Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm feem kev paub manufacturers thiab lwm tus neeg ntawm biotinoyl tripeptide nyob rau hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo biotinoyl tripeptide rau muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Biotinoyl Tripeptideyog ib qho khoom siv hluavtaws tsim los ntawm covalently khi biotin (vitamin B7 / H) nrog tripeptide sequence Gly His Lys (GHK) los ntawm kev cog lus amide. Nws cov mis molecular yog C24H38N8O6S, nrog rau qhov hnyav molecular ntawm 566.67 g / mol. Raws li ib tug tswv cuab ntawm tsev neeg vitamin B, biotin yog ib qho tseem ceeb ntawm carboxylase coenzymes thiab koom nrog hauv cov rog, carbohydrate, thiab protein metabolism. Nws cov thiophene nplhaib qauv endows nws nrog nws cov kev ua lom lom, cia nws khi nrog siab affinity rau streptavidin, uas yog dav siv nyob rau hauv kev tshawb nrhiav lom. GHK yog collagen degradation khoom uas ib txwm muaj nyob rau hauv tib neeg plasma, qaub ncaug, thiab zis. Cov histidine residue nyob rau hauv nws ib ntus muaj hlau chelating muaj peev xwm thiab tuaj yeem khi nrog tooj liab thiab hlau ions los ua kom muaj zog antioxidant; Lysine txhawb kev nkag mus rau peptide cell los ntawm kev cuam tshuam nrog cov cell membrane los ntawm tus nqi zoo.
Peb cov khoom Form
Biotinoyl Tripeptide-1 COA
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| Certificate of Analysis | ||
| Compound npe | Biotinoyl tripeptide-1 | |
| Qib | Pharmaceutical qib | |
| CAS Nr. | 299157-54-3 | |
| Ntau | 15g | |
| Ntim txheem | PE hnab + Al foil hnab | |
| Chaw tsim tshuaj paus | Shaanxi BLOOM TECH Co., Ltd | |
| Ntau No. | 202512090055 | |
| MFG | Peb 9, 2025 | |
| EXP | Peb 8 Dec 2028 | |
| Qauv |
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| Yam khoom | Enterprise txheem | Kev txheeb xyuas qhov tshwm sim |
| Qhov tshwm sim | Dawb los yog yuav luag dawb hmoov | Ua raws |
| Cov ntsiab lus dej | Tsawg dua lossis sib npaug li 5.0% | 0.47% |
| Poob rau ziab | Tsawg dua lossis sib npaug li 1.0% | 0.55% |
| Hnyav Hlau | Pb Tsawg dua lossis sib npaug li 0.5ppm | N.D. |
| Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Hg Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Cd Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Purity (HPLC) | Ntau dua lossis sib npaug li 99.0% | 99.90% |
| Ib leeg impurity | <0.8% | 0.26% |
| Tag nrho microbial suav | Tsawg dua lossis sib npaug li 750cfu / g | 70 |
| E. Coli | Tsawg dua lossis sib npaug li 2MPN / g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (los ntawm GC) | Tsawg dua lossis sib npaug li 5000ppm | 400 ppm |
| Cia | Khaws rau hauv qhov chaw kaw, tsaus, thiab qhuav hauv qab -20 degree | |
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| Tshuaj Formula | C24H38N8O6S | |
| Exact Mass | 566.26 | |
| Molecular Luj | 566.68 | |
| m/z | 566.26 (100.0%),567.27(26.0%),568.26(4.5%),568.27(3.2%),567.26(3.0%),568.27(1.2%),569.26(1.2%) | |
| Elemental Analysis | C,50.87;H,6.76;N,19.77;O,16.94;S,5.66 | |
Biotinoyl Tripeptideyog bioactive molecule tsim los ntawm covalent khi ntawm biotin (vitamin B7) thiab tripeptide (glycine histidine lysine, GHK). Nws cov qauv tshwj xeeb tso cai rau nws nrog ntau- lub hom phiaj ntawm kev ua haujlwm, uas yog siv dav hauv kev tu plaub hau, kho tawv nqaij, thiab tiv thaiv - kev laus.
Core mechanism ntawm kev ua
Cov txheej txheem ntawm kev ua ntawm cov tshuaj no yog ua raws li kev sib koom ua ke ntawm nws cov biotin thiab GHK tripeptide, uas tswj cov cellular metabolism thiab ua haujlwm los ntawm ntau yam - phiaj xwm kev tswj hwm, ua tiav cov txiaj ntsig lom neeg hauv qab no:
Qib Molecular: Lub hom phiaj ntawm cov txheej txheem ntawm cov plaub hau follicle hauv qab daim nyias nyias
Lub hauv paus daim nyias nyias ntawm cov hauv paus plaub hau yog cov qauv tseem ceeb uas txuas cov hauv paus plaub hau nrog cov txheej txheem dermis, thiab nws txoj kev ncaj ncees cuam tshuam ncaj qha rau lub peev xwm ntawm cov hauv paus plaub hau. Cov tshuaj no txhawb kev ua haujlwm ntawm lub hauv paus membrane los ntawm cov txheej txheem hauv qab no:
Collagen IV synthesis stimulation
Collagen IV yog lub hauv paus tseem ceeb ntawm lub hauv paus daim nyias nyias, tsim ib qho peb -cov qauv sib txuas uas muab kev txhawb zog rau cov hauv paus plaub hau.
Biotinoyl Tripeptide-1 upregulates cov noob qhia ntawm collagen IV (COL4A1/COL4A2) los ntawm activating lub transforming loj hlob yam tseem ceeb - (TGF - ) signaling txoj kev nyob rau hauv fibroblasts, txhawb nws synthesis thiab deposition.
Kev sim cov ntaub ntawv qhia tau hais tias tom qab 48 teev ntawm kev kho mob nrog 0.1% concentration, qhov tso tawm ntawm collagen IV nyob rau hauv fibroblasts nce 35%, ho txhim kho lub zog anchoring ntawm cov hauv paus plaub hau.
Laminin-5 activation
Laminin-5 yog lwm qhov tseem ceeb ntawm lub hauv paus membrane, koom nrog hauv kev ua kom cov plaub hau follicle hlwb mus rau cov matrix extracellular.
Biotinoyl Tripeptide-1 txhawb kev sib sau ua ke ntawm kev ua haujlwm trimer los ntawm kev txhawb nqa kev qhia ntawm 3, 3, thiab 2 subunits ntawm Laminin-5.
Cov kev tshawb fawb soj ntsuam tau pom tias tom qab 8 lub lis piam ntawm kev thov hauv zos ntawm 0.5% concentration, qhov tso tawm ntawm Laminin-5 nyob ib ncig ntawm cov hauv paus plaub hau nce 40% thiab cov plaub hau poob los ntawm 28%.
Matrix metalloproteinase (MMP) inhibition
MMP-2 thiab MMP-9 tuaj yeem degrade collagen IV thiab Laminin-5, ua rau hauv qab daus daim nyias nyias.
Biotinoyl Tripeptide-1 txo qhov degradation ntawm lub hauv paus membrane los ntawm downregulating cov noob qhia ntawm MMP-2 / MMP-9.
Cov kev sim tsiaj tau pom tias cov khoom xyaw no tuaj yeem txo MMP-2 kev ua haujlwm nyob ib puag ncig cov hauv paus plaub hau los ntawm 50% thiab ncua cov txheej txheem ntawm cov plaub hau follicle miniaturization.
Cellular theem: Ntau txoj hauv kev tswj ntawm cov plaub hau follicle loj hlob voj voog
Lub voj voog loj hlob ntawm cov hauv paus plaub hau tau muab faib ua theem kev loj hlob (Anagen), theem degeneration (Catagen), thiab theem telogen (Telogen), thiab lawv qhov tsis sib xws yog qhov ua rau cov plaub hau poob. Cov tshuaj no prolongs lub sij hawm loj hlob thiab shortens lub sij hawm so los ntawm cov hauv qab no mechanisms:
Cov noob txiv mis nyob hauv qab ntawm cov hauv paus plaub hau thiab zais ntau yam kev loj hlob (xws li IGF-1, FGF-7) los tswj cov plaub hau follicle.
Biotinoyl Tripeptide-1 txhawb kev hloov pauv ntawm cov qog nqaij hlav dermal papilla los ntawm G1 theem mus rau theem S thiab ua kom cov cell proliferation los ntawm upregulating kev qhia ntawm Cyclin D1 thiab CDK4.
Cov kev sim hauv vitro tau pom tias tom qab 72 teev ntawm kev kho mob nrog qhov concentration ntawm 0.05%, tus naj npawb ntawm dermal papilla hlwb nce 45% thiab tso tawm ntawm IGF-1 nce 30%.
Kev cai ntawm Ki-67 protein qhia
Ki-67 yog ib qho cim protein rau kev loj hlob ntawm tes, thiab nws cov theem qhia qhia txog qib kev ua haujlwm ntawm cov plaub hau follicle hlwb.
Biotinoyl Tripeptideactivates Wnt/ - catenin signaling pathway, upregulates Ki-67 gene expression, thiab txhawb kev sib txawv ntawm cov plaub hau follicle qia hlwb rau hauv cov plaub hau matrix hlwb.
Cov kev tshawb fawb soj ntsuam tau pom tias tom qab 12 lub lis piam ntawm kev thov hauv zos ntawm 0.2% concentration, qhov feem pua ntawm Ki-67 cov hlwb zoo hauv cov tawv taub hau biopsy tau nce los ntawm 15% mus rau 32%, thiab cov plaub hau ceev tau nce 25%.
Inhibition ntawm dihydrotestosterone (DHT) txoj kev
DHT yog tus neeg nruab nrab tseem ceeb ntawm androgenic alopecia (AGA), uas ua rau cov plaub hau luv luv los ntawm kev khi rau androgen receptors (AR).
Biotinoyl Tripeptide-1 blocks DHT kev txiav txim los ntawm cov txheej txheem hauv qab no:
Kev sib tw inhibition ntawm DHT thiab AR binding txo AR mediated gene transcription;
Downregulate qhov kev qhia ntawm 5 - reductase (5 - R) thiab txo qhov hloov pauv ntawm testosterone rau DHT;
Ua kom muaj aromatase, txhawb kev hloov pauv ntawm testosterone rau estradiol, thiab tawm tsam cov nyhuv DHT.
Cov kev sim tsiaj tau pom tias cov khoom xyaw no tuaj yeem txo DHT qib nyob ib puag ncig cov hauv paus plaub hau los ntawm 60%, thiab nce qhov feem pua ntawm cov hauv paus plaub hau thaum lub sij hawm loj hlob ntawm 40% mus rau 65%.
Qib Microenvironment: Optimizing plaub hau follicle khoom noj khoom haus thiab metabolism
Kev noj qab haus huv ntawm cov hauv paus plaub hau nyob ntawm cov ntshav txaus thiab kev sib pauv khoom noj. Cov tshuaj no txhim kho cov plaub hau follicle microenvironment los ntawm cov txheej txheem hauv qab no:
Kev nce qib ntawm Angiogenesis
Cov hlab ntsha nyob ib ncig ntawm cov plaub hau follicle muab cov pa oxygen thiab cov as-ham rau hauv cov follicle, thiab lawv qhov ntom ntom zoo sib cuam tshuam nrog kev ua hauv follicle.
Biotinoyl Tripeptide-1 txhawb nqa endothelial cell proliferation thiab lumen tsim los ntawm upregulating kev qhia ntawm vascular endothelial kev loj hlob yam (VEGF) thiab yooj yim fibroblast loj hlob factor (bFGF).
Cov kev tshawb fawb soj ntsuam tau pom tias tom qab siv hauv zos ntawm 0.3% concentration rau 16 lub lis piam, tawv taub hau microvascular ceev nce 35% thiab cov plaub hau txoj kab uas hla tau nce 12%.
Txhim khu kev tiv thaiv antioxidant
Cov plaub hau follicle hlwb rhiab heev rau oxidative kev nyuaj siab, thiab tsub zuj zuj ntawm reactive oxygen hom (ROS) tuaj yeem ua rau apoptosis ntawm cov plaub hau follicle qia hlwb.
Biotinoyl Tripeptide-1 exerts cov teebmeem antioxidant los ntawm cov txheej txheem hauv qab no:
Txhim kho kev ua haujlwm ntawm superoxide dismutase (SOD) thiab glutathione peroxidase (GPx), thiab tshem tawm ROS;
inhibit qhov kev qhia ntawm NADPH oxidase (NOX) thiab txo ROS tiam;
Ua kom Nrf2/ARE qhia txoj hauv kev los txhawb txoj kev qhia ntawm cov tshuaj antioxidant xws li HO-1 thiab NQO1.
Cov ntaub ntawv sim qhia tau hais tias cov khoom xyaw no tuaj yeem txo qis ROS qib hauv cov plaub hau follicle hlwb los ntawm 50% thiab nce cell ciaj sia taus ntawm 40%.
Lub zog metabolism optimization
Cov plaub hau follicle loj hlob yuav tsum muaj ntau ntawm ATP, thiab mitochondrial tsis ua haujlwm tuaj yeem ua rau cov plaub hau follicle atrophy.
Biotinoyl Tripeptide-1 txhim kho lub zog metabolism los ntawm cov txheej txheem hauv qab no:
Upregulation ntawm kev qhia ntawm peroxisome proliferator activated receptor gamma co activator protein-1 alpha (PGC-1 alpha) txhawb mitochondrial biosynthesis;
Ua kom lub AMPK taw qhia txoj hauv kev, txhim kho fatty acid oxidation thiab qabzib uptake;
Inhibit kev ua kom ntau dhau ntawm mTOR txoj hauv kev kom tsis txhob muaj hluav taws xob pov tseg.
Cov kev sim tsiaj tau pom tias cov khoom xyaw no tuaj yeem nce ATP cov ntsiab lus ntawm cov plaub hau follicle los ntawm 30% thiab cov mitochondrial membrane muaj peev xwm los ntawm 25%.
Daim ntawv thov kev tu plaub hau
Androgenic alopecia (AGA) kev kho mob
AGA yog hom plaub hau poob ntau tshaj plaws thiab zoo sib xws nrog qib siab ntawm DHT. Biotinoyl Tripeptide-1 txhim kho cov tsos mob ntawm AGA los ntawm inhibiting DHT txoj hauv kev thiab txhim kho cov plaub hau follicle.
Kev Kawm Tsim: Ob chav - dig muag, placebo- kev tshawb fawb tswj tau suav nrog 200 tus neeg mob nrog AGA, random muab rau 0.5% Biotinoyl Tripeptide-1 pawg lossis pab pawg placebo, uas tau txais cov tshuaj pleev ib ce ob zaug hauv ib hnub rau 24 lub lis piam.
Cov txiaj ntsig: Cov pab pawg kho mob tau pom qhov nce ntawm 34% ntawm cov plaub hau ntom ntom (vs. pawg placebo, 12%), 15% nce hauv cov plaub hau txoj kab uas hla (vs. pab pawg placebo, 5%), thiab tsis muaj kev cuam tshuam loj heev.
Kev Txhim Kho Ntawm So Cov Plaub Hau Loss (TE)
TE feem ntau tshwm sim los ntawm kev ntxhov siab, kev noj zaub mov tsis txaus, lossis tshuaj noj, thiab tshwm sim raws li cov plaub hau ploj. Biotinoyl Tripeptide-1 accelerates TE rov qab los ntawm kev ncua cov plaub hau follicle thiab txhawb kev loj hlob ntawm tes
Kev Tsim Kho Kev Kawm: Kev kawm qhib daim ntawv lo suav nrog 50 TE cov neeg mob uas tau txais cov tshuaj pleev ib ce ntawm 0.2% Biotinoyl Tripeptide-1 tshuaj ib zaug ib hnub rau 12 lub lis piam.
Qhov tshwm sim: Cov plaub hau poob qis los ntawm 40%, qhov feem pua ntawm cov hauv paus plaub hau thaum lub sij hawm loj hlob tau nce los ntawm 30% mus rau 55%, thiab cov tsos mob ntawm tawv taub hau khaus thiab dryness tau txo qis.
Kev txhawb nqa plaub muag thiab plaub muag
Biotinoyl Tripeptideua tiav thickening thiab loj hlob ntawm cov plaub muag thiab pob muag los ntawm stimulating lub activation ntawm cov plaub hau follicle qia hlwb thiab prolonging lub sij hawm loj hlob.
Kev Kawm Tsim: Ib txoj kev tshawb nrhiav kev tswj xyuas randomized suav nrog 100 tus neeg uas muaj cov plaub muag tsis sib xws, uas tau muab tso rau ntawm 0.3% Biotinoyl Tripeptide-1 pawg lossis pawg minoxidil, thiab siv tshuaj pleev ib ce ib hnub rau 8 lub lis piam.
Qhov tshwm sim: Ob pawg tau pom 40% nce ntawm cov plaub muag ntev, tab sis Biotinoyl Tripeptide-1 pab pawg pom tau tias 35% nce ntawm cov plaub muag ceev (piv rau 25% nce hauv pawg minoxidil), tsis muaj qhov cuam tshuam ntawm daim tawv muag.
Cov lus nug nquag
Biotinoyl tripeptide yog dab tsi?
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Ib qho tripeptide complex nrog biotin - vitamin H, tsim los tiv thaiv cov plaub hau poob, nkoos metabolism ntawm cov plaub hau follicle hlwb, txhawb cov plaub hau thiab plaub muag kev loj hlob. Ua haujlwm los qhib cov ntaub so ntswg kho cov noob qhia.
Puas yog biotinoyl tripeptide-1 zoo ib yam li biotin?
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Biotinoyl tripeptide-1 yog peptide-txhim kho daim ntawv ntawm biotin uas nkag mus rau hauv cov hauv paus plaub hau tob thiab txhawb kev tsim cov keratin. Nws tau raug pov thawj hauv kev kho mob kom cov plaub hau ceev thiab lub zog.
Puas yog biotinoyl tripeptide-1 zoo rau cov plaub hau loj hlob?
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Kev tshawb fawb qhia tias biotinoyl tripeptide-1 zoo inhibits 5 -reductase kev ua, txo DHT ntau lawm thiab yog li txhim kho plaub hau poob.
Cim npe nrov: biotinoyl tripeptide, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom