsim los ntawm condensation ntawm fatty acid oleic acid thiab ethanol. Hauv cov qauv kev saib xyuas ntawm daim tawv nqaij, nws ua haujlwm zoo ib yam li oleic acid - uas yog, raws li kev kho tawv nqaij, cov khoom muaj emollient.
Puas yog ethyl oleate txiv roj roj?
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304 stainless hlau ua tau raws li cov kev cai thoob ntiaj teb ntawm qib zaub mov, 316 stainless hlau tsis yog qib zaub mov lossis qib kho mob nkaus xwb. Txawm li cas los xij, kev siv qib kev kho mob no ua lub khob ntim khoom yuav tsis coj cov txiaj ntsig ntxiv rau txhua tus. Vim li cas thiaj hu 304 lossis 316? Qhov no feem ntau txhais raws li cov khoom muaj pes tsawg leeg. 316 stainless hlau tsis zoo li cov khoom siv ntxhia, tom qab siv tau tuaj yeem tso qee yam khoom los txhawb tib neeg kev nqus.1. Ethyl Oleate (EO) Nws yog dab tsi: Lub fatty acid ester tau los ntawm ethanol thiab oleic acid (feem ntau pom nyob rau hauv cov roj txiv roj).
Puas yog ethyl oleate toxic?
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Ethyl oleate yog nruab nrab thiab yog lipid ntau dua - daim ntawv soluble ntawm oleic acid. Lub compound yog ib qho ntawm cov fatty acid ethyl esters tsim tom qab tawg ntawm ethanol hauv lub cev. Ntxiv mus, ethyl oleate yog cov tshuaj lom neeg nruab nrab ntawm ethanol hauv plawv, siab, txiav, thiab lub hlwb.
Lub npe ntawm ethyl oleate yog dab tsi?
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Ethyl oleate, tseem hu uaethyl oleic acidlos yog fema 2450, belongs rau chav kawm ntawm cov organic tebchaw hu ua fatty acid esters. Cov no yog carboxylic ester derivatives ntawm fatty acid. Ethyl oleate yog ib qho hydrophobic molecule heev, xyaum insoluble (hauv dej), thiab kuj nruab nrab.
Cim npe nrov: ethyl oleate roj cas 111-62-6, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom