Tooj liab Truneptide

Tooj liab Truneptide-1, commonly known as GHK-Cu (Glycyl-L-Histidyl-L-Lysine-Copper), is a naturally occurring copper complex with significant biological activity. This article explores its chemical structure, mechanisms of action, and diverse applications in dermatology, regenerative medicine, and anti-aging therapies. Los ntawm kev tshuaj xyuas cov kev tshawb fawb, cov qauv kev lag luam, cov kev txiav txim siab ua lag luam xws li kev sib tw ua lag luam xws li kev sib tw ua haujlwm tau zoo li lub sijhawm muaj kev sib tw ntawm nws lub sijhawm yav tom ntej.

Beftiofur +. coa

Daim Ntawv Pov Thawj Kev Ntsuam Xyuas
Compound npe	Tooj Liab Colleptide Hmoov
Cas tsis .	89030-95-5
Teem nqi	Qib rau Qib Cosmetic
Qho ntau	Me nyuam
Ntim txheem ntim	Me nyuam
Tus tsim	Shaanxi Bloom Tech Co ., LTD
Lot tsis muaj .	20250415001
Mfg	Apr Tim .15} tha2025
Tus txeeb	Apr .15 tha2028
Lub tsev
Yam	Kev Lag Luam Kev Lag Luam	Kev tsom xam tau
Kev tshwm sim	Dawb rau off-dawb	Hloov
Dej Cov Ntsiab Lus	Tsawg dua los yog sib npaug rau 5.0%	0.16%
Cov hlau hnyav	PB tsawg dua lossis sib npaug rau 0.5ppm	N.D.
	Tsawg tsawg dua li lossis sib npaug rau 0.5ppm	N.D.
	Hg tsawg dua lossis sib npaug rau 0.5ppm	N.D.
	CD tsawg dua lossis sib npaug rau 0.5ppm	N.D.
Purity (hplc)	Ntau dua los yog sib npaug rau 99.0%	99.50%
Ib Leeg Cav	<0.8%	0.15%
TAG NRHO LICBIAL COUNT	Tsawg dua li lossis sib npaug rau 750cfu / g	50
E . coli	Tsawg dua los yog sib npaug rau 2mpn / g	N.D.
Tus ntses siav	N.D.	N.D.
Ethanol (los ntawm gc)	Tsawg dua los yog sib npaug rau 5000ppm	300ppm
Chaw ntim khoom	Khaws rau hauv ib lub kaw, tsaus thiab qhuav qhov chaw ntawm 2-8 degrees

► Molecular muaj pes tsawg leeg

GHK-CU muaj cov Glycyl-L-histidyl-L-l-l-l-l-l-l-l-l ion. Tus peptide sequents yog qhov tseem ceeb:

Glycine (g): muab hloov pauv rau peptide caj qaum .

Histidine (h): ua raws li ligand rau tooj liab khi los ntawm nws cov immidazole nplhaib .

Lysine (k): pab txhawb cov nyiaj amino pab pawg, txhim kho solubility .

Cov tooj liab ion yog kev sib koom tes los ntawm cov istrogen, lysine ε-amino pab pawg εino

► Lub cev siv zog thiab tshuaj

Zog

Solubility: dej-soluble ntawm nruab nrab PH; Insoluble hauv cov kuab tshuaj organic .

Ruaj khov: nkag siab pH, kub, thiab lub teeb {. kev ua tsis pom zoo ntawm pH <4, nrog tooj liab cej luam ntawm alkaline cov mob.

Molecular hnyav: ~ 340 da (peptide) + 63.5 da (cu) ~ 403 {}}}}}}}}}}}}}.

► synthesis thiab ruaj khov

GHK-CU yog synthesized los ntawm:

Tshuaj lom neeg synthesis: tau-theem peptide synthesis (SPPS) ntawm GHK, ua raws li los ntawm tooj liab complexation.

Cov hau kev biotechnological: fermentation-fighal ntau lawm siv cov qauv hloov pauv ntawm cov microbes engobes {}}

Cov Tswv Yim Teeb Meem suav nrog:

PT tswj: Kev tswj cov ph 5-7 hauv cov qauv .

Antioxidants: Ntxiv ascorbic acid lossis Edta kom tiv thaiv tooj liab-catalyzed oxidation .

Microencapsulation: Siv Liposomes lossis Nanoparticles los tiv thaiv kev ua tsis taus .

► Kev Kawm Kev Kawm Ntawv 1: Cov kab mob caj dab thiab cov kab zoo

Tus Neeg Mob Profile:

55-} Cov poj niam xyoo nrog Fitzpatrictrick tawv hom II thiab mob periorbital wrinkles.

Cov kev kho yav dhau los: cov tshuaj txhuam rov qab (txob txob) thiab hyaluronic acid cillers (ib ntus tshwm sim) .

Kev pab kho:

Nightly daim ntawv thov ntawm ib 0 {. 3% GHK-CU Derum rau 16 lub lis piam.

Kev ua si thaum sawv ntxov: SPF 50+ pascreen .

Qhov tshwm sim:

Lim tiam 8: Cov neeg mob siab tshaj tawm kev txhim kho hauv cov pa ntawm cov tawv nqaij thiab cov qauv .

Lub lim tiam 16: SCARICIC-tau qhab-nees txo nyob rau hauv wrinkle qhov loj (kev txhim kho kev pom zoo rau kev ua kom zoo nkauj "→ 2) .

Lub Hom Phiaj Ntsuas:

Daim tawv nqaij ntxiv nce los ntawm 25% (CAVTIME ®) .

Dermal collagen ntom txhim kho los ntawm 18% (ultrasound kev yees duab) .

Lub tshuab:
GHK-CU yuav:

Upregulated tgf- los txhawb collagen Kuv thiab III synthesis .

Inhibited Matrix MuamaloprotraProteinase -1 (mmp -1 .

Txhim kho fibroblast prodiferation thiab ECM ntau lawm .

► Kev Kawm Kev Kawm 2: Kev ua kom raug cov tawv nqaij-raug cov tawv nqaij

Tus Neeg Mob Profile:

60-} Cov txiv neej muaj yees muaj kev ua kom zoo nkauj (kev ntxhib los mos, thiab telangiectience) ntawm forearms .

Kev Kho Mob Yav Dhau Los: Tshuaj Peels (Hyperpigmentation Rov Qab) .

Kev pab kho:

Ob zaug ib hnub daim ntawv thov ntawm 0 .} 5% ghk-cu cream rau 24 lub lis piam.

Kev zam ntawm lub hnub kis thaum peak teev .

Qhov tshwm sim:

Lim tiam 12: Daim tawv nqaij ntxhib los mos; dyspigmentation txo los ntawm 30% (visia® tsom) .

Lim tiam 24: 40% kev txhim kho hauv cov tawv nqaij roughness (dermatop®) .

Cov kws tshawb nrhiav keeb kwm:

Nce cov epidermal tuab (15% vs .}} .

Txo hnub ci elastosis (verified ntawm biopsy) .

Lub tshuab:
GHK-CU yuav muaj:

Primulated keratinocyte proliferation kom thicken lub ovidermis .

Txo cov oxidative oxidative kev nyuaj siab ntawm tooj liab-nyob ntawm Superoxide SuperSroxide dismutase (Sod) kev ua si .

Downregulated pro-inflammatory cytokines (e {{1} g {}}}} {.

Mineation Kev Kawm 3: Post-Acne Antrophic Scars

Tus Neeg Mob Profile:

{28-} tus poj niam xyoo nrog mob rolling nti rau ntawm lub puab tsaig vim cystic pob txuv {}}

Kev khomob yav dhau los: microneedling (peb ntu) nrog kev txhim kho tsawg kawg .

Kev pab kho:

Kev Kho Mob:

Microneedling (1 {. mm ks 5 mm can) ua raws los ntawm kev tshaj tawm 0.5% GHK-CU Ntshav Qab Zib.

Kev thov ib hnub txhua hnub ntawm GHK-CU cream rau 12 lub lis piam .

Qhov tshwm sim:

Lim tiam 6: Caws pliav tob txo los ntawm 25% (ultrasound) .

Lim tiam 12: 40% txhim kho hauv kev pom kev pom kev hauv kev pom kev pom kev zoo (Goodman & Baron nplai: 3 → 2) .

Tus Neeg Mob Cov Lus Qhia: Muaj kev ntseeg siab ntxiv; tsis muaj ncej-inflammatory hyperpigmentation (pih) .

Lub tshuab:

Micrhoneedling Enhanced GHK-CU nkag mus, stimulating collagen thiab elastin ntau.

GHK-CU's Anti-inflammatory cuam tshuam txo erythema thiab o cov txheej txheem .

Phau ntawv: Kim thiab Al . (2020),Kev phais dermatologic.

Mineation Kev Kawm 4: Kev phais mob Pos-cappertrophic nti

Tus Neeg Mob Profile:

{{040-} Cov txiv neej muaj txiv neej nrog6- lub hlis hypertrophic caws pliav tom qab lub siab phais mob.}}

Cov Kev Kho Mob Yav dhau los: Silicone Gel Cov Ntawv (Kev Txhim Kho Ib nrab) .

Kev pab kho:

Intralesional txhaj tshuaj ntawm 0 {. 1% GHK-CU daws (0.5 ml) txhua 2 lub lis piam rau 8 lub lis piam.

Cov ntsiab lus ghok-cu gel thov txhua hnub .

Qhov tshwm sim:

Lim tiam 4: Caws pliav soften thiab txo qis erythema .

Lim tiam 8: 50% txo qis hauv caws pliav siab (ntsuas ntawm calipers) .

Vancouver Infarnal (VSS): Txo los ntawm 7 rau 3.

Lub tshuab:
GHK-CU yuav:

Inhibited tgf - 1} kom txo fibroobblast overactivity inactivity.

Txhawb nqa apoptosis ntawm myofibblasts los tiv thaiv kom tsis txhob muaj ECM Deposition .

Txhim kho angiogenesis kom txhim kho cawsxgenation .

Mine Kev Kawm Ntawv 9: Kev tawm tsam tsis zoo hauv cov tawv nqaij rhiab

Tus Neeg Mob Profile:

{40- Tus txiv neej laus nrog Seborrheic Dermatitis thiab keeb kwm ntawm cov tshuaj tsw qab thiab yog keeb kwm ntawm.

Pib 0 {{. 3% GHK-CU Ntshav Qab Rau Kev Laus.

Kev pab kho:

Kev thov ntshav qab zib hmo rau 10 hnub .

Qhov tshwm sim:

Hnub 5: Tsim erythema thiab scaling rau sab plhu .

PATE TEST: Qhov tshwm sim zoo rau GHK-CU (tab sis tsis yog tsheb ib leeg) .

Kev tswj:

Txiav txiav txim; Cov tsos mob daws nrog cov ntsiab lus ntsiab lus calcineurin inhibitors .

Tag:
Thaum tsis tshua muaj, GHK-CU tuaj yeem ua rau cov neeg tsis txaus siab lossis tawv nqaij .}}}}}}}}}}}}

► Kev kawm Kev Kawm 10: Siv sijhawm ntev hauv cov tawv nqaij hauv cov tawv nqaij ntev

Tus Neeg Mob Profile:

{50-} Cov poj niam xyoo nrog tus mob sab caj dab tsis txaus thiab cov ceg muaj txhab nyiaj rov qab.

Kho nrog 0 {. 5% ghk-cu gel rau 12 lub hlis.

Kev pab kho:

Kev thov ib hnub ntawm GHK-CU gel rau cov tshuaj kho mob .

Qhov tshwm sim:

Tsis muaj cov xwm txheej tsis zoo (e {{{. g}!, Tooj liab toysfunction) .

Kev Dag Zog Hauv Cheeb Tsam: Me Pruritus hauv thawj lub hli, daws nrog emollient siv .

Tag:
Lub sijhawm ntevh GHK-CU siv zoo li muaj kev nyab xeeb thaum ua tiav, nrog tsawg kawg kev pheej hmoo ntawm tooj liab accelulation {2 2}}

Cov kev tshawb fawb tau nthuav tawm GHK-Cu cov lus qhia txog kev ua kom zoo dua qub nrog kev kho cov plaub hau kom rov qab ua rau kev hloov kho cov plaub hau kom rov ua kom muaj kev sib tw kom rov ua kom muaj kev ruaj khov, tus neeg mob ua ntej, tus neeg mob ua ntej, thiab kev sib tw yuav tsum raug hais kom ua kom tiav nws lub chaw kuaj mob .

Raws li kev tshawb fawb nce zuj zus thiab thev naus laus zis, GHK-CU yog cov tshuaj sib koom tes zoo, cov plaub hau kev txhim kho, thiab cov ntaub so ntswg kom muaj peev xwm hloov kho tag nrho {}}

Cim npe nrov: Tooj liab Truneptide, cov chaw muag khoom, chaw tsim khoom, Hoobkas, lag luam wholesale, yuav, nqe, loj, loj, rau muag